CN1401350A - Medicine for treating burns and scald, and producing method thereof - Google Patents
Medicine for treating burns and scald, and producing method thereof Download PDFInfo
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- 206010053615 Thermal burn Diseases 0.000 title abstract description 6
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating burn and scald is prepared from more than 10 Chinese-medicinal materials including tortoise plastron, turtle shell, pangolin scales, elephant skin, etc. Its advantages are high curative effect, quickly taking its effect (10 min), short course of treatment (5-45 days), and no residual scar.
Description
The present invention is a kind of medicine (abbreviation burn powder) for the treatment of burn, is the field that belongs to Chinese medicine medical science, external used medicine of specifically a kind of quick treatment skin burn and preparation method thereof.
The method of the burn of modern medicine treatment at present has: (1) bandaging strapping: after this method is carried out debridement to wound surface, with the absorptive dressing wrapping of wound surface with thick-layer, wound surface is isolated from the outside, prevent to pollute and blot sepage, appear if any sepage the wrapping back, then add a cover and changed once in aseptic dressing 5-7 days, so that the wound surface drying; (2) exposure method: after the wound surface debridement, utilize 25～30 ℃ of baking bed control room temperatures, indoor humidity 50%～60% is dried wound surface, and the frequent room air of sterilization regularly keeps indoor air clean, is purpose to reach the oven dry wound surface; (3) wrapping or exposure method: must be at aseptic in-house operation, antibiotic to the patient infusion fluid infusion simultaneously, antiinflammatory, augment nutrition to reach therapeutic purposes; (4) wrapping or exposure method, the processing of counterweight II, III degree wound surface are to carry out detoxicating after the wait wound surface drying to cut eschar and skin grafting.
More than treat the therapy weak point of burn: (1) two kind of method all must can undergo surgery in sterilizing room; (2) counterweight I, II degree wound surface must be cut eschar and skin grafting; (3) medical expense costliness.
Chinese traditional treatment at present also has a lot of methods, and wherein curative effect has ZHENGHONGHUA YOU and burn cream method etc. preferably, though cure rate is short and curative effect is higher, but easy infection in therapeutic process, sometimes treatment time also drags longlyer, stays cicatrix after the recovery from illness, and most of patients has sequela.
The research of burn powder of the present invention is primarily aimed at the existing problem of above-mentioned therapy and carries out, I am engaged in the medical treatment practice of more than ten years, and secret prescription handed down in the family from generation to generation arranged, to collecting repeatedly and study about the various medicines of treatment burn, several ten kinds of Chinese medicines such as Carapax et Plastrum Testudinis, Carapax Trionycis, Squama Manis, Margarita, Cortex Phellodendri, Radix Et Rhizoma Rhei have been chosen at last, carry out the checking of prolonged and repeated test and clinical treatment, study finally successfully a kind ofly have antibiotic, antiinflammatory, heat clearing away, detoxify, remove the rotten and let fresh grow, the burn powder of function such as removing toxic substances and promoting tissue regeneration.
Burn powder is through clinical verification, and the burn patient is had outstanding especially effect, to surplus patient's dispenser ten minute, promptly feels pleasantly cool, and wound pain is alleviated immediately, and wound healing is also very fast.General treatment I degree burn only needs 5～7 days, II degree burn 7～15 days, and heavy II, III degree burn need not made skin graft, i.e. recovery from illness in 25～45 days.
Burn powder of the present invention through Colleges Of Traditional Chinese Medicine Of Guangxi Study of Medicinal Herbs chamber to rabbit scald, acute, toxicity test, concrete condition and result of the test are as follows: the granulation promoting test of one, scald property rabbit
(1) material
1, medication preparation: get burn powder and grind, face the time spent with mortar and accurately take by weighing medicated powder 2g, transfer to 10ml (promptly being made into 20%), be coated with wound outward with deionized water;
2, positive control drug: ZHENGHONGHUA YOU, beat Lian Hua company according to horse and produce lot number 960328;
3, depilatory: 8% sodium sulfide solution;
4, animal: Japan large ear rabbit is provided by Colleges Of Traditional Chinese Medicine Of Guangxi's Experimental Animal Center.
