CN1654060A - 'Kidney-Benefiting' glucose injection and its preparing process - Google Patents
'Kidney-Benefiting' glucose injection and its preparing process Download PDFInfo
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- CN1654060A CN1654060A CN 200410039420 CN200410039420A CN1654060A CN 1654060 A CN1654060 A CN 1654060A CN 200410039420 CN200410039420 CN 200410039420 CN 200410039420 A CN200410039420 A CN 200410039420A CN 1654060 A CN1654060 A CN 1654060A
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- alcohol
- filtrate
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- distilled water
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 27
- 229940093181 glucose injection Drugs 0.000 title claims abstract description 8
- 238000000034 method Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 707
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 263
- 239000012153 distilled water Substances 0.000 claims abstract description 181
- 238000007865 diluting Methods 0.000 claims abstract description 104
- 229940090044 injection Drugs 0.000 claims abstract description 91
- 238000002347 injection Methods 0.000 claims abstract description 91
- 239000007924 injection Substances 0.000 claims abstract description 91
- 238000002360 preparation method Methods 0.000 claims abstract description 24
- 239000008103 glucose Substances 0.000 claims abstract description 19
- 238000010438 heat treatment Methods 0.000 claims abstract description 19
- 230000001954 sterilising effect Effects 0.000 claims abstract description 19
- 239000000706 filtrate Substances 0.000 claims description 234
- 239000003814 drug Substances 0.000 claims description 164
- 229940079593 drug Drugs 0.000 claims description 162
- 238000004321 preservation Methods 0.000 claims description 120
- 239000000796 flavoring agent Substances 0.000 claims description 102
- 235000019634 flavors Nutrition 0.000 claims description 102
- 238000004064 recycling Methods 0.000 claims description 102
- 239000000243 solution Substances 0.000 claims description 84
- 239000007788 liquid Substances 0.000 claims description 81
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 54
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 45
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 36
- 241000628997 Flos Species 0.000 claims description 33
- 238000000605 extraction Methods 0.000 claims description 33
- 108010010803 Gelatin Proteins 0.000 claims description 27
- 229920000159 gelatin Polymers 0.000 claims description 27
- 239000008273 gelatin Substances 0.000 claims description 27
- 235000019322 gelatine Nutrition 0.000 claims description 27
- 235000011852 gelatine desserts Nutrition 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 27
- 235000018553 tannin Nutrition 0.000 claims description 27
- 229920001864 tannin Polymers 0.000 claims description 27
- 239000001648 tannin Substances 0.000 claims description 27
- 241000545442 Radix Species 0.000 claims description 20
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 238000001802 infusion Methods 0.000 claims description 18
- 239000012528 membrane Substances 0.000 claims description 18
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 15
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 238000000108 ultra-filtration Methods 0.000 claims description 12
- 210000003734 kidney Anatomy 0.000 claims description 10
- 208000020832 chronic kidney disease Diseases 0.000 claims description 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 3
- 230000002879 macerating effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 abstract description 8
- 239000009457 shenkang Substances 0.000 abstract description 5
- 239000000284 extract Substances 0.000 abstract description 2
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention is application of Shenkang glucose injection and its preparation process. The Shenkang injection is prepared with the extract of rhubarb, red sage and other Chinese medicinal materials, and through washing, decocting, letting stand, filtering, concentrating, alcohol precipitating, filtering, recovering alcohol, diluting with distilled water, adding glucose, filtering, diluting with injection water, regulating pH value, filtering, packing, and heating and pressurizing sterilization. The present invention has the advantages of less compounding pollution and convenient use.
Description
The present invention relates to a kind of injection kidney health glucose injection and preparation technology thereof who treats chronic renal failure.
Clinically mostly be to adopt oral medication with the treatment by Chinese herbs chronic renal failure at present, its weak point is to absorb slowly, and bioavailability is low, the course of treatment is long, and weak curative effect is especially poorer to the above curative effect of renal function injury moderate, and gastrointestinal reaction is bigger, unsuitable prolonged application.The Chinese medicine injection effect is rapid, the bioavailability height, short treating period, good effect, especially the patient more than the renal function injury moderate is had better effects, a patent " SHENKANG ZHUSHEYE and preparation technology thereof " (application number 96117626 notification numbers 1146358) of applying for as the applicant is to extract the Chinese medicine injection made from herbal mixture, need add the glucose injection dilution when its weak point is to use, operation inconvenience increases dosing easily and pollutes.The present invention is that the dosage form to the patent " SHENKANG ZHUSHEYE and preparation technology thereof " of the applicant application changes agent.
