CN107280005A - Sustained-release dropping pill containing Cordyceps militaris and okra and preparation method thereof - Google Patents
Sustained-release dropping pill containing Cordyceps militaris and okra and preparation method thereof Download PDFInfo
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- CN107280005A CN107280005A CN201710471602.9A CN201710471602A CN107280005A CN 107280005 A CN107280005 A CN 107280005A CN 201710471602 A CN201710471602 A CN 201710471602A CN 107280005 A CN107280005 A CN 107280005A
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- 241001264174 Cordyceps militaris Species 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 238000013268 sustained release Methods 0.000 title claims abstract description 21
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 21
- 241001075517 Abelmoschus Species 0.000 title claims description 47
- 239000000843 powder Substances 0.000 claims abstract description 52
- 239000012530 fluid Substances 0.000 claims abstract description 40
- 241000190633 Cordyceps Species 0.000 claims abstract description 36
- 239000011159 matrix material Substances 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 210000003097 mucus Anatomy 0.000 claims abstract description 25
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 22
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 22
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 22
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 22
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 22
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 240000000588 Hericium erinaceus Species 0.000 claims abstract description 20
- 235000007328 Hericium erinaceus Nutrition 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000009833 condensation Methods 0.000 claims abstract description 15
- 230000005494 condensation Effects 0.000 claims abstract description 15
- 235000012907 honey Nutrition 0.000 claims abstract description 14
- 238000002844 melting Methods 0.000 claims abstract description 14
- 230000008018 melting Effects 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000002826 coolant Substances 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 10
- 230000009514 concussion Effects 0.000 claims description 8
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- 238000000926 separation method Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 7
- 238000007654 immersion Methods 0.000 claims description 7
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- 239000007787 solid Substances 0.000 claims description 7
- 235000021355 Stearic acid Nutrition 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 6
- 239000008117 stearic acid Substances 0.000 claims description 6
- 244000068988 Glycine max Species 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 229940008099 dimethicone Drugs 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
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- 238000011081 inoculation Methods 0.000 claims 1
- 238000009413 insulation Methods 0.000 claims 1
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- 229940079593 drug Drugs 0.000 abstract description 8
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- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 208000012895 Gastric disease Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
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- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
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- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention proposes a kind of sustained-release dropping pill containing Cordyceps militaris and okra and preparation method thereof, including：Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder, honey and matrix, matrix are that mass ratio is 1:5 hydrophobic base and the mixture of hydrophilic matrix.Preparation method：1) preparation of Cordyceps militaris zymotic fluid；2) preparation of cordyceps mycelium extract solution；3) preparation of okra mucus；4) crushing of auxiliary material；5) mix：Hydrophobic base and hydrophilic matrix are weighed, with other raw materials and auxiliary material under water bath condition, is uniformly mixed, obtains melting decoction；6) prepared by dripping pill：By step 5) melting decoction be put into the water dropper tank in pill dripping machine, control system temperature for 95 DEG C, instilled in condensate liquid, shunk after complete after condensation is molded, produce dripping pill finished product.The dripping pill not only accommodates medication amount greatly, also has effects that to protect lung kidney-nourishing with protecting stomach.
Description
Technical field
The invention belongs to dripping pill technical field, and in particular to a kind of sustained-release dropping pill and its preparation containing Cordyceps militaris and okra
Method.
Background technology
Pill refers to solid or liquid medicine with after appropriate material (commonly referred to as matrix) heating fusing mixing, instilling not phase
In miscible condensate liquid, condensation is shunk and the pellets preparation that is made, mainly for being administered orally.From the composition and preparation method of pill
See, it has the following feature：1) equipment is simple and convenient to operate, beneficial to labour protection, and process cycle is short, productivity ratio is high；2)
Process conditions are easily controllable, steady quality, and dosage is accurate, and heated time is short, and the oxidizable and volatile medicine of tool is dissolved in matrix
Afterwards, its stability can be increased；3) matrix accommodates liquid drug amount greatly, therefore can solidify liquid drug, such as rue oil dripping pill oil-containing
Up to 83.5%；4) dripping pill prepared with solid dispersion technology, which has, absorbs the characteristics of rapid, bioavilability is high, and such as sallow is mould
Plain dripping pill effective dose is the 1/4 of 100 mesh fine powders, the 1/2 of micro mist (below 5 microns of particle diameter)；5) ear, ophthalmic remedy have been developed new
Formulation, ENT dept.'s preparation is generally liquid or semisolid formulation, and action time is not lasting, and dripping pill, which is made, can play prolongation of effect effect.