(2) method and result
Get 8 of rabbit, body weight 1.75～1.9kg, the male and female dual-purpose, cropping under the arm of every rabbit and left and right sides rib is sloughed hair with depilatory.Measure area, finished the position, and finished position scalpel standardized " # " font wound, size is 2 * 2cm, and the degree of depth is for scratching skin corium, till oozing of blood, inject 95% ethanol 1ml with cotton balls then, place " # " mid point burning 1.5min, area is 3 * 3cm.Different medicines is coated at 4 positions of every rabbit burn respectively, accomplishes the harmony of testing, and arrange by the Latin mode at the position of each medicine coating.Grouping: burn powder group (heavy dose of 20%, low dose of 10%), positive controls (the higher ZHENGHONGHUA YOU group of curative effect at present), blank group (deionized water), volume is 0.3ml.In scalding back 16h coating 2 times/day, continuous use seven days is observed wound situation (changing the situation dense, downright bad, that fur is grown etc.) every day.Behind the last coating second day, clean wound, observe the wound growing state.Carry out result's statistics with scoring method.Long new skin is 40 minutes, and endysising is 20 minutes, and not having incrustation is 20 minutes, and nothingization is dense to be 20 minutes.Observed result finds that the wound diameter of large and small dosage of burn powder and Flos Carthami line of oils obviously dwindles, and blank wound to bright group does not have obvious change.See Table 1.
Table 1 burn powder is to the influence of scald property rabbit (X ± S)
After group number of animals (only) medication wound healing (%) deionized water group 8 35.00 ± 29.76 ZHENGHONGHUA YOU groups 8 75.50 ± 28.16 2. the heavy dose of group 8 82.50 ± 12.82 of burn powder 1. the heavy dose of group 8 67.50 ± 10.35 of burn powder 1. annotate 1: represent that 1. 2. P＜0.01 represents P＜0.05
From experimental result as seen, healing has positive effect to burn powder to the rabbit burn wound, has remarkable meaning.
Two, in-vitro antibacterial experiment (one) material
Staphylococcus aureus (to medicine bacterium, sensitive organism), bacillus pyocyaneus.Strain is provided by Affiliated Hospital of Guangxi Medical University Bacteriology Room.(2) method and result
Connect the dilution method that continues with solid.With not commensurability medicine dissolution on culture medium, after high pressure, sterilization, the cooling different bacterial classification inoculations on culture medium, cultivate to take out in 24 hours for 37 ℃ and observe minimum inhibitory concentration (MIC) more than 0.1g/ml.
Three, acute toxicity testing
(1) material
1, medication preparation: make 100% suspension with distilled water standby.
2, animal: get 20 of Kunming kind white mice (osmanthus doctor's mover) No. 1104, body weight 20 ± 2g, male and female half and half.
(2) method and result
Get hungry 16 hours white mice, after weighing, with the medicine liquid irrigation stomach of 0.2ml/10g (20g/kg), the male and female sub-cage rearing is observed seven days animals and is had or not poisoning and dead the generation.All animals do not see obvious poisoning and dead the generation as a result, the flat no weight increase 4.30 ± 1.4g of male mouse after the medication, and rate of body weight gain is 21.62%.Female Mus average weight increases by 3.92 ± 1.81g, and rate of body weight gain is 20.09%.
Brief summary: through the experiment of rabbit burn property, burn powder is scalded wound to rabbit and had obvious granulation promoting, the antiinflammatory effect: chmice acute toxicity 20g/kg gives mice and once irritates stomach and observe and do not see overt toxicity a week; MIC is more than 0.1g/ml.This shows the burn powder amount be one have the exploitation meaning medicine is arranged.
Burn powder clinicing aspect situation is used burn spirit treatment burns patient 1000 many cases for many years through Shanglin County golden shower burn clinic, obtain remarkable result, firmly gets the praise of extensive patients.Think that this medical instrument is effective in cure fast, short treating period need not made skin graft, and no cicatrix or the few characteristics of cicatrix heal.Record according to these 573 cases of institute: I degree 197 examples of burning wherein, behind the coating, treated cure rate 100%, effective percentage 100% 5-7 days; II degree 223 examples of burning except that to there being the dense patient of seriousization to be used the antibiotics, all use this medicine to be coated with 5～15 days outward, effective percentage 100%, cure rate 95%; III degree 153 examples of burning, the 10-30 days course of treatment, cure rate 95%, effective percentage 100%.
