CN1381274A - 壳聚糖及胶原生物复合加药创可贴 - Google Patents
壳聚糖及胶原生物复合加药创可贴 Download PDFInfo
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Abstract
本发明公开了一种壳聚糖及胶原生物复合加药创可贴,含有外层压敏胶水刺布、中层吸水垫、内层无纺布、壳聚糖、I型胶原、药剂,而内层无纺布、壳聚糖、I型胶原、药剂四者重量配比为:无纺布∶壳聚糖∶I型胶原∶药剂为:(75－90)∶(1－10)∶(1－10)∶(0.05－5)。本发明生物复合创可贴用于创面愈合、具有良好的渗透性、弹性和柔韧性,既结构简单又结合了药的特性,使伤口能及时得到药物的治疗;而且具有生物活性,可以生物降解、抑制致病微生物生长,不仅成本低、使用方便,而且由于改良的生物学性能而便于家居生活应急之用。
Description
技术领域
本发明涉及一种医疗器械敷料，尤其涉及一种方便实用的复合创可贴。
背景技术
创面修复是外科乃至整个医学界所面临的最重要、最基本的问题之一。专家们预测，21世纪中，创伤的人数将成倍增长。创面敷料的使用需求也将会面临一个持续上升的新高潮。传统的敷料(纱布)常因血液凝固而附着于伤口面上，换药物时，伤口新生肉芽反复受损坏，延长了伤口愈合时间，给患者也带来了难以忍受的痛苦。随着现代医学，特别是分子生物学的迅速发展，现代研制敷料的概念已发生了根本的变化，即敷料不仅要覆盖创面，还应具有促进组织修复的功能，为新生组织提供生长环境，加速创口愈合、减少疤痕、防止细菌污染。
国内外已发表的研究文献和发明专利显示，用治愈伤口的创可贴具有良好的透气性和一定的透水性，并且方便实用，对创伤起到了包扎、隔离、防护等一定的应急作用。但创可贴本身对伤口不能真正起到治疗作用，而且长时间敷贴后，伤口炎症不能及时得到药物有效的治疗，又阻碍了伤口周围血液的正常循环，从而进一步恶化创伤炎症，影响人体健康。
胶原是制作复合生物敷料的常用原料。由于胶原在进化上十分保守，种属间差异很小，因而纯化的胶原有良好的生物相容性，不会引起异物、炎症和排斥反应，并且有较好的生物可降解性。胶原还具有与皮肤相似的粘附性。它的主要缺点是弹性差和有潜在感染危险。
壳聚糖从蟹壳、虾皮或真菌的膜中提取并经脱乙酰化而形成的一种多聚糖胺，对机体无毒，与生物体有良好的相容性，易于化学改性，并对许多细菌和真菌有较好的抗菌作用，还有良好的生物可降解性，它对创面渗出液吸收性好，透气性好，对伤口渗血有止血作用，且能促进创面愈合，并可作为药物的缓释放载体。但早期粘附性差、顺应性和弹性较差是其缺点。
发明内容
本发明的目的在于：提供一种添加有生物活性辅料、用于创面愈合、具有良好的渗透性、弹性和柔韧性的新型生物复合创可贴。
本发明所述的生物复合创可贴含有外层压敏胶水刺布、中层吸水垫、内层无纺布、壳聚糖、I型胶原、药剂，而内层无纺布、壳聚糖、I型胶原、药剂四者重量配比为：无纺布∶壳聚糖∶I型胶原∶药剂为：(75-90)∶(1-10)∶(1-10)∶(0.05-5)。
本发明药剂可为药剂为镇痛、消炎、抑菌、利于组织恢复的中、西合剂。
本发明药剂制备工艺为：选择壳聚糖、I型胶原和药剂，用缓冲液中和、乳化后，制得均一溶液，将内层无纺布浸于此溶液中，几分钟后取出红外线照射干燥，再与外层压敏胶水刺布、中层吸水垫复合后，经环氧乙烷辐照消毒制得。
本发明的生物复合创可贴用于创面愈合、具有良好的渗透性、弹性和柔韧性，既结构简单又结合了药的特性，使伤口能及时得到药物的治疗；而且具有生物活性，可以生物降解、抑制致病微生物生长，不仅成本低、使用方便，而且由于改良的生物学性能而便于家居生活应急之用。
具体实施方式
以下结合实施例对本发明进行详细说明。
实施例1
称取壳聚糖1kg和明胶1kg溶于0.05M醋酸至2％(W/V)，加入0.01kg单硬酯酸甘油酯搅匀，用胶体磨将溶液磨成均一液体，加入0.05％醋酸洗必泰1kg，再加入缓冲液调整溶液PH值至5-7，在室温下将该溶液搅拌1小时，然后在室温下保温一夜而在无尘气氛中除去溶液中残存的气泡，将8.5kg无纺布浸入此均匀溶液中。取出无纺布，经干燥通道红外灯照射后干燥，其它同一般创可贴制作，再经内外包装后经环氧乙烷辐照消毒即可入库。
实施例2
称取壳聚糖1 kg和明胶1kg溶于0.05M醋酸至2％(W/V)，加入0.01kg单硬酯酸甘油酯搅匀，用胶体磨将溶液磨成均一液体，加入0.1％6-氨基己酸0.1kg，再加入缓冲液调整溶液PH值至5-7，在室温下将该溶液搅拌1小时，然后在室温下保温一夜而在无尘气氛中除去溶液中残存的气泡，将8.5kg无纺布浸入此均匀溶液中。取出无纺布，经干燥通道红外灯照射后干燥，其它同一般创可贴制作，再经内外包装后经环氧乙烷辐照消毒即可入库。
Claims (2)
1、一种生物复合创可贴，其上附有药剂，其特征在于：含有无纺布、壳聚糖、I型胶原，此三者与药剂重量配比为：无纺布∶壳聚糖∶I型胶原∶药剂为：(75-90)∶(1-10)∶(1-10)∶(0.05-5)。
2、2、根据权利要求1所述的生物复合创可贴，其特征在于：药剂为镇痛、消炎、抑菌、止血、利于组织恢复的中、西合剂。
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| CN 02111594 CN1381274A (zh) | 2002-04-29 | 2002-04-29 | 壳聚糖及胶原生物复合加药创可贴 |
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| CN 02111594 CN1381274A (zh) | 2002-04-29 | 2002-04-29 | 壳聚糖及胶原生物复合加药创可贴 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485898B (zh) * | 2009-02-17 | 2012-08-22 | 大连雄伟保健品有限公司 | 一种止血愈合用湿巾及其制备方法 |
| CN105031711A (zh) * | 2015-06-17 | 2015-11-11 | 郑州大学 | 一种胶原/壳聚糖复合海绵生物敷料及其制备方法 |
| US10421777B2 (en) | 2016-01-14 | 2019-09-24 | Amnivor Medicare Private Limited | Process for extraction of fish collagen and formulations of 3D matrices of collagen for biomedical and therapeutic applications thereof |
-
2002
- 2002-04-29 CN CN 02111594 patent/CN1381274A/zh active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485898B (zh) * | 2009-02-17 | 2012-08-22 | 大连雄伟保健品有限公司 | 一种止血愈合用湿巾及其制备方法 |
| CN105031711A (zh) * | 2015-06-17 | 2015-11-11 | 郑州大学 | 一种胶原/壳聚糖复合海绵生物敷料及其制备方法 |
| US10421777B2 (en) | 2016-01-14 | 2019-09-24 | Amnivor Medicare Private Limited | Process for extraction of fish collagen and formulations of 3D matrices of collagen for biomedical and therapeutic applications thereof |
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