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CN111801136B - 神经刺激装置 - Google Patents

神经刺激装置 Download PDF

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CN111801136B
CN111801136B CN201980015093.6A CN201980015093A CN111801136B CN 111801136 B CN111801136 B CN 111801136B CN 201980015093 A CN201980015093 A CN 201980015093A CN 111801136 B CN111801136 B CN 111801136B
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microelectrode
membrane
leg
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CN111801136A (zh
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A·梅尔卡尼兹尼
Z·斯图兹卡
J·J·阮
P·哈比
A·乔丹
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Aleva Neurotherapeutics SA
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    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0539—Anchoring of brain electrode systems, e.g. within burr hole
    • A—HUMAN NECESSITIES
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0534—Electrodes for deep brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61N1/04—Electrodes
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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Abstract

本公开描述了一种包括内部支撑梳的可植入导线装置。支撑梳可以包括一个或多个面，其能够对准、布线和保持导线装置的内部导线。支撑梳可以使导线能够与包括引线装置的电极的微电极膜相互连接。

Description

神经刺激装置
相关申请的交叉引用
本申请要求在2018年3月2日提交的题为“神经刺激装置”的美国非临时专利申请No.15/910,278的优先权，该申请通过引用整体结合到本文中。
背景技术
深度脑刺激(DBS)可以包括神经刺激治疗，其涉及刺激人脑和身体的电刺激系统。DBS可用于治疗许多神经障碍。DBS可涉及电刺激大脑的目标区域。
发明内容
本公开描述了一种可以形成为圆柱形的刺激装置。内部地，刺激装置可以包括硅蚀刻的支撑梳，以对准、布线和保持电线。支撑梳可以使得电线与包括刺激装置的电极的微电极膜相互连接。刺激装置也可以包括内部支撑管，可以通过提供长边缘锚定系统来减少微电极膜从其环氧树脂模制件的机械移位。微电极膜可以卷绕成为三维构造，已增加在组装操作期间的自由度。
根据本公开的至少一个方面，可植入导线装置可以包括支撑梳。支撑梳可以包括附接面以及布线面。布线面可以包括多个槽。导线装置可以包括微电极膜。微电极膜可以包括主体。主体可以包括多个电极。微电极膜可以包括从主体延伸出的延伸部。延伸部可以包括第一面。延伸部的第一面可以包括与多个电极耦合的多个电触点。延伸部可以包括第二面。延伸部的第二面可以与支撑梳的附接面耦合。导线装置可以包括多个电线。多个电线中的每一个可以穿过多个槽中的相应一个槽并且与多个电触点中的相应一个电触点耦合。
