CN111317874A - Production method of sterile vacuum bottle - Google Patents
Production method of sterile vacuum bottle Download PDFInfo
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- CN111317874A CN111317874A CN202010146593.8A CN202010146593A CN111317874A CN 111317874 A CN111317874 A CN 111317874A CN 202010146593 A CN202010146593 A CN 202010146593A CN 111317874 A CN111317874 A CN 111317874A
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- glass bottle
- rubber plug
- silicon tube
- medicinal
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 239000011521 glass Substances 0.000 claims abstract description 91
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 64
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 64
- 239000010703 silicon Substances 0.000 claims abstract description 64
- 238000004140 cleaning Methods 0.000 claims abstract description 27
- 238000007789 sealing Methods 0.000 claims abstract description 16
- 244000043261 Hevea brasiliensis Species 0.000 claims abstract description 15
- 229920003052 natural elastomer Polymers 0.000 claims abstract description 15
- 229920001194 natural rubber Polymers 0.000 claims abstract description 15
- 238000004806 packaging method and process Methods 0.000 claims abstract description 13
- 230000000249 desinfective effect Effects 0.000 claims abstract description 11
- 238000003825 pressing Methods 0.000 claims abstract description 8
- 239000002390 adhesive tape Substances 0.000 claims abstract description 4
- 238000001514 detection method Methods 0.000 claims abstract description 4
- 229920001971 elastomer Polymers 0.000 claims description 52
- 238000005406 washing Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 10
- 239000007921 spray Substances 0.000 claims description 10
- 230000001680 brushing effect Effects 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- 229920002379 silicone rubber Polymers 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 3
- 238000009987 spinning Methods 0.000 claims description 3
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 7
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000010241 blood sampling Methods 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000006385 ozonation reaction Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/28—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
- B08B9/30—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking and having conveyors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/36—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by using brushes
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
Abstract
The invention discloses a production method of a sterile vacuum bottle, which comprises the following steps: step S1, cleaning and disinfecting the medicinal glass bottle; step S2, cleaning and disinfecting the natural rubber plug and the silicon tube; step S3, pressing the natural rubber stopper in the step S2 into the medicinal glass bottle in the step S1 through a capping machine, namely, the capping glass bottle is obtained; step S4, tightly packaging the bottle mouth and the outer part of the bottle neck of the glass bottle with the pressure cover in the step S3 by a bottle hoop through a hoop pressing machine, namely, obtaining the packaging glass bottle; step S5, sealing the glass bottle in the step S4 by using an outer cover, namely, the glass bottle is sealed; step S6, performing light detection on the sealed glass bottle in the step S5, and if no foreign matter exists, sticking a label on the wall of the bottle; and step S7, orderly putting the sealed glass bottles with labels in a packaging box, externally sticking trademarks on the box, and sealing the box by using an adhesive tape. The invention provides a production method, and the produced sterile vacuum bottle is sterile in the bottle, long in negative pressure state maintaining time, good in sealing performance and not prone to air leakage.
Description
Technical Field
The invention relates to the technical field of negative pressure vacuum sterility, in particular to a production method of a sterile vacuum bottle.
Background
At present, domestic vacuum bottles are mostly imported from foreign countries, however, the manufacturing process of the foreign vacuum bottles is mostly semi-automatic, after the bottles are sterilized, rubber plug silicon tubes are manually packaged, the production process is not advanced, secondary pollution is easy to occur, the price is high, the bottles are easy to damage in the transportation process, and defective goods are high; in addition, due to semi-automatic production of foreign vacuum bottles, the interior of the bottle is sterile, the negative pressure state is not long in holding time, the sealing performance is poor, and air leakage is easy to occur.
The sterility means that no living microorganisms exist in the object, and the negative pressure means the difference value between the pressure value of the measured object and the atmospheric value of the measuring place.
Disclosure of Invention
Aiming at the problems in the related art, the invention provides a production method of an aseptic vacuum bottle, which solves the problems that the aseptic vacuum bottle produced by the existing method is short in negative pressure state retention time, poor in sealing performance and easy to leak air.
In order to achieve the technical purpose, the technical scheme of the invention is as follows:
a production method of a sterile vacuum bottle is designed, and comprises the following steps:
step S1, cleaning and disinfecting the medicinal glass bottle;
step S2, cleaning and disinfecting the natural rubber plug and the silicon tube, wherein the silicon tube is inserted in the center of the natural rubber plug, and the natural rubber plug and the silicon tube are simply called as rubber plug silicon tubes;
step S3, pressing the natural rubber stopper in the step S2 into the medicinal glass bottle in the step S1 through a capping machine, namely, the capping glass bottle is obtained;
step S4, tightly packaging the bottle mouth and the outer part of the bottle neck of the glass bottle with the pressure cover in the step S3 by a bottle hoop through a hoop pressing machine, namely, obtaining the packaging glass bottle;
step S5, sealing the glass bottle in the step S4 by using an outer cover, namely, the glass bottle is sealed;
step S6, carrying out light detection on the sealed glass bottle in the step S5, observing whether foreign matters exist or not, and if no foreign matters exist, sticking a label on the wall of the bottle;
and step S7, orderly putting the sealed glass bottles with labels in a packaging box, externally sticking trademarks on the box, and sealing the box by using an adhesive tape.
Further, the specific step of step S1 is:
step S11, purchasing medicinal glass bottles from the market;
step S12, soaking the purchased medicinal glass bottle for 3-5 minutes by using clean water;
step S13, placing the cleaned medicinal glass bottle on a conveying belt of a cleaning device, opening a spray head to inject water into the medicinal glass bottle, cleaning the medicinal glass bottle by using a brush, inverting the medicinal glass bottle on the conveying belt after cleaning for 3 seconds, washing the medicinal glass bottle for 2 seconds by using the spray head, and conveying the washed medicinal glass bottle to a collection box through the conveying belt;
step S14, orderly arranging the medicinal glass bottles sent to the collecting box, putting the orderly arranged medicinal glass bottles into a high-pressure steam cabinet along with the collecting box, and then sterilizing for 30 minutes at the high temperature of 121 ℃ and the high pressure of 103 KPa;
and step S15, opening a pressure release valve on the high-pressure steam cabinet to reduce pressure and exhaust, opening the cabinet door when the pressure in the high-pressure steam cabinet is reduced to 0, taking out the collection box, and putting the medicinal glass bottle in the collection box into an assembly workshop.
Further, the specific step of step S2 is:
step S21, purchasing a rubber plug silicon tube from the market, wherein the specification of the rubber plug silicon tube is matched with that of the medicinal glass bottle;
step S22, placing the rubber plug silicon tube on a conveyor belt of a brushing device, and enabling the rubber plug silicon tube to enter a brushing workshop along with the conveyor belt;
step S23, placing the rubber plug silicon tube entering the washing workshop into a washing tank, and soaking for 3-5 minutes in clear water;
step S24, the soaked silicon rubber plug tube is washed for 3-5 seconds by a brush, and then washed for 1 second by clear water, and then the silicon rubber plug tube is placed on a conveyor belt after washing;
step S25, putting the rubber plug silicon tube on the conveyor belt into a disc-shaped spin dryer, and spinning after rotating for 3-5 seconds;
step S26, placing the dried rubber plug silicon tubes in a rubber plug silicon tube collecting box in sequence, then placing the rubber plug silicon tubes in a high-pressure steam cabinet for high-pressure steam disinfection, and disinfecting for 30 minutes at the high temperature of 121 ℃ and the high pressure of 103 KPa;
and step S26, placing the sterilized rubber plug silicon tube on a conveyor belt, and enabling the rubber plug silicon tube to enter an assembly workshop along with the conveyor belt.
Further, in the step S13, the transmission belt is connected with a chain, and the chain is connected with a rotating motor.
Further, in step S13, the cleaning device includes a conveyor belt, a spray head, and a brush, and the spray head and the brush are both disposed above the conveyor belt.
Further, in step S22, the conveyor belt is a chain type locking conveyor belt.
In step S4, the bottle collar is made of aluminum.
In step S5, the outer cover is made of plastic.
Further, in the step S15, the surface temperature of the glass bottle is higher than the room temperature.
Further, in the step S7, the sealed glass bottle contains a negative pressure of-0.5 to-0.7.
The invention has the beneficial effects that: the sterile vacuum bottle is fully automatic in manufacturing process, secondary pollution is avoided, the vacuum bottle and the rubber plug silicon tube can be conveyed to an assembly workshop through a chain after being sterilized, manual work is not needed, efficiency is improved, pollution risks are reduced, equipment is advanced, the bottle is sterile after being manufactured, the negative pressure state can be kept for a longer time, meanwhile, materials required for manufacturing the sterile vacuum bottle, medical glass bottles, rubber plug silicon tubes and aluminum bottle hoops are made of raw materials domestically, transportation cost is reduced, raw material cost is greatly reduced, and price of domestic sterile vacuum bottles is greatly reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a flow chart of a method of producing a sterile vacuum bottle according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments that can be derived by one of ordinary skill in the art from the embodiments given herein are intended to be within the scope of the present invention.
