CN1669571A - Chinese traditional medicine for treating enteritis and appendicitis, and method for preparing same - Google Patents
Chinese traditional medicine for treating enteritis and appendicitis, and method for preparing same Download PDFInfo
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Abstract
The invention relates to a Chinese traditional medicine for treating enteritis and appendicitis, and method for preparation, wherein the preparing process comprises charging astragalus root, pilose asiabell root, honeysuckle flower, radix paeoniae rubrathe, root of herbaceous peony, capsule of weeping forsythia, pangolin scales, Chinese honeylocust spine, extractum glycyrrhizae liquidum into water and boiling, concentrating the concentrated liquid, charging Chinese angelica root, cassia twig, Ligusticum wallichii, root of red rooted saliva, bark of peony root into ethanol for backflow extraction, filtrating, merging the soup, reclaiming ethanol, merging with the concentration liquid, charging sodium benzoate, charging distilled water and mixing.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation method thereof, be specifically related to a kind of treatment enteritis, typhlitic Chinese medicine and preparation method thereof.
Background technology
" acute appendicitis " is tcm clinical practice commonly encountered diseases and frequently-occurring disease, enteritis and acute and chronic appendicitis all belong to the traditional Chinese medical science " acute appendicitis " scope, due to the causes of disease such as how smooth, Enterozoa by eating and drinking without temperance, cold-damp discomfort, overstrain, feelings will, be one of the most common clinically acute abdomen, have 85% patient to betide 10-40 between year approximately.Though generally adopt the excision vermiform appendix to treat clinically for acute appendicitis, operative treatment can bring wound and misery to patient, and rehabilitation is slower, also need higher expense.Chronic appendicitis has clinically to be used oral or injection anti-inflammatory type medicine is treated, but still can not control chronic inflammatory disease sometimes, can not get radical cure.Have clinically with Chinese medicine at present and carry out the non-operative treatment acute appendicitis, but the reason therapeutic effect of filling a prescription because of its component is also unsatisfactory.
Summary of the invention
The objective of the invention is at treating enteritis, appendicitis weak point at present clinically, a kind of have heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation invigorating efficacies are provided, the oral administration safety height, therapeutic effect is good, method is simple, need not perform the operation the patient no pain, medical expense is low, is applicable to extensive crowd's treatment enteritis, typhlitic Chinese medicine and preparation method thereof.
Technical scheme of the present invention is:
A kind of treatment enteritis, typhlitic Chinese medicine is characterized in that being made by following Chinese medicine raw materials by weight proportion:
Flos Lonicerae 30～70 Radixs Astragali 30～70 Radix Paeoniae Rubra 30～70 Fructus Forsythiaes 20～50
Radix Codonopsis 30～70 Radix Angelicae Sinensis 30～70 Radix Salviae Miltiorrhizaes 30～70 Radix Paeoniae Albas 30～70
Cortex Moutan 20～50 Squama Maniss 5～25 Ramulus Cinnamomi 5～30 Rhizoma Chuanxiongs 5～30
Spina Gleditsiae 5～30 Radix Glycyrrhizaes 5～25.
Described treatment enteritis, typhlitic Chinese medicine is characterized in that the weight proportion of its each component is:
Flos Lonicerae 40～60 Radixs Astragali 40～60 Radix Paeoniae Rubra 40～60 Fructus Forsythiaes 30～40
Radix Codonopsis 40～60 Radix Angelicae Sinensis 40～60 Radix Salviae Miltiorrhizaes 40～60 Radix Paeoniae Albas 40～60
Cortex Moutan 30～40 armour-piercings 12～22 Ramulus Cinnamomi 10～20 Rhizoma Chuanxiongs 10～20
Spina Gleditsiae 10～20 Radix Glycyrrhizaes 10～15.
Described treatment enteritis, typhlitic Chinese medicine is characterized in that the weight proportion of its each component is:
Flos Lonicerae 50 Radixs Astragali 50 Radix Paeoniae Rubra 50 Fructus Forsythiaes 37.5
Radix Codonopsis 50 Radix Angelicae Sinensis 50 Radix Salviae Miltiorrhizaes 50 Radix Paeoniae Albas 50
Cortex Moutan 37.5 Squama Maniss 16.7 Ramulus Cinnamomi 15 Rhizoma Chuanxiongs 15
Spina Gleditsiae 15 Radix Glycyrrhizaes 13.3.