With the quickening and growth in the living standard of people's rhythm of life, high nutrition, low dose of health-care products are increasingly
It is welcomed by the people, and application of the dropping pill formulation as a kind of huge novel dosage forms of drugloading rate in field of health care products lacks it
Again few, therefore, developing the dropping pill formulation of a high nutritive value has very big market potential.
The content of the invention
The present invention proposes a kind of sustained-release dropping pill containing Cordyceps militaris and okra, and the dripping pill not only accommodates medication amount greatly, also had
There is to protect lung kidney-nourishing with protecting stomach.
The technical proposal of the invention is realized in this way：
A kind of sustained-release dropping pill containing Cordyceps militaris and okra, including following raw material are made with auxiliary material：
Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, the root of kudzu vine are thin
Powder, honey and matrix, the matrix are that mass ratio is 1:5 hydrophobic base and the mixture of hydrophilic matrix.
Preferably, Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam are thin
Powder, root of kudzu vine fine powder, the mass ratio of honey and matrix are 5:5:5:1:1:1:1:10.
Preferably, the hydrophobic base is stearic acid, and the hydrophilic matrix is polyethylene glycol.
It is a further object to provide a kind of preparation method of the sustained-release dropping pill containing Cordyceps militaris and okra, including
Following steps：
1) preparation of Cordyceps militaris zymotic fluid；
2) preparation of cordyceps mycelium extract solution；
3) preparation of okra mucus；
4) crushing of auxiliary material：Take Hericium erinaceus, Chinese yam, the root of kudzu vine to crush respectively, cross 40~60 mesh sieves, obtain Hericium erinaceus fine powder,
Chinese yam fine powder and root of kudzu vine fine powder；
5) mix：Hydrophobic base and hydrophilic matrix are proportionally weighed, fully melting is mixed under condition of water bath heating
It is even, add Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, the root of kudzu vine
Fine powder and honey, are uniformly mixed, and obtain melting decoction；
6) prepared by dripping pill：By step 5) melting decoction be put into the water dropper tank in pill dripping machine, controlling system temperature is
95 DEG C, instilled in condensate liquid, after condensation shaping is shunk completely, taken out, with the coolant for getting rid of oil machine removing dripping pill surface
Produce dripping pill finished product.
Preferably, the step 6) coolant be dimethicone.
Preferably, the step 1) be specially：By Cordyceps militaris access nutrient solution in, and at a temperature of 18~37 DEG C with
100~300 beats/min of concussion frequency concussion and cultivate 48~144 hours on shaking table, obtain strain liquid, then by strain liquid
Access in fluid nutrient medium, inoculum concentration is 5~10%, and ventilation or Anaerobic culturel 48~124 are small at a temperature of 20~37 DEG C
When, by biofermentation, obtain the cordyceps mycelium and Cordyceps militaris zymotic fluid of fermentation；The step 2) be specially：Will step
After the rapid cordyceps mycelium progress cell tissue 1) obtained is broken, is extracted with water, obtain cordyceps mycelium extract solution.
Preferably, the step 3) be specially：Fresh tender okra pod is selected, is cut into slices after cleaning up, plus distillation water logging
The weight ratio of bubble, distilled water and okra is 2~3:1, soaking temperature is 40~90 DEG C, and soak time is 1~2h, is used after immersion
Okra tissue is broken up and grinds to form uniform pastel by tissue refiner, and pastel then is carried out into separation of solid and liquid, obtained
Fluid purification removal of impurities obtain okra mucus.
Preferably, the step 5) heating bath temperature be：The temperature of heating water bath is 70 DEG C~100 DEG C.