附接面可以包括通道，以在微电极膜的第二面的至少一部分下方引导粘合剂。微电极膜的主体的第一面可以与支撑管耦合。支撑管可以包括与多个电极对准的多个不透射线的标记物。支撑管可以在第一端上包括多个城齿。第一端可以被配置为与支撑梳配合。
导线装置可以包括支撑管，支撑管可以包括多个不透射线的标记物。多个电线中的每个电线可以利用电线接合与多个电触点中的相应一个电触点耦合。
微电极膜的延伸部可以包括第一腿部和第二腿部。第一腿部可以包括延伸部的第一面和延伸部的第二面。第二腿部可以包括将多个电极的子集耦合到多个电触点的多个迹线。
延伸部的第一腿部和第二腿部可以围绕支撑梳卷绕。导线装置可以包括微电极膜的环氧树脂回填以形成探针轴。
根据本公开的至少一个方面，一种制造可植入导线装置的方法可以包括提供支撑梳。支撑梳可以包括附接面和布线面。布线面可以包括多个槽。该方法可以包括将微电极膜的第一部分与支撑梳的附接面耦合。微电极膜的第一部分可以包括多个电触点。该方法可以包括将多个电线中的每一个定位成穿过布线面的多个槽中的相应一个槽。该方法可以包括将多个电线中的每一个与多个电触点中的相应一个电触点耦合。该方法可以包括围绕支撑梳卷绕微电极膜的第二部分。
该方法可以包括形成微电极膜的第二部分。第二部分包括与多个电触点电连通的多个电极。该方法可以包括形成微电极膜的第三部分。第三部分可以包括将多个电极的一部分耦合到多个电触点的一部分的多条电迹线。
该方法可以包括将微电极膜的第二部分耦合到支撑管的外表面。微电极膜的第二部分可以包括多个电极。该方法可以包括用环氧树脂模制支撑梳。
该方法可以包括在支撑管中形成多个不透射线的标记物。该方法可以包括将多个不透射线的标记物与形成在微电极膜中的多个电极对准。多个不透射线的标记物可以从多个电极偏移。
该方法可以包括将多个电线中的每一个电线与多个电触点中的相应一个电触点进行电线接合。该方法可以包括卷绕微电极膜的第二部分以形成圆柱体。该方法可以包括用环氧树脂填充圆柱体。
该方法可以包括用环氧树脂对在附接面中形成的通道进行底部填充，以将微电极膜的第一部分与附接面耦合。该方法可以包括在硅中蚀刻出支撑梳。
该方法可以包括将微电极膜的第一边缘与微电极膜的第二边缘耦合以形成圆柱体。该方法可以包括将微电极膜的第一边缘和第二边缘插入支撑管的槽中。
附图说明
附图不是按比例绘制的。在各个附图中，相同的附图标记和名称表示相同的元件。为了清楚起见，不是每个部件都在每幅图中被标记。在附图中：
图1示出了执行神经刺激的示例系统。
图2示出了用于图1所示系统的刺激导线。
图3示出了图2所示的刺激导线的远端的透视图。
图4示出了用于图2所示的刺激导线的微电极膜的俯视图。
图5示出了处于卷绕构造的微电极膜。
图6示出了用于图2所示的刺激导线的示例支撑管。
图7示出了从支撑管的远端观察的与支撑管耦合的微电极膜。
图8-图10示出了用于图2所示的刺激导线的示例支撑梳。
图11-图14示出了图2所示的刺激导线的远端的视图。
图15示出了图2中所示的刺激导线中的支撑梳和微电极膜之间的界面的局部视图。
图16示出了可以用于图2所示的刺激导线的示例支撑梳的局部视图。
图17示出了支撑梳与支撑管的耦合的局部视图。
图18和图19示出了具有突出部的微电极膜的示例性配置。
图20示出了用于图1所示系统的示例性支撑管和标记物。
图21示出了用于图1所示系统中的具有圆形构造的示例性支撑梳。
图22示出了制造用在图1所示系统中的导线装置的示例方法。
具体实施方式
上文介绍并在下文更详细讨论的各种概念可以以多种方式中的任何方式来实现，因为所描述的概念不限于任何特定的实现方式。提供具体实现和应用的示例主要是出于说明性目的。
图1示出了用于执行神经刺激的示例系统50。系统50包括植入患者52的脑部54的刺激导线100。刺激导线100通过电缆56与刺激器58耦合。刺激器58产生治疗电刺激，该治疗电刺激可以通过刺激导线100传递到患者的脑部54。刺激导线100可以是可植入导线装置，其可以长期或短期地植入患者52体内。