Described treatment enteritis, typhlitic preparation method of Chinese medicine is characterized in that getting the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Chinese medicine of licorice root and decoct with water, and extract concentrated solution; Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Cortex Moutan got after the decoction add alcohol reflux again, collect filtrate, merge with concentrated solution, add sodium benzoate, adding distil water furnishing oral liquid state; Or merge with concentrated solution, continue to be concentrated into clear paste or spray drying, make graininess.
Described treatment enteritis, typhlitic preparation method of Chinese medicine, it is characterized in that getting the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Radix Glycyrrhizae and decoct with water 2～4 times, each 0.5～1.5 hour, filter, filtrate merges, be concentrated into relative density 0.9～1.15, add ethanol and make and contain the alcohol amount and reach 60～80%, stir evenly, left standstill 20～26 hours, filter filtrate recycling ethanol, concentrated solution relative density 1.15～1.20; Other gets Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Cortex Moutan and adds 70～80% alcohol reflux 2～4 times, each 0.5～1.5 hour, filters, filtrate merges, and reclaims ethanol, merges with above-mentioned concentrated solution, add sodium benzoate 2.5～3.5g, adding distil water transfers to 1000ml and becomes oral liquid.
Described treatment enteritis, typhlitic preparation method of Chinese medicine, it is characterized in that getting the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Radix Glycyrrhizae and decoct with water 2～4 times, each 0.5～1.5 hour, filter, filtrate merges, be concentrated into relative density 0.9～1.15, add ethanol and make and contain the alcohol amount and reach 60～80%, stir evenly, left standstill 20～26 hours, filter filtrate recycling ethanol, concentrated solution relative density 1.15～1.20; Other gets Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Cortex Moutan and adds 70～80% alcohol reflux 2～4 times, each 0.5～1.5 hour, filter, filtrate merges, and reclaims ethanol, merge with above-mentioned concentrated solution, continue to be concentrated into clear paste (relative density 1.25～1.35,60 ℃ of heat are surveyed), 1 part of qinghuo reagent, 2.5 parts in dextrin, stevioside 1% are made granule; Or 1 part of qinghuo reagent, 2.5 parts of soluble starches, stevioside 1% are made granule; Or continuing to be concentrated into relative density 1.10～1.18 (50～80 ℃ heat survey), spray drying is got 1 part of dry extract, lactose is made granule for 1～3 part.
The selected medicine of the present invention by monarch, minister, help, make the principles of formulating prescriptions to carry out compatibility.With Flos Lonicerae, Radix Paeoniae Rubra, Radix Astragali is monarch drug: the Flos Lonicerae sweet in the mouth is cold in nature, and function is a heat-clearing and toxic substances removing, and the carbuncle of loosing detumescence is for controlling the key medicine of all carbuncle furuncle sun diseases, single using promptly effectively; Radix Paeoniae Rubra bitter in the mouth cold nature, the function clearing away heat and cooling blood, eliminating stasis to stop pain is apt to away blood system, and the effect of invigorating blood circulation is stronger, and with controlling carbuncle sore tumefacting virus, normal and Flos Lonicerae, Fructus Forsythiae are used together; Radix Astragali sweet in the mouth slightly warm in nature, function tonifying Qi and lifting yang, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.More than three medicines all at primary symptom, play a leading role.Fructus Forsythiae bitter in the mouth cold nature, the function heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation can be assisted the monarch drug Flos Lonicerae, and the title of " persons particularly liable to develop skin infection's panacea " is arranged; Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Cortex Moutan all can blood circulation promoting and blood stasis dispelling, and wherein Radix Angelicae Sinensis still has the merit of enriching blood, and Radix Salviae Miltiorrhizae bitter in the mouth cold nature can blood circulation promoting and blood stasis dispelling, the removing heat from blood eliminating carbuncle, and the treatment acute appendicitis is swollen, often joins Flos Lonicerae, Fructus Forsythiae is equal to usefulness; Cortex Moutan function and Radix Paeoniae Rubra are quite similar, can invigorate blood circulation and can removing heat from blood the kind abdominalgia with intestinal abscess of controlling; The Radix Codonopsis sweet in the mouth is flat, and the energy invigorating the spleen and replenishing QI assists Radix Astragali QI invigorating to set upright.The above five tastes all can assist monarch drug at main symptom, are the present invention's ministerial drug.Radix Paeoniae Alba bitter in the mouth, acid, sweet, cold nature, yin fluid astringing, easing the affected liver to relieve pain can nourish blood.The hot temperature of Ramulus Cinnamomi, energy promoting the flow of QI-blood by warming the meridian, supporing yang activating QI; Rhizoma Chuanxiong is a gas medicine in the blood, energy promoting flow of QI and blood, wind-expelling pain-stopping; Spina Gleditsiae and Squama Manis are the traditional Chinese medical science eliminating carbuncle of invigorating blood circulation commonly used, the product of detumescence and apocenosis.The above five tastes are all assisted monarch drug and ministerial drug from different aspects, and at multiple accompanied symptoms, play the adjuvant drug effect.The Radix Glycyrrhizae sweet in the mouth is good at concocting all medicines, gives birth to the energy eliminating fire and detoxication, plays the messenger drug effect.
