CN1368219A - Nano medicine 'Compound Geqing' and its preparing process - Google Patents
Nano medicine 'Compound Geqing' and its preparing process Download PDFInfo
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- CN1368219A CN1368219A CN 01102553 CN01102553A CN1368219A CN 1368219 A CN1368219 A CN 1368219A CN 01102553 CN01102553 CN 01102553 CN 01102553 A CN01102553 A CN 01102553A CN 1368219 A CN1368219 A CN 1368219A
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- geqing
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 150000001875 compounds Chemical class 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 10
- 244000194101 Ginkgo biloba Species 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000269417 Bufo Species 0.000 claims description 9
- 235000011201 Ginkgo Nutrition 0.000 claims description 9
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 9
- 244000203593 Piper nigrum Species 0.000 claims description 9
- 235000008184 Piper nigrum Nutrition 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 235000013614 black pepper Nutrition 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000592346 Ginkgophyta Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 208000006673 asthma Diseases 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010014561 Emphysema Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 206010044302 Tracheitis Diseases 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241001161070 Calomela Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Compound Geqing" is prepared from the nanometre powders of 9 Chinese medicinal materials including dried toad, astragalus root, gingko, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The nano medicine ' Compound Geqing ' that the present invention relates to that a kind of QI invigorating is astringed the lung, relieving cough and asthma, temperature reduces phlegm drink the invention still further relates to the method for this medication preparation.
The compound clam white sheet is a kind of classical Chinese patent medicine, mainly contains that QI invigorating is astringed the lung, relieving cough and asthma, temperature reduce phlegm effects such as drink, are used for cough due to deficiency of the lung, asthma abundant expectoration, senile chronic tracheitis, emphysema, asthmatic bronchitis.But traditional compound clam white sheet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Compound Geqing ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Compound Geqing '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Bufo siccus 120-250 part nano astragalus 150-300 part nanometer Semen Ginkgo 50-130 part
Nanometer Radix Asteris 70-170 part nanometer Semen Armeniacae Amarum 70-170 part nanometer Radix Peucedani 40-90 part
Nanometric Radix Aconiti Lateralis Preparata 13-35 part nanometer Fructus Schisandrae Chinensis 40-90 part nanometer black pepper 10-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Bufo siccus 150-220 part nano astragalus 200-250 part nanometer Semen Ginkgo 70-110 part
Nanometer Radix Asteris 90-150 part nanometer Semen Armeniacae Amarum 90-150 part nanometer Radix Peucedani 50-80 part
Nanometric Radix Aconiti Lateralis Preparata 18-30 part nanometer Fructus Schisandrae Chinensis 50-80 part nanometer black pepper 15-25 part
The optimum weight proportioning of medicine of the present invention is:
90 parts of 225 parts of nanometer Semen Ginkgoes of 180 parts of nano astragalus of nanometer Bufo siccus
67.5 parts of 112.5 parts of nanometer Radix Peucedanis of 112.5 portions of nanometer Semen Armeniacae Amarums of nanometer Radix Asteris
22.5 parts of 67.5 parts of nanometer black peppers of 22.5 parts of nanometer Fructus Schisandrae Chinensis of nanometric Radix Aconiti Lateralis Preparata
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Compound Geqing ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Compound Geqing ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common compound clam white tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Compound Geqing ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as cough due to deficiency of the lung, asthma abundant expectoration, senile chronic tracheitis, emphysema, asthmatic bronchitis, and clinical efficacy significantly is better than traditional compound clam white sheet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
90 parts of 225 parts of nanometer Semen Ginkgoes of 180 parts of nano astragalus of nanometer Bufo siccus
67.5 parts of 112.5 parts of nanometer Radix Peucedanis of 112.5 portions of nanometer Semen Armeniacae Amarums of nanometer Radix Asteris
22.5 parts of 67.5 parts of nanometer black peppers of 22.5 parts of nanometer Fructus Schisandrae Chinensis of nanometric Radix Aconiti Lateralis Preparata
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
90 parts of 225 parts of nanometer Semen Ginkgoes of 180 parts of nano astragalus of nanometer Bufo siccus
67.5 parts of 112.5 parts of nanometer Radix Peucedanis of 112.5 portions of nanometer Semen Armeniacae Amarums of nanometer Radix Asteris
22.5 parts of 67.5 parts of nanometer black peppers of 22.5 parts of nanometer Fructus Schisandrae Chinensis of nanometric Radix Aconiti Lateralis Preparata
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano compound clam Calomelas needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
90 parts of 225 parts of nanometer Semen Ginkgoes of 180 parts of nano astragalus of nanometer Bufo siccus
67.5 parts of 112.5 parts of nanometer Radix Peucedanis of 112.5 portions of nanometer Semen Armeniacae Amarums of nanometer Radix Asteris
22.5 parts of 67.5 parts of nanometer black peppers of 22.5 parts of nanometer Fructus Schisandrae Chinensis of nanometric Radix Aconiti Lateralis Preparata
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the blue or green membrane of nano compound clam, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Compound Geqing ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Bufo siccus 120-250 part nano astragalus 150-300 part nanometer Semen Ginkgo 50-130 part
Nanometer Radix Asteris 70-170 part nanometer Semen Armeniacae Amarum 70-170 part nanometer Radix Peucedani 40-90 part
Nanometric Radix Aconiti Lateralis Preparata 13-35 part nanometer Fructus Schisandrae Chinensis 40-90 part nanometer black pepper 10-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Compound Geqing ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Bufo siccus 150-220 part nano astragalus 200-250 part nanometer Semen Ginkgo 70-110 part
Nanometer Radix Asteris 90-150 part nanometer Semen Armeniacae Amarum 90-150 part nanometer Radix Peucedani 50-80 part
Nanometric Radix Aconiti Lateralis Preparata 18-30 part nanometer Fructus Schisandrae Chinensis 50-80 part nanometer black pepper 15-25 part
3, nano medicine ' Compound Geqing ' according to claim 1, wherein the weight proportion of each nano raw material is:
90 parts of 225 parts of nanometer Semen Ginkgoes of 180 parts of nano astragalus of nanometer Bufo siccus
67.5 parts of 112.5 parts of nanometer Radix Peucedanis of 112.5 portions of nanometer Semen Armeniacae Amarums of nanometer Radix Asteris
22.5 parts of 67.5 parts of nanometer black peppers of 22.5 parts of nanometer Fructus Schisandrae Chinensis of nanometric Radix Aconiti Lateralis Preparata
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Compound Geqing 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Compound Geqing 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102553 CN1368219A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Compound Geqing' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102553 CN1368219A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Compound Geqing' and its preparing process |
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| Publication Number | Publication Date |
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| CN1368219A true CN1368219A (en) | 2002-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102553 Pending CN1368219A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Compound Geqing' and its preparing process |
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| CN (1) | CN1368219A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922275A (en) * | 2014-11-28 | 2015-09-23 | 山西佳能达华禹制药有限公司 | Compound haqing rectal administration preparation and preparation method thereof |
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2001
- 2001-02-01 CN CN 01102553 patent/CN1368219A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922275A (en) * | 2014-11-28 | 2015-09-23 | 山西佳能达华禹制药有限公司 | Compound haqing rectal administration preparation and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |