CN1380060A - Solution type spray of antimycotic medicine for external application and its preparation method - Google Patents
Solution type spray of antimycotic medicine for external application and its preparation method Download PDFInfo
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- CN1380060A CN1380060A CN 02111525 CN02111525A CN1380060A CN 1380060 A CN1380060 A CN 1380060A CN 02111525 CN02111525 CN 02111525 CN 02111525 A CN02111525 A CN 02111525A CN 1380060 A CN1380060 A CN 1380060A
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- type spray
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- arlacel
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- 239000007921 spray Substances 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000001857 anti-mycotic effect Effects 0.000 title claims description 7
- 239000002543 antimycotic Substances 0.000 title claims description 7
- 239000007788 liquid Substances 0.000 claims abstract description 9
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 claims abstract description 7
- 229960002607 sulconazole Drugs 0.000 claims abstract description 7
- 229960003483 oxiconazole Drugs 0.000 claims abstract description 6
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims abstract description 6
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims abstract description 5
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims abstract description 5
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims abstract description 5
- WHPAGCJNPTUGGD-UHFFFAOYSA-N Croconazole Chemical compound ClC1=CC=CC(COC=2C(=CC=CC=2)C(=C)N2C=NC=C2)=C1 WHPAGCJNPTUGGD-UHFFFAOYSA-N 0.000 claims abstract description 5
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims abstract description 5
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960004130 itraconazole Drugs 0.000 claims abstract description 5
- 229960004125 ketoconazole Drugs 0.000 claims abstract description 5
- 229960002509 miconazole Drugs 0.000 claims abstract description 5
- 229960004214 tioconazole Drugs 0.000 claims abstract description 5
- 229940121375 antifungal agent Drugs 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- 239000004094 surface-active agent Substances 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000003429 antifungal agent Substances 0.000 claims description 9
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 230000003078 antioxidant effect Effects 0.000 claims description 7
- 229920000136 polysorbate Polymers 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 5
- 229910002651 NO3 Inorganic materials 0.000 claims description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 4
- 150000003851 azoles Chemical class 0.000 claims description 4
- 229960002042 croconazole Drugs 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 150000002923 oximes Chemical class 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 229940040145 liniment Drugs 0.000 claims description 3
- 239000000865 liniment Substances 0.000 claims description 3
- 206010008190 Cerebrovascular accident Diseases 0.000 claims description 2
- 229920002517 Poloxamer 338 Polymers 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 2
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- -1 Tween-40 Polymers 0.000 claims description 2
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001993 poloxamer 188 Polymers 0.000 claims description 2
- 229940044519 poloxamer 188 Drugs 0.000 claims description 2
- 229920001992 poloxamer 407 Polymers 0.000 claims description 2
- 229940044476 poloxamer 407 Drugs 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
- 229940035024 thioglycerol Drugs 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000843 anti-fungal effect Effects 0.000 abstract description 2
- 239000011159 matrix material Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 229960004884 fluconazole Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- CRKGMGQUHDNAPB-UHFFFAOYSA-N Sulconazole nitrate Chemical compound O[N+]([O-])=O.C1=CC(Cl)=CC=C1CSC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 CRKGMGQUHDNAPB-UHFFFAOYSA-N 0.000 description 11
- 229960004718 sulconazole nitrate Drugs 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 206010040882 skin lesion Diseases 0.000 description 4
- 231100000444 skin lesion Toxicity 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000005374 membrane filtration Methods 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 229940098458 powder spray Drugs 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 206010012504 Dermatophytosis Diseases 0.000 description 1
- 241001460074 Microsporum distortum Species 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 230000009193 crawling Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000009513 drug distribution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及医药技术领域,是外用抗真菌药物的溶液型喷雾剂型及其制备方法。本发明将咪康唑、硫康唑、肟康唑(奥昔康唑)、噻康唑、氯康唑、酮康唑、氟康唑、伊曲康唑或它们的硝酸盐,制成溶液型喷雾剂。其优点在于,使用方便卫生,可直接将药液喷于患处,药物均匀分布于皮肤表面,药物穿过液体基质的速度快,起效快。还可喷于病灶周围部位的鞋袜或其它覆盖物上,起到隔断传染源的作用。The invention relates to the technical field of medicine, and relates to a solution-type spray formulation of antifungal drugs for external use and a preparation method thereof. In the present invention, miconazole, sulconazole, oxiconazole (oxiconazole), tioconazole, cloconazole, ketoconazole, fluconazole, itraconazole or their nitrates are prepared into solutions type spray. The utility model has the advantages that it is convenient and hygienic to use, the medicine liquid can be directly sprayed on the affected part, the medicine is evenly distributed on the skin surface, the speed of the medicine passing through the liquid matrix is fast, and the effect is quick. It can also be sprayed on the footwear or other coverings around the lesion to isolate the source of infection.
