CN1038212A - The preparation method of Aining injection - Google Patents

Abstract

A process for preparing anticancer injection features that the active components of Chinese-medicinal materials are extracted and then treated with lime milk and sulfur dioxide several times to remove impurities and retain the active components. And the process is simple. The prepared 'AINING' injection is suitable for treating liver cancer and lung cancer. Has obvious effect of relieving symptoms and eliminating pain. Can prolong the life of patients.

Description

The invention belongs to the preparation method of medicine

Cancer is extremely harmful to human health, accounting for the third cause of death. In addition to the certain curative effect of Western medicine in treating tumors, there are also obvious toxic effects, which lead to the termination of treatment. The characteristics of traditional Chinese medicine for treating tumors can obviously relieve symptoms, prolong the survival period of patients, and have no toxic side effects.

Aining injection of the present invention is a traditional Chinese medicine compound, which is a commonly used traditional Chinese medicine. Both "National Compilation of Chinese Herbal Medicine" and "Dictionary of Chinese Medicine" are included. After the inventor selected and cooperated with research for many years, and improved the production process, its product has been proved to have a certain anti-cancer effect in clinical trials.

At present, the preparation of Chinese herbal medicine injections is commonly used in seven methods such as hydroalcohol method, lime sulfur method, distillation method... But Chinese herbal medicine is of a great variety, only with its deficiency of above-mentioned preparation method just to be:

1. The preparation method is relatively limited in pertinence and cannot meet the needs of numerous single herbs and compound prescriptions. therefore

2. Unsatisfied with the extraction of active ingredients and removal of impurities.

The purpose of the present invention is to:

Aiming at the properties and characteristics of each drug in the Aining traditional Chinese medicine compound, different extraction methods and impurity removal methods are used for different active ingredients. Make the content of active ingredients higher, and remove impurities more thoroughly.

Invention content:

Aining injection is a traditional Chinese medicine compound, and its composition percentage (W%) is as follows:

Astragalus 20-30 Radix Paeoniae Rubra 6-10

Ginseng 6-12 Asparagus 6-10

Biejia 20-30 Licorice 3-5

Oyster 30-35 Toad 0.03-0.07

Bupleurum 6-10 Mylabris 0.1-0.4

The above-mentioned Chinese medicine compound is the main prescription of Aining Injection, and it is based on the principles of TCM syndrome differentiation and treatment. According to the patient's condition, addition and subtraction can be carried out on the basis of the main prescription. For example: For those who need to clear away heat and detoxify, you can add Lian Chi, Huang Lian, and Shuang Hua. Those who need softness and firmness can add Curcuma and Sansuo. Those who need to promote blood circulation and remove blood stasis can add angelica, safflower, and notoginseng. Those who need pain relief can add aconitum and Yuanhu. The above-mentioned compound prescription can also be reduced to the traditional Chinese medicine of bupleurum bupleuri and oyster, which still has a good anticancer effect.

Regardless of the main square or the addition and subtraction of the main square, it is prepared according to the following production process.

The preparation method of Aining injection:

The active ingredients can be decocted with water or extracted with ethanol.

Water decoction: in two steps.

Step 1: extract ginsenosides by percolation. First crush the ginseng, moisten it, put it into the infiltration cylinder, add 50-75% ethanol to soak for 3-4 hours, and let the liquid drain until light yellow. The filtrate is heated until alcohol-free, and the liquid medicine is set aside.

Step 2: Decoct in water to extract active ingredients, take all the traditional Chinese medicine (including the dregs of the first step) and add water slightly higher than the liquid medicine (5-10 times), boil three times, half an hour, one hour, two hours respectively, and put Filter the liquid medicine three times. Combine the medicinal liquid extracted in the first and second steps. Then add saturated milk of lime to PH10-13, then add sulfur dioxide or sulfurous acid to PH4-6, filter to remove impurities

Concentrate the filtrate so that the ratio of the crude drug to the liquid is 1:1-2, then add saturated milk of lime to the concentrated solution to pH 10-13, then add sulfur dioxide or sulfurous acid to pH 4.5-6, and divide the medicinal solution Pack it for high-pressure steam sterilization, filter the sterilized liquid, add double distilled water to dilute the ratio of crude drug and liquid to 1:1-15, pack it separately and then sterilize it under high pressure.