Preferably, the step 6) be specially：Start pill dripping machine, preheat 30min, feed temperature, material in instrument are set
Chassis temperature and condensation temperature are filled, starts the control button of each temperature, show value is reached, feed temperature should with chassis temperature
Be consistent, then start pill dripping machine stirring system, control mixing speed, by step 1) melting decoction by charge door, plus
In the batch can for entering pill dripping machine, 10min is stirred continuously, makes fluid temperature up to 95 DEG C, after being incubated 30 minutes, at 8 centimetres~10 centimetres
Drop away under, instilled in coolant, after dripping pill shrinks condensation shaping completely, taken with the speed of 50 drops/minute~60 drops/minute
Go out, dripping pill finished product is produced with the coolant for getting rid of oil machine removing dripping pill surface.
Further, the step 6) condensation temperature be 4~8 DEG C.
Preferably, the step 1) fluid nutrient medium in contain 10wt%~12wt% fructus hordei germinatus and 3wt%~5wt%
Soybean；The step 2) in the extraction extracted with water compare for 0.8~1:5, extraction temperature be 90~95 DEG C, extraction time be 2~
3h。
Beneficial effects of the present invention：
1st, the sustained-release dropping pill containing Cordyceps militaris and okra of the invention, it carries Cordyceps militaris zymotic fluid, cordyceps mycelium
Addition auxiliary material is prepared into dropping pill formulation after taking liquid, okra mucus extracted, and it is big not only to accommodate medication amount, with protect lung kidney-nourishing with
Protect effect of stomach, and by the direct solidification of liquid drug, simplified processing process, be highly suitable for zymotic fluid, mucus this
The processing of the material of nutrition is easily lost in class solidification.
2nd, carry out containing in substantial amounts of breeding, the metabolite and mycelium of gained in Cordyceps militaris liquid medium within
With former cordyceps effectiveness identical active ingredient, mycelium is typically only taken as edible part, zymotic fluid is then given up, and causes
Very big waste, therefore the present invention makes full use of zymotic fluid with mycelium while nutritive proportion is ensured.Gumbo mucus is
Important nutritional ingredient in gumbo, wherein the pectin contained, cow's milk glycan etc. have help digest, treat gastritis and gastric ulcer,
The effect of protecting skin and stomach lining, the mucin contained plays the role of protection coat of the stomach and promotes gastric secretion, improves appetite, changes
The diseases such as kind indigestion.Hericium erinaceus, Chinese yam, root of kudzu vine etc. are respectively provided with nourishing the stomach, protect the medicinal material of stomach effect, and it is assisted with Cordyceps militaris, gumbo
Protect stomach health with while make it that dripping pill is the effects such as playing nourishment for vitality, protecting lung kidney-nourishing, can be used for treating old spleen,
Gastric disease and intestines and stomach malabsorption.Honey is added in dripping pill can cover the bad flavor of medicinal substances extract, not only be more easy to
In taking, and contribute to the shaping of dripping pill, meanwhile, the matrix added in dripping pill can significantly delay release of the medicine in stomach,
It can ensure that human body is fully absorbed to nutriment, number of times is taken in reduction.