Description
Technical field: the present invention relates to medical technical field, is solution type spray of antimycotic medicine for external application and preparation method thereof.
Background technology: miconazole, sulconazole, oxime health azoles (oxiconazole), tioconazole, croconazole, ketoconazole, fluconazol, itraconazole or their nitrate, it is the antifungal drug of wide spectrum, efficient, low toxicity, be widely used in clinically both at home and abroad, the effect of treatment dermatophytosis, monilial infection is obvious.Its dosage form has cream, liniment, powder spray agent.But do not see solution type spray so far.The deficiency of cream is to pass cream base by medicine, and arrive to suffer from the speed of surface layer slower, thereby onset is slower.And painting medicine uses inconvenience, and often crawling is even to position that hair growth is arranged, is also wiped easily.The powder spray agent for be subject to medicated clothing friction or keratinization serious the position not too suitable, drug distribution is also inhomogeneous.
Summary of the invention: the present invention makes solution type spray with miconazole, sulconazole, oxime health azoles (oxiconazole), tioconazole, croconazole, ketoconazole, fluconazol, itraconazole or their nitrate.Its advantage is, health easy to use can directly be sprayed on the affected part with medicinal liquid, and medicine can be uniformly distributed in skin and suffer from surface layer, and it is fast that medicine passes the speed of fluid matrix, rapid-action.Be particularly useful for the large-area infection of body surface and the fungal infection at hair growth position.In addition, solution type spray also can be sprayed on the footgear or other covering at position around the focus, makes it play the effect that cuts off the source of infection.
The prescription and the proportioning of solution type spray of the present invention are as follows:
Antifungal drug 5-20g
Antioxidant 0.1-0.5g
Surfactant 5-60g
Propylene glycol 50-300ml
95% medicinal alcohol 400-800ml
Distilled water adds to 1000ml
Total amount 1000ml
Concrete preparation method is:
Proportioning by prescription is dissolved in antifungal agent and antioxidant 95% medicinal alcohol routinely, after the heating for dissolving, add surfactant and propylene glycol, stirring and evenly mixing, being placed to temperature is 25 ℃, adding distil water to cumulative volume is 1000ml, use membrane filtration, pack the medicinal liquid branch into medical airtight bottle, or the Manual pressure aerosol can, or the air-blast atomizing jar.
Above-described antifungal drug is miconazole, sulconazole, oxime health azoles (oxiconazole), tioconazole, croconazole, ketoconazole, fluconazol, itraconazole or their nitrate, and its concentration in preparation is 0.5-2% (w/v);
Described antioxidant can be selected 2,6 ditertiary butyl p cresol, BHA, thioglycerol for use; Its concentration in preparation is 0.01-0.05% (w/v);
Described surfactant can be selected tween 20, Tween-40, Tween-60, tween 80, the tween 85 of Tweens for use, the Arlacel-20 of spans, Arlacel-40, Arlacel-60, Arlacel-80, Arlacel-85, the poloxamer 188 of poloxamer class, poloxamer 338, poloxamer 407 can be selected any one independent use wherein for use; Also can select two class surfactants simultaneously for use, promptly any two apoplexy due to endogenous wind in above-mentioned three class surfactants respectively selects one, the mixing use; Also can select three class surfactants simultaneously for use, promptly in above-mentioned three class surfactants, respectively select one, mix and use; Its concentration in preparation is 0.5-6% (w/v);
The concentration of propylene glycol in preparation is 5-30% (v/v);
The concentration of ethanol in preparation is 40-80% (v/v).
