CN1593514A - Method for preparing a gynecopathy treating medicine - Google Patents
Method for preparing a gynecopathy treating medicine Download PDFInfo
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- CN1593514A CN1593514A CN 200410023315 CN200410023315A CN1593514A CN 1593514 A CN1593514 A CN 1593514A CN 200410023315 CN200410023315 CN 200410023315 CN 200410023315 A CN200410023315 A CN 200410023315A CN 1593514 A CN1593514 A CN 1593514A
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- Prior art keywords
- radix
- medicine
- powder
- angelicae sinensis
- herba andrographis
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- 239000003814 drug Substances 0.000 title claims abstract description 71
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 25
- 239000000284 extract Substances 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 241000746375 Andrographis Species 0.000 claims description 21
- 241000756943 Codonopsis Species 0.000 claims description 21
- 229940079593 drug Drugs 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000011812 mixed powder Substances 0.000 claims description 15
- 238000005516 engineering process Methods 0.000 claims description 10
- 238000002386 leaching Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002105 nanoparticle Substances 0.000 claims description 6
- 239000011858 nanopowder Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 4
- 238000005453 pelletization Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 abstract description 3
- 244000118350 Andrographis paniculata Species 0.000 abstract 2
- 241000213006 Angelica dahurica Species 0.000 abstract 2
- 241001127579 Flemingia philippinensis Species 0.000 abstract 2
- 244000179291 Mahonia aquifolium Species 0.000 abstract 2
- 241000913745 Spatholobus Species 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 2
- 235000018553 tannin Nutrition 0.000 description 9
- 229920001864 tannin Polymers 0.000 description 9
- 239000001648 tannin Substances 0.000 description 9
- 238000011160 research Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000012567 medical material Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000006071 cream Substances 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229940126532 prescription medicine Drugs 0.000 description 2
- 244000061520 Angelica archangelica Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010336 energy treatment Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing a gynecopathy treating medicine by using prickly, mahonia stem, root of Fructus Rosae Laevigatae, Moghania philippinensis, spatholobus stem, Chinese angelica root, pilose asiabell root, green chiretta as raw material through the steps of, disintegrating Chinese angelica root, pilose asiabell root and green chiretta into micrometer level particles and nanometer level particles in crushing machine, placing prickly and mahonia stem in extractor, extracting twice by watering and boiling 2 hours for one extraction, compressing into extract for later use, placing root of Fructus Rosae Laevigatae, Moghania philippinensis and spatholobus stem in extractor, extracting twice by watering and boiling 2 hours for one extraction, compressing into extract for later use, bed blending the powder with the two extracts, drying, tabletting to obtain tablet form medicine, or obtaining capsule form medicine through loading.
Description
Technical field
The present invention relates to a kind of process for preparing medicine for the treatment of gynaecopathia, referring in particular to Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis is the manufacture method of gynecological's Chinese patent medicine of raw material.
Background technology
My company is " FUKE QIANJIN PIAN " of raw material production with Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis, existing history for many years." FUKE QIANJIN PIAN " not only becomes the pillar product of my company, and become the gynecological inflammation oral medication commonly used that China's technical field of Chinese patent medicine has much popularity and welcome by the patient, as far back as on October 21st, 1998, production method with regard to " FUKE QIANJIN PIAN ", applied for patent, the patent No. is ZL98112696.0.
Above-mentioned this disclosed " a kind of process for preparing medicine for the treatment of gynaecopathia " is selected medical material to be divided into two classes handle: the one, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis three flavor Chinese crude drugs are made fine powder; And in addition other Chinese medicine of the five flavours material Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis and Caulis Spatholobi Chinese medicine of the five flavours material are put together, make by decocting in water, extraction, after concentrating and produce tablet extractum; Granulate behind the last and aforementioned powder mixing, after tabletting, become final products.
Though production practices for many years show above-mentioned process and are successfully effective, but in present drug market increasingly competitive today, how to guarantee further medicament curative effect enhancement under the product quality premise, improve the crude drug utilization rate, and from production technology, innovate, tap the latent power, become the main direction of FUKE QIANJIN PIAN research and production.
Technology contents
Purpose of the present invention: be intended on the basis of forefathers to FUKE QIANJIN PIAN series of products and technical study, under the prerequisite that does not change its basic prescription compatibility, a kind of more scientific and rational process for preparing medicine that can treat gynaecopathia is proposed, wish that it can further improve the utilization rate of Chinese material medicine resource, simultaneously medicament curative effect enhancement better.
