CN1325632A - Process for preparing enzymolyzed silkworm product and its usage - Google Patents
Process for preparing enzymolyzed silkworm product and its usage Download PDFInfo
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- CN1325632A CN1325632A CN00107796A CN00107796A CN1325632A CN 1325632 A CN1325632 A CN 1325632A CN 00107796 A CN00107796 A CN 00107796A CN 00107796 A CN00107796 A CN 00107796A CN 1325632 A CN1325632 A CN 1325632A
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- silkworm
- enzymolysis
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- pupa
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Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to the enzymolysis technique of biological engineering. The enzymolysis is carried out on silkworm (larva, chrysalis, moth) by utilization of papainase, bromelain , thus the small molecule active polypeptide and twenty odd amino acids, various vitamins, and trace elements which can be easily absorbed by human body it can be used as health care product and raw material of nutrient solution.
Description
The present invention relates to a kind of zymolysis technique with modern biological project, silkworm (larva, pupa, moth) is carried out the enzymolysis goods of enzymolysis, is the enzymolysis goods that carry out enzymolysis with the pure natural plant compound protease.These goods can further be mixed with oral liquid, capsule, than capsule, tablet, beverage and other nutrient and healthcare products or medicine.
In recent years, China has obtained positive progress to the research of the peptide of natural activity.This technology and product belong to the product of distinct Chinese characteristics as Chinese medicine.Develop many artificial chemically synthesized peptides or gene peptide abroad, its raw material from the aminoacid of chemosynthesis, carry out the synthetic pretty young woman on this basis and connect.This peptide belongs to single peptide, is used for treating or certain sub-health population being kept healthy.But it is as Western medicine, and how many a little side effect human body is had.And with China's traditional biological food, carry out enzyme action with the pure natural plant enzyme, obtain a large amount of micromolecule active polypeptides, behind people's clothes, peptide is brought into play the liveliness proof active function from many aspects at human body, single peptide nutrition health-care functions than synthetic is bigger, more extensive, safer, human body is not had any poison pay effect.
Synthetic or single peptide difficulty height of making by genetic engineering, expense is big, the active polypeptide method made from the enzymolysis biology is simple and easy, belong to pure natural biological product, silkworm itself is a kind of natural battalion product, rich in protein, fat, vitamin and trace element are arranged, and its contained nutrient substance is very abundant, and the micromolecule active polypeptide that its enzymolysis or human body are very easily absorbed is a kind of high-class healthy product.
The purpose of this invention is to provide a kind of zymolysis technique that uses modern biological project, silkworm (larva, pupa, moth) is carried out enzymolysis with the compound plant protein enzyme, obtain micromolecule active polypeptide, 20 gynaminic acid, multivitamin and comprise the various trace elements of calcium.
Another object of the present invention provides a kind of preparation method of preparation above-mentioned enzymolysis silkworm (larva, pupa, moth) goods, promptly uses the plant mixing protease, the method for enzymolysis silkworm (larva, pupa, moth).
The present invention also has a purpose to provide the purposes of this enzymolysis silkworm (larva, pupa, moth) goods.
Enzymolysis silkworm provided by the invention (larva, pupa, moth) goods contain micromolecule active polypeptide and comprise the pure-natural biological material of the several amino acids of taurine.
Enzymolysis silkworm of the present invention (larva, pupa, moth) molecular weight is at 1000-40.
Enzymolysis silkworm (larva, pupa, moth) solution is hydrolyzed to 16-20 hour through 12HHCl at 110 ℃, and reuse 835-50 type aminase analyser is analyzed.
The preparation method of enzymolysis silkworm of the present invention (larva, pupa, moth) goods will be got the water that silkworm (larva, pupa, moth) adds 1-4 times of weight, reacts 6-48 hour down at 35-80 ℃ with the plant compound protease, stirs enzymolysis.Described plant compound protease is papain and bromelain, the two weight ratio 1: 0-1.
When PH5-9, carry out during enzymolysis, after enzymolysis is finished, adopt the inactivation treatment of heating.Usually being heated to boils gets final product, and cooled and filtered is got enzymolysis solution, carries out sterilization treatment, and this solution is through concentrating, spray drying or lyophilization enzymolysis silkworm (larva, pupa, moth) dry powder.
Enzymolysis silkworm of the present invention (larva, pupa, moth) goods can grow leukocyte, erythrocyte, promotion growth promoter, appetite stimulator; resisting fatigue; facilitation is played in operation and wound healing; leukocyte to the tumor chemoradiotherapy patient; erythrocytopenia and to the damage of human tissue organ; growth, reparation and protective effect are arranged, can stimulate the phagocytic activity of granulocyte and macrophage, various bioactive substances in the human body (as the activation of enzyme source, biological oxidation etc.) are played activate and facilitation.
The present invention is that the pure natural plant compound protease carries out enzymolysis to silkworm (larva, pupa, moth), have more specificity and popularity than single enzyme hydrolysis method of planting, protein digestion to silkworm is more thorough, especially make silkworm (larva, pupa, moth) protein be decomposed into micromolecule active polypeptide, aminoacid, and can preserve various pure natural vitamin that silkworm (larva, pupa, moth) contained and trace element etc.Have plurality of health care functions, nontoxic pair of effect of goods, and be a kind of easy and lower-cost biological engineering enzymolysis technology production technology.The yet all nontoxic pair effect of the enzyme preparation that is adopted, ADI does not need particular provisions.It is a kind of industrial method that is suitable for.
To help to understand the present invention by following example, but be not limited to content of the present invention.
Embodiment:
Claim silkworm (larva, pupa, moth) 1000g, add distilled water 1500g, bromelain 3-6g, papain 10-15g, stirring reaction was heated to and boils, cools off, filters after 10-15 hour in the time of 20-60 ℃, promptly get enzymolysis silkworm solution behind the pressure sterilizing, this solution appearance is light brown, slightly fishy smell.
