CN1365794A - Nano medicine 'Xingnaojing' and its preparing process - Google Patents
Nano medicine 'Xingnaojing' and its preparing process Download PDFInfo
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- CN1365794A CN1365794A CN 01101993 CN01101993A CN1365794A CN 1365794 A CN1365794 A CN 1365794A CN 01101993 CN01101993 CN 01101993 CN 01101993 A CN01101993 A CN 01101993A CN 1365794 A CN1365794 A CN 1365794A
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- nano
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- xingnaojing
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000008918 xingnaojing Substances 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000402754 Erythranthe moschata Species 0.000 claims abstract description 10
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000164439 Curcuma angustifolia Species 0.000 claims 1
- 244000111489 Gardenia augusta Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000407170 Curcuma Species 0.000 description 4
- 241000157835 Gardenia Species 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010021888 Nervous system infections Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000010513 Stupor Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 206010010075 Coma hepatic Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 201000001059 hepatic coma Diseases 0.000 description 1
- 208000007386 hepatic encephalopathy Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre medicine "Xingnaojing" is prepared from the nanometer powders of 4 Chinese medicinal materials including musk, curcuma root, borneol, and copejasmine through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind ofly revive, relieving convulsion, cure mainly the nano medicine ' Xingnaojing ' of nervous system infection, the invention still further relates to the method for this medication preparation.
XINGNAOJING ZHUSHEYE is a kind of classical Chinese patent medicine, mainly contain regulate nervus centralis function, heart tonifying, excited breathing, resisting pathogenic microbes, antiinflammatory, analgesic, protect the liver, effect such as function of gallbladder promoting, be used for stupor due to a variety of causes, tic and infectious fever.But traditional XINGNAOJING ZHUSHEYE absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Xingnaojing ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Xingnaojing '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano musk 4-11 part nanometer Radix Curcumae 18-42 part nanometer Borneolum Syntheticum 0.5-1.5 part
Nanometer Fructus Gardeniae 18-42 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano musk 6-9 part nanometer Radix Curcumae 24-36 part nanometer Borneolum Syntheticum 0.8-1.2 part
Nanometer Fructus Gardeniae 24-36 part
The optimum weight proportioning of medicine of the present invention is:
1.0 parts of 30 parts of nanometer Borneolum Syntheticums of 7.5 parts of nanometer Radix Curcumaes of nano musk
30 parts of nanometer Fructus Gardeniaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get XINGNAOJING preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Xingnaojing ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common XINGNAOJING ZHUSHEYE preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup of nano medicine ' Xingnaojing ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as stupor, tic and the toxic encephalopthy that nervous system infections such as hepatic coma, epidemic encephalitis type B cause, various infectious fevers, and clinical efficacy significantly is better than traditional XINGNAOJING ZHUSHEYE.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
1.0 parts of 30 parts of nanometer Borneolum Syntheticums of 7.5 parts of nanometer Radix Curcumaes of nano musk
30 parts of nanometer Fructus Gardeniaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
1.0 parts of 30 parts of nanometer Borneolum Syntheticums of 7.5 parts of nanometer Radix Curcumaes of nano musk
30 parts of nanometer Fructus Gardeniaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the quiet powder needle injection of nano consciousness restoring, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
1.0 parts of 30 parts of nanometer Borneolum Syntheticums of 7.5 parts of nanometer Radix Curcumaes of nano musk
30 parts of nanometer Fructus Gardeniaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the quiet membrane of nano consciousness restoring, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Xingnaojing ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano musk 4-11 part nanometer Radix Curcumae 18-42 part nanometer Borneolum Syntheticum 0.5-1.5 part
Nanometer Fructus Gardeniae 18-42 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Xingnaojing ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano musk 6-9 part nanometer Radix Curcumae 24-36 part nanometer Borneolum Syntheticum 0.8-1.2 part
Nanometer Fructus Gardeniae 24-36 part
3, nano medicine ' Xingnaojing ' according to claim 1, wherein the weight proportion of each nano raw material is:
1.0 parts of 30 parts of nanometer Borneolum Syntheticums of 7.5 parts of nanometer Radix Curcumaes of nano musk
30 parts of nanometer Fructus Gardeniaes
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Xingnaojing 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Xingnaojing 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101993 CN1365794A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Xingnaojing' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101993 CN1365794A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Xingnaojing' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365794A true CN1365794A (en) | 2002-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01101993 Pending CN1365794A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Xingnaojing' and its preparing process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1365794A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358496C (en) * | 2004-12-13 | 2008-01-02 | 北京正大绿洲医药科技有限公司 | 'Xingnaojing' dripping pills for treating cephalitis and hepatic coma and preparation process thereof |
| CN102406897A (en) * | 2011-11-28 | 2012-04-11 | 无锡济民可信山禾药业股份有限公司 | A kind of Xingnaojing solid pharmaceutical composition and preparation method thereof |
| CN102406890A (en) * | 2010-07-07 | 2012-04-11 | 西安安健药业有限公司 | Modified composition, preparation method and application thereof |
-
2001
- 2001-01-18 CN CN 01101993 patent/CN1365794A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358496C (en) * | 2004-12-13 | 2008-01-02 | 北京正大绿洲医药科技有限公司 | 'Xingnaojing' dripping pills for treating cephalitis and hepatic coma and preparation process thereof |
| CN102406890A (en) * | 2010-07-07 | 2012-04-11 | 西安安健药业有限公司 | Modified composition, preparation method and application thereof |
| CN102406897A (en) * | 2011-11-28 | 2012-04-11 | 无锡济民可信山禾药业股份有限公司 | A kind of Xingnaojing solid pharmaceutical composition and preparation method thereof |
| CN102406897B (en) * | 2011-11-28 | 2013-11-20 | 无锡济民可信山禾药业股份有限公司 | Xingnaojing solid medicinal composition and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |