[go: up one dir, main page]

CN111228196B - Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof - Google Patents

Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof Download PDF

Info

Publication number
CN111228196B
CN111228196B CN202010169726.3A CN202010169726A CN111228196B CN 111228196 B CN111228196 B CN 111228196B CN 202010169726 A CN202010169726 A CN 202010169726A CN 111228196 B CN111228196 B CN 111228196B
Authority
CN
China
Prior art keywords
parts
soothing
extract
baby
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202010169726.3A
Other languages
Chinese (zh)
Other versions
CN111228196A (en
Inventor
陈伟阶
孙永
潘美红
徐小建
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Kangaroo Mama Group Co.,Ltd.
Original Assignee
Guangdong Kangaroo Mommy Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Kangaroo Mommy Biotechnology Co ltd filed Critical Guangdong Kangaroo Mommy Biotechnology Co ltd
Priority to CN202010169726.3A priority Critical patent/CN111228196B/en
Publication of CN111228196A publication Critical patent/CN111228196A/en
Application granted granted Critical
Publication of CN111228196B publication Critical patent/CN111228196B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

本发明提供一种基于小麦胚芽提取液的组合物、舒缓婴童面霜及其制备方法。所述组合物包括:修复组分A、修复组分B和溶剂小麦胚芽提取物;所述修复组分A包括小麦神经酰胺、植物抗敏剂、德敏舒、马齿苋提取物、卡卡杜里提取物、水解小麦蛋白和植物组合物;所述修复组分B包括西班牙橄榄油、乳木果油、椰果油、德肤修和生育酚。所述组合物对于脆弱、敏感、反应性强的皮肤,具有很好的营养和舒缓功效,可令肌肤滋养和再生、抵御失水,使皮肤摆脱干燥等功效。添加本发明所述基于小麦胚芽提取液的组合物制得的舒缓婴童面霜能达到从内部肌肤底层加强防护作用,外部舒缓滋润,令肌肤柔润健康。

Figure 202010169726

The invention provides a wheat germ extract-based composition, a soothing baby face cream and a preparation method thereof. The composition includes: repair component A, repair component B and solvent wheat germ extract; the repair component A includes wheat ceramide, plant anti-allergic agent, Deminshu, purslane extract, kaka Duri extract, hydrolyzed wheat protein and botanical composition; the repairing component B includes Spanish olive oil, shea butter, coconut oil, defuxiu and tocopherol. The composition has good nutritional and soothing effects on fragile, sensitive and highly reactive skin, and can nourish and regenerate the skin, resist dehydration, and free the skin from dryness. The soothing baby face cream prepared by adding the composition based on the wheat germ extract of the present invention can achieve a protective effect from the inner bottom layer of the skin, and externally soothes and moisturizes, making the skin soft and healthy.

Figure 202010169726

Description

Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition based on a wheat germ extracting solution, soothing infant cream and a preparation method thereof.
Background
The skin of the infant is obviously different from the components in structure, components and function, wherein the thickness of the horny layer and the epidermis of the infant is 20-30% thinner than that of an adult in terms of the basic structure of the skin, the horny cell is smaller, the lipid content of the infant is rapidly reduced after the infant is separated from a parent body, so that the permeation of drug molecules through the skin of the infant is more direct and easier than that of the adult, the systemic absorption of the drug molecules is more than that of the adult, the reaction on harmful substances and allergic substances is stronger, the external-use efficacy additive for the infant is very careful, and a special skin care product is preferably used to avoid the harm of irritant substances such as essence, alcohol, pigments and the like.
The infant absorbs water faster than the adult, can maintain higher water content than the adult, but the skin barrier function of the infant is not completely developed, so the water loss speed is higher, the transdermal water loss rate (TEWL), namely the data of stratum corneum skin permeability and skin hydration degree, can analyze the strength of the skin barrier function, and the data shows that the TEWL of the infant is obviously different from that of the adult.
At present, infant moisturizing products in the market are mainly declared to be from simple and natural sources, the effects of the infant moisturizing products are moisturizing, on the basis that the skin barrier cannot be strengthened, most of the infant moisturizing products can only reduce the damaged inflammation of the skin or temporarily moisten the skin surface layer by strengthening the moisturizing degree of the skin surface layer or adding soothing raw materials, and the problems that the skin barrier of an infant is incomplete and the lipid content is low cannot be fundamentally solved.
CN109925245A discloses a sleeping baby skin lotion and a preparation method thereof, wherein the components of the sleeping baby skin lotion comprise 3-5 parts of caprylic/capric triglyceride, 3-5 parts of shea butter, 2-5 parts of squalane, 0.1-0.3 part of wheat germ oil, 0.01-0.3 part of sodium hyaluronate, 0.01-0.3 part of arginine, 0.1-1 part of wheat gluten, 0.1-1 part of chamomile extract, 1-3 parts of polydimethylsiloxane, 2-11 parts of emulsifier, 1-6 parts of polyalcohol humectant, and also can comprise tocopherol acetate, thickener and the like. The formula of the invention contains various plant oil and fat with moisturizing and nourishing functions and plant extract, which are easy to be absorbed by human body and can well moisturize skin.
CN109793688A discloses a moisturizing and anti-pollution infant cleaning composition and a preparation method thereof, comprising the following components by weight percent: 2-5% of carboxymethyl chitosan, 0.1-0.3% of sodium hyaluronate, 0.2-0.5% of wheat alcohol-soluble protein, 0.2-0.5% of shea butter, 1-4% of rosemary leaf extract, 7-9% of camellia extract, 7-10% of lauryl alcohol ether ammonium sulfate, 0.3-0.5% of ricinoleic acid amide propyl trimethyl ammonium chloride and the like.
Therefore, the development of a skin care product which can achieve the effect of strengthening the protection from the bottom layer of the skin inside the infant, relieve and moisten the outside and make the skin soft, moist and healthy is the key point of the current research.
Disclosure of Invention
The invention aims to provide a composition based on a wheat germ extracting solution, a soothing baby cream and a preparation method thereof. The baby soothing cream prepared by adding the composition based on the wheat germ extracting solution can achieve the effect of strengthening protection from the inner skin bottom layer, and the external part is soothing and moist, so that the skin is soft, moist and healthy.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a composition based on a wheat germ extract, said composition comprising: a repairing component A, a repairing component B and a solvent wheat germ extract;
the repair component A comprises wheat ceramide, plant anti-allergy agent, chlorphenamine maleate, purslane extract, kakakadu extract, hydrolyzed wheat protein and plant composition;
the repair component B comprises olive oil, shea butter, coconut oil, Defu and tocopherol.