One, the raw material of burn powder of the present invention and prescription (weight portion)
300～400 parts in 0.4～0.6 part of water of 5～25 parts of Fel Ursis of 5～25 parts of Radix Scutellariae of 10～30 portions of Cortex Phellodendris of 10～30 portions of Rhizoma Coptidis of 10～20 parts of Radix Et Rhizoma Rhei of 4～8 parts of Radix Sophorae Flavescentiss of 18～62 portions of Flos Loniceraes of 5～20 parts of Margaritas of 5～30 parts of Corium elephatiss of 40～60 parts of Squama Maniss of 40～60 parts of Carapax Trionycis of Carapax et Plastrum Testudinis, 4～6 parts of vaseline of 0.5～3 part of concentration, 95% ethanol
Two, the manufacture method of burn powder of the present invention
(1) 18～62 parts of Margaritas, 40～60 parts of Carapax et Plastrum Testudiniss, 40～60 parts of Carapax Trionycis, 5～30 parts of Squama Maniss, Corium elephatis are put into calcining furnace for 5～20 parts, heat temperature raising, 500 ℃ of constant temperature, through calcining in 24 hours, the cooling back was taken out and is pulverized powdered, crosses 800 mesh sieves.The medicated powder that will sieve is put into calcining kiln again, heat temperature raising, and 300 ℃ of constant temperature, through roasting in 72 hours, it is standby that medicated powder is taken out in cooling;
(2) will put into stainless-steel pan after 4～8 parts of Flos Loniceraes, 10～20 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Rhizoma Coptidis, 5～25 parts of cleanings of Cortex Phellodendri, add water and be warming up to 200 ℃, decocted 2 hours, remove medicinal residues, with the liquid medicine distillation, it is standby that distillate is taken out in the cooling back;
(3) Fel Ursi is put into stainless steel ware, add 4～6 parts of concentration 95% ethanol, soaked through 24 hours, it is standby that Fel Ursi is dissolved fully;
(4) medicated powder, distillate, liquid medicine, Fel Ursi solution and the vaseline of above-mentioned (one), (two), (three) procedure gained are put into rustless steel container for 0.4～0.6 part, stir into suspension at normal temperatures, again suspension is carried out high temperature, autoclave sterilization, draw medicated powder, promptly available bottle is packaged as finished product.
Embodiment one
(1) Example formulations (weight portion)
300 parts in 0.5 part of water of 20 parts of Fel Ursis of 20 parts of Radix Scutellariae of 20 portions of Cortex Phellodendris of 5 portions of Rhizoma Coptidis of 20 portions of Flos Loniceraes of 52 parts of Radix Et Rhizoma Rhei of 12 parts of Margaritas of 10 parts of Radix Sophorae Flavescentiss of 10 parts of Corium elephatiss of 42 parts of Squama Maniss of 50 parts of Carapax Trionycis of Carapax et Plastrum Testudinis, 0.5 part of vaseline of 1 part of concentration, 95% ethanol
(2) embodiment manufacture method
(1) in calcining furnace, add 10 parts of 52 parts of Margaritas, 42 parts of Carapax Trionycis, 10 parts of Squama Maniss, Corium elephatis after, it is heat temperature raising, 500 ℃ of constant temperature, through calcining in 24 hours, the cooling back was taken out and is pulverized powdered, cross 800 mesh sieves, the medicated powder that will sieve is put into calcining kiln again, heat temperature raising, 300 ℃ of constant temperature, through roasting in 72 hours, take out medicated powder (about 100 parts) standby after cooling.
(2) in stainless-steel pan, add 300 parts in 20 parts of 20 parts of 20 parts of 20 parts of 12 parts of 5 parts of Flos Loniceraes, Radix Sophorae Flavescentiss, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendris, Radix Scutellariae through cleaning and water, intensification is heated to 200 ℃, decocts 2 hours, removes medicinal residues, with the liquid medicine distillation, it is standby to obtain distillate (about 100 parts).
