CN111803138B - A mask-type respiratory pathogen sampling device - Google Patents
A mask-type respiratory pathogen sampling device Download PDFInfo
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- CN111803138B CN111803138B CN202010794594.3A CN202010794594A CN111803138B CN 111803138 B CN111803138 B CN 111803138B CN 202010794594 A CN202010794594 A CN 202010794594A CN 111803138 B CN111803138 B CN 111803138B
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- pipe
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- air
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- 244000052769 pathogen Species 0.000 title claims abstract description 49
- 230000001717 pathogenic effect Effects 0.000 title claims abstract description 31
- 238000005070 sampling Methods 0.000 title claims abstract description 19
- 230000000241 respiratory effect Effects 0.000 title claims description 12
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 238000004321 preservation Methods 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 238000009792 diffusion process Methods 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 abstract description 8
- 230000005540 biological transmission Effects 0.000 abstract description 7
- 230000003044 adaptive effect Effects 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 description 4
- 239000003761 preservation solution Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 244000000010 microbial pathogen Species 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 210000001989 nasopharynx Anatomy 0.000 description 3
- 101100269850 Caenorhabditis elegans mask-1 gene Proteins 0.000 description 2
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000003300 oropharynx Anatomy 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4055—Concentrating samples by solubility techniques
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B2010/0083—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements for taking gas samples
- A61B2010/0087—Breath samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a mask type respiratory tract pathogen sampling device which comprises a mask, a gas transmission pipe, a collecting pipe, a pipe cover, a gas dispersing coil pipe, an exhaust pipe and a refrigerating box, wherein a one-way valve air suction port and an air outlet are formed in the mask, the collecting pipe is detachably provided with the pipe cover, the gas dispersing coil pipe and the exhaust pipe are inserted in the pipe cover, the gas dispersing coil pipe penetrates through the bottom of the collecting pipe, one end of the gas transmission pipe is connected to the air outlet of the mask, the other end of the gas transmission pipe is connected to the pipe orifice of the gas dispersing coil pipe, pathogen collecting and preserving liquid is contained in the collecting pipe, and the collecting pipe can be placed in the refrigerating box in an adaptive mode. The invention has the innovation points that the mask intercepts the gas exhaled by a sampled person, leads the gas to be immersed in the air dispersing coil pipe filled with the sampling preservation liquid, and then dissolves the pathogen carried in the bubble in the pathogen collecting preservation liquid through the micropore exhaust on the spiral air dispersing coil pipe so as to achieve the purpose of efficiently collecting respiratory tract pathogens.
Description
Technical Field
The invention belongs to the technical field of pathogen sampling tools, and particularly relates to a mask type respiratory pathogen sampling device.
Background
Currently, the sampling of respiratory infectious disease pathogens (such as novel coronaviruses, influenza viruses, measles viruses, tubercle bacillus, etc.) mostly uses a swab to scrape the mucous membrane of the oropharynx or nasopharynx, and then the viruses on the swab are eluted for detection and analysis. However, this method has three disadvantages, namely, firstly, because the focus reproduction point of most pathogens of respiratory tract infectious diseases is in the lung of the lower respiratory tract, the amount of pathogens remained on the oropharynx and nasopharynx mucous membrane walls of the upper respiratory tract is small, so that the pathogens which can be scraped are not too much, secondly, the surface area of the swab head is very limited, mucous membrane cells which can adhere to the swab head and the pathogens are very limited, and thirdly, the swab is required to be extended to the rear part of the upper respiratory tract to collect as much as possible in order to scrape the pathogens, but the sampled person can feel very uncomfortable, especially when the nasopharynx is used for sampling. Therefore, it is highly desirable to invent a sampling tool that can collect a large amount of pathogens exiting the lower respiratory tract lesion propagation site without causing too much discomfort to the person being sampled.
Disclosure of Invention
The invention provides a mask type respiratory pathogen sampling device aiming at the defects of the prior art.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
A mask type respiratory tract pathogen sampling device comprises a mask, a gas transmission pipe, a collecting pipe, a pipe cover, a gas dispersing coil pipe and a gas exhaust pipe, wherein a one-way valve air suction port and a gas outlet are formed in the mask, the pipe cover is detachably arranged on the collecting pipe, the gas dispersing coil pipe and the gas exhaust pipe are inserted in the pipe cover, the gas dispersing coil pipe extends to the bottom of the collecting pipe, one end of the gas transmission pipe is connected to the gas outlet on the mask, the other end of the gas transmission pipe is connected to the pipe orifice of the gas dispersing coil pipe on the pipe cover, and pathogen collecting and preserving liquid is contained in the collecting pipe.
