CN1245152C - Nano-silver aqueous solution preparation and its preparation method, use and using method - Google Patents
Nano-silver aqueous solution preparation and its preparation method, use and using method Download PDFInfo
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- CN1245152C CN1245152C CN 200410022463 CN200410022463A CN1245152C CN 1245152 C CN1245152 C CN 1245152C CN 200410022463 CN200410022463 CN 200410022463 CN 200410022463 A CN200410022463 A CN 200410022463A CN 1245152 C CN1245152 C CN 1245152C
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- solution preparation
- water solution
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- silver
- nano silver
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title abstract description 7
- 239000007864 aqueous solution Substances 0.000 title description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 13
- 239000002270 dispersing agent Substances 0.000 claims abstract description 13
- 239000003381 stabilizer Substances 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 210000003708 urethra Anatomy 0.000 claims abstract description 11
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 6
- 229910052709 silver Inorganic materials 0.000 claims description 11
- 239000004332 silver Substances 0.000 claims description 11
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical group [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 5
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 5
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 5
- 235000010265 sodium sulphite Nutrition 0.000 claims description 5
- 208000029162 bladder disease Diseases 0.000 claims description 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical group [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims description 4
- 208000026533 urinary bladder disease Diseases 0.000 claims description 4
- 239000000654 additive Substances 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 231100000572 poisoning Toxicity 0.000 abstract description 2
- 230000000607 poisoning effect Effects 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 2
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 12
- 239000003085 diluting agent Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 208000019802 Sexually transmitted disease Diseases 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 201000007094 prostatitis Diseases 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000170793 Phalaris canariensis Species 0.000 description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000000680 avirulence Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229940083025 silver preparation Drugs 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 208000007190 Chlamydia Infections Diseases 0.000 description 1
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- 206010063057 Cystitis noninfective Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010028470 Mycoplasma infections Diseases 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 241000224527 Trichomonas vaginalis Species 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229940038705 chlamydia trachomatis Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a nano silver water solution preparation which is made from ingredients: 0.05 to 1.5 wt% of nano silver, 0.5 to 1.5 wt% of dispersing agent, 0.05 to 0.2 wt% of reductant, 0.5 to 10 wt% of stabilizer, and 1000 wt% of deionized water. The present invention also relates to a method for preparing the nano silver water solution preparation, a purpose for treating male venereal diseases, and a use method by injecting medicines into urinary bladders through urethras. All reductants and stabilizers in the nano silver water solution preparation are licensed by FDA of US or the ministry of health of China. The nano silver water solution preparation can be applied to additives of foods or medicines, the dosage is smaller than the largest limited quantity, and thus, the nano silver water solution preparation has no stimulation function on human bodies, and can not cause adverse reaction of poisoning and the like after being used for a long term.
Description
(1) technical field:
The present invention relates to a kind of nanometer silver preparation, particularly a kind of nano-silver water solution preparation with antiinflammatory, antibacterial action; The invention still further relates to preparation method, purposes and the using method of above-mentioned nano-silver water solution preparation.
(2) background technology:
Modern medicine confirms, nanometer silver has outstanding antibacterial ability, has a broad antifungal spectrum, to the Glanz positive bacteria, the Glanz negative bacterium, fungus, anaerobe all has tangible antibacterial functions, especially to the same tool sterilizing ability of drug resistance pathogenic bacterium, as staphylococcus aureus, escherichia coli, gonococcus, candida albicans, bacillus pyocyaneus, micrococcus scarlatinae, bacillus subtilis, pneumobacillus, pathogenic bacterium such as anaerobe, also can kill chlamydia trachomatis, and avirulence, no anaphylaxis, nonirritant, therefore be made into powder, antiinflammatory film and gel are used clinically, as application number is 01110767.7, name is called " aggregation-preventing nanometer wide-spectrum antibacterial silve powder and inductrial production process ", application number is 01129505.8, name is called " nanometer silver gynaecopathia antimicrobial inflammation-relieving film and industrialized producing technology thereof " and application number is 01129507.4, name is called " nanometer silver antimicrobial inflammation-relieving gel for curing prostatitis and industrialized producing technology thereof ", these powder, antibacterial film and gel can be used for the treatment of vaginitis, male prostatitis and senile organic prostatitis, its using method is by vagina or the direct administration of rectum, because powder, antiinflammatory film and gel all can't inject urethra and bladder, therefore still unmanned nanometer silver preparation for treating male venereal disease and urethra and the bladder disease used.