This enzymolysis silkworm solution is surveyed molecular weight distribution with the G-25 column chromatography method, wherein molecular weight＜1000 account for 30%, molecular weight＞1000 account for 30%, show be one based on the aminoacid of small-molecular peptides and the mixture of polypeptide.
Claims (7)
1, a kind of peptide and aminoacid enzymolysis silkworm (larva, pupa, moth) goods of containing.It is characterized in that peptide molecular weight is between 1000-235.It is the mixture of a kind of micromolecule active polypeptide, aminoacid, multivitamin and microelement element.
2, its feature of the described enzymolysis silkworm of a kind of and claim 1 (larva, pupa, moth) contains 20 seed amino acids, that is: taurine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, cystine, methionine, valine, leucine, isoleucine, tyrosine, phenylalanine, ornithine, lysine, histidine, tryptophan, arginine.
3, a kind of enzymolysis silkworm as claimed in claim 2 (larva, pupa, moth) goods, its feature contains calcium, phosphorus, ferrum, zinc and iodine.
4, the enzymolysis goods preparation method of a kind of enzymolysis silkworm as claimed in claim 3 (larva, pupa, moth), it is characterized in that silkworm (larva, pupa, moth) is added the water of 1-5 times of weight, carry out enzymolysis with the white enzyme of the compound silkworm of plant (papain, bromelain), the required enzyme unit of every gram silkworm (larva, pupa, moth) is the 2000-10000 gram.
5, the preparation method of a kind of enzymolysis silkworm as claimed in claim 4 (larva, pupa, moth), it is characterized in that solution ebuillition of heated with enzymolysis after, cooling, filter.
6, the preparation method of a kind of enzymolysis silkworm as claimed in claim 5 (larva, pupa, moth) is characterized in that through lyophilization or spray drying.
7, a kind of purposes as claim 1,2,3,4,5,6 described enzymolysis silkworm (larva, pupa, moth) goods is with health product, nutriment or medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00107796A CN1325632A (en) | 2000-05-26 | 2000-05-29 | Process for preparing enzymolyzed silkworm product and its usage |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00107914.X | 2000-05-26 | ||
| CN00107796A CN1325632A (en) | 2000-05-26 | 2000-05-29 | Process for preparing enzymolyzed silkworm product and its usage |
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| Publication Number | Publication Date |
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| CN1325632A true CN1325632A (en) | 2001-12-12 |
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| CN00107796A Pending CN1325632A (en) | 2000-05-26 | 2000-05-29 | Process for preparing enzymolyzed silkworm product and its usage |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100356872C (en) * | 2006-01-18 | 2007-12-26 | 周维海 | Compound silkworm chrysalis polypeptide functional food |
| CN1908183B (en) * | 2006-08-16 | 2010-09-29 | 上海奥利实业有限公司 | Enzymatic mixed peptides of natural proteins with endothelin antagonism |
| CN105520135A (en) * | 2015-12-20 | 2016-04-27 | 雷西云 | Healthy food with function of treating osteoporosis |
| CN105661554A (en) * | 2016-01-14 | 2016-06-15 | 安徽生物肽产业研究院有限公司 | Silkworm chrysalis small molecule peptide chelate for improving immunity and preparation method thereof |
| CN107440085A (en) * | 2017-07-11 | 2017-12-08 | 四川省蚕业科技开发总公司 | A kind of production technology of edible silkworm chrysalis |
| CN108409854A (en) * | 2018-02-10 | 2018-08-17 | 海盐县凌特生物科技有限公司 | A kind of small-molecular-weight silkworm chrysalis collagen |
| CN110089618A (en) * | 2019-06-18 | 2019-08-06 | 武汉天天好生物制品有限公司 | A kind of soya-bean polypeptides of low sodium content and preparation method thereof |
| US11337451B2 (en) * | 2013-11-11 | 2022-05-24 | Aaron T. Dossey | Insect products and methods of manufacture and use thereof |
| CN120093881A (en) * | 2025-03-14 | 2025-06-06 | 珠海鹏鲲生物医药科技有限公司 | A Chinese medicine compound preparation for treating scalds, large-area burns, deep chemical burns and gunshot wounds, and its preparation method and application |
-
2000
- 2000-05-29 CN CN00107796A patent/CN1325632A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100356872C (en) * | 2006-01-18 | 2007-12-26 | 周维海 | Compound silkworm chrysalis polypeptide functional food |
| CN1908183B (en) * | 2006-08-16 | 2010-09-29 | 上海奥利实业有限公司 | Enzymatic mixed peptides of natural proteins with endothelin antagonism |
| US11337451B2 (en) * | 2013-11-11 | 2022-05-24 | Aaron T. Dossey | Insect products and methods of manufacture and use thereof |
| CN105520135A (en) * | 2015-12-20 | 2016-04-27 | 雷西云 | Healthy food with function of treating osteoporosis |
| CN105661554A (en) * | 2016-01-14 | 2016-06-15 | 安徽生物肽产业研究院有限公司 | Silkworm chrysalis small molecule peptide chelate for improving immunity and preparation method thereof |
| CN107440085A (en) * | 2017-07-11 | 2017-12-08 | 四川省蚕业科技开发总公司 | A kind of production technology of edible silkworm chrysalis |
| CN108409854A (en) * | 2018-02-10 | 2018-08-17 | 海盐县凌特生物科技有限公司 | A kind of small-molecular-weight silkworm chrysalis collagen |
| CN110089618A (en) * | 2019-06-18 | 2019-08-06 | 武汉天天好生物制品有限公司 | A kind of soya-bean polypeptides of low sodium content and preparation method thereof |
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