In the invention, the wheat-derived component contained in the solvent wheat germ extract has protein, amino acid, various minerals, oligo-and polysaccharides, phenolic compounds, tocopherol and the like, and has the functions of structure reconstruction and regeneration, and the functions of relieving and protecting. The natural vitamin E and glutathione contained in the compound are excellent antioxidants, the antioxidant mechanism is that the compound can be concentrated around unsaturated fatty acid peroxy radicals, and the compound is an effective peroxy radical scavenger and prevents peroxidation in cells. Meanwhile, vitamin E can keep the connection of the tissues, inhibit lipid peroxidation and keep the skin of the infant elastic, smoother, tender, moist and rich in elasticity. Moreover, based on the characteristics of fragile, sensitive and strong reactivity of the skin of the infants, the wheat germs can supplement nutrition to the skin and eliminate stimulation. The product of the hydrolyzed wheat germ macromolecular protein can provide more nutrient components for the skin, can quickly form a transparent elastic biomembrane on the surface of the skin, can keep moisture for a long time and condition the skin, and is smooth, fine and flexible.
In the invention, the repairing component A is an aqueous phase repairing component and comprises wheat ceramide, a plant anti-allergy agent, destruck, a purslane extract, a kakali extract, hydrolyzed wheat protein and a plant composition, all the components are matched with each other, so that the synergistic effect is achieved, the absorption of effective substances in the wheat germ extract by a human body can be promoted, the moistening and moisturizing effects can be further improved, the skin protective barrier can be enhanced after long-term use, and the external damage can be better resisted. The wheat germ extract contains plant ceramide, can effectively preserve moisture and promote regeneration, has the effects of efficiently preserving moisture and promoting the permeation of other nutrient substances, and has a high moisture-preserving effect on skin. Wherein Deminshu is a soothing product of Dexinxin Germany and its trade name is
Figure BDA0002408756770000031
Deminshu 143535, which contains butanediol, 1, 2-pentanediol and hydroxyphenylpropylamidobenzoic acid, can effectively inhibit skin erythema, pruritus and anaphylactic reaction caused by histamine, and inhibit the anaphylactic reaction when the histamine release of mast cells is inhibited, thereby achieving the purposes of relieving skin, relieving itching and removing redness in time. Wherein, the purslane extractive has the comprehensive performance of preventing dryness and aging, increasing the comfort of the skin, eliminating free radicals and improving the comfort of the skin. The natural vitamin C content of the kakacadi extract is 100 times of that of oranges, the kacadi extract has excellent moisturizing and antioxidant effects, and is rich in various valuable plant nutrients such as vitamin E, folic acid, zinc, magnesium, calcium and the like. Wherein, the hydrolyzed wheat protein is mainly amino acidGliadin and glutenin, and is rich in cystine, and has effects of keeping moisture, resisting oxidation, softening and refining skin.
In the invention, the repairing component B is an oil phase repairing component and comprises Spanish olive oil, shea butter, coconut oil, Defu oil and tocopherol, all the components are matched with each other, so that the synergistic effect is achieved, the absorption of effective substances in the wheat germ extract by a human body can be promoted, the moistening and moisturizing effects can be further improved, the skin protective barrier can be enhanced after long-term use, and the external damage can be better resisted. Wherein, the spanish olive oil is rich in unsaturated fatty acid and various vitamins, and the ratio of linolenic acid and linoleic acid which can not be synthesized by human body in the nutrient components of the olive oil is similar to that of breast milk, so the olive oil is easy to be absorbed by the skin of infants. Wherein, the shea butter contains a large amount of unsaponifiable lipid, can provide abundant vitamins A, D, E, F and the like for the skin, supplements enough nutrient components for the skin, can effectively help cells to regenerate and promote the microcirculation, has good functions of moistening and moisturizing, the dermolide is a raw material of the mollissima, is sold as SymRelief dermolide 153884, comprises hexyldecanol, hexadecylhydroxyproline palmitamide, stearic acid, brassinosteroids and a-bisabolol which are synergistically compounded to be close to main components of a sebum protective layer, and a skin cuticle bimolecular model similar to natural skin ceramide is formed by the hexyldecanol, the hexadecylhydroxyproline palmitamide, the stearic acid and the brassinol, so that a lipid bimolecular layer similar to the skin can be rapidly recombined, and a natural anti-inflammatory component a-bisabolol is added, so that the skin self-protection barrier function can be rapidly restored and reconstructed.
Preferably, the mass ratio of the repairing component A, the repairing component B and the solvent wheat germ extract is (3-8): (50-80). Within the range of the mixture ratio, the soothing effect of the composition can be further improved, and the skin can be nourished and regenerated, the water loss resistance can be resisted, and the skin can fundamentally get rid of the effects of dryness and the like.
Here, "3 to 8" may be, for example, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, etc.
Wherein, "50 to 80" may be, for example, 50, 55, 60, 65, 70, 75, 80, 85, 90, etc.
Preferably, the repair component A comprises the following components in parts by weight: 0.5-2 parts of wheat ceramide, 1-5 parts of plant anti-allergy agent, 0.1-0.5 part of chlorpheniramine maleate, 0.1-2 parts of purslane extract, 0.1-1 part of kakadu extract, 0.1-0.5 part of hydrolyzed wheat protein and 0.05-0.2 part of plant composition.
In the repairing component A of the present invention, the content of the wheat ceramide is 0.5-2 parts, for example, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.
In the repairing component A, the content of the plant anti-allergic agent is 1-5 parts, for example, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts and the like.
In the repairing component A of the present invention, the content of desmin is 0.1-0.5 parts, for example, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, etc.
In the repairing component A, the purslane extract content is 0.1-2 parts, such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 part, 1.4 part, 1.6 part, 1.8 part, 2 parts and the like.
In the repairing component A, the content of the kakakauri extract is 0.1-1 part, and can be, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like.
In the repair component A of the present invention, the content of the hydrolyzed wheat protein is 0.1 to 0.5 part, for example, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, etc.
In the repairing component A of the present invention, the content of the plant composition is 0.05 to 0.2 part, for example, 0.05 part, 0.07 part, 0.09 part, 0.1 part, 0.12 part, 0.14 part, 0.18 part, 0.2 part, etc.
Preferably, the plant anti-allergic agent comprises centella asiatica extract, licorice extract, chamomile extract, scutellaria baicalensis extract, rosemary extract, tea extract, and polygonum cuspidatum extract. The plant anti-allergy agent is a plant-derived allergy-relieving product of the Korean bailousi extract, contains a centella asiatica extract, a liquorice extract, a chamomile extract, a scutellaria baicalensis extract, a rosemary extract, a tea extract and a polygonum cuspidatum extract, can repair skin damage caused by atopic dermatitis, and has good effects on anti-allergy and anti-allergy of sensitive skin and treatment of hormone-dependent dermatitis.
