CN1686187A - 小儿清肺化痰泡腾颗粒及其制法 - Google Patents
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Abstract
小儿清肺化痰泡腾颗粒，属于以中草药配制的治疗肺热感冒的药物。它由原料药和辅料制成，原料药的重量比为：麻黄90、前胡225、黄芩225、紫苏子225、石膏675、苦杏仁225、葶苈子279、竹茹225；药物混合物与辅料的质量配比为：药物混合物10％～80％，辅料20％～90％。其制法为：按比例取上述药材，先加水煎煮石膏，再加其余的7味药煎煮数次，合并煎液，滤过，滤液浓缩；加乙醇，搅拌均匀，然后静置，滤过，滤液回收乙醇；接着将溶液浓缩成流浸膏；最后分为两份，一份加入酸性辅料，另一份加入碱性辅料，搅拌均匀，制粒，干燥，过筛，即制得。本品具有良好的发汗解表、消里退热功效，服用安全、有效、方便，稳定性良好。
Description
技术领域
本发明属于一种治疗肺热感冒的药物，具体而言属于以中草药为原料配制的泡腾颗粒剂。
背景技术
小儿肺热感冒是婴幼儿常见的呼吸道疾病，常有呼吸气促、咳嗽痰喘、喉中作响等症状。肺热感冒会影响患者的生活和正常发育。数千年来我国在治疗外感发热病症方面，积累了丰富的经验，传统的中医和草医有许多方剂。市售的“小儿清肺化痰口服液”就是其中一个品种。近年有一些用于退热的中草药配方申请了发明专利，例如95106240.9号“退热口服液”、00121310.5号“一种退热药物及其制备方法”、02159199.7号“一种小儿退热药物”、2004100040659.6“小儿柴桂退热泡腾颗粒及其制法”等。
上述的种种治疗肺热感冒的药剂，均有一定效果。但医生们仍然在探索更好的药方，以尽快减轻患者痛苦、恢复病人健康。
发明内容
本发明的目的就在于提供一种采用中药为原料制成的治疗肺热感冒的泡腾颗粒剂，使小儿患者可以在更短时间内，症状得以缓解并消失。
本发明的解决方案是基于市售的“小儿清肺化痰口服液”，参考发明人的医疗实践经验，为方便婴幼儿患者服用推出的新剂型。
本发明的小儿清肺化痰泡腾颗粒是由原料药和辅料制成的，其中原料药的组分及其用量(用量为重量份)如下：
麻黄90 前胡225 黄芩225 紫苏子225 石膏675
苦杏仁225 葶苈子279 竹茹225
上述药物的混合物与辅料的质量配比为：
药物混合物 10％～80％，
辅料 20％～90％
其中的辅料可以是酸性辅料，包括枸橼酸、酒石酸、磷酸二氢钠、焦磷酸二氢二钠、亚硫酸氢钠等，以及碱性辅料，包括碳酸氢钠、碳酸钠、碳酸氢钾、甘氨酸碳酸钠、倍半碳酸钠等；还需加入填充剂可溶淀粉、蔗糖粉。
所用酸性辅料和碱性辅料的质量配比为：
酸性辅料 40％～50％
碱性辅料 50％～60％。
上述中草药中，麻黄(Ephedra sinica)，性温、味辛苦，有发汗、平喘、利水的作用，可治发热恶寒、头痛鼻塞、咳嗽气喘(见江苏新医学院编《中药大辞典》2221页)；前胡(Peucedanum praeruptorum)，性凉，味苦辛，有宣散风热、下气、消痰的作用，可治风热头痛、痰热咳嗽(见《中药大辞典》1723页)；黄芩(Scutellaria baicalensis)，性寒、味苦，有清热燥湿、泻火解毒、凉血除热的功效，可治壮热烦渴、肺热咳嗽(见《中药大辞典》2017页)；紫苏子，是紫苏(Purilla frutescens)的种子，味辛、性温，有消痰、润肺的作用，可治咳逆、痰喘、气滞(见《中药大辞典》2355页)；苦杏仁，即杏仁，是杏(Prunus armeniaca)的干燥种子，性温、味苦，有祛痰止咳、平喘的功效，可治外感咳嗽、喘满、喉痹(见《中药大辞典》1100页)；石膏(Cypsum)，性寒、味辛甘，有解肌清热、除烦止渴的功效，可治壮热不退、心烦神昏(见《中药大辞典592页)；葶苈子(Lepidiumapetalum)，性寒、味辛苦，有下气行水的功效，可治肺壅喘急、痰饮咳嗽(见《中药大辞典》2319页)；竹茹(Phyllostachys nigra)，性凉、味甘，有清热凉血的功效，可烦热呕吐、痰热咳喘(见《中药大辞典)》900页)。