图2示出了刺激导线100。刺激导线100包括远端110和近端112。远端110包括多个电极108。近端112包括多个端子触点116。每个端子触点116与至少一个电极108电耦合。例如，电线(或其它电迹线)可以从端子触点116中的一个穿过主体114的内部延伸到朝远端110设置的触点，该触点与电极108电连通。
图3示出了刺激导线100的远端110的透视图。作为概述，远端110包括具有多个电极108的微电极膜104。微电极膜104与支撑管132耦合。远端110还包括支撑梳102。支撑梳102可以使线106能够附接至微电极膜104。远端110还包括探头轴140。下面结合图4-图9等描述远端110的部件，并且结合图10-图17等进一步描述组装的远端110。
远端110包括微电极膜104。图4示出了微电极膜104的俯视图。图4示出了平面构造的微电极膜104。微电极膜104包括主体120和延伸部122。主体120包括多个电极108。延伸部122包括多个触点118。触点118可以经由迹线124与电极108耦合。
微电极膜104包括主体120。主体120可以包括多个电极108。主体120可包括约4个至约64个之间、约8个至约32个之间、约8个至约24个之间、或约4个至约12个之间的电极108。电极108可以被配置为定向或全向电极。例如，在全向配置中，电极108可基本上延伸主体120的高度126，使得当微电极膜104被形成为圆柱体时(如图5所示)，电极108基本上围绕(例如，至少80％或至少90％)远端110的圆周缠绕。在定向配置中，如图4所示，电极108仅延伸微电极膜104的高度126的一部分。例如，在定向配置中，电极108可各自仅在主体120的高度126的约10％和约80％之间、约10％和约60％之间、约10％和约40％之间、或约10％和约25％之间延伸。电极108可以按列分组以跨越高度126。一个或多个定向配置的电极108可以电耦合在一起以形成全向电极108。通过连接微电极膜104内的两个迹线124或通过经由电线106连接终端触点116，可以电地发生至少两个定向配置的电极108之间的耦合以形成全向电极108。
微电极膜104可以包括多个迹线124。迹线124可以将电极108与一个或多个触点118耦合。微电极膜104可以包括相同数量的触点118和电极108，使得每个电极108与单个触点118耦合。微电极膜104可以包括比电极108更少的触点118，使得多于一个电极108与相同的触点118耦合(以形成例如全向电极)。每个迹线124可以与电极108形成一个或多个连接。例如，迹线124可以分支成两个或更多个外围迹线，外围迹线在围绕电极108的外围的若干点处与电极108耦合。与电极108中的每一个进行多个连接可以增加微电极膜104的可靠性。
延伸部122可以包括触点118。触点118可提供界面，在该界面处，电线106与微电极膜104耦合。例如，每个电线106可以与触点118中的相应一个触点进行电线接合或激光接合。
延伸部122可包括第一腿部128和第二腿部130。触点118可设置在第一腿部128的第一面上。第一腿部128还可包括朝向第一腿部128的每一端设置的开口158。开口158可以是穿过第一腿部128的孔。开口158可以与形成在支撑梳102的附接面中的入口对准(并且在下文中结合附图中的图8进一步描述)。第二腿部130可以包括从触点118延伸到电极108的迹线124的子集。与沿着单个腿部布线迹线124的系统相比，使迹线124的子集沿着第二腿部130延伸可以使得更大数量的迹线124(并且因此电极108)能够被并入微电极膜104中。
图5示出了卷绕构造的微电极膜104。如图所示，主体120的相对边缘朝向彼此卷绕以形成圆柱体。第二腿部130绕第一腿部128卷绕以形成圆柱体的第二部分。如图5和图6所示，主体120可以绕支撑管卷绕。
图6示出了示例性支撑管132。支撑管132可以包括多个标记物134。支撑管132可以包括槽136。支撑管132的近端可以包括多个城齿138。
