CN111407681A - Application of sodium alginate hydrogel nano-carrier in whitening cream - Google Patents
Application of sodium alginate hydrogel nano-carrier in whitening cream Download PDFInfo
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- CN111407681A CN111407681A CN202010231845.7A CN202010231845A CN111407681A CN 111407681 A CN111407681 A CN 111407681A CN 202010231845 A CN202010231845 A CN 202010231845A CN 111407681 A CN111407681 A CN 111407681A
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- Prior art keywords
- sodium alginate
- alginate hydrogel
- whitening
- carrier
- polypropylene oxide
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 44
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 38
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 38
- 230000002087 whitening effect Effects 0.000 title claims abstract description 37
- 239000006071 cream Substances 0.000 title claims abstract description 25
- 239000002539 nanocarrier Substances 0.000 title claims abstract description 15
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 10
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 10
- -1 polypropylene Polymers 0.000 claims abstract description 30
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- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims abstract description 28
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- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 7
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 7
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- OFGVZFQUFJYSGS-CPDXTSBQSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O OFGVZFQUFJYSGS-CPDXTSBQSA-N 0.000 claims abstract description 5
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- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 claims description 5
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 14
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an application of a sodium alginate hydrogel nano-carrier in whitening cream, which comprises a whitening antibacterial composition, polypropylene oxide-sodium alginate hydrogel and the like, wherein the whitening antibacterial composition comprises bilobalide, berberine, hexapeptide-10, carnosine, vitamin E, vitamin C and the like; the whitening and antibacterial skin care product is prepared by wrapping whitening components and antibacterial components with polypropylene oxide-sodium alginate hydrogel, wherein the polypropylene oxide-sodium alginate hydrogel is a nano-scale carrier and has the capability of being quickly absorbed by skin and penetrating through cell membranes, the whitening components and the antibacterial components are loaded into skin cells, and the skin care product penetrates into the bottom of the skin to remove melanin, inhibit the invasion of bacteria, lock a large amount of water and provide the skin with long-term moisturizing, antibacterial and whitening states.
Description
Technical Field
The invention specifically relates to an application of a sodium alginate hydrogel nano-carrier in whitening cream, and belongs to the technical field of cosmetics.
Background
The cosmetic is a chemical industrial product or a fine chemical product which is applied, sprayed or the like to any part of the surface of a human body to achieve the purposes of cleaning, maintaining, beautifying, decorating and changing the appearance, or correcting the smell of the human body and keeping a good state. With the development of economy and the continuous improvement of quality of life, the consciousness of the young Chinese for protecting the skin is increased year by year, the amount of the consumption products of cosmetics is increased year by year, and a trend of rapid rise is presented. But the effect of the cosmetic products on the market is not satisfactory, the products are difficult to penetrate through the skin, the water retention is poor, the functionalization is single, the allergy is easy to cause and the like.
Berberine is an important alkaloid and is a Chinese medicament which is used for a long time in China. Can be extracted from Coptidis rhizoma, cortex Phellodendri, and radix Berberidis. It has obvious bacteriostasis. The berberine hydrochloride is also called berberine hydrochloride, and its chemical structure is shown in figure. The berberine has the inhibition effect on pathogenic microorganisms and various bacteria such as shigella dysenteriae, tubercle bacillus, pneumococcus, typhoid bacillus, diphtheria bacillus and the like, has small side effect, is a natural and easily-obtained medicinal component, and therefore, the berberine has excellent antibacterial effect and wide application prospect in antibacterial products. Although berberine has strong physiological activity, it is a planar molecule, the molecule is packed tightly, the attraction force between molecules is large due to hydrogen bond action, the water solubility is poor, the molecule is not easy to enter the cell, thereby greatly influencing the bioavailability and the application of the berberine, and not achieving the effect of inhibiting bacteria for the skin.
The ginkgolides are substances extracted from ginkgo trees, human cells contain more lipid and are easily attacked and damaged by free radicals, peroxidation liposomes can be formed when the content of the free radicals in the cells is excessive, skin melanin is increased, color spots and other adverse effects are generated, the ginkgolides are beneficial to consolidating the antioxidation of the cells, the formation of lipid peroxides is prevented, and the formation of the color spots and the generation of melanin are reduced.
But the ginkgolides and the berberine are difficult to enter deep cells of the skin and exert the effects of the ginkgolides and the berberine.