Compared with the prior art, the Aining liquid preparation process of the present invention has the following advantages: 1. The content of the extracted active ingredients is high. 2. Good effect in removing impurities. 3. The process is simple.

Example: 1

Astragalus 28 catties, Ginseng 8 catties, Biejia 28 catties, Oyster 40 catties, Bupleurum 8 catties, Chishao 8 catties, Asparagus 8 catties, Licorice 4 catties, Toad Su 40g, Mylabris 200g.

Ginseng is crushed and wetted, put into the percolation cylinder and soaked in 70% ethanol for about 3-4 hours to collect the percolation liquid until it turns light yellow, and recover the ethanol liquid for later use. Take the above-mentioned ginseng residue and all other medicines, add water to immerse the medicines, boil for half an hour, boil for one hour for the second decoction, and boil for two hours for the third decoction. Combine and filter the three medicinal liquids and ginseng percolation liquid, then add saturated milk of lime to a pH above 10, then pass sulfur dioxide to a pH of 5, and filter the medicinal liquid to concentrate crude drug and liquid at a ratio of 1:2. Then add saturated milk of lime to more than PH10, and pass through sulfur dioxide to PH5. The medicinal liquid is subpackaged for high-pressure sterilization, and the medicinal liquid is filtered and diluted with distilled water for subpackage, and then autoclaved and sterilized.

Example 2:

Take 10 jin of Bupleurum chinensis and 100 jin of oysters, add water, soak and boil three times, boil for half an hour, one hour, and two hours respectively, combine and filter the three medicinal liquids, and the following preparation process is the same as in Example 1.

Claims (5)

1. A method for preparing an anti-cancer injection, characterized in that Aining is a Chinese medicine compound, which is formed by extracting active ingredients, removing impurities, removing impurities for the second time, and diluting and sterilizing. The composition percentage (W%) of the compound is as follows: Astragalus 20-30 Radix Paeoniae Rubra 6-10 Ginseng 6-12 Asparagus 6-10 Biejia 20-30 Licorice 3-5 Oyster 30-35 Toad 0.03-0.07 Bupleurum 6-10 Mylabris 0.1-0.4 2. The preparation method of anticancer injection according to claim 1, characterized in that the extracted active ingredients can be extracted by water or alcohol. (1) Water extraction: in two steps: A. First extract the ginseng with 50-75% ethanol according to the percolation method, and filter the liquid for later use. B decoct the traditional Chinese medicine (including ginseng residue extracted with alcohol) three times with water and filter. The above-mentioned two-step extraction filtrates were combined. (2) Alcohol extraction: Extract the active ingredients of traditional Chinese medicine by dipping or percolating with 50-75% ethanol. 3. The preparation method of anti-cancer injection according to claim 1, characterized in that the removal of impurities is to add saturated lime milk to the liquid extracted by water or alcohol to pH 10-13, and then add sulfur dioxide or sulfurous acid To PH4-6, the medicinal liquid is filtered and concentrated, so that the ratio of the crude drug to the medicinal liquid is 1:1-2. 4. The preparation method of anticancer injection according to claim 1, characterized in that the second removal of impurities is to add saturated lime milk to the concentrated solution to pH 10-13, and then add sulfur dioxide or sulfurous acid to PH4-6, subpackaged and sterilized. 5. The preparation method of anti-cancer injection according to claim 1, characterized in that said dilution and sterilization is to filter and dilute the sterilizing solution so that the ratio of crude drug to medicinal solution is 1:1-15, then subpackage and sterilize .