(3) in container, add 0.5 part of 1 part of Fel Ursi and concentration 95% ethanol, soaked, treat that Fel Ursi is standby after dissolving fully through 24 hours.
With 0.5 part in (1), (2), (3) procedure gained medicated powder, liquid medicine, distillate, Fel Ursi solution and vaseline, insert in the lump in the rustless steel container, stir at normal temperatures, the suspension that draws is behind autoclave sterilization, get 200 parts in medicated powder approximately, go into the bottle packing.
So burn powder of the present invention is to the damage to body surface of the burn of the scald of hot water, deep fat and charcoal fire, flame, electricity, light and atomic radiation, chemical substance, even injures diseases such as muscle, skeleton and all have outstanding curative effect.Mainly be the suitable and heavy control of selected compatibility of drugs to part, now the Main Ingredients and Appearance with this medicine is analyzed as follows:
Carapax et Plastrum Testudinis has the nourishing YIN for suppressing the hyperactive YANG effect; Carapax Trionycis has nourishing YIN for suppressing the hyperactive YANG, the effect of eliminating stagnation softening the hard mass; Squama Manis has promoting blood circulation to restore menstrual flow, the dense effect of detumescence row; Corium elephatis energy hemostasia and promoting granulation, convergence healing effect; Margarita has the relieving palpitation arresting convulsion, the convergence promoting muscle growth functions; Flos Lonicerae contains pyrite class, triterpenes and organic acid etc., and contains abundant volatile oil, Shi Cheng etc., has effects such as antibacterial, antiviral, analgesic, antiinflammatory, hemostasis, antioxidation and immunomodulating; Radix Sophorae Flavescentis contains Radix Sophorae Flavescentis total alkaloids, multiple alkaloid, golden yellow staphylococcus is had obvious inhibitory action and radiation resistance; Cortex Phellodendri contains berberine, phellodendrine, Cortex Phellodendri copper, and streptococcus, staphylococcus are had inhibitory action; Radix Scutellariae contains the scutellarin glycoside, and green pus stalk bacterium, staphylococcus, streptococcus are had inhibitory action, and can antiinflammatory, bring down a fever, analgesic activity; Rhizoma Coptidis contains berberine, coptisine, 13-methyl-.psi.-coptisine., palmatine, and streptococcus, gold color staphylococcus are had strong the inhibition and the has a broad antifungal spectrum effect; Radix Et Rhizoma Rhei contains chrysophanic acid, chrysophanol, emodin, aloe-emodin, and has a broad antifungal spectrum has antibiotic, antiinflammatory, hemostasis, clots absorbing, detumescence, antipruritic, convergence, suppresses to ooze out and regulates effect such as immunity; Fel Ursi contains the Bears gallbladder that goes to itch and looses, and has effects such as the heat of clearing away heart-fire, suppressing the hyperactive liver, heat-clearing and toxic substances removing, calmness, antibiotic, antiinflammatory.Therefore, burn powder of the present invention be melt antiinflammatory, antibiotic, invigorate blood circulation, ease pain, several effectiveness such as convergence are high violent, the gentle medicine of the property of medicine is in one, anti inflammatory detoxication, assistant is with promoting blood circulation for tissue regeneration, reach the purpose of metabolism, have antibiotic, antiinflammatory, hemostasis and pain-relieving, repellent antipruritic, dial the function of poison convergence, removing the necrotic tissue and promoting granulation.
The major advantage of burn powder: (1) wound healing is fast, short treating period, surplus patient's dispenser ten minute after, pleasantly cool sense namely being arranged, They hurt Pain is alleviated thereupon. I degree burn only needs recovery from illness in 5--7 days; The recovery from illness in 7--15 days of II degree burn; Heavy II, III degree burn were fully recovered in 25-45 days substantially.
(2) cure rate height generally reaches more than 95%, no scar after wound face is cured, or few scar, Do not stay deformity (except burning-off);
(3) need not desinfection chamber, but all dispensers whenever and wherever possible adapt to vast rural area and promote and salvage at scene;
(4) treatment cost is cheap.