Disclosure of Invention
The invention relates to an application cream of a hydrogel nano-carrier in whitening cream. Wrapping bilobalide and berberine in polypropylene oxide-sodium alginate hydrogel. When the polypropylene oxide-sodium alginate hydrogel enters cells as a carrier, the polypropylene oxide-sodium alginate hydrogel is hydrolyzed in a meta-acid microenvironment in the cells, and the sodium alginate has acid resistance, so that the hydrogel carrier is slowly hydrolyzed in the cells to slowly release ginkgolides and berberine in the cells, the acting time is prolonged, and the antibacterial effect and the whitening effect are improved. The main components of the whitening cream prevent bacteria from invading in vitro by inhibiting the formation of peroxide substances and melanin, and simultaneously, the chitosan and the sodium alginate have good water retention performance, thereby finally achieving the effects of moisture retention, antibiosis and whitening.
In order to achieve the purpose, the invention adopts the technical scheme that.
The preparation of the whitening cream comprises the following components in percentage by weight:
3-11% of polypropylene oxide-sodium alginate hydrogel, 0.5-2.3% of ginkgolide, 0.3-1.6% of berberine, 100.2-0.8% of hexapeptide, 0.3-0.6% of carnosine, 0.2-0.8% of vitamin E, 0.1-0.6% of vitamin C, 0.3-1.6% of olive oil, 0.6-1.3% of grape seed oil, 0.3-1.6% of urea, 0.6-0.9% of phytosterol/octyldodecanol lauroyl glutamate, 1-5% of sodium citrate, 0.05-0.5% of methyl hydroxybenzoate and the balance of water which is 100%, wherein the ginkgolide and the berberine are wrapped by the polypropylene oxide-sodium alginate hydrogel.
The structural formula of the polypropylene oxide-sodium alginate hydrogel is shown as the formula (I):
wherein n is 20-50; and m is 20-50.
The preparation method of the whitening cream comprises the following steps:
1) weighing the raw materials of the formula components, wrapping bilobalide and berberine with polypropylene oxide-sodium alginate hydrogel, and then placing in a water bath at 35-65 ℃ for constant temperature for 20-30 min.
2) Adding water, urea, hexapeptide-10, and carnosine into a water phase dissolving kettle, heating to 65 deg.C, and maintaining constant temperature for 3 hr.
3) Adding phytosterol/octyldodecanol lauroyl glutamate, olive oil and grape seed oil into an oil phase dissolving kettle, heating to 60-70 ℃, uniformly mixing, and keeping constant temperature for 2-3 h to obtain an oil phase.
4) Cooling oil phase, water phase and polypropylene oxide-sodium alginate hydrogel loaded with ginkgolide and berberine to 25 deg.C, delivering into emulsifying pot, adding vitamin E and vitamin C, heating to 55 deg.C, mixing, homogenizing and emulsifying for about 15 min.
5) After emulsification is finished, cooling the temperature of the material body to normal temperature, adding a potassium sorbate preservative, finally adjusting the pH value to be neutral by using sodium citrate, and discharging.
Besides the specific requirements of the components, other auxiliary materials such as essence, pigment, surfactant and the like can be added or used within the range of not damaging the effect of the whitening antibacterial cream, and the common content can be selected by a person skilled in the art according to the conventional standard.
Vitamin C can inhibit pigmentation, not only can effectively prevent black spots and freckles, but also can discharge redundant pigments out of the body, thoroughly improve dull complexion and enable the skin to become white and bright again.
Vitamin E has antioxidant effect, thereby protecting sebum and cell membrane proteins and moisture in skin. It also can promote the regeneration and activity of human cells and delay the aging process of cells.
Hexapeptide-10 is a bioactive polypeptide, which can reduce existing facial wrinkles and effectively prevent new wrinkles, and has excellent anti-wrinkle effect.
Carnosine is a dipeptide consisting of two amino acids, β -alanine and L-histidine, and is a crystalline solid, and muscle and brain tissues contain high concentrations of carnosine, which has strong antioxidant ability and is beneficial to the human body, and has been shown to scavenge Reactive Oxygen Species (ROS) formed by over-oxidation of fatty acids in cell membranes during oxidative stress, and α - β unsaturated aldehydes.
The ginkgolides are substances extracted from ginkgo trees, human cells contain more lipid and are easily attacked and damaged by free radicals, peroxidation liposomes can be formed when the content of the free radicals in the cells is excessive, skin melanin is increased, color spots and other adverse effects are generated, the ginkgolides are beneficial to consolidating the antioxidation of the cells, the formation of lipid peroxides is prevented, and the formation of the color spots and the generation of melanin are reduced.
Berberine is an important alkaloid and is a Chinese medicament which is used for a long time in China. Can be extracted from Coptidis rhizoma, cortex Phellodendri, and radix Berberidis. It has obvious bacteriostasis. The berberine hydrochloride is also called berberine hydrochloride, and its chemical structure is shown in figure. The berberine has the advantages of inhibiting pathogenic microorganisms, various bacteria such as dysentery bacillus, tubercle bacillus, pneumococcus, typhoid bacillus, diphtheria bacillus and the like, having small side effect and being a natural and easily-obtained medicinal component, so the berberine has excellent antibacterial effect.
The invention has the beneficial effects that:
the polypropylene oxide-sodium alginate hydrogel nano carrier used in the invention releases whitening substances to achieve the whitening effect after entering cells, and releases antibacterial substances to achieve the antibacterial effect.
The hydrogel nano whitening antibacterial cream has biocompatibility and small diameter, is easy to permeate cell membranes, transports whitening antibacterial components into cells, slowly releases the whitening antibacterial components, and has high-efficiency whitening antibacterial effect.
The invention provides an application of a hydrogel nano-carrier in whitening cream, which is prepared by adding mild plant extract components, namely ginkgolide and berberine, and matching with basic raw materials, can deeply penetrate into the skin bottom for whitening and resisting bacteria, can regulate the water-oil balance of the skin, naturally whiten the skin, eliminate wrinkles and fine pores, and is tender, smooth, healthy and beautiful.
Drawings
FIG. 1 molecular formula of polypropylene oxide-sodium alginate hydrogel.
FIG. 2 is a bar graph showing cytotoxicity of polypropylene oxide-sodium alginate hydrogel (1-50 mg/m L) and Hacat epidermal cells obtained in the present invention.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1-4 preparation of a polypropylene oxide-sodium alginate hydrogel nano-carrier in whitening cream, example 5 is a control group, and all the components are mass fractions
The preparation method of the polypropylene oxide-sodium alginate nano hydrogel whitening antibacterial cream comprises the following steps:
1) weighing the raw materials of the formula components, wrapping bilobalide and berberine with polypropylene oxide-sodium alginate hydrogel, and then placing in a water bath at 35-65 ℃ for constant temperature for 20-30 min.
2) Adding water, urea, hexapeptide-10, and carnosine into a water phase dissolving kettle, heating to 65 deg.C, and maintaining constant temperature for 3 hr.
3) Adding phytosterol/octyldodecanol lauroyl glutamate, olive oil and grape seed oil into an oil phase dissolving kettle, heating to 60-70 ℃, uniformly mixing, and keeping constant temperature for 2-3 h to obtain an oil phase.
4) Cooling oil phase, water phase and polypropylene oxide-sodium alginate hydrogel loaded with ginkgolide and berberine to 25 deg.C, delivering into emulsifying pot, adding vitamin E and vitamin C, heating to 55 deg.C, mixing, homogenizing and emulsifying for about 15 min.
5) After emulsification is finished, cooling the temperature of the material body to normal temperature, adding a potassium sorbate preservative, finally adjusting the pH value to be neutral by using sodium citrate, and discharging.
Example 6
The test method comprises the following steps: the polypropylene oxide-sodium alginate nano hydrogel whitening antibacterial cream obtained in the examples 1 to 4 is used as a test sample 1 to 4, and the cream obtained in the example 5 is used as a control sample 1; randomly extracting 300 female volunteers in 18-30 years old, with more skin melanin and color spots, working in areas with more bacteria content and having experience of using face cream in the same area, after using the test samples 1-4 and the control sample 1 respectively, designing a scoring standard, scoring, removing the maximum value and the minimum value of each group of data, taking the average number, and then recording the scoring result into a table 3.
Grading standard: the scoring criteria are referenced in table 2.
And (4) grading results: as can be seen from Table 3, the long-acting nano hydrogel whitening antibacterial cream obtained by the formula and the preparation method has the advantages of high apparent score, good compatibility of each component of the formula, no color difference and long retention time of more than 2 hours.
TABLE 2 Scoring criteria
Example 7 determination of solubility
Respectively adding 5 parts of 0.5g of ginkgolide and berberine into 50m L of deionized water to obtain turbid mixed turbid solutions of ginkgolide and berberine, numbering 1-5, and respectively adding 1.5g, 2g, 2.5g, 3g and 3.5g of polypropylene oxide-sodium alginate hydrogel into the solution 1-5, heating and stirring at 60 ℃ for 20min, cooling to room temperature, and observing the dissolution conditions of ginkgolide and berberine, wherein the turbid solution 1 is turbid, the turbidity of the solution 2 is further reduced, and the turbid solution 3-5 is clarified.