The preparation method of the medicine of this treatment gynaecopathia is a raw material with Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis still, it is characterized in that preparing as follows:
A, will in pulverizer, be ground into by Radix Angelicae Sinensis, Radix Codonopsis, the Herba Andrographis that prescription is chosen based on the micron particles of 0.1-10 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby.
B, will place extractor together, and add water and extract twice, cross leaching liquid by the method that per 2 hours decocting in water extract once by Fructus Zanthoxyli Dissiti, the Caulis Mahoniae that prescription is chosen; Then in concentrator, be condensed into proportion and be 1.08/80 ℃ standby extractum.
C, will place extractor together, and add water and extract twice by the method that per 2 hours decocting in water extract once by Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the Caulis Spatholobi that prescription is chosen, cross leaching liquid after, in concentrator, be condensed into proportion and be 1.08/80 ℃ standby extractum.
D, with the extractum mixed pelletization in the powder that obtains in the A technology and B, the C technology, drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
The mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the fine powder based on particle diameter 10-150 μ m.
The mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the micropowder based on particle diameter 0.1-10 μ m.
The mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the nano powder based on particle diameter＜0.1 μ m.
Described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis mixed powder are made up of two kinds of powders in fine powder, micropowder, three kinds of granule powders of nano powder at least.
A kind of process for preparing medicine for the treatment of gynaecopathia according to above technical scheme proposition, with ZL98112696.0, the preparation method of having implemented is compared, be Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are used as medicine with fine powder, micropowder and nano-particle mixed powder, the effective ingredient of medicine is obtained fully, comprehensively stripping, created condition for improving medicine at the intravital bioavailability of people; Simultaneously, be Fructus Zanthoxyli Dissiti, Caulis Mahoniae, and after Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi separate decocting in water and extract, make from Fructus Zanthoxyli Dissiti and Caulis Mahoniae and the effective alkaloid content of berberine arranged from what obtain, and the content of tannin that extracts from Radix Rosae Laevigatae and Radix Flemingiae Philippinensis all has fairly obvious increase, not only, also provide technical guarantee for the clinical efficacy that strengthens medicine for the utilization rate that improves herb resource provides the technical support foundation.
The specific embodiment
Medicine---the preparation method of the medicine of FUKE QIANJIN PIAN of this treatment gynaecopathia after innovation improves that proposes according to technique scheme, its prescription is still continued to use the prescription compatibility of ZL98112696.0 patent, and promptly this medicine (FUKE QIANJIN PIAN) is still by respectively being Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis, the Fructus Zanthoxyli Dissiti of 9 weight portions and respectively being Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the common prescription of Caulis Spatholobi eight flavor Chinese crude drugs of 16 weight portions.
Concrete preparation method is as follows:
A, will in pulverizer, be ground into by Radix Angelicae Sinensis, Radix Codonopsis, the Herba Andrographis that prescription is chosen based on the micron particles of 0.1-10 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby.
B, will place extractor together, and add water and extract twice, cross leaching liquid by the method that per 2 hours decocting in water extract once by Fructus Zanthoxyli Dissiti, the Caulis Mahoniae that prescription is chosen; Then in concentrator, be condensed into proportion and be 1.08/80 ℃ standby extractum.
C, will place extractor together, and add water and extract twice by the method that per 2 hours decocting in water extract once by Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the Caulis Spatholobi that prescription is chosen, cross leaching liquid after, in concentrator, be condensed into proportion and be 1.08/80 ℃ standby extractum.
D, with the extractum mixed pelletization in the powder that obtains in the A technology and B, the C technology, drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
The mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the fine powder based on particle diameter 10-150 μ m.It is main micropowder that this mixed powder also can adopt particle diameter 0.1～10 μ m; Or based on the nano powder of particle diameter＜0.1 μ m.
Certainly, described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis mixed powder can also be made up of two kinds of powders in fine powder, micropowder, three kinds of granule powders of nano powder at least.
Why the research staff of this seminar proposes once more for " FUKE QIANJIN PIAN ", innovation and improvement in two kinds of explained hereafter of this treatment medicine for gynecopathy, and one is based on the research that concerns between herbal pharmaceutical bound pair drug particles and the drug effect; Further optimize the test result of drug effect in the two pharmacological research experiments that are based on " FUKE QIANJIN PIAN " prescription medicine.