本发明的小儿清肺化痰泡腾颗粒的制备方法为：按比例取麻黄、前胡、黄芩、紫苏子、石膏、苦杏仁、葶苈子、竹茹8味药材，先将石膏加水煎煮0.5～2.0小时后，再加其余的麻黄等7味药煎煮1～5次，每次0.5～3.0小时；合并煎液，滤过，滤液浓缩至相对密度为1.0～1.5(50℃)的浸膏；加乙醇使含醇量达50％～90％，搅拌均匀，然后静置12～96小时；滤过，滤液回收乙醇至无醇未为止；接着将水溶液浓缩成流浸膏；最后分为两份，一份加入酸性辅料，另一份加入碱性辅料，然后搅拌均匀，制粒，干燥，过筛，检验合格后装袋，即制得小儿清肺化痰泡腾颗粒。
以上制法的优选工艺条件为：石膏加水煎煮1.0小时；加其余的麻黄等7味药煎煮2次，每次1.0小时；浓缩至相对密度为1.18～1.22(50℃)的浸膏；加乙醇使含醇量达70％；静置48小时。酸性辅料选用枸橼酸较好，碱性辅料选用碳酸氢钠为最好。
本发明的小儿清肺化痰泡腾颗粒是基于市售的小儿清肺化痰口服液，由贵阳高新瑞得科技开发有限公司进一步研制而成的，它具有良好的发汗解表、消里退热功效。临床上用于婴幼儿外感发热，主治发热、头痛身痛、流涕、口渴、咽红、苔黄、便于等症。本品服用安全、有效、方便，药物稳定性良好。该药在临床已取得良好的疗效。
具体实施方式
实施例 按以下方法制备小儿清肺化痰泡腾颗粒：
按比例取麻黄90g、前胡225g、黄芩225g、紫苏子225g、石膏675g、苦杏仁225g、葶苈子279g、竹茹225g共8味药材，先将石膏加水煎煮1.0小时后，再加其余的麻黄等7味药煎煮2次，每次1.0小时；合并煎液，滤过，滤液浓缩至相对密度为1.20(50℃)的浸膏；加乙醇使含醇量达70％，搅拌均匀，然后静置48小时；滤过，滤液回收乙醇至无醇未为止；接着将水溶液浓缩成流浸膏；最后分为两份，一份加入酸性辅料枸橼酸，另一份加入碱性辅料碳酸氢钠，然后搅拌均匀，制粒，干燥，过筛，检验合格后装袋，即制得小儿清肺化痰泡腾颗粒。
Claims (5)
1 小儿清肺化痰泡腾颗粒，由原料药和辅料制成，其特征在于原料药的重量比如下：
麻黄90 前胡225 黄芩225 紫苏子225 石膏675
苦杏仁225 葶苈子279 竹茹225
上述药物的混合物与辅料的质量配比为：
药物混合物 10％～80％，
辅料 20％～90％。
2 按照权利要求1所述的小儿清肺化痰泡腾颗粒，其特征在于其中的辅料可以是酸性辅料，包括枸橼酸、酒石酸、磷酸二氢钠、焦磷酸二氢二钠、亚硫酸氢钠等，以及碱性辅料，包括碳酸氢钠、碳酸钠、碳酸氢钾、甘氨酸碳酸钠、倍半碳酸钠等；再加入填充剂可溶淀粉、蔗糖粉。
3 按照权利要求1或2所述的小儿清肺化痰泡腾颗粒，其特征在于所用酸性辅料和碱性辅料的质量配比为：
酸性辅料 40％～50％
碱性辅料 50％～60％。
4 按照权利要求1所述的小儿清肺化痰泡腾颗粒的制法，其特征为：按比例取麻黄、前胡、黄芩、紫苏子、石膏、苦杏仁、葶苈子、竹茹8味药材，先将石膏加水煎煮0.5～2.0小时后，再加其余的麻黄等7味药煎煮1～5次，每次0.5～3.0小时；合并煎液，滤过，滤液浓缩至相对密度为1.0～1.5(50℃)的浸膏；加乙醇使含醇量达50％～90％，搅拌均匀，然后静置12～96小时；滤过，滤液回收乙醇至无醇未为止；接着将水溶液浓缩成流浸膏；最后分为两份，一份加入酸性辅料，另一份加入碱性辅料，然后搅拌均匀，制粒，干燥，过筛，检验合格后装袋，即制得小儿清肺化痰泡腾颗粒。
5 按照权利要求4所述的小儿清肺化痰泡腾颗粒的制法，其特征在于以上制法的优选工艺条件为：石膏加水煎煮1.0小时；加其余的麻黄等7味药煎煮2次，每次1.0小时；浓缩至相对密度为1.18～1.22(50℃)的浸膏；加乙醇使含醇量达70％；静置48小时；酸性辅料选用枸橼酸较好，碱性辅料选用碳酸氢钠为最好。
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