支撑管132可包括不透辐射的金属(例如医用级不锈钢)、非金属材料(例如塑料)或其组合。支撑管132可以包括多个标记物134。标记物134可以是不透射线的。例如，当用CT扫描仪或X射线对刺激导线100成像时，标记物134是可见的。当支撑管132由不透辐射的金属制造时，标记物134可以是支撑管132的主体中的孔或空隙。标记物134可以穿过支撑管132的壁。当标记物134是穿过支撑管132的壁的孔时，与具有标记物134的支撑管132的部分相比，没有标记物134的区域可以是相对更不透射线的。电极108可以与标记物134对准。电极108可以与标记物134之间的区域对准。支撑管132可以用塑料材料制造，并且标记物134可以通过局部掺杂聚合物(例如硼轰击)或者通过用掺杂聚合物(例如硼掺杂塑料)回填而制成不透辐射的。
支撑管132可以包括多个城齿138。城齿138可以是从支承管132的一端延伸的多个延伸部。每个城齿138可以与相邻城齿138分开间隙或垛口。城齿138中的每一个的长度可以是大约在大约0.2mm和大约2mm之间、大约0.4mm和大约1.5mm之间、大约0.2mm和大约1mm之间、或大约0.4mm和大约0.6mm之间。城齿138可具有约0.1mm至约2mm、约0.1mm和约1.5mm之间、约0.1mm和约1mm之间、约0.1mm和约0.5mm之间、或约0.2mm和约4mm之间的周向节距。
城齿138被构造为与支撑梳102配合。城齿138被构造成与刺激导线100的探针轴配合。探针轴可以通过环氧树脂过模制工艺形成。城齿138可提供凹槽和凸脊，环氧树脂可流入其中并结合以形成探针轴。
支撑管132可以包括槽136。槽136可以在支撑管132的长度上延伸。槽136可穿过支撑管132的壁，或者可在支撑管132的外表面中形成通道。
图7示出了从支撑管132的远端观察时与支撑管132耦合的微电极膜104。包括电极108的主体120的第一面可以面向外并且远离支撑管132。微电极膜的主体120的第二面与支撑管132的外表面耦合以形成圆柱体。主体120的相对边缘插入穿过槽136。
图8示出了支撑梳102的附接面和支撑梳102的第一布线面144。附接面142包括通道148。支撑梳102的附接面142被配置为与微电极膜104的面耦合。通道148被配置为在微电极膜104的与附接面142耦合的面的一部分下方引导粘合剂。通道148可以在约5μm和约40μm之间、在约10μm和约30μm之间、或在约10μm和约20μm之间。在刺激导线100的制造期间，微电极膜104的面可以通过机械装置(例如夹具)与支撑梳102的附接面142耦合。入口150可延伸超过微电极膜104的与附接面142耦合的部分。可以将粘合剂添加到入口150。毛细管作用可沿着通道148的长度并在微电极膜104的与附接面142耦合的面下方输送粘合剂。一旦粘合剂固化，就可释放用于将微电极膜104保持在附接面142上的机械装置。
支撑梳102可以包括第一布线面144。第一布线面144可以包括多个槽152(其也可以被称为通道152)。第一布线面144可以包括用于每个电线106的槽152。在制造过程中，每个触点118可以基本上与槽152中的一个对齐，以便于将电线106与触点118耦合。例如，每根电线106可穿过相应的槽152以与不同的触点118对齐。槽152的间距可以与触点118的间距相匹配。
图9示出了支撑梳102的第二布线面154。第二布线面154与附接面142相对。第二布线面154可以包括多个指状物156。指状物156是凸起的突出部，其可以在第二布线面154中形成通道157。每个通道157可终止于通向第一布线面144上的槽152的孔159中。
图10示出了第二布线面154，其中电线106沿第二布线面154穿过。电线106可以进入由指状物156限定的通道157。从通道157起，电线106可以穿过通道157的端部处的孔159，并且进入第一布线面144上的相应槽152中的一个槽中。电线106的颜色编码可以使得能够实现电线106从端子触点116中的每一个到远端110的对应电极108的适当布线。