For confirming curative effect and be used for the treatment of enteritis, appendicitis acute attack person clinically, carried out based on antiinflammatory, analgesic, pain relieving, antibacterial and immune pharmacodynamics test in conjunction with it:
Utilize mice and rabbit to carry out based on antiinflammatory, antipyretic analgesic, antibacterial and immune pharmacodynamics test, the result is as follows: mice dosage calculates by 1/20,1/40 and 1/80 of maximum tolerated dose of the present invention, is respectively 10g/kg, 5g/kg, 2.5g/kg; Be respectively 7g/kg, 3.5g/kg and 1.75g/kg by the body surface area conversion for the dosage of rat; The dosage of rabbit is pressed LD
501/40 and 1/80, be respectively 3.7g/kg and 1.85g/kg.Experiment shows: it is swollen that the present invention can suppress the mouse ear that chondrus ocellatus Holmes causes that rat paw is swollen and Oleum Tiglii causes significantly, shows tangible antiinflammatory action; Improve nonspecific immunity and humoral immune function, immunoreation does not have influence to delayed; Improve chemistry and physics method and cause the threshold of pain bitterly, tool pain relieving effect; Also suppress the fever in rabbits reaction that defatted milk powder causes, the blood viscosity that prolongs clotting time and reduction normal rat proves its effect of invigorating blood circulation.The result shows: the present invention has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation invigorating efficacies
The present invention is to the acute toxicity test of mice:
Get 20 of 18-22g mices, male and female half and half, in disposable gastric infusion at 8 o'clock in the morning, the administration capacity is 0.4ml/10g (being equivalent to 200g/kg) with medicinal liquid of the present invention, observes continuously 7 days, record mouse toxicity reaction and death toll day by day, experimental result shows, to after the mice perfusion, hypokinesia at first occurs, very fast recovery is normal, no animal dead phenomenon.Give mouse stomach administration 200g/kg, calculate by kg body weight, consumption (100g every day is equivalent to be grown up, be equivalent to 1.43g/kg) 140 times, press system number conversion, be equivalent to more than 15 times of 70kg adult consumption every day, then animal is dead in a week, shows its LD
50Must be greater than 200g/kg.Its result shows the maximum tolerated dose of mice administration more than 200g/kg, and oral administration is very safe.Prove that oral administration safety of the present invention is very big.
The present invention is to the long term toxicity test of rat:
Get the wistar rat and select two dosage groups for use, be respectively 75g/kg and 22.5g/kg (be equivalent to be grown up clinical consumption 45 times and 13.5 times), select distilled water blank group simultaneously for use.Because clinical application amount of the present invention is bigger, concentrate back (5g crude drug/ml) give the volume of rat gastric infusion still bigger, the multiple of toxicity test is difficult to improve, according to the pertinent regulations in " new Chinese medicine preclinical study guide ", with maximum concentration, maximum filling body of stomach is long-pending irritates stomach to rat, gastric infusion is 7 days weekly, and continuous 4 weeks are after the condition raising, each rat well-grown, activity freely, hair color is glossy, diet and urine all normal, stool is pitch color (may be medicine color due to), tangible toxic reaction is not found in body weight natural increase, animal dead also do not occur.The blood routine of each rat, blood parameters are all in normal range, and important organ histopathologic examination does not find tangible toxic lesion.