This example is illustrated with a 250ml glass vial for pharmaceutical use:
as shown in fig. 1, a method for producing a sterile vacuum bottle according to an embodiment of the present invention includes the following steps:
step S1, cleaning and disinfecting a 250ml medicinal glass bottle;
step S2, cleaning and disinfecting the natural rubber plug and the silicon tube, wherein the silicon tube is inserted in the center of the natural rubber plug, and the natural rubber plug and the silicon tube are simply called as rubber plug silicon tubes;
step S3, pressing the natural rubber stopper in the step S2 into the 250ml medical glass bottle in the step S1 through a capping machine, namely, the capping glass bottle is obtained;
step S4, tightly packaging the bottle mouth and the outer part of the bottle neck of the glass bottle with the pressure cover in the step S3 by a bottle hoop through a hoop pressing machine, namely, obtaining the packaging glass bottle;
step S5, sealing the glass bottle in the step S4 by using an outer cover, namely, the glass bottle is sealed;
step S6, carrying out light detection on the sealed glass bottle in the step S5, observing whether foreign matters exist or not, and if no foreign matters exist, sticking a label on the wall of the bottle;
and step S7, orderly putting the sealed glass bottles with labels in a packaging box, externally sticking trademarks on the box, and sealing the box by using an adhesive tape.
In this embodiment, the specific step of step S1 is:
step S11, purchasing 250ml medicinal glass bottle from market;
step S12, soaking the purchased 250ml medical glass bottle for 5 minutes by using clear water;
step S13, placing the cleaned 250ml medicinal glass bottle on a conveying belt of a cleaning device, opening a spray head to inject water into the medicinal glass bottle, cleaning the medicinal glass bottle by using a brush, inverting the medicinal glass bottle on the conveying belt after cleaning for 3 seconds, washing the medicinal glass bottle for 2 seconds by using the spray head, and conveying the washed medicinal glass bottle to a collection box through the conveying belt;
step S14, orderly arranging 250ml medicinal glass bottles sent to the collecting box, putting 100 bottles in each box, putting the orderly arranged medicinal glass bottles into a high-pressure steam cabinet along with the collecting box, and then sterilizing for 30 minutes at high temperature of 121 ℃ and high pressure of 103 KPa;
step S15, opening a pressure release valve on the high-pressure steam cabinet to reduce pressure and exhaust, opening a cabinet door when the pressure in the high-pressure steam cabinet is reduced to 0, taking out the collection box, and putting 250ml of medicinal glass bottles in the collection box into an assembly workshop;
in this embodiment, the specific step of step S2 is:
step S21, purchasing a rubber plug silicon tube from the market, wherein the specification of the rubber plug silicon tube is matched with the specification of a 250ml medicinal glass bottle;
step S22, placing the rubber plug silicon tube on a conveyor belt of a brushing device, and enabling the rubber plug silicon tube to enter a brushing workshop along with the conveyor belt;
step S23, placing the rubber plug silicon tube entering the washing workshop into a washing tank, and soaking for 5 minutes in clear water;
step S24, the soaked rubber plug silicon tube is washed for 5 seconds by a brush, and then washed for 1 second by clear water after washing, and then the rubber plug silicon tube is placed on a conveyor belt after washing;
step S25, putting the rubber plug silicon tube on the conveyor belt into a disc-shaped spin dryer, and spinning after 5 seconds of running;
step S26, placing the dried rubber plug silicon tubes in a rubber plug silicon tube collecting box in sequence, then placing the rubber plug silicon tubes in a high-pressure steam cabinet for high-pressure steam disinfection, and disinfecting for 30 minutes at the high temperature of 121 ℃ and the high pressure of 103 KPa;
step S26, placing the sterilized rubber plug silicon tube on a conveyor belt, and enabling the rubber plug silicon tube to enter an assembly workshop along with the conveyor belt;
in this embodiment, in step S13, the transmission belt is connected to a chain, and the chain is connected to a rotating motor.
In this embodiment, in step S13, the cleaning device includes a conveyor belt, a spray head, and a brush, and the spray head and the brush are both disposed above the conveyor belt, which is beneficial for cleaning.
In this embodiment, in the step S22, the conveyor belt is a chain-type locked conveyor belt, which can increase the stability of the transmission.