图11-图14示出了远端110的不同视图。图11-图14中所示的每个视图示出了相对于先前的图旋转90度的刺激导线100的远端110的视图。例如，图11可以说是示出了远端110的顶视图，图12可以说是示出了远端110的第一侧视图，图13可以说是示出了远端110的底视图，并且图14可以说是示出了远端110的第二侧视图。前面的“顶部”、“第一侧”、“第二侧”和“底部”被提供仅用于参考，因为远端110的任何面都可以用作“顶部”、“底部”等。例如，电极108围绕远端110的圆周的放置使得远端110的任何面(或角度)能够用作远端110的顶部、底部或侧面。
一起参考图11-图14，其中，远端110包括微电极膜104。微电极膜104包括多个电极108。电极108经由电线106与端子触点116耦合。远端110还包括支撑梳102。支撑梳102可以便于在远端110的轴内管理电线106。支撑梳102还可将电线106的终止端固定或保持在微电极膜104的触点附近。将电线106的终止端定位在微电极膜104的触点附近可以实现制造中的改进的效率，因为支撑梳102可以提供电线106和微电极膜104的触点118之间的对准。
图15示出了支撑梳102和微电极膜104之间的界面的放大图。图15示出了卷绕的或圆柱形构造的微电极膜104。微电极膜104的延伸部122围绕支撑梳102卷绕，使得支撑梳102位于由卷绕的(或圆柱形)微电极膜104限定的腔内。第二腿部130围绕支撑梳102缠绕并且朝向支撑梳的第二布线面154(在图15中被图示为支撑梳102的背面)定位。第一腿部128可与附接面142耦合。
微电极膜104的第一腿部128可以与附接面142耦合。第一腿部128可以包括第一面和与第一面相对的第二面，第一面包括触点118，第二面可以与支撑梳102耦合。第二面可以与附接面142耦合。第一腿部128可以定位在附接面142上，使得开口158基本上与入口150对齐。例如，在围绕支撑梳102卷绕延伸部122之前，粘合剂可以通过第一腿部128中的开口158被输送到入口150。通过毛细管作用，粘合剂可以流过通道148并且在第一腿部128下方流动以将第一腿部128(例如，第一腿部128的第二面)与附接面142耦合。
通过将第一腿部128与附接面142连接，触点118可基本上与槽152对准。触点118可从槽152偏移。例如，每个触点118可以定位在相邻的槽152之间。槽152可以实现电线管理，并且将电线106定位在正确的位置以与触点118接合。例如，电线106可穿过每个槽152以与触点118中的一个触点对准。电线106可以与触点118耦合。电线106可以与触点118电线接合或焊接。
图16示出了支撑梳102的放大视图。图16基本上示出了图15中支撑梳102的背面(和远端110)。
如所示出的，微电极膜104的第二腿部130围绕支撑梳102卷绕。电线106沿着支撑梳102的第二布线面154通过。每个电线106穿过由指状物156形成的通道。电线106可以穿过形成在通道157的端部处的孔159并且进入槽152中。指状物156(和由此形成的通道)可以使得能够沿着支撑梳102并到槽152来布线电线106，在该槽处电线106可以与触点118耦合。
图17示出了支撑梳102与支撑管132的耦合的放大视图。支撑梳102的第一端可以包括被配置成装配在支撑管132的一部分内的钮或其它结构。城齿138可以在支撑梳102的第一端处围绕该钮。探针轴140可通过环氧树脂包覆成型工艺形成。环氧树脂可以流入城齿138之间的区域中，以形成与支撑管132耦合的探针轴140。探头轴140的环氧树脂可以将支撑梳102和第二腿部130包封在刺激导线的远端110的主体内。探针轴140可由注射成型或微加工工艺形成。
图18和图19示出了微电极膜104的示例性构造和用于将微电极膜104形成为圆柱体的方法。图19示出了处于部分卷绕状态的微电极膜104的主体120部分。主体120的第一边缘可以包括多个突出部160。相对边缘(或朝向相对边缘)可包括多个槽162。主体120可包括用于每个突出部160的槽162。突出部160可以是渐细的，随着突出部160从主体120延伸出而变窄。例如，突出部160可以成形为类似箭头的头部。每个突出部160可以滑入相应的一个槽162中。突出部160可包括倒钩，一旦突出部160插入槽162中并越过倒钩，倒钩就将突出部160锁定到槽162中。图19示出了具有完全插入到槽162中以形成圆柱体的突出部160的主体120。