Example 8
Cytotoxicity test
Inoculating Hacat epidermal cells into a cell culture flask, and placing at 37 deg.C and 5% CO2Culturing in environment, selecting 1640 culture medium containing 10% fetal calf serum and 0.5% double antibody, inoculating cultured cells in 96-well plate with cell density of 8000 cells/m L, and continuously culturing at 37 deg.C and 5% CO2Culturing for 48h in the environment. Removing culture medium from 96-well plate, washing with precooled PBS for 3 times, adding 1640 complete culture medium containing polypropylene oxide-sodium alginate hydrogel with different gradients, and continuously maintaining at 37 deg.C and 5% CO2Culturing for 24h in the environment, removing the culture medium in a 96-well plate, adding 200 mu L of MTT solution diluted to 5mg/ml by 1640 complete culture medium into each well, wrapping the MTT solution by tinfoil for further culturing for 4h, removing the solution, adding 100 mu L of DMSO, fully dissolving formazan attached in the 96-well plate, transferring the 96-well plate into a microplate reader, setting the scanning wavelength to be 577nm, measuring the absorbance of the 96-well plate, and determining the cell survival rate according to the value of the absorbance.
FIG. 2 is a bar graph showing cytotoxicity of the polypropylene oxide-sodium alginate hydrogel (1-50 mg/m L) obtained in the present invention and Hacat epidermal cells, and it can be seen from FIG. 2 that the polypropylene oxide-sodium alginate hydrogel obtained in the present invention is non-toxic to normal cells, and is a high-affinity cosmetic carrier.
Claims (4)
1. The application of the sodium alginate hydrogel nano-carrier in the whitening cream is characterized in that: the whitening cream comprises the following components in percentage by weight: 3-11% of polypropylene oxide-sodium alginate hydrogel, 0.5-2.3% of ginkgolide, 0.3-1.6% of berberine, 100.2-0.8% of hexapeptide, 0.3-0.6% of carnosine, 0.2-0.8% of vitamin E, 0.1-0.6% of vitamin C, 0.3-1.6% of olive oil, 0.6-1.3% of grape seed oil, 0.3-1.6% of urea, 0.6-0.9% of phytosterol/octyldodecanol lauroyl glutamate, 1-5% of sodium citrate, 0.05-0.5% of methyl hydroxybenzoate and the balance of water to 100%, wherein the ginkgolide and the berberine are wrapped by the polypropylene oxide-sodium alginate hydrogel;
the polypropylene oxide-sodium alginate hydrogel is shown as a formula (I):
wherein n is 20-50; m is 20-50;
the preparation method of the whitening cream comprises the following steps:
1) weighing the raw materials of the formula components, wrapping bilobalide and berberine with polypropylene oxide-sodium alginate hydrogel, and then placing in a water bath at 35-65 ℃ for constant temperature for 20-30 min;
2) putting water, urea, hexapeptide-10 and carnosine into a water phase dissolving kettle, heating to 65 ℃, and keeping constant temperature for 3 hours;
3) putting phytosterol/octyldodecanol lauroyl glutamate, olive oil and grape seed oil into an oil phase dissolving kettle, heating to 60-70 ℃, uniformly mixing, and keeping constant temperature for 2-3 hours to obtain an oil phase;
4) cooling oil phase, water phase and polypropylene oxide-sodium alginate hydrogel loaded with ginkgolide and berberine to 25 deg.C, delivering into emulsifying pot, adding vitamin E and vitamin C, heating to 55 deg.C, mixing, homogenizing and emulsifying for about 15 min;
5) after emulsification is finished, cooling the temperature of the material body to normal temperature, adding a potassium sorbate preservative, finally adjusting the pH value to be neutral by using sodium citrate, and discharging.
2. The application of the sodium alginate hydrogel nano-carrier in the whitening cream as claimed in claim 1, wherein the hydrogel nano-carrier is used as a carrier to increase the content of bilobalide and berberine in the whitening cream.
3. The application of the sodium alginate hydrogel nano-carrier in the whitening cream as claimed in claim 1, wherein the hydrogel nano-carrier can delay the loss of water in skin and achieve long-term moisture retention.
4. The application of the sodium alginate hydrogel nano-carrier in the whitening cream as claimed in claim 1, wherein the hydrogel nano-carrier loads whitening components and antibacterial components into skin cells.
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