The object of the present invention is to provide a kind ofly SHENKANG ZHUSHEYE is changed agent to become injection kidney health glucose injection and preparation technology thereof, can reduce dosing and pollute, easy to use.
The present invention extracts the injection kidney health glucose injection of making by Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the Radix Astragali, Flos Carthami, and its raw material is made up of for 10～20 parts 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes, 40～70 parts of the Radixs Astragali, Flos Carthami.Can obtain by following 6 kinds of process routes during preparation:
Preparation technology 1:
With 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution, adds ethanol and makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70～80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; 40～70 parts of the Radixs Astragali, Flos Carthami is cleaned with distilled water respectively for 10～20 parts, decoct three times with 6～12 times of distilled water, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution and adds ethanol and make that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; Merge above-mentioned reserve liquid, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100～500ml infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 2:
With 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol and make that to contain alcohol amount be 70～80%, transfer PH7.5, one night of airtight placement, filter, filtrate recycling ethanol is not to there being the alcohol flavor, contains crude drug 2g, cold preservation 12～48 hours with distilled water diluting to every 1ml, filter filtrate for later use; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there not being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70～80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; 40～70 parts of the Radixs Astragali, 10～20 parts on Flos Carthami is clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol again and make that to contain the alcohol amount be 70～80% with distilled water diluting, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use with distilled water diluting to every 1ml; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 3:
With 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, waving most alcohol does not extremely have the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; 10～20 parts of 40～70 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～40,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, and filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filters, and filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 4:
With 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1～2 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there not being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate for later use; 10～20 parts on Flos Carthami is clean with distilled water, use 6～12 times 80 ℃ distilled water warm macerating secondaries respectively, decocting time was respectively 1 hour, merged the secondary decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Flos Carthami concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter filtrate and Radix Salviae Miltiorrhizae, big yellow filtrate merges, and uses ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40～70 parts of the Radixs Astragali are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 5:
With 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40～70 parts of the Radixs Astragali, 10～20 parts on Flos Carthami is clean with distilled water, decoct three times with 6～12 times of distilled water, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 6:
With 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1～2 hour, merged three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40～70 parts of the Radixs Astragali, 10～20 parts on Flos Carthami is clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
The invention has the advantages that can reduce dosing pollutes, easy to use.
With specific embodiment the present invention is elaborated below:
Embodiment 1:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution, adds ethanol and makes that to contain the alcohol amount be 60%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; 55 parts of the Radixs Astragali, Flos Carthami is cleaned with distilled water respectively for 15 parts, decoct three times with 8 times of distilled water, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution and adds ethanol and make that to contain the alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; Merge above-mentioned reserve liquid, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100～500ml infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 2:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol and make that to contain alcohol amount be 80%, transfer PH7.5, one night of airtight placement, filter, filtrate recycling ethanol is not to there being the alcohol flavor, contains crude drug 2g, cold preservation 12～48 hours with distilled water diluting to every 1ml, filter filtrate for later use; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there not being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 80%, cold preservation 1248 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; 55 parts of the Radixs Astragali, 15 parts on Flos Carthami is clean with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol again and make that to contain the alcohol amount be 80% with distilled water diluting, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use with distilled water diluting to every 1ml; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 3:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, waving most alcohol does not extremely have the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there not being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; 10～20 parts of 40～70 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, and with 8 times of distilled water decoctions three times, decocting time was respectively 1 hour respectively, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～40,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, and filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filters, and filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 4:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1～2 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain the alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there not being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate for later use; 15 parts on Flos Carthami is clean with distilled water, use 8 times 80 ℃ distilled water warm macerating secondaries respectively, decocting time was respectively 1 hour, merged the secondary decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Flos Carthami concentrated solution adds ethanol makes that to contain the alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter filtrate and Radix Salviae Miltiorrhizae, big yellow filtrate merges, and uses ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 55 parts of the Radixs Astragali are clean with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 5:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 15 parts of 55 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 8 times of distilled water, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 6:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 15 parts of 55 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Claims (6)