The invention has the innovation points that firstly, the spiral coil pipe with micropores is adopted to release a large amount of gas exhaled by a sampled person in solution in a dispersing way, so that pathogens carried in the gas are eluted in pathogen collecting and preserving liquid in an enrichment way, secondly, the gas exhaled by the sampled person is guided into a pathogen collecting pipe through a special mask, the gas guided out of the mask is exhaled from the lung of the sampled person and contains a large amount of pathogens, and thirdly, the sampled person has good medical compliance on wearing the mask, and can wear the mask and elute the pathogens for a long time by the sampled person, so that the collection amount of the pathogens is improved.
Furthermore, the tube body of the collecting tube is a 50ml pointed bottom or round bottom centrifuge tube commonly used in laboratories, and the tube cover is refitted, so that the tube body can be conveniently matched with other related instruments in subsequent experiments by using a conventional centrifuge tube.
Further, the lower part of the air dispersing coil is spirally coiled, air dispersing holes are densely distributed on the periphery of the tube wall of the lower part of the air dispersing coil, and when the air exhaled by a subject is exhausted out of the air dispersing coil, the air is fully contacted and mixed with pathogen collecting and preserving liquid through a plurality of fine air dispersing holes, so that pathogenic microorganisms in the exhaled air are fully dissolved in the pathogen collecting and preserving liquid.
Further, the pore diameter of the air dispersing hole is 0.1-0.3 mm, the smaller the pore diameter is, the larger the surface area of the air bubble is, the more the area contacted with the pathogen collecting preservation solution is, and the more the chance of dissolving in the pathogen preserving solution is. In addition, the design of the small aperture can enable more air dispersing holes to be arranged on the spiral coil on the limited spiral coil.
The cold storage box comprises a hollow box body, a slot, a waistband and a water injection port, wherein the slot for placing a collecting pipe is arranged at the top of the box body, the collecting pipe can be placed in the cold storage box in a fitting manner, the waistband is arranged on the box body, a person to be sampled can conveniently and comfortably hang on the person to be sampled for a long time, the water injection port is arranged on the upper surface of the box body, water or other refrigerants can be injected into the cold storage box through the water injection port, and therefore pathogenic microorganisms dissolved into the collecting box can be better kept in biological activity at low temperature under the condition of precooling of the cold storage box.
Further, the air-dispersing pipe also comprises a check valve, and the air inlet end of the air-dispersing pipe is provided with the check valve, so that preserving fluid in the collecting pipe is prevented from flowing back into the air pipe.
Further, the blast pipe on be provided with filtration membrane and waterproof ventilated membrane, guarantee that collection pipe in preserving liquid can not the spun condition under, can filter the exhaust gas in the collection pipe, prevent that the pathogen from escaping and causing environmental pollution.
The invention has the advantages that the mask is adopted to collect pathogens exhaled by the sampled person from the lung, and then the pathogen collection preservation solution is used to carry out elution treatment on the exhaled gas, so that the pathogens carried in the exhaled gas are eluted into the pathogen collection preservation solution, thereby achieving the purpose of conveniently and largely collecting pathogens of lower respiratory tract infection. The device has the advantages of simple structure, convenient use, good medical availability, capability of collecting pathogenic microorganisms of lower respiratory tract infection, large enrichment collection amount, capability of keeping the biological activity of pathogens and the like, and each component can be flexibly disassembled, is convenient to transport and use, has low manufacturing cost and strong practicability, and is suitable for collecting pathogens of various respiratory tract infectious diseases.
Drawings
FIG. 1 is a schematic diagram of a mask type respiratory pathogen sampling device according to the present invention;
Fig. 2 is a schematic diagram of the structure of a tube cover and an air dispersing coil in a mask type respiratory pathogen sampling device according to the invention.
Detailed Description
The invention is described in detail below with reference to the attached drawing figures:
In the description of the present invention, it should be noted that, directions or positional relationships indicated by "left", "right", "upper", "lower", etc. are directions or positional relationships based on those shown in the drawings, or directions or positional relationships in which the inventive product is conventionally put in use, are merely for convenience of describing the present invention and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific direction, be configured and operated in a specific direction, and therefore should not be construed as limiting the present invention.