Claims (2)
1, a kind of medicine for the treatment of burn is characterized in that it is by the made medicine of following materials of weight proportions:
5～20 parts of 5～30 parts of Corium elephatiss of 40～60 parts of Squama Maniss of 40～60 parts of Carapax Trionycis of Carapax et Plastrum Testudinis
10～30 parts of 10～20 parts of Radix Et Rhizoma Rhei of 4～8 parts of Radix Sophorae Flavescentiss of 18～62 portions of Flos Loniceraes of Margarita
0.5～3 part of 5～25 parts of Fel Ursi of 5～25 parts of Radix Scutellariae of 10～30 portions of Cortex Phellodendris of Rhizoma Coptidis
4～6 parts of concentration 95% ethanol
0.4～0.6 part in vaseline
300～400 parts in water
2, the described a kind of manufacture method for the treatment of the medicine of burn of claim 1 is characterized in that it makes according to following preparation method:
(1) with 18～62 parts of Margaritas, 40～60 parts of Carapax et Plastrum Testudiniss, 40～60 parts of Carapax Trionycis, 5～30 parts of Squama Maniss, Corium elephatis is put into calcining furnace for 5～20 parts, heat temperature raising, 500 ℃ of constant temperature, through calcining in 24 hours, the cooling back was taken out and is ground pure powdered, crosses 800 mesh sieves.The medicated powder that will sieve is put into the calcining kiln heat temperature raising again, 300 ℃ of constant temperature, and through roasting in 72 hours, it is standby that medicated powder is taken out in the cooling back;
(2) with 4～8 parts of Flos Loniceraes, 10～20 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Rhizoma Coptidis, put into stainless-steel pan after 5～20 parts of cleanings of Cortex Phellodendri, add water and heat up, be heated to 200 ℃, decocted 2 hours, and removed medicinal residues, liquid medicine is distilled, it is standby that distillate is taken out in the cooling back;
(3) Fel Ursi is put into rustless steel container, add 4～6 parts of the ethanol of concentration 95%, soaked through 24 hours, it is standby to make Fel Ursi dissolve the back fully
(4) with medicated powder, the distillate of above (), (two), (three) operation gained, 0.4～0.6 part of liquid medicine, Fel Ursi solution, vaseline are put into rustless steel container, stir into suspension at normal temperatures, again suspension is carried out high temperature, autoclave sterilization, the medicated powder that draws can be bottled and is finished product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011307048A CN1175850C (en) | 2001-08-21 | 2001-08-21 | Medicine for treating burns and scald, and producing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011307048A CN1175850C (en) | 2001-08-21 | 2001-08-21 | Medicine for treating burns and scald, and producing method thereof |
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| CN1175850C CN1175850C (en) | 2004-11-17 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658609B (en) * | 2009-09-16 | 2011-06-22 | 白瑞 | Medicine for removing toxic substances and promoting tissue regeneration and preparation method thereof |
| CN101468171B (en) * | 2007-12-28 | 2011-08-24 | 何顺洪 | Medicament for weight-reducing of fat people and weight-gaining of thin people |
| CN105596769A (en) * | 2016-03-02 | 2016-05-25 | 翟玉金 | Traditional Chinese medicine for treating scalds, bedsores and hemorrhoid |
| CN113786473A (en) * | 2021-10-20 | 2021-12-14 | 海南三元星生物科技股份有限公司 | Marine organism antibacterial peptide medicine and preparation method thereof |
-
2001
- 2001-08-21 CN CNB011307048A patent/CN1175850C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101468171B (en) * | 2007-12-28 | 2011-08-24 | 何顺洪 | Medicament for weight-reducing of fat people and weight-gaining of thin people |
| CN101658609B (en) * | 2009-09-16 | 2011-06-22 | 白瑞 | Medicine for removing toxic substances and promoting tissue regeneration and preparation method thereof |
| CN105596769A (en) * | 2016-03-02 | 2016-05-25 | 翟玉金 | Traditional Chinese medicine for treating scalds, bedsores and hemorrhoid |
| CN113786473A (en) * | 2021-10-20 | 2021-12-14 | 海南三元星生物科技股份有限公司 | Marine organism antibacterial peptide medicine and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1175850C (en) | 2004-11-17 |
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