1, a kind of injection kidney health glucose injection for the treatment of chronic renal failure, its raw material is by 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes, 40～70 parts of the Radixs Astragali, 10～20 parts of compositions of Flos Carthami, it is characterized in that making: with 10～20 parts of Radix Et Rhizoma Rhei by following preparation technology, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1～2 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merge concentrated solution, add ethanol and make that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70～80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; 40～70 parts of the Radixs Astragali, Flos Carthami is cleaned with distilled water respectively for 10～20 parts, decoct three times with 6～12 times of distilled water, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution and adds ethanol and make that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; Merge above-mentioned reserve liquid, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100～500ml infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
2, the preparation technology of injection kidney caring freeze dried injection as claimed in claim 1, it is characterized in that comprising following preparation process: with 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1～2 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70～80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there not being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70～80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12～48 hours filters filtrate for later use; 40～70 parts of the Radixs Astragali, 10～20 parts on Flos Carthami is clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol again and make that to contain the alcohol amount be 70～80% with distilled water diluting, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use with distilled water diluting to every 1ml; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
3, the preparation technology of injection kidney caring freeze dried injection as claimed in claim 1, it is characterized in that comprising following preparation process: with 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1～2 hour, merged three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, to there being the tannin reaction, placed 2～4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; 10～20 parts of 40～70 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1～40,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, and filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filters, and filtrate is with 1～20,000 fenestra ultrafiltration, and ultrafiltrate is standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
4, the preparation technology of injection kidney caring freeze dried injection as claimed in claim 1, it is characterized in that comprising following preparation process: with 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1～2 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add 3～5% gelatin solution with distilled water diluting, do not react to there being tannin after fully stirring, placed 2～4 hours, and added ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filter filtrate for later use; 10～20 parts on Flos Carthami is clean with distilled water, use 6～12 times 80 ℃ distilled water warm macerating secondaries respectively, decocting time was respectively 1 hour, merged the secondary decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Flos Carthami concentrated solution adds ethanol makes that to contain the alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter filtrate and Radix Salviae Miltiorrhizae, big yellow filtrate merges, and uses ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40～70 parts of the Radixs Astragali are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
5, the preparation technology of injection kidney caring freeze dried injection as claimed in claim 1, it is characterized in that comprising following preparation process: with 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water, and decocting time was respectively 1～2 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40～70 parts of the Radixs Astragali, 10～20 parts on Flos Carthami is clean with distilled water, decoct three times with 6～12 times of distilled water, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
6, the preparation technology of injection kidney caring freeze dried injection as claimed in claim 1, it is characterized in that comprising following preparation process: with 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6～12 times of distilled water respectively, and decocting time was respectively 1～2 hour, merge three times decocting liquid, after leaving standstill 12～48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3～5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2～4 hours, add ethanol and make that to contain alcohol amount be 70～80%, cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40～70 parts of the Radixs Astragali, 10～20 parts on Flos Carthami is clean with distilled water, decoct three times with 6～12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12～48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, and cold preservation 12～48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2～6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45～70%, cold preservation 12～48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2～6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2～0.5% active carbon heated and boiled 15～30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100～500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
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| CNB2004100394207A CN100434093C (en) | 2004-02-11 | 2004-02-11 | 'Kidney-Benefiting' glucose injection and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100394207A CN100434093C (en) | 2004-02-11 | 2004-02-11 | 'Kidney-Benefiting' glucose injection and its preparing process |
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| Publication Number | Publication Date |
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| CN1654060A true CN1654060A (en) | 2005-08-17 |
| CN100434093C CN100434093C (en) | 2008-11-19 |
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| CN100434093C (en) | 2008-11-19 |
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Effective date of registration: 20091002 Address after: Shaanxi province Xi'an Fengjing Industrial Park Fengjing Road No. 6 Patentee after: XI'AN SHIJISHENGKANG PHARMACEUTICAL INDUSTRY Co.,Ltd. Address before: Shaanxi city of Xi'an province high tech Zone Tang Yan Road No. 35 room B2003 Mong modern city Patentee before: Wu Fang |
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Granted publication date: 20081119 |
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Addressee: Lv Yanying Document name: Notice of Termination of Patent Rights |
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