Preferably, the botanical composition comprises neroli extract, freesia cubeba extract and magnolia extract. The plant composition is a skin barrier improving agent of Guangzhou Hehe vast company, contains bitter orange flower extract, litsea cubeba extract and magnolia flower extract, and can enhance cell activity and improve skin micro-ecological balance.
Preferably, the repair component B comprises the following components in parts by weight: 1-5 parts of spanish olive oil, 0.5-5 parts of shea butter, 0.5-5 parts of coconut oil, 0.1-1 part of Defu and 0.1-1 part of tocopherol.
In the repairing component B of the present invention, the content of the Spanish olive oil is 1-5 parts, for example, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.
In the repairing component B of the present invention, the shea butter content is 0.5-5 parts, for example, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.
In the repair component B of the present invention, the coconut oil content is 0.5-5 parts, for example, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.
In the repairing component B of the present invention, the content of the dermapharmaceutical is 0.1-1 part, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, etc.
In the repairing component B of the present invention, the content of tocopherol is 0.1 to 1 part, and may be, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, etc.
In a second aspect, the invention provides a soothing baby cream, which comprises the following components in parts by weight: 60-90 parts of a wheat germ extracting solution-based composition, 0.5-2.5 parts of an emulsifier, 0.8-2 parts of a thickener, 3-10 parts of an emollient, 3-10 parts of a humectant and 0.2-1 part of a pH regulator.
In the soothing baby cream, the content of the composition based on the wheat germ extracting solution is 60-90 parts, and can be 60 parts, 62 parts, 64 parts, 66 parts, 68 parts, 70 parts, 72 parts, 74 parts, 76 parts, 78 parts, 80 parts, 82 parts, 84 parts, 86 parts, 88 parts, 90 parts and the like.
In the soothing baby cream, the content of the emulsifier is 0.5-2.5 parts, such as 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts and the like.
In the soothing baby cream, the content of the thickening agent is 0.8-2 parts, such as 0.8 part, 0.9 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts and the like.
In the soothing baby face cream, the content of the emollient is 3-10 parts, such as 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and the like.
In the soothing baby cream, the content of the pH regulator is 0.2-1 part, and can be, for example, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like.
Preferably, the emulsifier comprises any one of wheat emulsifier, EM-90, MON-L, A-165, M68, SP-60, monoglyceride, 1618 alcohol, SSE-20 or SS, or a combination of at least two thereof.
Preferably, the thickener comprises any one of or a combination of at least two of carbomer 940, U21, 2020, EG or xanthan gum.
Preferably, the emollient comprises any one or combination of at least two of 2-EHP, GTCC, DC200/100cst, or DC200/350 cst.
Preferably, the humectant comprises any one or a combination of at least two of glycerol, propylene glycol, butylene glycol, hexylene glycol, betaine, or pentylene glycol.
Preferably, the pH adjusting agent comprises any one of arginine, aminomethyl propanol, potassium hydroxide, or triethanolamine, or a combination of at least two thereof.
Preferably, the soothing baby facial cream further comprises 0.01-0.1 parts of chelating agent, such as 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts and the like.
Preferably, the chelating agent is EDTA-2 Na.
Preferably, the soothing baby facial cream further comprises 0.1-1 parts of preservative, such as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part and the like.
Preferably, the preservative is jasmonate.
In a third aspect, the invention provides a preparation method of the soothing baby cream as described in the second aspect, and the preparation method of the soothing baby cream comprises the following steps: the baby soothing cream is prepared by mixing the composition based on wheat germ extract as described in the first aspect, an emulsifier, a thickener, an emollient, a humectant and a pH adjuster in formula amounts.
Preferably, the preparation method of the soothing baby cream specifically comprises the following steps:
(1) mixing and stirring wheat germ extract, thickening agent and humectant to obtain water phase mixed solution; mixing and stirring the emulsifier, the emollient and the repairing component B in an oil phase to obtain an oil phase mixed solution;
(2) mixing the water phase mixed liquor and the oil phase mixed liquor obtained in the step (1) and homogenizing to obtain homogenized liquor;
(3) and (3) adding a pH regulator into the homogeneous liquid obtained in the step (2) to regulate the pH, adding a repairing component A, and mixing to obtain the soothing baby cream.
Preferably, the temperature for mixing and stirring the aqueous phase in the step (1) is 80-90 ℃, for example, 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃, 86 ℃, 87 ℃, 88 ℃, 89 ℃, 90 ℃ and the like.
Preferably, the temperature for mixing and stirring the oil phase in the step (1) is 75 to 85 ℃, for example, 75 ℃, 76 ℃, 77 ℃, 78 ℃, 79 ℃, 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃ and the like.
Preferably, the temperature for mixing and homogenizing in the step (2) is 80-82 ℃, for example, 80 ℃, 81 ℃, 82 ℃ and the like can be realized.
Preferably, the temperature for adjusting pH in step (3) is 55-65 deg.C, such as 55 deg.C, 56 deg.C, 57 deg.C, 58 deg.C, 59 deg.C, 60 deg.C, 61 deg.C, 62 deg.C, 63 deg.C, 64 deg.C, 65 deg.C, etc.
Preferably, the temperature for adding and mixing the repairing component A in the step (3) is 40-45 ℃, for example, 40 ℃, 41 ℃, 42 ℃, 43 ℃, 44 ℃, 45 ℃ and the like.
Preferably, the preparation method of the soothing baby cream specifically comprises the following steps:
(1) mixing wheat germ extract, thickener and humectant at 80-90 deg.C with water, and stirring to obtain water phase mixture; mixing emulsifier, emollient and repairing component B at 75-85 deg.C under stirring to obtain oil phase mixed solution;
(2) mixing the water phase mixed liquor and the oil phase mixed liquor obtained in the step (1) at 80-82 ℃ for homogenization to obtain a homogenized liquor;
(3) and (3) cooling to 55-65 ℃, adding a pH regulator into the homogenized liquid obtained in the step (2) to regulate the pH, cooling to 40-45 ℃, adding a repairing component A, and mixing to obtain the soothing baby cream.
Compared with the prior art, the invention has the following beneficial effects:
(1) the components of the composition disclosed by the invention are matched with each other, so that the composition has a synergistic effect, has good nutrition and relieving effects on fragile, sensitive and strong-reactivity skin, and has the effects of nourishing and regenerating the skin, resisting water loss, enabling the skin to get rid of dryness and the like. The baby soothing cream prepared by adding the composition based on the wheat germ extracting solution can achieve the effect of strengthening protection from the inner skin bottom layer, and the external part is soothing and moist, so that the skin is soft, moist and healthy.