图20示出了示例性支撑管132和标记物134。图20所示的示例性支撑管132可以由非磁性或非不透辐射的材料制成。标记物134可以由不透辐射的材料制成。支撑管132可以包括多个凹槽164。凹槽164可以成形为接收标记物134。标记物134可以用粘合剂、夹子或压力配合法固定到凹槽164中。当微电极膜104与支撑管132耦合时，电极108可以与标记物134对准。
图21示出了圆形构造的示例支撑梳102。支撑梳102可以包括围绕支撑梳102的外周的多个槽152。微电极膜104的延伸部分可以是盘形的，并且可以包括朝向延伸部分的外周分布的多个触点118。电线106可以穿过每个槽152并朝向触点118。槽152可以使电线106与触点118对准。电线106可以被电线接合或焊接到触点118。
图22示出了制造导线装置的示例方法200。方法200可包括提供支撑梳(块202)。方法200可包括定位多个电线(块204)。方法200可包括将支撑梳与微电极膜耦合(块206)。方法200可包括将电线与微电极膜耦合(块208)。方法200可包括卷绕微电极膜(块210)。
如上所述，方法200可以包括提供支撑梳(块202)。还参考图1-图21，支撑梳102可以包括附接面142和第一布线面144。第一布线面144可以包括多个槽152。微电极膜104可以包括第二布线面154。第二布线面154可以包括在第二布线面154上形成通道的多个指状物156。通道157可终止于孔159中，该孔将第二布线面154的通道157与第一布线面144的槽152连接。附接面142可以包括通道148。
支撑梳102可以通过注射成型工艺、微机械加工工艺、光刻工艺或3D打印工艺制造。支撑梳102可以由硅、塑料、金属、液晶聚合物(LCP)或其它材料制成。不透射线的材料可以被包括在支撑梳102中，以使远端110在X射线期间能够被看到。例如，在注射成型工艺中使用的聚合物可以掺杂有不透辐射的材料，例如硫酸钡(BaSO4)、硼，或者可以将金属环、带或部件结合到支撑梳102中。
方法200可包括定位电线(块204)。参见图10，其中，电线106可展开并沿第二布线面154延伸。第二布线面154可以布置电线106。第二布线面154可包括可限定通道157的多个指状物156。电线106可穿过相应的通道157并穿过在通道157端部处的孔159，该孔将通道157与槽152耦合。每根电线106可以穿过相应的一个槽152。槽152可以保持和定位电线106。例如，槽152可将每根电线106保持为固定地接近相应的触点118。
方法200可包括将支撑梳102与微电极膜104耦合(块206)。微电极膜104可以包括不同的部分。例如，微电极膜104可包括主体120和延伸部122。主体120可以包括多个电极108。延伸部122可以包括多个腿部。一个腿部可以包括多个触点118。延伸部分122和主体120都可以包括多个迹线124。
微电极膜104可以包括绝缘层和导电层的堆叠。微电极膜可以是薄膜、微机电系统(MEMS)电极膜。导电层可以包括迹线124、触点118和电极108。不同的导电层可以通过绝缘层彼此隔离。绝缘层也可以将导电层(或其部分)与外部环境隔离。微电极膜104可以使用增材制造工艺被制造为平面膜。
通过将微电极膜104的第一部分与附接面142耦合，微电极膜104可以与支撑梳102耦合。例如，延伸部122的一部分可与附接面142耦合。延伸部分122的第一腿部128可以包括多个触点118，其可以与附接面142耦合。与具有触点118的面相对的面可以与附接面142耦合，使得触点118背离支撑梳102。
当微电极膜104与支撑梳102耦合时，延伸部122的开口158可以与支撑梳102的入口150对准。通过将粘合剂施加到入口150，微电极膜104可以与支撑梳102耦合。毛细力可将粘合剂从入口150驱动并通过通道148，以填充微电极膜104和由通道148形成的支撑梳102之间的空间。一旦被固化了，粘合剂可以将微电极膜104与支撑梳102耦合。