In this embodiment, in step S4, the bottle collar is made of aluminum, which is light and has good ductility, and is beneficial to sealing the bottle opening.
In this embodiment, in step S5, the outer cover is made of plastic, which is advantageous for assembly.
In this embodiment, in step S15, the surface temperature of the medicinal glass bottle is higher than room temperature, and when the medicinal glass bottle is cooled to room temperature, a negative pressure may be formed in the bottle, and the negative pressure may further increase the sealing property of the medicinal glass bottle.
In this embodiment, in step S7, the sealed glass bottle contains a negative pressure of-0.5 to-0.7.
In practical application, the ozone self-blood-treatment blood sampling container can be used as a blood sampling container during ozone self-blood treatment:
firstly, 200ml of blood can be collected, 200ml of ozone gas with therapeutic concentration is filled into a vacuum bottle after the blood is collected, and the vacuum bottle is a processor for fusing the blood and the ozone, namely blood ozonization; the vacuum bottle, the scalp needle, the blood transfusion device, the filter, the connecting pipe and the OZON 2000 type high-pressure ozone therapeutic apparatus form a totally-enclosed therapeutic system. Ensures that one needle is used for one set during treatment, and can repeatedly collect and transfuse 10 times, 200ml blood is collected and transfused each time, and 2000ml of ozonization treatment blood is totally obtained in the treatment process of 60 minutes.
To facilitate further understanding of the above technical solution, the working process thereof will now be described:
as shown in fig. 1, the production line of such aseptic vacuum bottles mainly includes three: the device comprises a medicinal glass bottle cleaning line, a rubber plug silicon tube cleaning line and an assembly line, wherein the medicinal glass bottle cleaning line and the rubber plug silicon tube cleaning line are synchronously carried out, so that the cleaned medicinal glass bottle and the rubber plug silicon tube can be assembled in an assembly workshop in time; in addition, the medical glass bottle is taken out from the high-pressure steam disinfection cabinet and then the rubber plug silicon tube is immediately put in, the temperature of the bottle body is about 100 ℃, condensed water appears in the bottle after the bottle is placed at room temperature, the finished product manufactured by the process flow is in a sterile state in the bottle and contains negative pressure of-0.5 to-0.7, so that the sterile vacuum bottle has better sealing performance.
The medical glass bottle cleaning line is characterized in that after the medical glass bottle is soaked, cleaned and washed, the medical glass bottle is disinfected in high-pressure steam, the disinfected medical glass bottle is decompressed, then is taken out to be collected, and then is sent into an assembly workshop.
The rubber plug silicon tube cleaning line comprises a rubber plug silicon tube, wherein the rubber plug silicon tube is a natural rubber plug and a silicon tube which are integrated, the rubber plug silicon tube and the silicon tube are soaked, cleaned and washed, the rubber plug silicon tube is placed into high-pressure steam for sterilization after being dried, the rubber plug silicon tube after being sterilized is decompressed, then is taken out and collected, and then is sent into an assembly workshop.
The assembly line is used for assembling the medicinal glass bottle and the rubber plug silicon tube which synchronously enter the assembly workshop, sealing the bottle mouth by using the outer cover after the assembly is finished, irradiating by using lamplight after the sealing, detecting whether foreign matters exist in the bottle, and if the foreign matters do not exist, determining the bottle as a qualified product and then packaging; if foreign matters exist, the foreign matters are judged to be unqualified, and the foreign matters are taken out in time and placed in a specified area.
In the description of the present invention, it is to be understood that the indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings and are only for convenience in describing the present invention and simplifying the description, but are not intended to indicate or imply that the indicated devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are not to be construed as limiting the present invention.
In the present invention, unless otherwise explicitly specified or limited, for example, it may be fixedly attached, detachably attached, or integrated; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A method for producing a sterile vacuum bottle is characterized by comprising the following steps:
step S1, cleaning and disinfecting the medicinal glass bottle;
step S2, cleaning and disinfecting the natural rubber plug and the silicon tube, wherein the silicon tube is inserted in the center of the natural rubber plug, and the natural rubber plug and the silicon tube are simply called as rubber plug silicon tubes;
step S3, pressing the natural rubber stopper in the step S2 into the medicinal glass bottle in the step S1 through a capping machine, namely, the capping glass bottle is obtained;
step S4, tightly packaging the bottle mouth and the outer part of the bottle neck of the glass bottle with the pressure cover in the step S3 by a bottle hoop through a hoop pressing machine, namely, obtaining the packaging glass bottle;
step S5, sealing the glass bottle in the step S4 by using an outer cover, namely, the glass bottle is sealed;
step S6, carrying out light detection on the sealed glass bottle in the step S5, observing whether foreign matters exist or not, and if no foreign matters exist, sticking a label on the wall of the bottle;
and step S7, orderly putting the sealed glass bottles with labels in a packaging box, externally sticking trademarks on the box, and sealing the box by using an adhesive tape.