(2) The moisturizing cream provided by the invention is faint and light in fragrance with plants, is safe and natural, is mild and non-irritant, has a very good moisturizing effect, can enhance a skin protective barrier after long-term use, better resists external invasion, and protects the driving of the growing road of infants.
Drawings
Figure 1 is a graph of SDS model skin integrity data.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The following examples soothe the various component manufacturers and sources in the baby cream are as follows: the plant antiallergic agent is a plant-derived allergy relieving product of Bai Lao Si Te Korea, and comprises herba Centellae extract, Glycyrrhrizae radix extract, flos Matricariae Chamomillae extract, Scutellariae radix extract, herba Rosmarini officinalis extract, folium Camelliae sinensis extract and rhizoma Polygoni Cuspidati extract; demingshu is a soothing product of Dezhixin in Germany and its trade name is
Figure BDA0002408756770000102
Dexrazoxane 143535; defu is a raw material of Dexin, and is sold under the trade name of SymRelief Defu 153884; the plant composition is a skin barrier improving agent prepared from Guangzhou He vast company, and contains neroli extract, freesia extract, and Magnolia flower extract.
Example 1
The embodiment provides a soothing baby cream, which comprises the following components in parts by weight:
Figure BDA0002408756770000101
Figure BDA0002408756770000111
the preparation method of the soothing baby cream provided by the embodiment specifically comprises the following steps:
(1) mixing wheat germ extract, thickening agent (carbomer 940, xanthan gum, EG), humectant (glycerol, propylene glycol, betaine, 1, 2-hexanediol, allantoin) and chelating agent at 85 deg.C, and stirring to obtain water phase mixture; mixing emulsifier (wheat emulsifier, MON-L, A-165, 1618 alcohol), emollient (GTCC, DC200/100cst), and repairing component B at 80 deg.C, and stirring to obtain oil phase mixture;
(2) mixing the water phase mixed liquor and the oil phase mixed liquor obtained in the step (1) at 80 ℃ and homogenizing to obtain homogenized liquor;
(3) and (3) cooling to 60 ℃, adding triethanolamine into the homogenized liquid obtained in the step (2) to adjust the pH value, cooling to 42 ℃, adding the repairing component A and the preservative, and mixing to obtain the soothing baby cream.
Example 2
The embodiment provides a soothing baby cream, which comprises the following components in parts by weight:
Figure BDA0002408756770000112
Figure BDA0002408756770000121
the preparation method of the soothing baby cream provided by the embodiment specifically comprises the following steps:
(1) mixing wheat germ extract, thickening agent (carbomer 940, xanthan gum, EG), humectant (glycerol, propylene glycol, betaine, 1, 2-hexanediol, allantoin) and chelating agent at 86 deg.C, and stirring to obtain water phase mixture; mixing emulsifier (wheat emulsifier, MON-L, A-165, 1618 alcohol), emollient (GTCC, DC200/100cst), and repairing component B at 78 deg.C, and stirring to obtain oil phase mixture;
(2) mixing the water phase mixed liquor and the oil phase mixed liquor obtained in the step (1) at 81 ℃ for homogenization to obtain a homogenized liquor;
(3) and (3) cooling to 62 ℃, adding triethanolamine into the homogenized liquid obtained in the step (2) to adjust the pH, cooling to 43 ℃, adding the repairing component A and the preservative, and mixing to obtain the soothing baby cream.
Example 3
The embodiment provides a soothing baby cream which comprises the following components in parts by weight:
Figure BDA0002408756770000122
Figure BDA0002408756770000131
the preparation method of the soothing baby cream provided in this example is the same as that of example 1.
Example 4
The embodiment provides a soothing baby cream, which comprises the following components in parts by weight:
Figure BDA0002408756770000132
Figure BDA0002408756770000141
the preparation method of the soothing baby cream provided in this example is the same as that of example 1.
Example 5
This example provides a soothing baby cream, differing from example 1 only in that the solvent wheat germ extract content is reduced to 37.35 parts; in repair component a: increasing the content of wheat ceramide to 3 parts, increasing the content of plant anti-allergy agent to 5 parts, increasing the content of chlorphenamine to 2.2 parts, increasing the content of purslane extract to 3 parts, increasing the content of kacaduri extract to 2.4 parts, increasing the content of hydrolyzed wheat protein to 2.3 parts, and increasing the content of plant composition to 2.1 parts; in repair component B: the content of the olive oil in Spain is increased to 4 parts, the content of the shea butter is increased to 3.5 parts, the content of the coconut oil is increased to 3 parts, the content of the Defu oil is increased to 2.5 parts, and the content of the tocopherol is increased to 2.3 parts. The contents of other components and the preparation method are the same as those of example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Example 6
This example provides a soothing baby cream, differing from example 1 only in that the solvent wheat germ extract content was increased to 62.45 parts; in repair component a: reducing wheat ceramide to 0.1 part, reducing plant anti-allergy agent to 0.1 part, reducing chlorpheniramine to 0.1 part, reducing purslane extract to 0.1 part, reducing kacaduri extract to 0.1 part, reducing hydrolyzed wheat protein to 0.1 part, and still keeping the plant composition at 0.1 part; in repair component B: spanish olive oil to 2.86 parts, shea butter to 2.36 parts, coconut oil to 1.86 parts, Defu oil to 1.36 parts, tocopherol to 1.16 parts. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Example 7
This example provides a soothing baby cream, differing from example 1 only in that the solvent wheat germ extract content was increased to 62.05 parts; in repair component a: increasing wheat ceramide to 1.6 parts, plant anti-allergy agent to 3.6 parts, dexrazoxane to 0.8 part, purslane extract to 1.6 parts, kacaduri extract to 1 part, hydrolyzed wheat protein to 0.9 part, and plant composition to 0.7 part; in repair component B: the content of olive oil in Spain is reduced to 0.1 part, the content of shea butter is reduced to 0.1 part, the content of coconut oil is reduced to 0.1 part, the content of Defu is reduced to 0.1 part, and the content of tocopherol is reduced to 0.1 part. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 1
The comparative example provides a soothing baby cream, which is different from example 1 in that 61.45 parts of solvent wheat germ extract is replaced by 61.45 parts of deionized water, and the contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 2
This comparative example provides a soothing baby cream which differs from example 1 only in that no rejuvenating component a is added to the soothing baby cream; the content of the solvent wheat germ extract is increased to 62.45 parts; in the repair component B: the content of the olive oil in Spain is increased to 3 parts, the content of the shea butter is increased to 2.5 parts, the content of the coconut oil is increased to 2 parts, the content of the Defu oil is increased to 1.5 parts, and the content of the tocopherol is increased to 1.3 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 3
This comparative example provides a soothing baby cream which differs from example 1 only in that the rejuvenating cream does not contain the repairing component B and the content of the solvent wheat germ extract is increased to 63.25 parts; in repair component a: wheat ceramide is increased to 1.5 parts, plant anti-allergy agent is increased to 3.5 parts, dexrazoxane is increased to 0.7 part, purslane extract is increased to 1.5 parts, kacaduri extract is increased to 0.9 part, hydrolyzed wheat protein is increased to 0.8 part, and plant composition is increased to 0.6 part. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 4
This comparative example provides a soothing baby cream which differs from example 1 only in that wheat ceramide is not added to the repair component a, the plant anti-allergy agent is increased to 3.2 parts, dexrazoxane is increased to 0.36 parts, the purslane extract is increased to 1.16 parts, the kacadini extract is increased to 0.46 parts, the hydrolysed wheat protein is increased to 0.36 parts, and the botanical composition is increased to 0.16 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 5
This comparative example provides a soothing baby cream which differs from example 1 only in that no phytoalexin is added to repair component a, wheat ceramide is increased to 1.5 parts, dexrazoxane is increased to 0.7 parts, purslane extract is increased to 1.5 parts, kacadili extract is increased to 0.9 parts, hydrolysed wheat protein is increased to 0.8 parts, botanical composition is increased to 0.6 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 6
This comparative example provides a soothing baby cream which differs from example 1 only in that desmoshu was not added to repair component a, wheat ceramide was increased to 1.04 parts, plant anti-allergy agent was increased to 3.04 parts, purslane extract was increased to 1.04 parts, kacadii extract was increased to 0.44 parts, hydrolyzed wheat protein was increased to 0.34 parts, and the botanical composition was still 0.1 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby face cream provided in the embodiment is the same as that of the embodiment 1
Comparative example 7
This comparative example provides a soothing baby cream which differs from example 1 only in that purslane extract is not added to repair component a, wheat ceramide is increased to 1.2 parts, plant anti-allergy agent is increased to 3.1 parts, dexrazoxane is increased to 0.4 parts, kacadili extract is increased to 0.6 parts, hydrolyzed wheat protein is increased to 0.5 parts, and botanical composition is increased to 0.2 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1.
Comparative example 8
This comparative example provides a soothing baby cream which differs from example 1 only in that no kacaduri extract is added to repair component a, wheat ceramide is increased to 1.03 parts, plant anti-sensitizers are increased to 3.07 parts, dexrazoxane is increased to 0.27 parts, purslane extract is increased to 1.00 parts, hydrolyzed wheat protein is increased to 0.37 parts, botanical composition is increased to 0.15 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1.
Comparative example 9
This comparative example provides a soothing baby cream which differs from example 1 only in that hydrolyzed wheat protein is not added to repair component a, wheat ceramide is increased to 1.05 parts, plant anti-allergy agent is increased to 3.05 parts, dexrazoxane is increased to 0.25 parts, kacadimi extract is increased to 0.45 parts, purslane extract is increased to 1.05 parts, botanical composition is increased to 0.15 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 10
This comparative example provides a soothing baby cream which differs from example 1 only in that the repair component a was not supplemented with a botanical composition, wheat ceramide was increased to 1.02 parts, botanical anti-sensitizers were increased to 3.02 parts, dexrazoxane was increased to 0.22 parts, kacadimi extract was increased to 0.42 parts, purslane extract was increased to 1.01 parts, hydrolyzed wheat protein was increased to 0.11 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 11
This comparative example provides a soothing baby cream which differs from example 1 only in that no spanish olive oil is added to the repair component B, the shea butter is increased to 2 parts, the coconut oil is increased to 1.5 parts, the dermatan is increased to 1 part, and the tocopherol is increased to 0.8 part. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 12
This comparative example provides a soothing baby cream which differs from example 1 only in that in the repair component B there is no shea butter added, the amount of spanish olive oil is increased to 2.3 parts, the amount of coconut oil is increased to 1.4 parts, the amount of dermatan is increased to 0.9 part, and the amount of tocopherol is increased to 0.7 part. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 13
This comparative example provides a soothing baby cream which differs from example 1 only in that coconut oil is not added to the repair component B, spanish olive oil is added to 2.25 parts, shea butter is added to 1.75 parts, dehusurf is added to 0.75 parts, and tocopherol is added to 0.55 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 14
This comparative example provides a soothing baby cream which differs from example 1 only in that no dermabrasion is added to repair component B, spanish olive oil is increased to 2.2 parts, shea butter is increased to 1.6 parts, coconut oil is increased to 1.1 parts, tocopherol is increased to 0.4 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Comparative example 15
This comparative example provides a soothing baby cream which differs from example 1 only in that no tocopherol is added to the repair component B, spanish olive oil is increased to 2.075 parts, shea butter is increased to 1.575 parts, coconut oil is increased to 1.075 parts, and dehusurf is increased to 0.575 parts. The contents of other components and the preparation method are the same as example 1. The preparation method of the soothing baby cream provided in this example is the same as that of example 1
Test example 1
Safety performance testing
Safety performance tests were performed on the soothing baby cream provided in example 1 and the soothing baby cream provided in comparative example 1, as follows:
and (3) testing items: acute skin irritation test
The test method comprises the following steps: toxicology test method 4, skin irritation/Corrosion test, chapter six, technical Specification for cosmetic safety (2015 edition)
The detection environment is a common animal house; the room temperature is 21-23 ℃, and the relative humidity is 55-65%.
Experimental animals the ordinary-grade New Zealand white rabbits were used and were provided by the Guangdong province medical Experimental animal center (Sanshui base) (Experimental animal production license number: SCXK () 2019-. The weight of the experimental animal is 2.3-2.5 kg.
Experimental animal number/sex 4/male parent ═ 2:2
Sample treatment: directly sampling a sample stock solution as a test substance.
And (3) observing time points: skin reactions were observed at the sites given the test subjects 1, 24, 48, and 72 hours after removal of the test subjects.
The testing steps are as follows: (1) 4 healthy adult New Zealand rabbits were selected and selected, respectively. 24h before the test, both sides of the spine of the experimental animal were shaved, and 2 depilated regions (each depilated region having a size of about 3cmx3cm) were prepared, and the test was performed after confirming that the skin of the animal was intact. (2) 0.5mL of example 1 was applied evenly to 2.5cm x2.5cm of left depilatory area on skin, covered with patch, and then secured with a non-irritating adhesive patch and bandage. The same right depilated area was covered with the patch of comparative example 1 as a control. After being applied for 4h, the residual test substance is removed by warm water. Observing skin reactions of tested parts at 1h, 24h, 48h and 72h after removing the tested substances, scoring the skin irritation reactions according to a table 1 'skin irritation reaction scoring', recording the skin reaction score of each observation time point, calculating the average value of tested animal integrals, and judging the skin irritation intensity according to a method table 2 'skin irritation intensity grading' according to the highest integral average value of each observation time point of 1h, 24h, 48h and 72 h.