方法200可包括将电线与微电极膜耦合(块208)。此外，参照图15，其中，电线106可穿过第二布线面154上的相应通道并进入相应槽152中。槽152可以将每根电线106定位在触点118之一附近。电线106可以利用电线接合、焊接或激光接合与触点118耦合。
方法200可包括卷绕微电极膜(块210)。微电极膜104的延伸部122可以围绕支撑梳102卷绕。微电极膜104的主体120可以围绕支撑梳102卷绕。围绕支撑梳102卷绕延伸部122可以将延伸部122的第二腿部130放置在支撑梳102的第二布线面154附近。
微电极膜104的主体120可围绕支撑管132卷绕。微电极膜104可以与支撑管132的外表面耦合。支撑管132可以包括槽136。主体120的相对边缘可以插入到槽136中。
一旦微电极膜104被卷绕，微电极膜104和支撑梳102可被放置在模具中。模具可以用环氧树脂填充。环氧树脂包覆成型可以形成探头轴140。探头轴140可以包住延伸部122、支撑梳102和导线106的至少一部分。探针轴140可以流入城齿138中并与支撑管132耦合。
尽管在附图中以特定顺序描绘了操作，但是这样的操作不需要以所示的特定顺序或以顺序执行，并且不需要执行所有示出的操作。可以以不同的顺序执行这里描述的动作。
各种系统组件的分离不需要在所有实现方式中分离，并且所描述的程序组件可以被包括在单个硬件或软件产品中。
现在已经描述了一些说明性的实现方式，很明显，前述内容是说明性的而非限制性的，已经通过示例的方式呈现。特别地，尽管本文呈现的许多示例涉及方法动作或系统元素的特定组合，但是那些动作和那些元素可以以其他方式组合以实现相同的目的。结合一个实施方式讨论的动作、元件和特征不旨在被排除在其他实施方式或实施方式中的类似角色之外。
这里使用的措辞和术语是为了描述的目的，而不应被认为是限制。在此使用的“包括”、“包含”、“具有”、“含有”、“涉及”、“特征在于”及其变化，意味着包括其后列出的项目、其等价物和附加项目，以及由其后列出的项目专门组成的替代实施方式。在一个实施方式中，本文描述的系统和方法由所有描述的元件、动作或部件中的一个、多于一个的每个组合或所有描述的元件、动作或部件组成。
如本文所用，术语“约”和“基本上”将被本领域普通技术人员理解，并且将根据其所使用的上下文而在一定程度上变化。如果在使用该术语的上下文中，本领域普通技术人员不清楚该术语的使用，“约”将意味着高达特定术语的正负10％。
对本文以单数形式提及的系统和方法的实现方式或元件或动作的任何引用也可以涵盖包括多个这些元件的实现方式，并且对本文的任何实现方式或元件或动作的任何复数引用也可以涵盖仅包括单个元件的实现方式。单数或复数形式的引用不旨在将本公开的系统或方法、其组件、动作或元件限制为单个或复数配置。对基于任何信息、动作或元素的任何动作或元素的引用可以包括其中动作或元素至少部分地基于任何信息、动作或元素的实现方式。
本文公开的任何实施方式可以与任何其他实施方式或实施例组合，并且对“实施方式”、“一些实施方式”、“一个实施方式”等的引用不一定是相互排斥的，并且旨在指示结合实施方式描述的特定特征、结构或特性可以被包括在至少一个实施方式或实施例中。这里使用的这些术语不一定全部指相同的实现方式。任何实施方式可以以与本文公开的方面和实施方式一致的任何方式与任何其他实施方式包括地或排他地组合。
除非明确地相反指示，否则如本说明书和权利要求书中所使用的不定冠词“一”和“一个”应理解为意指“至少一个”。
对“或”的引用可以被解释为包括性的，使得使用“或”描述的任何术语可以指示所有所描述的术语中的单个、多于一个、以及任何一个。例如，对“‘A’和‘B’中的至少一个“的引用可以仅包括“A”、仅包括“B”、以及包括“A”和“B”。结合“包括”或其它开放术语使用的这些引用可包括附加项目。
在附图、详细描述或任何权利要求中的技术特征之后跟随有附图标记的情况下，包括附图标记以增加附图、详细描述和权利要求的可理解性。因此，参考标记或它们的不存在对任何权利要求要素的范围都没有任何限制作用。
