CN1362134A - Nano blood stasis arthralgia treating medicine and its preparation - Google Patents
Nano blood stasis arthralgia treating medicine and its preparation Download PDFInfo
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- CN1362134A CN1362134A CN 01100187 CN01100187A CN1362134A CN 1362134 A CN1362134 A CN 1362134A CN 01100187 CN01100187 CN 01100187 CN 01100187 A CN01100187 A CN 01100187A CN 1362134 A CN1362134 A CN 1362134A
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000008280 blood Substances 0.000 title claims description 24
- 210000004369 blood Anatomy 0.000 title claims description 24
- 208000006820 Arthralgia Diseases 0.000 title claims description 16
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000004863 Frankincense Substances 0.000 claims abstract description 10
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000002775 capsule Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 244000020518 Carthamus tinctorius Species 0.000 claims description 9
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 9
- 241000903946 Clematidis Species 0.000 claims description 9
- 241000234653 Cyperus Species 0.000 claims description 9
- 241001057584 Myrrha Species 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 235000005412 red sage Nutrition 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 241000241550 Cyathula Species 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- WLYGSPLCNKYESI-RSUQVHIMSA-N Carthamin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@]1(O)C(O)=C(C(=O)\C=C\C=2C=CC(O)=CC=2)C(=O)C(\C=C\2C([C@](O)([C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(O)=C(C(=O)\C=C\C=3C=CC(O)=CC=3)C/2=O)=O)=C1O WLYGSPLCNKYESI-RSUQVHIMSA-N 0.000 abstract 1
- 241000208809 Carthamus Species 0.000 abstract 1
- 241000218158 Clematis Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 231100000862 numbness Toxicity 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 206010014080 Ecchymosis Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
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- 238000009472 formulation Methods 0.000 description 2
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- 210000003205 muscle Anatomy 0.000 description 2
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- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
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- 235000019615 sensations Nutrition 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Yuxuebi preparation medicine. It is made up by using 11 Chinese medicinal materials of nano frankincense, nano clematis, nano carthamus, nano salvia, nano myrrh and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of blood circulation promoting and blood stasis dispelling, dredging collateral to stop pain, cure mainly the nano blood stasis arthralgia treating preparation medicine of the arthromyodynia of obstruction of collaterals by blood stasis, the invention still further relates to the method for this medication preparation.
Blood stasis numbness capsule is a kind of classical Chinese patent medicine, mainly contains effects such as blood circulation promoting and blood stasis dispelling, dredging collateral to stop pain, is used for the arthromyodynia of obstruction of collaterals by blood stasis, and disease sees that the muscle arthralgia is violent, is sensation of pricking more, and the position is fixing not to be moved, and the sore spot tenderness can have rhabdion or ecchymosis.But traditional blood stasis numbness capsule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano blood stasis arthralgia treating preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano blood stasis arthralgia treating preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Olibanum 5-50 part nanometer Radix Clematidis 10-60 part nano safflower 5-50 part
Nano red sage 8-60 part nanometer Myrrha 5-50 part nanometer Radix Cyathulae 5-50 part
Nanometer Rhizoma Chuanxiong 5-55 part nano Chinese angelica 5-40 part nanometer Rhizoma Curcumae Longae 5-70 part
Nano cyperus tuber 5-40 part nano astragalus 10-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Olibanum 15-40 part nanometer Radix Clematidis 20-40 part nano safflower 10-30 part
Nano red sage 15-40 part nanometer Myrrha 10-30 part nanometer Radix Cyathulae 10-40 part
Nanometer Rhizoma Chuanxiong 10-35 part nano Chinese angelica 10-30 part nanometer Rhizoma Curcumae Longae 10-50 part
Nano cyperus tuber 8-25 part nano astragalus 20-50 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 30 parts of nano safflowers of 25 parts of nanometer Radix Clematidis of nanometer Olibanum
30 parts of 20 parts of nanometer Radix Cyathulaes of 25 parts of nanometer Myrrhas of nano red sage
15 parts in 20 parts of nanometer Rhizoma Curcumae Longaes of 15 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
30 parts of 15 parts of nano astragalus of nano cyperus tuber
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get blood stasis numbness preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano blood stasis arthralgia treating preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common blood stasis numbness capsule preparations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano blood stasis arthralgia treating preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the arthromyodynia of obstruction of collaterals by blood stasis, and disease sees that the muscle arthralgia is violent, is sensation of pricking more, and the position is fixing not to be moved, and the sore spot tenderness can have treatment of conditions such as rhabdion or ecchymosis, and clinical efficacy significantly is better than traditional blood stasis numbness capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 30 parts of nano safflowers of 25 parts of nanometer Radix Clematidis of nanometer Olibanum
30 parts of 20 parts of nanometer Radix Cyathulaes of 25 parts of nanometer Myrrhas of nano red sage
15 parts in 20 parts of nanometer Rhizoma Curcumae Longaes of 15 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
30 parts of 15 parts of nano astragalus of nano cyperus tuber
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 30 parts of nano safflowers of 25 parts of nanometer Radix Clematidis of nanometer Olibanum
30 parts of 20 parts of nanometer Radix Cyathulaes of 25 parts of nanometer Myrrhas of nano red sage
15 parts in 20 parts of nanometer Rhizoma Curcumae Longaes of 15 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
30 parts of 15 parts of nano astragalus of nano cyperus tuber
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano blood stasis arthralgia treating powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
20 parts of 30 parts of nano safflowers of 25 parts of nanometer Radix Clematidis of nanometer Olibanum
30 parts of 20 parts of nanometer Radix Cyathulaes of 25 parts of nanometer Myrrhas of nano red sage
15 parts in 20 parts of nanometer Rhizoma Curcumae Longaes of 15 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
30 parts of 15 parts of nano astragalus of nano cyperus tuber
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano blood stasis arthralgia treating membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, cervical region and affected part.
Claims (6)
1, a kind of nano blood stasis arthralgia treating preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Olibanum 5-50 part nanometer Radix Clematidis 10-60 part nano safflower 5-50 part
Nano red sage 8-60 part nanometer Myrrha 5-50 part nanometer Radix Cyathulae 5-50 part
Nanometer Rhizoma Chuanxiong 5-55 part nano Chinese angelica 5-40 part nanometer Rhizoma Curcumae Longae 5-70 part
Nano cyperus tuber 5-40 part nano astragalus 10-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano blood stasis arthralgia treating preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Olibanum 15-40 part nanometer Radix Clematidis 20-40 part nano safflower 10-30 part
Nano red sage 15-40 part nanometer Myrrha 10-30 part nanometer Radix Cyathulae 10-40 part
Nanometer Rhizoma Chuanxiong 10-35 part nano Chinese angelica 10-30 part nanometer Rhizoma Curcumae Longae 10-50 part
Nano cyperus tuber 8-25 part nano astragalus 20-50 part
3, nano blood stasis arthralgia treating preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 30 parts of nano safflowers of 25 parts of nanometer Radix Clematidis of nanometer Olibanum
30 parts of 20 parts of nanometer Radix Cyathulaes of 25 parts of nanometer Myrrhas of nano red sage
15 parts in 20 parts of nanometer Rhizoma Curcumae Longaes of 15 parts of nano Chinese angelicas of nanometer Rhizoma Chuanxiong
30 parts of 15 parts of nano astragalus of nano cyperus tuber
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano blood stasis arthralgia treating preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano blood stasis arthralgia treating preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100187 CN1362134A (en) | 2001-01-04 | 2001-01-04 | Nano blood stasis arthralgia treating medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100187 CN1362134A (en) | 2001-01-04 | 2001-01-04 | Nano blood stasis arthralgia treating medicine and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1362134A true CN1362134A (en) | 2002-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100187 Pending CN1362134A (en) | 2001-01-04 | 2001-01-04 | Nano blood stasis arthralgia treating medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362134A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100382838C (en) * | 2005-12-14 | 2008-04-23 | 辽宁本溪三药有限公司 | A traditional Chinese medicine for treating blood stasis and its preparation method |
| CN115814041A (en) * | 2022-12-26 | 2023-03-21 | 辽宁上药好护士药业（集团）有限公司 | A Chinese medicinal composition for treating headache, and its preparation method |
-
2001
- 2001-01-04 CN CN 01100187 patent/CN1362134A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100382838C (en) * | 2005-12-14 | 2008-04-23 | 辽宁本溪三药有限公司 | A traditional Chinese medicine for treating blood stasis and its preparation method |
| CN115814041A (en) * | 2022-12-26 | 2023-03-21 | 辽宁上药好护士药业（集团）有限公司 | A Chinese medicinal composition for treating headache, and its preparation method |
| CN115814041B (en) * | 2022-12-26 | 2023-11-03 | 辽宁上药好护士药业（集团）有限公司 | A Chinese medicinal composition for treating headache, and its preparation method |
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