(3) summary of the invention:
The present invention will disclose a kind of nano-silver water solution preparation that can inject urethra and bladder.The present invention also will disclose preparation method, purposes and the using method of above-mentioned nano-silver water solution preparation.
The composition and the weight fraction of nano-silver water solution preparation of the present invention are as follows:
Nanometer silver 0.05～1.5, dispersant 0.5～1.5, Reducing agent 0.05～0.2, stabilizing agent are 0.5～10, deionized water 1000.
The preferred weight of above-mentioned each composition of aqueous solution preparation is divided into:
Nanometer silver 0.08～1.2, dispersant 0.8～1.2, Reducing agent 0.1～0.15, stabilizing agent are 0.8～2, deionized water 1000.
The optimum weight of above-mentioned each composition of nano-silver water solution preparation is divided into:
Nanometer silver 0.35, dispersant 1, Reducing agent 0.12, stabilizing agent are 1, deionized water 1000.
Reducing agent generally uses sulphite described in the above-mentioned nano-silver water solution preparation, preferably uses sodium metabisulfite or sodium sulfite; Described stabilizing agent preferably uses V
E,, V
COr different V
CIn a kind of, or between them with any proportional quantity, the mixture that is arbitrarily made with; Described dispersant generally uses the high molecular polymer class, and surfactant-based and organic acid dispersant preferably uses triethanolamine.
Nano-silver water solution preparation of the present invention can be made according to a conventional method, but its preparation method is best:
1) takes by weighing raw material in proportion;
2) with ultrasound wave nanometer silver powder is made dispersion treatment;
3) add deionized water and make diluent;
4) in diluent, add Reducing agent and stabilizing agent and dispersant;
5) fill, sealing are preserved.
Wherein said Reducing agent generally uses sulphite, preferably uses sodium metabisulfite or sodium sulfite; Described stabilizing agent preferably uses V
E,, V
COr different V
CIn a kind of, or between them with any proportional quantity, the mixture that is arbitrarily made with; Described dispersant generally uses the high molecular polymer class, and surfactant-based and organic acid dispersant preferably uses triethanolamine.
Nano-silver water solution preparation of the present invention is particularly suitable for treating urethra, bladder disease and male venereal disease.
The using method of nano-silver water solution preparation of the present invention when being used for the treatment of urethra, bladder disease and male venereal disease is to inject bladder by urethra.
Because the present invention is a kind of aqueous solution preparation, therefore easily inject urethra and bladder, can be used for treating urethra and bladder inflammation, particularly treat male venereal disease.What the present invention was the most outstanding is also advantageous in that, all Reducing agents in the nano-silver water solution preparation of the present invention and stabilizing agent all are through U.S. FDA or ministry of Health of China approval, can be applied to the additive in food or the medicine, and use amount is limited the quantity of less than maximum, therefore human body is not had stimulation, life-time service can not cause untoward reaction such as poisoning.Safety testing shows this product avirulence, no anaphylaxis, to skin, mucosa nonirritant, and no sensitization, rapid-action, good effect has no side effect.Employed adjuvant or additive all can be buied from market among the present invention, also can adopt the conventional similar product that uses in the industry, therefore are convenient to large-scale industrialization production.
(4) specific embodiment:
Below further specify the present invention by specific embodiment, but embodiment only be used for the explanation, can not limit the scope of the invention.
Embodiment one
1) ratio takes by weighing nanometer silver 0.35 gram, triethanolamine 1 gram, sodium metabisulfite 0.12 gram, V
E1 gram, deionized water 1000 grams;
2) nanometer silver powder is made dispersion treatment with ultrasound wave;
3) add deionized water and make diluent;
4) in diluent, add sodium metabisulfite, triethanolamine and V
E
5) stir, fill, sealing are preserved.
The said goods is to killing effect such as the following table of various pathogenic bacterias:
As seen from the above table, product of the present invention can be killed multiple sexually transmitted disease (STD) pathogenic bacteria in 8～12 hours, be a kind of medicine of good treatment sexually transmitted disease (STD).
It is as follows that the said goods is used for the male venereal disease therapeutic effect:
Treat clinical std patient 38 examples, be the male, age between 25～53, wherein infection of staphylococcus aureus person 3 examples, charrin's disease person 5 examples, candida albicans infection person 4 examples, gonococcal infection person 7 examples, mycoplasma infection person's 9 examples, chlamydia infection person 5 examples, trichomonas vaginalis infection person 5 examples.
