CN1366973A - Nano Guishe preparation medicine and preparation method - Google Patents
Nano Guishe preparation medicine and preparation method Download PDFInfo
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- CN1366973A CN1366973A CN 01102169 CN01102169A CN1366973A CN 1366973 A CN1366973 A CN 1366973A CN 01102169 CN01102169 CN 01102169 CN 01102169 A CN01102169 A CN 01102169A CN 1366973 A CN1366973 A CN 1366973A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 241000756943 Codonopsis Species 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 19
- 241000213006 Angelica dahurica Species 0.000 claims description 8
- 241001061264 Astragalus Species 0.000 claims description 8
- 241000272060 Elapidae Species 0.000 claims description 8
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 8
- 235000006533 astragalus Nutrition 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 8
- 229910052709 silver Inorganic materials 0.000 claims description 8
- 239000004332 silver Substances 0.000 claims description 8
- 210000004233 talus Anatomy 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000270295 Serpentes Species 0.000 abstract description 5
- 241000272074 Bungarus Species 0.000 abstract 1
- 241001390814 Coniophanes Species 0.000 abstract 1
- 241000270708 Testudinidae Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 241000270666 Testudines Species 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 2
- 208000010228 Erectile Dysfunction Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano guishe preparation medicine. It is made up by using 15 Chinese medicinal materials of nano living tortoise, nano cobra, nano bungarus, nano black-striped snake, nano codonopsis and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano Guishe preparation medicine of a kind of enriching yin and nourishing kidney, benefiting QI for activating blood circulation, channels sootheing and network vessel quickening, expelling wind and removing dampness, the invention still further relates to the method for this medication preparation.
Turtle and Snake liquor is a kind of classical Chinese patent medicine, mainly contains effects such as enriching yin and nourishing kidney, benefiting QI for activating blood circulation, channels sootheing and network vessel quickening, expelling wind and removing dampness, is used for oldaged physically weak, feels dizzy, soreness of waist and knee, sexual impotence frequent micturition, numb limbs and tense tendons, joint aches.But traditional turtle and Snake liquor absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Guishe preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Guishe preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Testudinis 100-200 alive part nano-glasses Serpentis 35-80 part nanometer silver krait 35-80 part
Nanometer Zaocys 35-80 part nanometer Radix Codonopsis 15-40 part nanometer Cortex Eucommiae 10-30 part
Nanometer Fructus Jujubae 12-30 part nanometer Fructus Lycii 12-30 part nano Chinese angelica 10-25 part
Nanometer Herba Cynomorii 10-25 part nano astragalus 10-25 part nanometer Cortex Cinnamomi 10-25 part
Nanometer Hunan Radix Achyranthis Bidentatae 6-18 nanometer Rhizoma Chuanxiong 6-18 part nanometer Herba Taxilli 6-18 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Testudinis 120-180 alive part nano-glasses Serpentis 40-60 part nanometer silver krait 40-60 part
Nanometer Zaocys 40-60 part nanometer Radix Codonopsis 20-30 part nanometer Cortex Eucommiae 15-25 part
Nanometer Fructus Jujubae 15-25 part nanometer Fructus Lycii 15-25 part nano Chinese angelica 12-18 part
Nanometer Herba Cynomorii 12-18 part nano astragalus 12-18 part nanometer Cortex Cinnamomi 12-18 part
Nanometer Hunan Radix Achyranthis Bidentatae 8-15 part nanometer Rhizoma Chuanxiong 8-15 part nanometer Herba Taxilli 8-12 part
The optimum weight proportioning of medicine of the present invention is:
50 parts of 50 parts of nanometer silver kraits of nanometer 150 parts of nano-glasses Serpentiss of Testudinis alive
20 parts of 25 parts of nanometer Cortexs Eucommiae of 50 parts of nanometer Radix Codonopsis of nanometer Zaocys
15 parts of 20 parts of nano Chinese angelicas of 20 parts of nanometer Fructus Lycii of nanometer Fructus Jujubae
15 parts of 15 parts of nanometer Cortex Cinnamomis of 15 parts of nano astragalus of nanometer Herba Cynomorii
10 parts of 10 parts of nanometer Herba Taxillis of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Hunan Radix Achyranthis Bidentatae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Testudinis Serpentis preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Guishe preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common turtle and Snake liquor preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution of nano Guishe preparation medicine etc. had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for oldaged physically weak, feels dizzy, soreness of waist and knee, sexual impotence frequent micturition, numb limbs and tense tendons, joint aches, clinical efficacy significantly is better than traditional turtle and Snake liquor.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