Micron Chinese medicine and nanometer Chinese medicine are meant that adopting the modern high technology nanotechnology to combine with the process of preparing Chinese medicine of Chinese medicine tradition and preparation technique develops; can keep Chinese medicine to have pharmacodynamics material base, particle diameter to be respectively 0.1-10 μ m micron particles or particle diameter new medicine less than 0.1 μ m nano-scale particle.
Modern medicine is all thought material base that Chinese medicine prevents and cures diseases from biological activity position or active chemical components, and therefore, general traditional medicine scholar's attention mainly concentrates on to seek to be had on the various bioactive chemical compounds.But through the modern science personnel traditional Chinese medical science, Chinese medicine further investigation are shown: living organism is an extremely complex physical chemical process to absorption, metabolism, the drainage of medicine, the pharmacodynamics effect that Chinese medicine produces can not give the credit to the distinctive chemical composition of this medicine uniquely, and is also closely related with the physical state of medicine etc.Therefore, changing the physical state of medicine, is the raising drug effect, also is a kind of method that is worth trying to explore of development newtype drug and drug manufacture new method.
There have been many scientific and technical personnel some Chinese crude drug to be changed the test of drug unit size (volume) in the disclosed at present documents and materials, test shows: use different processing methods, change primary crude drug and make granularity, the biological activity of its medicine and availability all can be greatly improved.Its reason is: the Chinese medicine granularity is more little, and the dissolution of its effective ingredient is big more.
Just be based on above-mentioned theory research and document foundation; medicine---the prescription characteristics of " FUKE QIANJIN PIAN " of the scientific research personnel of this seminar binding energy treatment gynaecopathia; Chinese medicine angelica, Radix Codonopsis and Herba Andrographis that the flavor of three in the raw material is pulverized in proposition; powder particle diameter in pulverizer proposes following requirement; powder after pulverizing; require particle diameter to reach the micron particles of 0.1-10 mu m range or particle diameter nano-scale particle less than 0.1 μ m, and by at least 95% the powder rate be left and taken standby.The result who so does had both improved the level of resources utilization of Chinese crude drug, make again in the Chinese crude drug active substance gastrointestinal absorption more comprehensively, more abundant, improve bioavailability.
In addition, why research worker of the present invention proposes that Fructus Zanthoxyli Dissiti, Caulis Mahoniae are separated decocting in water with Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi is extracted, and this is based on our the deep progress to the research and the test of prescription medicine galenic pharmacy.This five kinds of Chinese medicine, especially the first four traditional Chinese medicine in this prescription, their pharmacological action is: contain alkaloid-berberine hydrochloride in Caulis Mahoniae and the Fructus Zanthoxyli Dissiti, contain tannin in Radix Rosae Laevigatae and the Radix Flemingiae Philippinensis.Therefore, what of the berberine hydrochloride that extracts in these four kinds of medical materials, content of tannin not only can play an important role to drug effect, and to produce prescription all significant to further adjusting later on.
Testing program and result are as follows:
One group: Radix Rosae Laevigatae 150 grams, Radix Flemingiae Philippinensis 150 grams.
Two groups: Caulis Mahoniae 150 grams, Fructus Zanthoxyli Dissiti 84.4 grams.
Three groups: Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, each 150 gram of Caulis Mahoniae, Fructus Zanthoxyli Dissiti 84.4 grams.
Experimental implementation: the medical material of specified in packets is pressed into fragment, places 3 decocting in water extractors respectively, add 6 times of decoctings to the medical material amount and boil 2 times, each 2 hours, filtration was condensed into dried cream respectively with filtrate and accurate the title quantitatively gets 3 parts of dried cream samples.
Keep sample: 3 parts of dried cream samples are also indicated accurate weight, and are standby.
Sample is denoted as: 3-1,3-2,3-3 (totally 3 increments).
Measure: the content of tannin in one group, the content of berberine hydrochloride in two groups, the content of tannin and berberine hydrochloride in three groups.The data rows following table:
Compatibility changes the test data table
| Label | Dried cream heavy (g) | Tannin | Berberine hydrochloride | Content of tannin | Content of berberine hydrochloride |
| ????3-1 | ????28.4612 | ????23.60％ | ?/ | ??6.7168g | ??/ |
| ????3-2 | ????9.5329 | ????/ | ?4.0475mg/g | ??/ | ??0.3858mg |
| ????3-3 | ????33.7912 | ????9.800％ | ?0.7845mg/g | ??3.3115g | ??0.2651mg |
Test shows: after the medical material of Radix Rosae Laevigatae, Radix Flemingiae Philippinensis (containing the tannin composition) and Caulis Mahoniae, Fructus Zanthoxyli Dissiti (containing alkaloid) adopts and separate and merges decoction and test, with Radix Rosae Laevigatae and Radix Flemingiae Philippinensis and Caulis Mahoniae, Fructus Zanthoxyli Dissiti separate boil separately get after, the content of its working substance tannin has increased by one times with respect to old merging decocting method; Equally, separately boil the berberine hydrochloride that from Caulis Mahoniae and Fructus Zanthoxyli Dissiti, obtains after getting and also increase by 45.5%.This result fully shows: this two classes medical material is unwell to close to be fried in shallow oil, and should separately decoct.
Claims (5)
1, a kind of process for preparing medicine for the treatment of gynaecopathia is a raw material with Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis, it is characterized in that preparing as follows:
A, will in pulverizer, be ground into by Radix Angelicae Sinensis, Radix Codonopsis, the Herba Andrographis that prescription is chosen based on the micron particles particle diameter of 0.1-10 μ m particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
B, will place extractor together, and add water and extract twice, cross leaching liquid by the method that per 2 hours decocting in water extract once by Fructus Zanthoxyli Dissiti, the Caulis Mahoniae that prescription is chosen; Then in concentrator, be condensed into proportion and be 1.08/80 ℃ standby extractum;
C, will place extractor together, and add water and extract twice by the method that per 2 hours decocting in water extract once by Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the Caulis Spatholobi that prescription is chosen, cross leaching liquid after, in concentrator, be condensed into proportion and be 1.08/80 ℃ standby extractum;
D, with the extractum mixed pelletization in the powder that obtains in the A technology and B, the C technology, drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
2, a kind of process for preparing medicine for the treatment of gynaecopathia as claimed in claim 1 is characterized in that: the mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the fine powder based on particle diameter 10-150 μ m.
3, a kind of process for preparing medicine for the treatment of gynaecopathia as claimed in claim 1, it is characterized in that: the mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the micropowder based on particle diameter 0.1～10 μ m.
4, a kind of process for preparing medicine for the treatment of gynaecopathia as claimed in claim 1 is characterized in that: the mixed powder that described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis are ground into is the nano powder based on particle diameter＜0.1 μ m.
5, a kind of process for preparing medicine for the treatment of gynaecopathia as claimed in claim 1 is characterized in that: described Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis mixed powder, form by at least two kinds of powders mixing in fine powder, micropowder, three kinds of granule powders of nano powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100233154A CN1330335C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100233154A CN1330335C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1593514A true CN1593514A (en) | 2005-03-16 |
| CN1330335C CN1330335C (en) | 2007-08-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100233154A Expired - Lifetime CN1330335C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109470788A (en) * | 2018-11-14 | 2019-03-15 | 株洲千金药业股份有限公司 | A kind of method of quality control of FUKE QIANJIN PIAN |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017157260A1 (en) | 2016-03-17 | 2017-09-21 | 株洲千金药业股份有限公司 | Phenylpropanoid and preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1078079C (en) * | 1998-10-21 | 2002-01-23 | 株洲千金药业股份公司 | Process for preparing Chinese medicine 'Qianjin tablets' for treating gynopathy |
| CN1158087C (en) * | 1999-12-07 | 2004-07-21 | 株洲千金药业股份有限公司 | Process for preparing 'Qianjin' capsule to treat ganopathy |
| CN1170549C (en) * | 1999-12-07 | 2004-10-13 | 株洲千金药业股份有限公司 | Process for preparing 'Qianjin' capsule to treat genopathy |
| CN1360941A (en) * | 2000-12-29 | 2002-07-31 | 杨孟君 | Nanometer women's Qianjin Medicine and its prepn |
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2004
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109470788A (en) * | 2018-11-14 | 2019-03-15 | 株洲千金药业股份有限公司 | A kind of method of quality control of FUKE QIANJIN PIAN |
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| CN1330335C (en) | 2007-08-08 |
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Granted publication date: 20070808 |