As shown in figures 1-2, a mask type respiratory pathogen sampling device comprises a mask 1, a gas transmission pipe 2, a collecting pipe 3, a pipe cover 4, a gas dispersing coil pipe 5, a gas exhaust pipe 6, a gas dispersing hole 7, a refrigerating box 8 and a check valve 9, wherein the mask 1 is provided with a one-way valve air suction port 11 and a gas outlet 12, the collecting pipe 3 is detachably provided with the pipe cover 4, the collecting pipe 3 adopts a 50ml universal pointed bottom or round bottom centrifuge pipe, and a pathogen collecting preservation solution is arranged in the pipe. One innovation point of the embodiment is to reform a 50ml centrifuge tube which is common in a laboratory, and only the air dispersing coil 5 and the air exhaust pipe 6 are needed to be inserted and arranged on the tube cover 4. Before the air dispersing coil pipe 5 is not used, the pipe openings of the air dispersing coil pipe 5 and the air exhaust pipe 6 are covered by rubber covers, so that the pathogen collecting and preserving liquid preassembled in the air dispersing coil pipe is prevented from being polluted or leaked. After all parts of the collecting pipe are assembled, the air dispersing coil pipe 5 extends to the lower part of the collecting pipe 3, a filtering membrane and a waterproof breathable membrane are arranged at the pipe orifice of the exhaust pipe 6, and the filtering membrane is positioned at the outer side. One end of the gas pipe 2 is sleeved and inserted on the gas outlet 12, the other end of the gas pipe 2 is sleeved and connected with the air dispersing coil pipe 5, and the air dispersing coil pipe 5 is provided with a check valve 9 at the end connected with the gas pipe 2, so that preserving fluid can be prevented from flowing back into the gas pipe 2.
The end of the air diffusing coil 5 of the present embodiment is closed, and is composed of a straight pipe and a spiral coil, the spiral coil is located at the lower part of the air diffusing coil 5, the straight pipe passes through the middle of the spiral coil, the upper end of the straight pipe protrudes out of the pipe cover 4, and the lower end of the straight pipe is connected with the bottom of the spiral coil. The lower half parts of the spiral coil pipe and the straight pipe are provided with air vents 7, the air vents 7 are orderly and densely distributed on the spiral coil pipe and the straight pipe, and the aperture of the air vents 7 is 0.2mm. The refrigeration box 8 comprises a hollow box body 81, a slot 82, a waistband 83 and a water injection port 84, wherein the slot 82 for placing the collecting pipe 3 is arranged at the upper part of the box body 81, the waistband 83 is arranged on the box body 81, and the water injection port 84 is arranged on the upper surface of the box body 81. When a user needs to wear the refrigerated container for a long time to collect pathogens, the precooled refrigerated box 8 can be taken out from the refrigerated cabinet, hung on the body, then the collecting pipe 3 is inserted, and the air pipe 2 is connected.
While particular embodiments of the present invention have been illustrated and described in detail, it should be noted that various changes and modifications could be made to the above-described embodiments without departing from the spirit of the invention and the scope of the appended claims.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010794594.3A CN111803138B (en) | 2020-08-10 | 2020-08-10 | A mask-type respiratory pathogen sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010794594.3A CN111803138B (en) | 2020-08-10 | 2020-08-10 | A mask-type respiratory pathogen sampling device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111803138A CN111803138A (en) | 2020-10-23 |
| CN111803138B true CN111803138B (en) | 2025-01-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010794594.3A Active CN111803138B (en) | 2020-08-10 | 2020-08-10 | A mask-type respiratory pathogen sampling device |
Country Status (1)
| Country | Link |
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| CN (1) | CN111803138B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115005886A (en) * | 2022-07-06 | 2022-09-06 | 白泽晨 | Respiratory tract pathogenic microorganism collection system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008119552A (en) * | 2008-02-27 | 2008-05-29 | Kochikai | Virus collector |
| CN107132085A (en) * | 2017-06-30 | 2017-09-05 | 莫廷英 | A kind of metal mask for facilitating gas collecting |
| CN111228623A (en) * | 2020-03-06 | 2020-06-05 | 广州和普乐健康科技有限公司 | breathing mask |
| CN212438678U (en) * | 2020-08-10 | 2021-02-02 | 刘思聪 | Mask type respiratory tract pathogen sampling device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2104451A4 (en) * | 2006-01-25 | 2010-01-06 | Pipex Inc | Droplet collection devices and methods to detect and control airborne communicable diseases utilizing rfid |
| JP2009028053A (en) * | 2008-10-07 | 2009-02-12 | Kochikai | Influenza virus separator and method for separating influenza virus |
| CN111317926B (en) * | 2020-03-05 | 2021-05-07 | 华中科技大学 | a disinfectant mask |
-
2020
- 2020-08-10 CN CN202010794594.3A patent/CN111803138B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008119552A (en) * | 2008-02-27 | 2008-05-29 | Kochikai | Virus collector |
| CN107132085A (en) * | 2017-06-30 | 2017-09-05 | 莫廷英 | A kind of metal mask for facilitating gas collecting |
| CN111228623A (en) * | 2020-03-06 | 2020-06-05 | 广州和普乐健康科技有限公司 | breathing mask |
| CN212438678U (en) * | 2020-08-10 | 2021-02-02 | 刘思聪 | Mask type respiratory tract pathogen sampling device |
Also Published As
| Publication number | Publication date |
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| CN111803138A (en) | 2020-10-23 |
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