50 parts of 50 parts of nanometer silver kraits of nanometer 150 parts of nano-glasses Serpentiss of Testudinis alive
20 parts of 25 parts of nanometer Cortexs Eucommiae of 50 parts of nanometer Radix Codonopsis of nanometer Zaocys
15 parts of 20 parts of nano Chinese angelicas of 20 parts of nanometer Fructus Lycii of nanometer Fructus Jujubae
15 parts of 15 parts of nanometer Cortex Cinnamomis of 15 parts of nano astragalus of nanometer Herba Cynomorii
10 parts of 10 parts of nanometer Herba Taxillis of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Hunan Radix Achyranthis Bidentatae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
50 parts of 50 parts of nanometer silver kraits of nanometer 150 parts of nano-glasses Serpentiss of Testudinis alive
20 parts of 25 parts of nanometer Cortexs Eucommiae of 50 parts of nanometer Radix Codonopsis of nanometer Zaocys
15 parts of 20 parts of nano Chinese angelicas of 20 parts of nanometer Fructus Lycii of nanometer Fructus Jujubae
15 parts of 15 parts of nanometer Cortex Cinnamomis of 15 parts of nano astragalus of nanometer Herba Cynomorii
10 parts of 10 parts of nanometer Herba Taxillis of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Hunan Radix Achyranthis Bidentatae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Guishe membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest or affected part.
Claims (6)
1, a kind of nano Guishe preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Testudinis 100-200 alive part nano-glasses Serpentis 35-80 part nanometer silver krait 35-80 part
Nanometer Zaocys 35-80 part nanometer Radix Codonopsis 15-40 part nanometer Cortex Eucommiae 10-30 part
Nanometer Fructus Jujubae 12-30 part nanometer Fructus Lycii 12-30 part nano Chinese angelica 10-25 part
Nanometer Herba Cynomorii 10-25 part nano astragalus 10-25 part nanometer Cortex Cinnamomi 10-25 part
Nanometer Hunan Radix Achyranthis Bidentatae 6-18 nanometer Rhizoma Chuanxiong 6-18 part nanometer Herba Taxilli 6-18 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Guishe preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Testudinis 120-180 alive part nano-glasses Serpentis 40-60 part nanometer silver krait 40-60 part
Nanometer Zaocys 40-60 part nanometer Radix Codonopsis 20-30 part nanometer Cortex Eucommiae 15-25 part
Nanometer Fructus Jujubae 15-25 part nanometer Fructus Lycii 15-25 part nano Chinese angelica 12-18 part
Nanometer Herba Cynomorii 12-18 part nano astragalus 12-18 part nanometer Cortex Cinnamomi 12-18 part
Nanometer Hunan Radix Achyranthis Bidentatae 8-15 part nanometer Rhizoma Chuanxiong 8-15 part nanometer Herba Taxilli 8-12 part
3, nano Guishe preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
50 parts of 50 parts of nanometer silver kraits of nanometer 150 parts of nano-glasses Serpentiss of Testudinis alive
20 parts of 25 parts of nanometer Cortexs Eucommiae of 50 parts of nanometer Radix Codonopsis of nanometer Zaocys
15 parts of 20 parts of nano Chinese angelicas of 20 parts of nanometer Fructus Lycii of nanometer Fructus Jujubae
15 parts of 15 parts of nanometer Cortex Cinnamomis of 15 parts of nano astragalus of nanometer Herba Cynomorii
10 parts of 10 parts of nanometer Herba Taxillis of 10 parts of nanometer Rhizoma Chuanxiongs of nanometer Hunan Radix Achyranthis Bidentatae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Guishe preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Guishe preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102169 CN1366973A (en) | 2001-01-20 | 2001-01-20 | Nano Guishe preparation medicine and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102169 CN1366973A (en) | 2001-01-20 | 2001-01-20 | Nano Guishe preparation medicine and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1366973A true CN1366973A (en) | 2002-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102169 Pending CN1366973A (en) | 2001-01-20 | 2001-01-20 | Nano Guishe preparation medicine and preparation method |
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| Country | Link |
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| CN (1) | CN1366973A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314385C (en) * | 2005-10-18 | 2007-05-09 | 江苏隆力奇生物科技股份有限公司 | Nano snake oil skin care preparation |
-
2001
- 2001-01-20 CN CN 01102169 patent/CN1366973A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314385C (en) * | 2005-10-18 | 2007-05-09 | 江苏隆力奇生物科技股份有限公司 | Nano snake oil skin care preparation |
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