The specific embodiment:
Embodiment one: prepare 1% sulconazole nitrate spray
Prescription:
Sulconazole nitrate 10.0g
2,6 ditertiary butyl p cresol (BHT) 0.1g
Tween 80 20.0g
Propylene glycol 100.0ml
95% medicinal alcohol 600.0ml
Distilled water adds to 1000ml
Total amount 1000ml
The concrete operations step:
With sulconazole nitrate 10.0g, 2,6-ditertbutylparacresol 0.1g is dissolved in 95% medicinal alcohol 600ml, after the 30-50 ℃ of heating for dissolving, add 20.0g tween 80,100ml propylene glycol, stirring and evenly mixing, being placed to temperature is 25 ℃, adding distil water to cumulative volume is 1000ml, use membrane filtration, with the medicinal liquid Manual pressure aerosol can of packing into.
Embodiment two: prepare 0.5% sulconazole nitrate spray
Prescription:
Sulconazole nitrate 5.0g
2,6 ditertiary butyl p cresol (BHT) 0.1g
Tween 80 20.0g
Propylene glycol 100.0ml
95% medicinal alcohol 600.0ml
Distilled water adds to total amount 1000ml
Total amount 1000ml
The concrete operations step:
With sulconazole nitrate 5.0g, 2,6-ditertbutylparacresol 0.1g is dissolved in 95% medicinal alcohol 600ml, after the 40-60 ℃ of heating for dissolving, add 20.0g tween 80,100ml propylene glycol, stirring and evenly mixing, being placed to temperature is 25 ℃, adding distil water to cumulative volume is 1000ml, use membrane filtration, with the medicinal liquid Pneumatic pressure aerosol can of packing into.
The prepared medicinal liquid of the present invention also can be used as liniment or lotion uses.The preparation method of the solution type spray of other antifungal agent is the same.
The animal efficacy of medicine observing of the solution type spray of external anti-fungal infection:
With the sulconazole nitrate spray is example:
Each 30 of Cavia porcelluss, male and female are not limit, and are divided into three groups, 10 every group.The back unhairing is used the sand paper scratch mark, inoculates the normal saline solution of Trichophyton mentagrophytes, makes the infection model of Trichophyton mentagrophytes, occurs erythema and edema after three days, implements administration.Give normal saline first group of every day, spray with 1% sulconazole nitrate spray second group of every day, and spray with 0.5% sulconazole nitrate spray the 3rd group of every day.Once a day, each consumption is that medicinal liquid evenly covers affected part.Respectively at administration the 5th day and 10 days, the skin lesion of observing Cavia porcellus improved situation and fungus removing situation.The index that skin lesion obviously improves is no erythema, no edema.The investigation method that fungus is removed situation is, gets the tissue of infection site and cultivates, and whether observe has conk.As do not have conk and be fungus and thoroughly remove.Observed result sees Table 1..
The animal efficacy of medicine observing of table 1. sulconazole nitrate spray
| Observing time | Observation index | The normal saline group | 0.5% sulconazole | 1% sulconazole |
| After the administration the 5th day | Skin lesion obviously improves number of animals (only) | ????0 | ????3 | ????8 |
| Fungus is thoroughly removed number of animals (only) | ????0 | ????1 | ????6 | |
| After the administration the 10th day | Skin lesion obviously improves number of animals (only) | ????2 | ????10 | ????10 |
| Fungus is thoroughly removed number of animals (only) | ????0 | ????10 | ????10 |
By table 1 as seen, 0.5% and 1% sulconazole nitrate spray is very obvious to the therapeutic effect that Trichophyton mentagrophytes infects Cavia porcellus.
Claims (4)
1. the solution type spray of antimycotic medicine for external application, formulated by antifungal drug, antioxidant, surfactant, propylene glycol, medicinal alcohol and water, it is characterized in that described antifungal drug is selected from miconazole, sulconazole, oxime health azoles (oxiconazole), tioconazole, croconazole, ketoconazole, fluconazol, itraconazole, or their nitrate.
2. by the solution type spray of the described antimycotic medicine for external application of claim 1, it is characterized in that described antioxidant is selected from 2,6 ditertiary butyl p cresol, or BHA, or thioglycerol.
3. press the solution type spray of claim 1 or 2 described antimycotic medicine for external application, it is characterized in that described surfactant is selected from 1-3 surfactant of Tweens, spans and poloxamer apoplexy due to endogenous wind, wherein Tweens selects one of tween 20, Tween-40, Tween-60, tween 80, tween 85, spans selects one of Arlacel-20, Arlacel-40, Arlacel-60, Arlacel-80, Arlacel-85, and the poloxamer class is selected one of poloxamer 188, poloxamer 338, poloxamer 407.