Embodiment
Embodiment 1
A kind of sustained-release dropping pill containing Cordyceps militaris and okra, including following raw material are made with auxiliary material：
Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, the root of kudzu vine are thin
Powder, honey and matrix, the matrix are that mass ratio is 1:5 stearic acid and the mixture of polyethylene glycol.Cordyceps militaris zymotic fluid, pupa
Cordyceps mycelia extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder, the mass ratio of honey and matrix are
5:5:5:1:1:1:1:10。
Preparation method：
1) preparation of Cordyceps militaris zymotic fluid：Cordyceps are accessed into the culture containing 10wt% fructus hordei germinatus and 5wt% soybean
In liquid, and at a temperature of 37 DEG C with 100 beats/min of concussion frequency on shaking table concussion and cultivate 144 hours, obtain strain
Liquid, then accesses strain liquid in fluid nutrient medium, inoculum concentration is 10%, and ventilation or Anaerobic culturel at a temperature of 37 DEG C
124 hours, by biofermentation, obtain the cordyceps mycelium and Cordyceps militaris zymotic fluid of fermentation；
2) preparation of cordyceps mycelium extract solution：By step 1) obtained cordyceps mycelium carries out cell tissue and crushes
Afterwards, with water to extract than for 1:5, extraction temperature is 95 DEG C, and extraction time is that 3h is extracted, and obtains cordyceps mycelium and extracts
Liquid；
3) preparation of okra mucus：Fresh tender okra pod is selected, is cut into slices after cleaning up, plus distilled water immersion, steam
Distilled water and the weight of okra ratio are 2:1, soaking temperature is 80 DEG C, and soak time is 1h, with tissue refiner by Huang after immersion
Gumbo tissue is broken up and grinds to form uniform pastel, pastel then is carried out into separation of solid and liquid, obtained fluid purification removal of impurities
Okra mucus is obtained, wherein, the method for separation of solid and liquid is separated or the separation of Buchner funnel suction filtration for centrifuge；
4) crushing of auxiliary material：Monkey can be obtained all by 40 mesh sieves by taking Hericium erinaceus, Chinese yam, the root of kudzu vine to be crushed to pulverizer
Head mushroom fine powder, Chinese yam fine powder and root of kudzu vine fine powder；
5) material is mixed：According to 1:5 ratios weigh hydrophobic base and hydrophilic matrix, the water under the conditions of temperature is 70 DEG C
Bath heating fully melting is mixed, and hydrophobic base is stearic acid, and hydrophilic matrix is polyglycol polymer, according still further to ratio
Add cordyceps zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder
And honey, it is stirred continuously 30 minutes, is sufficiently mixed uniform in a heated condition；
(6) prepared by dripping pill：Start pill dripping machine, preheat 30min, set instrument in feed temperature, material fill chassis temperature and
Condensation temperature, starts the control button of each temperature, reaches show value, feed temperature should be consistent with chassis temperature, so
Start pill dripping machine stirring system afterwards, control mixing speed, by the decoction of melting by charge door, in the batch can for adding pill dripping machine,
10min is stirred continuously, makes fluid temperature up to 95 DEG C, after being incubated 30 minutes, in 8 centimetres of drops away under, with the speed of 50 drops/minute
Instill in coolant, coolant is dimethicone, condensation temperature is 8 DEG C, after dripping pill shrinks condensation shaping completely, is taken out,
Dripping pill finished product is produced with the coolant for getting rid of oil machine removing dripping pill surface.
The dripping pill finished product roundness preferably, meet pharmacopoeial requirements, from the point of view of weight differential angle, the dripping pill weight differential compared with
It is small, only 0.054, from the point of view of the tablets in vitro time, it almost releases the drug completely in 12h, meets the requirements.
Embodiment 2
A kind of sustained-release dropping pill containing Cordyceps militaris and okra, including following raw material are made with auxiliary material：
Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, the root of kudzu vine are thin
Powder, honey and matrix, the matrix are that mass ratio is 1:4 stearic acid and the mixture of polyethylene glycol.Cordyceps militaris zymotic fluid, pupa
Cordyceps mycelia extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder, the mass ratio of honey and matrix are
5:5:5:1:1:1:1:10。
Preparation method：
1) preparation of Cordyceps militaris zymotic fluid：Cordyceps are accessed into the culture containing 12wt% fructus hordei germinatus and 3wt% soybean
In liquid, and at a temperature of 18 DEG C with 300 beats/min of concussion frequency on shaking table concussion and cultivate 48 hours, obtain strain liquid,