In sum, the present invention has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation invigorating efficacies, and the oral administration safety height is used for the treatment of enteritis, the appendicitis therapeutic effect is good, and method is simple, need not perform the operation, and the patient no pain, medical expense is low, is easy to extensively be suitable for.
The specific embodiment
Take by weighing Chinese medicine (g of unit) by following prescription:
Flos Lonicerae 50 Radixs Astragali 50 Radix Paeoniae Rubra 50 Fructus Forsythiaes 37.5
Radix Codonopsis 50 Radix Angelicae Sinensis 50 Radix Salviae Miltiorrhizaes 50 Radix Paeoniae Albas 50
Cortex Moutan 37.5 Squama Maniss 16.7 Ramulus Cinnamomi 15 Rhizoma Chuanxiongs 15
Spina Gleditsiae 15 Radix Glycyrrhizaes 13.3.
Preparation method one: select the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Radix Glycyrrhizae decocts with water 3 times, each 1 hour, filters, filtrate merges, be concentrated into relative density 1.10～1.15,60 ℃ of heat are surveyed, and add ethanol and make and contain the alcohol amount and reach 70%, stir evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, concentrated solution is equipped with a month (relative density 1.15-1.20,60 ℃ of heat are surveyed), other gets Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Cortex Moutan adds 75% alcohol reflux 3 times, each 1 hour, filter, filtrate merges, and reclaims ethanol, merges with above-mentioned dope, add sodium benzoate 3g, adding distil water transfers to 1000ml and becomes oral liquid.
Preparation method two: select the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Radix Glycyrrhizae decocts with water 3 times, each 1 hour, filter, filtrate merges, and is concentrated into relative density 1.10～1.15,60 ℃ of heat are surveyed, add ethanol and make and contain the alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol, concentrated solution standby (relative density 1.15-1.20,60 ℃ of heat are surveyed), other gets Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, it is each 1 hour that Cortex Moutan adds 75% alcohol reflux 3 times, filter, filtrate merges, and reclaims ethanol, merge with above-mentioned dope, continue to be concentrated into clear paste (relative density 1.25～1.35,60 ℃ of heat are surveyed), 1 part of qinghuo reagent, 2.5 parts in dextrin, stevioside 1% is made granule; Or 1 part of qinghuo reagent, 2.5 parts of soluble starches, stevioside 1% are made granule; Or continuing to be concentrated into relative density 1.10～1.18 (50～80 ℃ heat survey), spray drying is got 1 part of dry extract, lactose is made granule for 1～3 part.
Claims (6)
1, a kind of treatment enteritis, typhlitic Chinese medicine is characterized in that being made by following Chinese medicine raw materials by weight proportion:
Flos Lonicerae 30～70 Radixs Astragali 30～70 Radix Paeoniae Rubra 30～70 Fructus Forsythiaes 20～50
Radix Codonopsis 30～70 Radix Angelicae Sinensis 30～70 Radix Salviae Miltiorrhizaes 30～70 Radix Paeoniae Albas 30～70
Cortex Moutan 20～50 Squama Maniss 5～25 Ramulus Cinnamomi 5～30 Rhizoma Chuanxiongs 5～30
Spina Gleditsiae 5～30 Radix Glycyrrhizaes 5～25.
2, treatment enteritis according to claim 1, typhlitic Chinese medicine is characterized in that the weight proportion of its each component is:
Flos Lonicerae 40～60 Radixs Astragali 40～60 Radix Paeoniae Rubra 40～60 Fructus Forsythiaes 30～40
Radix Codonopsis 40～60 Radix Angelicae Sinensis 40～60 Radix Salviae Miltiorrhizaes 40～60 Radix Paeoniae Albas 40～60
Cortex Moutan 30～40 Squama Maniss 12～22 Ramulus Cinnamomi 10～20 Rhizoma Chuanxiongs 10～20
Spina Gleditsiae 10～20 Radix Glycyrrhizaes 10～15.
3, treatment enteritis according to claim 1, typhlitic Chinese medicine is characterized in that the weight proportion of its each component is:
Flos Lonicerae 50 Radixs Astragali 50 Radix Paeoniae Rubra 50 Fructus Forsythiaes 37.5
Radix Codonopsis 50 Radix Angelicae Sinensis 50 Radix Salviae Miltiorrhizaes 50 Radix Paeoniae Albas 50
Cortex Moutan 37.5 Squama Maniss 16.7 Ramulus Cinnamomi 15 Rhizoma Chuanxiongs 15
Spina Gleditsiae 15 Radix Glycyrrhizaes 13.3.