4. the preparation method of the solution type spray of the described antimycotic medicine for external application of claim 3, it is characterized in that the concentration of each composition in preparation is respectively: antifungal drug 0.5-2% (W/V), antioxidant 0.01-0.05% (W/V), surfactant 0.5-6% (W/V), propylene glycol 5-30% (V/V), medicinal alcohol 40-80% (V/V), by this proportioning antifungal agent and antioxidant are dissolved in 95% medicinal alcohol, after the heating for dissolving, add surfactant and propylene glycol, stirring and evenly mixing, being placed to temperature is 25 ℃, and adding distil water filters to corresponding volume again, pack the medicinal liquid branch into medical airtight bottle, as liniment or lotion; Be sub-packed in aerosol can, as spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111525 CN1380060A (en) | 2002-04-28 | 2002-04-28 | Solution type spray of antimycotic medicine for external application and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111525 CN1380060A (en) | 2002-04-28 | 2002-04-28 | Solution type spray of antimycotic medicine for external application and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1380060A true CN1380060A (en) | 2002-11-20 |
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| CN 02111525 Pending CN1380060A (en) | 2002-04-28 | 2002-04-28 | Solution type spray of antimycotic medicine for external application and its preparation method |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198153A (en) * | 2011-06-14 | 2011-09-28 | 李平 | Nano-silver spray for treating skin diseases, and preparation method thereof |
| CN102321036A (en) * | 2011-07-13 | 2012-01-18 | 王健祥 | Preparation method of fluconazole soluble salt |
| WO2016196928A1 (en) * | 2015-06-04 | 2016-12-08 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| CN106580929A (en) * | 2016-12-02 | 2017-04-26 | 贺敏 | Skin disease medicine composition, preparation method and application thereof |
| CN108379343A (en) * | 2018-03-09 | 2018-08-10 | 广州卡士德汽车用品有限公司 | A kind of shoes bactericidal deodorant and preparation method thereof |
| CN111249233A (en) * | 2018-11-30 | 2020-06-09 | 中南大学湘雅三医院 | Anti-ear fungus spray and its preparation method and spray device |
| CN111249219A (en) * | 2018-11-30 | 2020-06-09 | 中南大学湘雅三医院 | Ear drops for treating ear fungus and preparation method thereof |
| CN112043714A (en) * | 2020-09-25 | 2020-12-08 | 安徽省公众检验研究院有限公司 | Preparation method of compound miconazole spraying agent |
| CN112957319A (en) * | 2021-02-05 | 2021-06-15 | 王京海 | Antifungal liquid and preparation method and application thereof |
-
2002
- 2002-04-28 CN CN 02111525 patent/CN1380060A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198153A (en) * | 2011-06-14 | 2011-09-28 | 李平 | Nano-silver spray for treating skin diseases, and preparation method thereof |
| CN102321036A (en) * | 2011-07-13 | 2012-01-18 | 王健祥 | Preparation method of fluconazole soluble salt |
| WO2016196928A1 (en) * | 2015-06-04 | 2016-12-08 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| IL256070A (en) * | 2015-06-04 | 2018-01-31 | Pellepharm Inc | Preparations containing fish suppressant compounds "Hog" for topical administration and uses |
| CN106580929A (en) * | 2016-12-02 | 2017-04-26 | 贺敏 | Skin disease medicine composition, preparation method and application thereof |
| CN108379343A (en) * | 2018-03-09 | 2018-08-10 | 广州卡士德汽车用品有限公司 | A kind of shoes bactericidal deodorant and preparation method thereof |
| CN111249233A (en) * | 2018-11-30 | 2020-06-09 | 中南大学湘雅三医院 | Anti-ear fungus spray and its preparation method and spray device |
| CN111249219A (en) * | 2018-11-30 | 2020-06-09 | 中南大学湘雅三医院 | Ear drops for treating ear fungus and preparation method thereof |
| CN111249219B (en) * | 2018-11-30 | 2023-08-11 | 中南大学湘雅三医院 | Ear drops for treating fungus in auditory canal and preparation method thereof |
| CN112043714A (en) * | 2020-09-25 | 2020-12-08 | 安徽省公众检验研究院有限公司 | Preparation method of compound miconazole spraying agent |
| CN112957319A (en) * | 2021-02-05 | 2021-06-15 | 王京海 | Antifungal liquid and preparation method and application thereof |
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