Then strain liquid is accessed in fluid nutrient medium, inoculum concentration is 5%, and ventilation or Anaerobic culturel 72 are small at a temperature of 30 DEG C
When, by biofermentation, obtain the cordyceps mycelium and Cordyceps militaris zymotic fluid of fermentation；
2) preparation of cordyceps mycelium extract solution：By step 1) obtained cordyceps mycelium carries out cell tissue and crushes
Afterwards, with water to extract than for 0.8:5, extraction temperature is 90 DEG C, and extraction time is that 3h is extracted, and obtains cordyceps mycelium and carries
Take liquid；
3) preparation of okra mucus：Fresh tender okra pod is selected, is cut into slices after cleaning up, plus distilled water immersion, steam
Distilled water and the weight of okra ratio are 2:1, soaking temperature is 60 DEG C, and soak time is 2h, with tissue refiner by Huang after immersion
Gumbo tissue is broken up and grinds to form uniform pastel, pastel then is carried out into separation of solid and liquid, obtained fluid purification removal of impurities
Okra mucus is obtained, wherein, the method for separation of solid and liquid is separated or the separation of Buchner funnel suction filtration for centrifuge；
4) crushing of auxiliary material：Monkey can be obtained all by 60 mesh sieves by taking Hericium erinaceus, Chinese yam, the root of kudzu vine to be crushed to pulverizer
Head mushroom fine powder, Chinese yam fine powder and root of kudzu vine fine powder；
5) material is mixed：According to 1:4 ratios weigh hydrophobic base and hydrophilic matrix, under the conditions of temperature is 100 DEG C
Heating water bath fully melts mixing, and hydrophobic base is stearic acid, and hydrophilic matrix is polyglycol polymer, according still further to than
It is thin that example adds cordyceps zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, the root of kudzu vine
Powder and honey, are stirred continuously 30 minutes in a heated condition, are sufficiently mixed uniform；
(6) prepared by dripping pill：Start pill dripping machine, preheat 30min, set instrument in feed temperature, material fill chassis temperature and
Condensation temperature, starts the control button of each temperature, reaches show value, feed temperature should be consistent with chassis temperature, so
Start pill dripping machine stirring system afterwards, control mixing speed, by the decoction of melting by charge door, in the batch can for adding pill dripping machine,
10min is stirred continuously, makes fluid temperature up to 95 DEG C, after being incubated 30 minutes, in 10 centimetres of drops away under, with the speed of 60 drops/minute
Degree is instilled in coolant, and coolant is dimethicone, and condensation temperature is 4 DEG C, after dripping pill shrinks condensation shaping completely, is taken
Go out, dripping pill finished product is produced with the coolant for getting rid of oil machine removing dripping pill surface.
The dripping pill finished product roundness preferably, meet pharmacopoeial requirements, from the point of view of weight differential angle, the dripping pill weight differential compared with
Greatly, it is 0.194, this is probably that, because the amount of hydrophilic matrix is less, melting decoction is more sticky during dripping, causes drop
The more difficult dripping of ball, produces the phenomenon of the influence dripping pill quality such as adhesion, therefore is excluded.
Embodiment 3
Remaining is identical with the embodiment 2, and difference is, the mixed proportion of hydrophobic base and hydrophilic matrix is
1:6。
The dripping pill finished product roundness preferably, meet pharmacopoeial requirements, from the point of view of weight differential angle, the dripping pill weight differential compared with
It is small, it is 0.074, from the point of view of the tablets in vitro time, its tablets in vitro time is 8h, is released the drug too fast, it is impossible to reach sustained release purpose, therefore
Excluded.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God is with principle, and any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (10)
1. a kind of sustained-release dropping pill containing Cordyceps militaris and okra, it is characterised in that be made including following raw material and auxiliary material：
Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder,
Honey and matrix, the matrix are that mass ratio is 1:5 hydrophobic base and the mixture of hydrophilic matrix.
2. the sustained-release dropping pill according to claim 1 containing Cordyceps militaris and okra, it is characterised in that Cordyceps militaris zymotic fluid,
Cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder, the mass ratio of honey and matrix
For 5:5:5:1:1:1:1:10.
3. the sustained-release dropping pill according to claim 1 or 2 containing Cordyceps militaris and okra, it is characterised in that the hydrophobicity
Matrix is stearic acid, and the hydrophilic matrix is polyethylene glycol.
4. the preparation method of the sustained-release dropping pill containing Cordyceps militaris and okra as claimed in claim 1, it is characterised in that including with
Lower step：
1) preparation of Cordyceps militaris zymotic fluid；
2) preparation of cordyceps mycelium extract solution；
3) preparation of okra mucus；
4) crushing of auxiliary material：Take Hericium erinaceus, Chinese yam, the root of kudzu vine to crush respectively, cross 40~60 mesh sieves, obtain Hericium erinaceus fine powder, Chinese yam
Fine powder and root of kudzu vine fine powder；
5) mix：Hydrophobic base and hydrophilic matrix are proportionally weighed, fully melting is mixed under condition of water bath heating, then
Add Cordyceps militaris zymotic fluid, cordyceps mycelium extract solution, okra mucus, Hericium erinaceus fine powder, Chinese yam fine powder, root of kudzu vine fine powder and
Honey, is uniformly mixed, and obtains melting decoction；
6) prepared by dripping pill：By step 5) melting decoction be put into the water dropper tank in pill dripping machine, control system temperature for 95 DEG C,
Instilled in condensate liquid, after condensation shaping is shunk completely, taken out, drop is produced with the coolant for getting rid of oil machine removing dripping pill surface
Ball finished product.
5. the preparation method of the sustained-release dropping pill according to claim 4 containing Cordyceps militaris and okra, it is characterised in that described
Step 6) coolant be dimethicone.
6. the preparation method of the sustained-release dropping pill according to claim 4 containing Cordyceps militaris and okra, it is characterised in that described
Step 1) be specially：Cordyceps militaris is accessed in nutrient solution, and with 100~300 beats/min of concussion at a temperature of 18~37 DEG C
Frequency concussion and cultivate 48~144 hours on shaking table, obtain strain liquid, then access strain liquid in fluid nutrient medium, inoculation
Measure as 5~10%, and ventilation or Anaerobic culturel 48~124 hours at a temperature of 20~37 DEG C, by biofermentation, sent out
The cordyceps mycelium and Cordyceps militaris zymotic fluid of ferment；The step 2) be specially：By step 1) obtained cordyceps mycelium
After progress cell tissue is broken, extracted with water, obtain cordyceps mycelium extract solution.
7. the preparation method of the sustained-release dropping pill according to claim 4 containing Cordyceps militaris and okra, it is characterised in that described
Step 3) be specially：Fresh tender okra pod is selected, is cut into slices after cleaning up, plus distilled water immersion, distilled water and okra
Weight ratio is 2~3:1, soaking temperature is 40~90 DEG C, and soak time is 1~2h, with tissue refiner by okra after immersion
Tissue is broken up and grinds to form uniform pastel, pastel then is carried out into separation of solid and liquid, obtained fluid purification removal of impurities is obtained
Okra mucus.
8. the preparation method of the sustained-release dropping pill according to claim 4 containing Cordyceps militaris and okra, it is characterised in that described
Step 5) heating bath temperature be：The temperature of heating water bath is 70 DEG C~100 DEG C.
9. the preparation method of the sustained-release dropping pill according to claim 4 containing Cordyceps militaris and okra, it is characterised in that described
Step 6) be specially：Start pill dripping machine, preheat 30min, set the feed temperature in instrument, material to fill chassis temperature and condensation temperature
Degree, starts the control button of each temperature, reaches show value, feed temperature should be consistent with chassis temperature, then start
Pill dripping machine stirring system, controls mixing speed, by step 1) melting decoction by charge door, in the batch can for adding pill dripping machine,
Be stirred continuously 10min, make fluid temperature up to 95 DEG C, insulation 30 minutes after, in 8 centimetres~10 centimetres of drops away under, with 50 drop/point
The speed of clock~60 drops/minute is instilled in coolant, after dripping pill shrinks condensation shaping completely, is taken out, and drop is removed with oil machine is got rid of
The coolant on ball surface produces dripping pill finished product.
10. the preparation method of the sustained-release dropping pill according to claim 6 containing Cordyceps militaris and okra, it is characterised in that institute
State step 1) fluid nutrient medium in contain 10wt%~12wt% fructus hordei germinatus and 3wt%~5wt% soybean；The step 2) in
The extraction extracted with water is compared for 0.8~1:5, extraction temperature is 90~95 DEG C, and extraction time is 2~3h.
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Cited By (1)
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| CN108888750A (en) * | 2017-08-01 | 2018-11-27 | 楼良水 | Cordyceps sinensis pueraria lobata compound with function of blood sugar reduction |
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Application publication date: 20171024 |