4, treatment enteritis according to claim 1, typhlitic preparation method of Chinese medicine is characterized in that getting the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Chinese medicine of licorice root and decoct with water, and extract concentrated solution; Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Cortex Moutan got after the decoction add alcohol reflux again, collect filtrate, merge with concentrated solution, add sodium benzoate, adding distil water furnishing oral liquid state; Or merge with concentrated solution, continue to be concentrated into clear paste or spray drying, make graininess.
5, treatment enteritis according to claim 1, typhlitic preparation method of Chinese medicine, it is characterized in that getting the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Radix Glycyrrhizae and decoct with water 2～4 times, each 0.5～1.5 hour, filter, filtrate merges, be concentrated into relative density 0.9～1.15, add ethanol and make and contain the alcohol amount and reach 60～80%, stir evenly, left standstill 20～26 hours, filter filtrate recycling ethanol, concentrated solution relative density 1.15～1.20; Other gets Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Cortex Moutan and adds 70～80% alcohol reflux 2～4 times, each 0.5～1.5 hour, filters, filtrate merges, and reclaims ethanol, merges with above-mentioned concentrated solution, add sodium benzoate 2.5～3.5g, adding distil water transfers to 1000ml and becomes oral liquid.
6, treatment enteritis according to claim 1, typhlitic preparation method of Chinese medicine, it is characterized in that getting the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Forsythiae, Squama Manis, Spina Gleditsiae, Radix Glycyrrhizae and decoct with water 2～4 times, each 0.5～1.5 hour, filter, filtrate merges, be concentrated into relative density 0.9～1.15, add ethanol and make and contain the alcohol amount and reach 60～80%, stir evenly, left standstill 20～26 hours, filter filtrate recycling ethanol, concentrated solution relative density 1.15～1.20; Other gets Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Cortex Moutan and adds 70～80% alcohol reflux 2～4 times, each 0.5～1.5 hour, filter, filtrate merges, and reclaims ethanol, merge with above-mentioned concentrated solution, continue to be concentrated into clear paste (relative density 1.25～1.35,60 ℃ of heat are surveyed), 1 part of qinghuo reagent, 2.5 parts in dextrin, stevioside 1% are made granule; Or 1 part of qinghuo reagent, 2.5 parts of soluble starches, stevioside 1% are made granule; Or continuing to be concentrated into relative density 1.10～1.18 (50～80 ℃ heat survey), spray drying is got 1 part of dry extract, lactose is made granule for 1～3 part.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101780253A (en) * | 2010-02-28 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine compound for treating intestinal abscess and preparation method thereof |
| CN101361927B (en) * | 2008-09-26 | 2010-11-03 | 陈其仁 | Medicine combination for treating intestinal catarrh |
| CN105327223A (en) * | 2015-11-30 | 2016-02-17 | 刘双英 | Chinese and Western medicine for treating appendicitis and preparation method thereof |
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| CN107595974A (en) * | 2017-10-19 | 2018-01-19 | 张泽钧 | A kind of Chinese medicine for treating acute simple appendicitis |
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| CN1092996A (en) * | 1992-11-06 | 1994-10-05 | 王琳辉 | A kind of medicine for the treatment of colitis |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361927B (en) * | 2008-09-26 | 2010-11-03 | 陈其仁 | Medicine combination for treating intestinal catarrh |
| CN101780253A (en) * | 2010-02-28 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine compound for treating intestinal abscess and preparation method thereof |
| CN101780253B (en) * | 2010-02-28 | 2011-04-06 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine compound for treating intestinal abscess and preparation method thereof |
| CN106389798A (en) * | 2015-07-30 | 2017-02-15 | 天明制药股份有限公司 | Extraction method of spina date seed decoction and poria, largehead atractylodes rhizome and rhizoma glycyrrhizae decoction prescription |
| CN105327223A (en) * | 2015-11-30 | 2016-02-17 | 刘双英 | Chinese and Western medicine for treating appendicitis and preparation method thereof |
| CN107595974A (en) * | 2017-10-19 | 2018-01-19 | 张泽钧 | A kind of Chinese medicine for treating acute simple appendicitis |
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