在不脱离本发明的特征的情况下，本文所述的系统和方法可以以其它特定形式来实施。前述实现方式是说明性的，而不是对所描述的系统和方法的限制。因此，本文所述的系统和方法的范围由所附权利要求而不是前述说明书来指示，并且在权利要求的等同方案的含义和范围内的变化被包含在其中。

Claims (15)

1.一种可植入的导线装置，包括：
支撑梳，包括：
附接面；以及
包括多个槽的布线面；
微电极膜，包括：
具有多个电极的主体；
从所述微电极膜的所述主体延伸出的第一腿部，所述第一腿部包括：
第一面，所述第一面具有与所述多个电极耦合的多个电触点；
第二面，所述第二面与所述支撑梳的附接面耦合；以及
开口，所述开口被限定为穿过所述第一腿部并且与所述支撑梳的所述附接面的入口对准；以及
从所述微电极膜的所述主体延伸出的第二腿部，所述第二腿部的至少一部分从所述第一腿部的一部分分离，所述第二腿部包括多个迹线，所述多个迹线将所述微电极膜的所述多个电极的子集耦合到所述第一腿部的所述第一面上的所述多个电触点；并且
所述第一腿部和所述第二腿部围绕支撑梳卷绕；
多个电线，所述多个电线中的每一个穿过所述多个槽中的相应一个槽并且与所述多个电触点中的相应一个电触点耦合；以及
支撑管，所述支撑管包括与所述多个电极对准的多个不透射线的标记物，所述支撑管与所述微电极膜的所述主体的面耦合。
2.根据权利要求1所述的导线装置，其中所述附接面包括通道，以在所述微电极膜的第二面的至少一部分下方引导粘合剂。
3.根据权利要求1所述的导线装置，其中所述支撑管在第一端上包括多个城齿，所述第一端被配置为与所述支撑梳配合。
4.根据权利要求1所述的导线装置，其中所述多个电线中的每个电线利用电线接合与所述多个电触点中的相应一个电触点耦合。
5.根据权利要求1所述的导线装置，包括回填微电极膜的环氧树脂。
6.一种方法，包括：
提供支撑梳，所述支撑梳包括：
附接面；以及
包括多个槽的布线面；
将从微电极膜的主体延伸出的第一腿部与所述支撑梳的附接面耦合，所述微电极膜的第一腿部包括：
第一面，所述第一面具有与所述微电极膜的多个电极耦合的多个电触点；
第二面，所述第二面与所述支撑梳的附接面耦合；以及
开口，所述开口被限定为穿过所述第一腿部并且与所述支撑梳的所述附接面的入口对准；
将多个电线中的每一个定位成穿过所述布线面的所述多个槽中的相应一个槽；
将所述多个电线中的每一个与所述多个电触点中的相应一个电触点耦合；
形成从所述微电极膜的主体延伸出的第二腿部，所述第二腿部包括多个迹线，所述多个迹线将所述微电极膜的所述多个电极的子集耦合到所述第一腿部的所述第一面上的所述多个电触点，所述第二腿部的至少一部分从所述第一腿部的一部分分离；
将所述微电极膜的所述第二腿部耦合到支撑管的外表面，所述支撑管包括多个不透射线的标记物；
将所述多个不透射线的标记物与形成在所述微电极膜中的所述多个电极对准；以及
围绕所述支撑梳卷绕所述微电极膜的所述第一腿部和所述第二腿部。
7.根据权利要求6所述的方法，包括：
形成所述微电极膜的第三部分，所述第三部分包括将所述多个电极的一部分耦合到所述多个电触点的一部分的多条电迹线。
8.根据权利要求6所述的方法，包括：
用环氧树脂填充所述支撑管。
9.根据权利要求6所述的方法，包括：
在所述支撑管中形成所述多个不透射线的标记物。
10.根据权利要求6所述的方法，包括：
将所述多个电线中的每一个电线与所述多个电触点中的相应一个电触点进行电线接合。
11.根据权利要求6所述的方法，包括：
卷绕所述微电极膜的第二腿部以形成圆柱体；以及
用环氧树脂填充所述圆柱体。
12.根据权利要求6所述的方法，包括：
用环氧树脂对在所述附接面中形成的通道进行底部填充，以将所述微电极膜的第一腿部与所述附接面耦合。
13.根据权利要求6所述的方法，包括：
在硅中蚀刻出支撑梳。
14.根据权利要求6所述的方法，包括：
将所述微电极膜的第一边缘与所述微电极膜的第二边缘耦合以形成圆柱体。
15.根据权利要求6所述的方法，包括：
将所述微电极膜与所述支撑管耦合；以及
将所述微电极膜的第一边缘和第二边缘插入所述支撑管的槽中。
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