2. The method for producing an aseptic vacuum bottle as claimed in claim 1, wherein the specific steps of step S1 are as follows:
step S11, purchasing medicinal glass bottles from the market;
step S12, soaking the purchased medicinal glass bottle for 3-5 minutes by using clean water;
step S13, placing the cleaned medicinal glass bottle on a conveying belt of a cleaning device, opening a spray head to inject water into the medicinal glass bottle, cleaning the medicinal glass bottle by using a brush, inverting the medicinal glass bottle on the conveying belt after cleaning for 3 seconds, washing the medicinal glass bottle for 2 seconds by using the spray head, and conveying the washed medicinal glass bottle to a collection box through the conveying belt;
step S14, orderly arranging the medicinal glass bottles sent to the collecting box, putting the orderly arranged medicinal glass bottles into a high-pressure steam cabinet along with the collecting box, and then sterilizing for 30 minutes at the high temperature of 121 ℃ and the high pressure of 103 KPa;
and step S15, opening a pressure release valve on the high-pressure steam cabinet to reduce pressure and exhaust, opening the cabinet door when the pressure in the high-pressure steam cabinet is reduced to 0, taking out the collection box, and putting the medicinal glass bottle in the collection box into an assembly workshop.
3. The method for producing an aseptic vacuum bottle as claimed in claim 1, wherein the specific steps of step S2 are as follows:
step S21, purchasing a rubber plug silicon tube from the market, wherein the specification of the rubber plug silicon tube is matched with that of the medicinal glass bottle;
step S22, placing the rubber plug silicon tube on a conveyor belt of a brushing device, and enabling the rubber plug silicon tube to enter a brushing workshop along with the conveyor belt;
step S23, placing the rubber plug silicon tube entering the washing workshop into a washing tank, and soaking for 3-5 minutes in clear water;
step S24, the soaked silicon rubber plug tube is washed for 3-5 seconds by a brush, and then washed for 1 second by clear water, and then the silicon rubber plug tube is placed on a conveyor belt after washing;
step S25, putting the rubber plug silicon tube on the conveyor belt into a disc-shaped spin dryer, and spinning after rotating for 3-5 seconds;
step S26, placing the dried rubber plug silicon tubes in a rubber plug silicon tube collecting box in sequence, then placing the rubber plug silicon tubes in a high-pressure steam cabinet for high-pressure steam disinfection, and disinfecting for 30 minutes at the high temperature of 121 ℃ and the high pressure of 103 KPa;
and step S26, placing the sterilized rubber plug silicon tube on a conveyor belt, and enabling the rubber plug silicon tube to enter an assembly workshop along with the conveyor belt.
4. The method of claim 2, wherein in step S13, the conveyor belt is connected to a chain, and the chain is connected to a rotating motor.
5. The method as claimed in claim 2, wherein the cleaning device comprises a conveyor, a nozzle and a brush, and the nozzle and the brush are disposed above the conveyor in step S13.
6. The method of claim 3, wherein in step S22, the conveyor belt is a chain-type locking conveyor belt.
7. An aseptic vacuum bottle manufacturing method as claimed in claim 1, wherein in step S4, the bottle collar is made of aluminum.
8. An aseptic vacuum bottle manufacturing method as claimed in claim 1, wherein in step S5, the outer cover is made of plastic.
9. The method for producing an aseptic vacuum bottle as defined in claim 2, wherein in step S15, the temperature of the surface of the glass bottle for pharmaceutical use is higher than room temperature.
10. The method of claim 1, wherein in step S7, the sealed glass bottle contains a negative pressure of-0.5 to-0.7.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010146593.8A CN111317874A (en) | 2020-03-05 | 2020-03-05 | Production method of sterile vacuum bottle |
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| CN202010146593.8A CN111317874A (en) | 2020-03-05 | 2020-03-05 | Production method of sterile vacuum bottle |
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| CN111317874A true CN111317874A (en) | 2020-06-23 |
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| CN110384704A (en) * | 2019-07-25 | 2019-10-29 | 汕头金石粉针剂有限公司 | A kind of cefodizime sodium for injection and preparation method thereof |
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Application publication date: 20200623 |
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