CN1381274A - Adhesive bandage containing chitosan and collagen - Google Patents
Adhesive bandage containing chitosan and collagen Download PDFInfo
- Publication number
- CN1381274A CN1381274A CN 02111594 CN02111594A CN1381274A CN 1381274 A CN1381274 A CN 1381274A CN 02111594 CN02111594 CN 02111594 CN 02111594 A CN02111594 A CN 02111594A CN 1381274 A CN1381274 A CN 1381274A
- Authority
- CN
- China
- Prior art keywords
- collagen
- adhesive bandage
- chitosan
- medicament
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 12
- 239000000853 adhesive Substances 0.000 title claims description 12
- 230000001070 adhesive effect Effects 0.000 title claims description 12
- 102000008186 Collagen Human genes 0.000 title abstract description 7
- 108010035532 Collagen Proteins 0.000 title abstract description 7
- 229920001436 collagen Polymers 0.000 title abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 17
- 239000004745 nonwoven fabric Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 102000012422 Collagen Type I Human genes 0.000 claims description 6
- 108010022452 Collagen Type I Proteins 0.000 claims description 6
- 230000000844 anti-bacterial effect Effects 0.000 claims description 4
- 230000036592 analgesia Effects 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000004744 fabric Substances 0.000 abstract description 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000003364 biologic glue Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 12
- 208000027418 Wounds and injury Diseases 0.000 description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 238000003756 stirring Methods 0.000 description 4
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000012456 homogeneous solution Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241000371997 Eriocheir sinensis Species 0.000 description 1
- 208000032420 Latent Infection Diseases 0.000 description 1
- 206010048629 Wound secretion Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
A composite biologic adhesive bandage is composed of pressure-sensitive adhesive hydroentangled cloth, hygroscopic pad, non-woven cloth, chitosan, I-type collagen and medicine preparation. Its advantages are high penetability, elasticity, flexibility, bioactivity and biodegradability, and low cost.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments dressing, relate in particular to a kind of convenient and practical compound adhesive bandage.
Background technology
Wound repair is one of surgery and even most important, the most basic problem that whole medical circle faced.The brainstrust prediction, in 21 century, the number of wound will be doubled and redoubled.The user demand of Wound dressing also will face a new upsurge that continues to rise.Traditional dressing (gauze) is often because of blood coagulation is attached on the wound face, and when changing dressings thing, wound newly granulates and is damaged repeatedly, has prolonged wound healing time, has also brought insufferable misery for the patient.Along with modern medicine, particularly molecular biological developing rapidly, basic variation has taken place in the notion of modern development dressing, be that flap coverage is not only wanted in dressing, also should have the function that promotes tissue repair, for cambium provides growing environment, quicken wound healing, reduce cicatrix, prevent germ contamination.
Research document of having delivered and patent of invention show both at home and abroad, have air permeability and good and certain water penetration with the adhesive bandage that heals a wound, and convenient and practical, wound have been played certain emergencing actions such as wrapping, isolation, protection.But adhesive bandage itself can not really play therapeutical effect to wound, and after applying ointment or plaster for a long time, the wound inflammation can not in time obtain medicine and effectively treat, and has hindered the normal circulation of wound circumference blood again, thereby has further worsened the wound inflammation, influences health.
Collagen is the raw material commonly used of making compound bio dressing.Because collagen is very conservative on evolving, the kind differences is very little, thereby the collagen of purification has excellent biological compatibility, can not cause foreign body, inflammation and rejection, and biodegradability is preferably arranged.Collagen also has the adhesiveness similar to skin.Its major defect is poor flexibility and latent infection danger is arranged.
Chitosan extracts from the film of Carapax Eriocheir sinensis, dried small shrimps or fungus and through deacetylated and a kind of poly osamine that form; nontoxic to body; with organism the good compatibility is arranged, be easy to chemical modification, and many antibacterials and fungus are had antibacterial action preferably; also has good biodegradability; it is good to the wound fluid absorbability, and good permeability has anastalsis to the wound oozing of blood; and can promote wound healing, and the slow release that can be used as medicine is put carrier.But early stage poor adhesion, compliance and elasticity are relatively poor to be its shortcoming.
Summary of the invention
The objective of the invention is to: provide a kind of and be added with the biological activity adjuvant, be used for wound healing, have good penetration, elasticity and the compound adhesive bandage of flexible new bio.
The compound adhesive bandage of biology of the present invention contains outer pressure sensitive adhesive spun laced fabric, middle level adsorptive pads, internal layer non-woven fabrics, chitosan, type i collagen, medicament, and internal layer non-woven fabrics, chitosan, type i collagen, medicament weight proportion are: non-woven fabrics: chitosan: type i collagen: medicament is: (75-90): (1-10): (1-10): (0.05-5).
Medicament of the present invention can be medicament be analgesia, antiinflammatory, antibacterial, be beneficial to organized renewing in, western mixture.
Medicament preparation technology of the present invention is: select chitosan, type i collagen and medicament, after buffer neutralization, emulsifying, make uniform solution, the internal layer non-woven fabrics is dipped in this solution, take out the infrared ray radiation drying after a few minutes, again with outer pressure sensitive adhesive spun laced fabric, middle level adsorptive pads compound after, the ethane via epoxyethane irradiation sterilization makes.
The compound adhesive bandage of biology of the present invention is used for wound healing, has good penetration, elasticity and pliability, and is not only simple in structure but also combine the characteristic of medicine, makes wound can in time obtain the treatment of medicine; And biologically active, can biodegradation, suppress the pathogenic microorganism growth, not only cost is low, easy to use, and because the biology performance of improveing is convenient to the emergent usefulness of life staying idle at home.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.
Embodiment 1
Take by weighing chitosan 1kg and gelatin 1kg and be dissolved in 0.05M acetic acid to 2% (W/V), adding the 0.01kg mono stearate glyceryl ester stirs evenly, with colloid mill solution is worn into homogeneous liquid, add 0.05% chlorhexidine acetate 1kg, add buffer again and adjust the solution pH value to 5-7, at room temperature with this solution stirring 1 hour, at room temperature be incubated a night then and in dustless atmosphere, remove bubble remaining in the solution, the 8.5kg non-woven fabrics is immersed in this homogeneous solution.Take out non-woven fabrics, drying passage infrared lamp irradiation after drying, other is made with general adhesive bandage, and the ethane via epoxyethane irradiation sterilization can be put in storage after exterior and interior packing again.
Embodiment 2
Take by weighing chitosan 1 kg and gelatin 1kg and be dissolved in 0.05M acetic acid to 2% (W/V), adding the 0.01kg mono stearate glyceryl ester stirs evenly, with colloid mill solution is worn into homogeneous liquid, add 0.1%6-aminocaproic acid 0.1kg, add buffer again and adjust the solution pH value to 5-7, at room temperature with this solution stirring 1 hour, at room temperature be incubated a night then and in dustless atmosphere, remove bubble remaining in the solution, the 8.5kg non-woven fabrics is immersed in this homogeneous solution.Take out non-woven fabrics, drying passage infrared lamp irradiation after drying, other is made with general adhesive bandage, and the ethane via epoxyethane irradiation sterilization can be put in storage after exterior and interior packing again.
Claims (2)
1, the compound adhesive bandage of a kind of biology, has medicament on it, it is characterized in that: contain non-woven fabrics, chitosan, type i collagen, this three and medicament weight proportion are: non-woven fabrics: chitosan: type i collagen: medicament is: (75-90): (1-10): (1-10): (0.05-5).
2,2, the compound adhesive bandage of biology according to claim 1, it is characterized in that: medicament be analgesia, antiinflammatory, antibacterial, stop blooding, be beneficial to organized renewing in, western mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111594 CN1381274A (en) | 2002-04-29 | 2002-04-29 | Adhesive bandage containing chitosan and collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111594 CN1381274A (en) | 2002-04-29 | 2002-04-29 | Adhesive bandage containing chitosan and collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1381274A true CN1381274A (en) | 2002-11-27 |
Family
ID=4741661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02111594 Pending CN1381274A (en) | 2002-04-29 | 2002-04-29 | Adhesive bandage containing chitosan and collagen |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1381274A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485898B (en) * | 2009-02-17 | 2012-08-22 | 大连雄伟保健品有限公司 | Moisture paper tissue for hemostasia and healing and preparation method thereof |
| CN105031711A (en) * | 2015-06-17 | 2015-11-11 | 郑州大学 | Collagen/chitosan composite sponge biological dressing and preparation method thereof |
| US10421777B2 (en) | 2016-01-14 | 2019-09-24 | Amnivor Medicare Private Limited | Process for extraction of fish collagen and formulations of 3D matrices of collagen for biomedical and therapeutic applications thereof |
-
2002
- 2002-04-29 CN CN 02111594 patent/CN1381274A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485898B (en) * | 2009-02-17 | 2012-08-22 | 大连雄伟保健品有限公司 | Moisture paper tissue for hemostasia and healing and preparation method thereof |
| CN105031711A (en) * | 2015-06-17 | 2015-11-11 | 郑州大学 | Collagen/chitosan composite sponge biological dressing and preparation method thereof |
| US10421777B2 (en) | 2016-01-14 | 2019-09-24 | Amnivor Medicare Private Limited | Process for extraction of fish collagen and formulations of 3D matrices of collagen for biomedical and therapeutic applications thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |