CN1362228A

CN1362228A - Nano heart fire-clearing away bezoar medicine and its preparation

Info

Publication number: CN1362228A
Application number: CN 01100727
Authority: CN
Inventors: 杨孟君
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-01-08
Filing date: 2001-01-08
Publication date: 2002-08-07

Abstract

The present invention discloses a nano Niuhuang-qingxin preparation medicine. It is made up by using the Chinese medicinal materials of nano bovine bezoar, nano cinnaber, nano coptis, nano astragalus, nano gardenia and nano curcums as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which is most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.

Description

The nano bezoar preparation medicine and preparation method thereof that clears away heart-fire

The present invention relates to a kind of heat-clearing and toxic substances removing, tranquillizing the mind by relieving convulsion, the nano bezoar that the cures mainly epidemic encephalitis type B preparation medicine that clears away heart-fire the invention still further relates to the method for this medication preparation.

Bezoar Sedative Pills is a kind of classical Chinese patent medicine, mainly contains effects such as resisting pathogenic microbes, antiinflammatory, blood pressure lowering, analgesic, relieving convulsion, calmness, is used for closing in the pathogenic heat, dysphoria, unconsciousness and delirium, infantile hyperpyrexia faint from fear.But traditional Bezoar Sedative Pills disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.

The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano bezoar of the increase evident in efficacy preparation medicine that clears away heart-fire.

The preparation method that another object of the present invention provides this nano bezoar to clear away heart-fire preparation medicine.

To achieve these goals, the present invention takes following technical scheme:

Medicine of the present invention is to make (consumption is a weight portion) by following component:

Nano bezoar 6-14 part nanometer Cinnabaris 40-80 part nanometer coptis 120-280 part

Nano astragalus 80-160 part nanometer Fructus Gardeniae 80-160 part nanometer Radix Curcumae 40-120 part

The formula optimization weight proportion scope of medicine of the present invention is:

Nano bezoar 8-12 part nanometer Cinnabaris 50-70 part nanometer coptis 160-240 part

Nano astragalus 100-140 part nanometer Fructus Gardeniae 100-140 part nanometer Radix Curcumae 60-100 part

The optimum weight proportioning of medicine of the present invention is:

200 parts of 60 parts of nanometer coptis of 10 parts of nanometer Cinnabaris of nano bezoar

80 parts of 120 parts of nanometer Radix Curcumaes of 120 parts of nanometer Fructus Gardeniaes of nano astragalus

Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.

The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.

One of method of above-mentioned each component being made medicine of the present invention is:

1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces

2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:

1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;

2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;

3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.

3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.

Two of medicine method for making of the present invention is:

1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;

3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get clear away heart-fire preparation nano powder with the instantaneous drying of hypersonic velocity jet;

4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.

It is identical that above-mentioned two kinds of methods are made the clear away heart-fire pharmacological effect of preparation medicine of nano bezoar.

A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale; common Bezoar Sedative Pills preparation material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1-200nm; the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.

Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.

The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.

The present invention has also created the nano bezoar new drug formulation that the suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution etc. of preparation medicine has no precedent in the past that clears away heart-fire.

Pharmaceutical preparation of the present invention can be used for epidemic encephalitis type B, measles toxicity encephalitis, and bronchopneumonia, treatment of conditions such as the concurrent meningoencephalitis of pertussis, clinical efficacy significantly is better than traditional Bezoar Sedative Pills.

The present invention's added solvent in microwave extracting is water or ethanol.

The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.

Embodiment 1:

Prepare nano raw material by preceding method:

Production method is as follows:

In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.

Embodiment 2:

Prepare nano raw material by preceding method:

Production method is as follows:

In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard; do not add any adjuvant; make the nano bezoar powder needle injection that clears away heart-fire; every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.

Embodiment 3:

Prepare nano raw material by preceding method:

Production method is as follows:

In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard; filmogen adopts polyvinyl alcohol; make the nano bezoar membrane that clears away heart-fire, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: back, chest.

Claims

1, a kind of nano bezoar preparation medicine that clears away heart-fire is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:

And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.

2, the nano bezoar according to claim 1 preparation medicine that clears away heart-fire, wherein the weight proportion of each nano raw material is:

3, the nano bezoar according to claim 1 preparation medicine that clears away heart-fire, wherein the weight proportion of each nano raw material is:

4, according to claim 1 or the 2 or 3 described nano bezoars preparation medicine that clears away heart-fire, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.

5, according to the clear away heart-fire pharmaceutical methods of preparation medicine of claim 1 or 2 or 3 described nano bezoars, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour: above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.

6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.