Therapeutic Method is to adopt the mode of this product being injected bladder from urethra.Inject a deuterzooid product every day, inject 40ml at every turn, treating six days is a course of treatment, treats two courses of treatment continuously, and cure rate is 95%.The cooperation antibiotic therapy of in particular cases can following the doctor's advice.
Embodiment two
1) takes by weighing nanometer silver 0.15 gram, triethanolamine 1 gram, sodium sulfite 0.05 gram, V
E, V
CWith different V
CEach 0.5 gram, deionized water 1000 grams;
2) nanometer silver powder is made dispersion treatment with ultrasound wave;
3) add deionized water and make diluent;
4) in diluent, add sodium sulfite, triethanolamine, V
E, and different V
C
5) stir, fill, sealing are preserved.
Claims (5)
1, a kind of nano-silver water solution preparation, the weight distribution ratio of its each composition is as follows: nanometer silver 0.05～1.5, dispersant 0.5～1.5, Reducing agent 0.05～0.2, stabilizing agent are 0.5～10, deionized water 1000; Wherein said Reducing agent is a sulphite; Described stabilizing agent is a kind of among VE, VC or the different VC, or the mixture of forming with any proportional quantity, combination in any mode between them; Described dispersant is a triethanolamine.
2, nano-silver water solution preparation according to claim 1 is characterized in that: described sulphite is sodium metabisulfite or sodium sulfite.
3, nano-silver water solution preparation according to claim 1 and 2 is characterized in that wherein the weight distribution ratio of each composition is as follows:
Nanometer silver 0.08～1.2, dispersant 0.8～1.2, Reducing agent 0.1～0.15, stabilizing agent 0.8～2, deionized water 1000.
4, nano-silver water solution preparation according to claim 3 is characterized in that wherein the weight distribution ratio of each composition is as follows:
Nanometer silver 0.35, dispersant 1, Reducing agent 0.12, stabilizing agent are 1, deionized water 1000.
5, control the application of the medicine of urethra, bladder disease and male venereal disease in preparation according to the described nano-silver water solution preparation of claim 1～4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410022463 CN1245152C (en) | 2004-04-30 | 2004-04-30 | Nano-silver aqueous solution preparation and its preparation method, use and using method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410022463 CN1245152C (en) | 2004-04-30 | 2004-04-30 | Nano-silver aqueous solution preparation and its preparation method, use and using method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1569366A CN1569366A (en) | 2005-01-26 |
| CN1245152C true CN1245152C (en) | 2006-03-15 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410022463 Expired - Fee Related CN1245152C (en) | 2004-04-30 | 2004-04-30 | Nano-silver aqueous solution preparation and its preparation method, use and using method |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473965A (en) * | 2005-08-04 | 2015-04-01 | 林成龙 | Composition containing silver nanoparticles and application thereof |
| US20090011046A1 (en) * | 2005-08-04 | 2009-01-08 | Chenlung Lin | Composition Comprising Silver Nanoparticles and the Use Thereof |
| CN100425375C (en) * | 2006-04-03 | 2008-10-15 | 庄平 | Nano-class silver colloidal solution and preparation method thereof |
| JP5632852B2 (en) | 2010-08-27 | 2014-11-26 | Ｄｏｗａエレクトロニクス株式会社 | Low temperature sinterable silver nanoparticle composition and electronic article formed using the composition |
| CN103817753B (en) * | 2014-03-21 | 2015-11-25 | 德华兔宝宝装饰新材股份有限公司 | A kind of Nano Silver floor of antimildew and antibacterial |
| CN103832205B (en) * | 2014-03-21 | 2016-03-30 | 德华兔宝宝装饰新材股份有限公司 | A kind of Nano Silver decoration veneer |
| CN103862988B (en) * | 2014-03-21 | 2016-02-03 | 德华兔宝宝装饰新材股份有限公司 | A kind of Nano Silver decoration veneer of antimildew and antibacterial |
| CN103817348B (en) * | 2014-03-21 | 2015-12-02 | 德华兔宝宝装饰新材股份有限公司 | A kind of nano-silver water solution and the using method for Recombinant Wood thereof |
| CN103817754B (en) * | 2014-03-21 | 2015-09-16 | 德华兔宝宝装饰新材股份有限公司 | A kind of Nano Silver floor |
| CN105640986A (en) * | 2014-11-28 | 2016-06-08 | 广东工业大学 | Silver nanoparticle composition for control of lung cancer and prostate cancer |
-
2004
- 2004-04-30 CN CN 200410022463 patent/CN1245152C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1569366A (en) | 2005-01-26 |
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