TABLE 1
Figure BDA0002408756770000201
Table 2 skin irritation intensity grading
Figure BDA0002408756770000202
Figure BDA0002408756770000211
The test results show that the test substance example 1 causes erythema stimulation response to rabbit skin at the observation time of 1 h. The highest integral mean value of each observation time point of 24h, 48h and 72h is 0.00 and is in a non-irritant range of 0-less than 0.5, so that the infant moisturizing cream which takes the wheat germ extracting solution as the matrix and mainly comprises various plant repairing components has non-irritant reaction in an animal irritation test in the embodiment 1 of the invention, various natural components of the wheat germ extracting solution are mild and safe, and various repairing components mainly comprise various relieving and repairing components. The test object of comparative example 1 is observed to cause irritation responses such as erythema, edema and the like on the rabbit skin at the observation time points of 1h, 24h, 48h and 72h respectively. The highest integral mean value of each observation time point of 24h, 48h and 72h is 0.87 and is in the range of light irritation of 0.5 to less than 2.0.
Test example 2
Cosmetic Performance test
Each of the cosmetic base performance tests were performed on the soothing baby creams provided in examples 1-7 and the soothing baby creams provided in comparative examples 1-15 as follows:
(1) the characteristics are as follows: visual inspection is adopted.
(2) pH value: measuring the pH value according to a general test method for cosmetics of GBT 13531.1-2008;
(3) viscosity: according to the viscosity testing method of GB-T10247-1988, the testing instrument is an electronic rotary viscometer of Bohler fly LVDV-S +15-2000000cP type;
(4) stability: according to the national standard of GBT 34857 and 2017, the moisturizing cream in the embodiment 1 is sampled, is packaged in a transparent cosmetic bottle and a test sample bottle, is respectively placed under the experimental conditions of-18 ℃, 25 ℃, 45 ℃ and 48 ℃, and is subjected to continuous test on the appearance, the fragrance, the pH value, the viscosity and other items for 30 days, and is observed whether the unfavorable phenomena of bleeding, layering, separation, precipitation, discoloration, peculiar smell, demulsification and the like occur;
the results of the basic performance tests of the above cosmetic are shown in table 3 below:
TABLE 3
Figure BDA0002408756770000221
Figure BDA0002408756770000231
As can be seen from the results of the basic performance tests of the cosmetics in Table 3, the soothing baby facial cream provided by the embodiments 1 to 7 of the invention is milky white cream, uniform, free of particles, good in stability, natural and light in smell, 5.0 to 7.0 in pH (25 ℃), and 90000mpa & s or more in viscosity (25 ℃) of the moisturizing facial cream, so that the soothing baby facial cream disclosed by the invention has the characteristics of being mild and non-irritant, and has no bad phenomena such as water separation, layering, separation, precipitation, discoloration, peculiar smell, demulsification and the like within 30 days, which indicates that the stability is good.
Test example 3
Skin barrier function test
The test evaluation is carried out on 75 testers with 5-12 years old skin without allergic history and healthy in batches, and the lower the TEWL value of the skin is, the larger the reduced change rate is, which indicates that the barrier function for preventing water loss is stronger. The rate of change of TEWL values was:
TEWL change rate ═ (measured value-blank control value)/blank control value · 100%
Using equipment
Figure BDA0002408756770000232
Dual MPA 580, Probe Tewameter TM300, was tested by a skin moisture loss tester. 3cm of each forearm of the subject2The area of the size is a test area, and the test area of the arm should be cleaned with clear water and sit still in a constant temperature independent environment (22 +/-1 ℃) and an environment with the relative humidity of 50 +/-5% for 30-60 minutes before the test of the subject. Then using a pipette at 2.0mg sample/cm2The samples were evenly spread in the test area with latex gloves, and the initial blank control value, 5min, 2h, 4h TEWL values were measured and the TEWL change rate at the fourth hour was calculated and the results are shown in table 4 below:
TABLE 4
Figure BDA0002408756770000241
Figure BDA0002408756770000251
From the experimental results in table 4, it can be seen that the difference of the change rate of the hydration degree of the soothing baby cream prepared in the examples 1 to 7 of the present invention in the fourth hour is greater than-54.69%, which indicates that the components of the wheat germ extract-based composition of the present invention have scientific and reasonable compatibility and synergistic interaction, and the composition has good nutrition and soothing effects on fragile, sensitive and highly reactive skin. Among them, it can be seen that the change rate of the hydration degree of the skin after using the soothing and moisturizing cream of example 1 is greatly reduced within four hours, while the change rate of the hydration degree of comparative example 1 (without adding solvent wheat germ extract) is small, and the barrier function for preventing water loss is poor, while the soothing baby facial cream prepared by adding the composition based on the wheat germ extract of example 1 can achieve the effect of strengthening the protection from the bottom layer of the internal skin, effectively improve the barrier function for water loss, and the external part is soothing and moisturizing, so that the skin is soft and healthy.
Test example 4
Moisture retention efficacy test
According to the evaluation guideline for moisturizing efficacy of cosmetics in the industry standard of cosmetics, 30 volunteers were selected, the soothing baby cream provided in examples 1 to 7 and the soothing baby cream provided in comparative examples 1 to 15 were applied to both forearms in random batches, and the moisture content of the skin was measured before, 5min after, 2h after, and 4h after application, to evaluate the moisturizing efficacy of the product on the surface layer of the skin. The results of the moisture value change are shown in Table 5 below:
TABLE 5
Figure BDA0002408756770000252
Figure BDA0002408756770000261
The experimental results in table 5 show that the moisture value of the soothing baby cream prepared in examples 1-7 of the present invention is above 62.00, which indicates that the composition based on wheat germ extract solution of the present invention has scientific and reasonable compatibility of the components, synergistic effect, good nutrition and soothing effects on fragile, sensitive and highly reactive skin, and has the effects of nourishing and regenerating skin, resisting water loss, and getting the skin dry.
Test example 5
Sensory evaluation test
The soothing baby creams provided in examples 1-7 and the soothing baby creams provided in comparative examples 1-15 were selected for skin feel evaluation according to sensory analysis in the cosmetics industry.
1. Evaluation items: spreadability, absorbency, mildness, overall feel.
2. A grading system: the score is 1-10 points, and the higher the total score is, the stronger the characteristic of the project index is.
3. The experimental scheme is as follows: 75 trained evaluators, female, aged 20-30 years were selected. The test was carried out in a constant temperature independent environment (22. + -. 1 ℃ C.), with a relative humidity of 50. + -.5%, after resting and sitting for 30-60 minutes, and the results are shown in Table 6.
TABLE 6
Test sample Spreadability Absorbency of Mildness property Moisture retention Whole feeling Total score
Example 1 9.2 9.5 10 9.5 10 48.2
Example 2 9.0 9.4 9.0 9.0 9.0 45.4
Example 3 8.3 8.2 9.5 8.0 9.3 43.0
Example 4 8.0 8.0 9.0 9.2 9.0 43.2
Example 5 9.1 9.5 9.4 9.7 9.8 47.0
Example 6 9.3 9.2 9.0 9.2 9.3 46.0
Example 7 9.4 9.0 9.1 9.6 9.0 46.1
Comparative example 1 7.0 7.2 7.5 7.8 7.0 28.9
Comparative example 2 6.7 6.7 5.0 5.5 6.1 30.0
Comparative example 3 5.2 6.0 6.5 5.0 6.3 29.0
Comparative example 4 4.8 5.5 6.0 5.5 6.2 28.0
Comparative example 5 5.0 5.8 5.9 6.0 6.6 29.3
Comparative example 6 5.0 5.5 5.8 5.8 6.0 28.1
Comparative example 7 5.1 5.7 5.8 5.7 5.8 28.1
Comparative example 8 5.0 5.2 5.2 5.5 6.0 26.9
Comparative example 9 5.5 6.0 5.5 5.2 5.6 27.8
Comparative example 10 5.6 5.6 5.4 5.4 5.5 27.5
Comparative example 11 6.3 5.0 5.5 6.0 5.7 28.5
Comparative example 12 4.8 5.2 5.8 5.5 5.7 27.0
Comparative example 13 4.7 5.5 6.4 5.4 5.3 27.3
Comparative example 14 6.0 6.3 5.3 5.2 6.0 28.8
Comparative example 15 5.6 6.1 5.8 5.7 5.3 28.5
As is clear from the experimental results in table 6, in the sensory evaluation test of the soothing baby creams prepared in examples 1 to 7 of the present invention, the spreadability score was 8.0 or more, the absorbency score was 8.0 or more, the mildness score was 9.0 or more, the moisture retention score was 8.0 or more, the overall feeling score was 9.0 or more, and the overall total score was 43.0 or more; in contrast, the soothing baby creams prepared in comparative examples 1 to 15 had a spreadability score of 7.0 or less, an absorbency score of 7.5 or less, a mildness score of 7.5 or less, a moisture retention score of 8.0 or less, a general feeling score of 7.0 or less, and a general total score of 30.0 or less in the sensory evaluation test. This fully demonstrates that the compositions of the present invention have very good nutritional and soothing effects on fragile, sensitive, and reactive skin, and can nourish and regenerate skin, resist water loss, and get skin free from dryness. The baby soothing cream prepared by adding the composition based on the wheat germ extracting solution can achieve the effect of strengthening protection from the inner skin bottom layer, and the external part is soothing and moist, so that the skin is soft, moist and healthy.
Test example 6
Skin sensitivity test (SDS model)
Comparative test of barrier repair ability of soothing baby cream provided in example 1 and soothing baby cream provided in comparative examples 1, 7, 11, 14, 30 volunteers with healthy skin and no history of allergy were selected and 3cm of each of them was divided on the inner side of the forearm of the subject2The area of size is the test area, 2% SDS is applied for 24h to break the skin barrier (closed environment), after which the residual SDS solution is removed and the corresponding area is applied twice daily with the products of the examples and the comparative example (2 mg/cm)2) The SDS treatment was applied and after 9 days of treatment the data obtained were analysed by selecting part of the comparative examples and the data of the final skin barrier integrity of example 1. Data showing the skin barrier integrity of example 1 and comparative examples 1, 7, 11, and 14 are shown in fig. 1.
According to experimental results, the soothing baby facial cream prepared in the embodiment 1 can better restore and restore the highest integrity degree of the skin, and almost approaches the skin state before injury. The composition of the invention is fully characterized in that the wheat germ extract liquid is selected as a solvent, two repairing components comprising purslane, chlorphenamine maleate, centella asiatica, olive fruit, coconut fruit, avocado and the like are added, the wheat germ extract liquid can be used for reconstructing a structure by skin to supplement natural nutrient components for the skin, such as amino acids, minerals and oligosaccharides, help the skin to rebuild the structure, stimulate skin cells, provide nutrition to the skin, promote the regeneration of the skin structure, regain the new skin, the wheat germ extract has real visible film forming effect and can form a layer of barrier on skin, the layer of membrane can protect the epidermis layer of the skin from external damage, 2 groups of repair components are added to be synergistic with the wheat germ extracting solution, and finally, the soothing moisturizing cream which can maintain the skin moisture fullness, the hydration degree balance and reduce the TEWL value can be obtained.
The applicant states that the present invention is illustrated by the above examples of the wheat germ extract-based composition, soothing baby cream and the preparation method thereof, but the present invention is not limited to the above detailed methods, i.e. it does not mean that the present invention must be implemented by the above detailed methods. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims (16)

1.一种舒缓婴童面霜,其特征在于,所述舒缓婴童面霜按重量份数计包括:基于小麦胚芽提取液的组合物60-90份、乳化剂0.5-2.5份、增稠剂0.8-2份、润肤剂3-10份、保湿剂3-10份和pH调节剂0.2-1份;1. A soothing baby face cream, characterized in that, the soothing baby face cream comprises in parts by weight: 60-90 parts of compositions based on wheat germ extract, 0.5-2.5 parts of emulsifiers, 0.8 parts of thickeners -2 parts, 3-10 parts of emollient, 3-10 parts of moisturizing agent and 0.2-1 part of pH adjuster; 所述基于小麦胚芽提取液的组合物包括:质量比为(3-8):(3-8):(50-80)的修复组分A、修复组分B和溶剂小麦胚芽提取物;The composition based on the wheat germ extract comprises: repairing component A, repairing component B and solvent wheat germ extract in a mass ratio of (3-8):(3-8):(50-80); 所述修复组分A按重量份数计包括:小麦神经酰胺0.5-2份,植物抗敏剂1-5份、德敏舒0.1-0.5份、马齿苋提取物0.1-2份、卡卡杜里提取物0.1-1份、水解小麦蛋白0.1-0.5份和植物组合物0.05-0.2份;The repairing component A includes in parts by weight: 0.5-2 parts of wheat ceramide, 1-5 parts of plant anti-allergic agent, 0.1-0.5 parts of Deminshu, 0.1-2 parts of purslane extract, Kaka Duri extract 0.1-1 part, hydrolyzed wheat protein 0.1-0.5 part and plant composition 0.05-0.2 part; 所述植物抗敏剂包括积雪草提取物、甘草提取物、母菊提取物、黄芩提取物、迷迭香提取物、茶叶提取物和虎杖提取物;The plant anti-allergic agents include Centella asiatica extract, licorice extract, Matricaria extract, Scutellaria baicalensis extract, rosemary extract, tea extract and Polygonum cuspidatum extract; 所述植物组合物包括苦橙花提取物、小苍兰提取物和玉兰花提取物;The botanical composition includes bitter orange blossom extract, freesia extract and magnolia flower extract; 所述修复组分B按重量份数计包括:西班牙橄榄油1-5份、乳木果油0.5-5份、椰果油0.5-5份、德肤修0.1-1份和生育酚0.1-1份;The repairing component B includes in parts by weight: 1-5 parts of Spanish olive oil, 0.5-5 parts of shea butter, 0.5-5 parts of coconut oil, 0.1-1 part of Defuxiu and 0.1-1 part of tocopherol 1 serving; 所述润肤剂包括GTCC和DC200/100cst;The emollients include GTCC and DC200/100cst; 所述保湿剂包括甘油、丙二醇、1,2-己二醇、甜菜碱和尿囊素。The humectants include glycerin, propylene glycol, 1,2-hexanediol, betaine and allantoin. 2.根据权利要求1所述的舒缓婴童面霜,其特征在于,所述乳化剂包括小麦乳化剂、EM-90、A-165、M68、SP-60、单甘脂、1618醇、SSE-20或SS中的任意一种或至少两种的组合。2. The soothing baby cream according to claim 1, wherein the emulsifier comprises wheat emulsifier, EM-90, A-165, M68, SP-60, monoglyceride, 1618 alcohol, SSE- Any one of 20 or SS or a combination of at least two. 3.根据权利要求1所述的舒缓婴童面霜,其特征在于,所述增稠剂包括U21和/或汉生胶。3. The soothing cream for infants and children according to claim 1, wherein the thickener comprises U21 and/or xanthan gum. 4.根据权利要求1所述的舒缓婴童面霜,其特征在于,pH调节剂包括精氨酸、氨甲基丙醇、氢氧化钾或三乙醇胺中的任意一种或至少两种的组合。4. The soothing cream for infants and children according to claim 1, wherein the pH adjusting agent comprises any one or a combination of at least two of arginine, aminomethyl propanol, potassium hydroxide or triethanolamine. 5.根据权利要求1所述的舒缓婴童面霜,其特征在于,所述舒缓婴童面霜还包括螯合剂0.01-0.1份。5 . The soothing baby face cream according to claim 1 , wherein the soothing baby face cream further comprises 0.01-0.1 part of a chelating agent. 6 . 6.根据权利要求5所述的舒缓婴童面霜,其特征在于,所述螯合剂为EDTA-2Na。6. The soothing baby face cream according to claim 5, wherein the chelating agent is EDTA-2Na. 7.根据权利要求1所述的舒缓婴童面霜,其特征在于,所述舒缓婴童面霜还包括防腐剂0.1-1份。7 . The soothing baby face cream according to claim 1 , wherein the soothing baby face cream further comprises 0.1-1 part of a preservative. 8 . 8.根据权利要求7所述的舒缓婴童面霜,其特征在于,所述防腐剂为馨酰酮。8. The soothing cream for infants and children according to claim 7, wherein the preservative is cysteinyl ketone. 9.根据权利要求1-8中任一项所述的舒缓婴童面霜的制备方法,其特征在于,所述舒缓婴童面霜的制备方法为步骤:按配方量将所述的基于小麦胚芽提取液的组合物、乳化剂、增稠剂、润肤剂、保湿剂和pH调节剂混合,制得所述舒缓婴童面霜。9. The preparation method of the soothing baby face cream according to any one of claims 1-8, wherein the preparation method of the soothing baby face cream is the step of: extracting the described wheat germ based on formula quantity The composition of liquid, emulsifier, thickener, emollient, humectant and pH adjuster are mixed to prepare the soothing baby face cream. 10.根据权利要求9所述的舒缓婴童面霜的制备方法,其特征在于,所述舒缓婴童面霜的制备方法具体包括以下步骤:10. The preparation method of the soothing baby face cream according to claim 9, wherein the preparation method of the soothing baby face cream specifically comprises the following steps: (1)将溶剂小麦胚芽提取物、增稠剂和保湿剂进行水相混合搅拌,得到水相混合液;将乳化剂、润肤剂和修复组分B进行油相混合搅拌,得到油相混合液;(1) carry out water phase mixing and stirring with solvent wheat germ extract, thickener and moisturizing agent to obtain water phase mixed solution; emulsifier, emollient and repairing component B are carried out oil phase mixing and stirring to obtain oil phase mixing liquid; (2)将步骤(1)得到的水相混合液和油相混合液混合均质,得到均质液;(2) mixing and homogeneously mixing the water-phase mixed solution and the oil-phase mixed solution obtained in step (1) to obtain a homogeneous solution; (3)向步骤(2)得到的均质液中加入pH调节剂调节pH,再加入修复组分A混合,得到所述舒缓婴童面霜。(3) adding a pH regulator to the homogeneous solution obtained in step (2) to adjust the pH, and then adding the repairing component A and mixing to obtain the soothing baby face cream. 11.根据权利要求10所述的舒缓婴童面霜的制备方法,其特征在于,步骤(1)所述水相混合搅拌的温度为80-90℃。11 . The preparation method of the soothing baby face cream according to claim 10 , wherein the temperature of mixing and stirring the water phase in step (1) is 80-90° C. 11 . 12.根据权利要求10所述的舒缓婴童面霜的制备方法,其特征在于,步骤(1)所述油相混合搅拌的温度为75-85℃。12 . The preparation method of the soothing baby face cream according to claim 10 , wherein the temperature at which the oil phase is mixed and stirred in the step (1) is 75-85° C. 12 . 13.根据权利要求10所述的舒缓婴童面霜的制备方法,其特征在于,步骤(2)所述混合均质的温度为80-82℃。13 . The preparation method of the soothing baby cream according to claim 10 , wherein the temperature of the mixing and homogenizing in step (2) is 80-82° C. 14 . 14.根据权利要求10所述的舒缓婴童面霜的制备方法,其特征在于,步骤(3)所述调节pH的温度为55-65℃。14 . The preparation method of the soothing baby cream according to claim 10 , wherein the temperature for adjusting pH in step (3) is 55-65° C. 15 . 15.根据权利要求10所述的舒缓婴童面霜的制备方法,其特征在于,步骤(3)所述加入修复组分A混合的温度为40-45℃。15 . The preparation method of the soothing baby face cream according to claim 10 , wherein the temperature at which the repairing component A is added and mixed in step (3) is 40-45° C. 16 . 16.根据权利要求10所述的舒缓婴童面霜的制备方法,其特征在于,所述舒缓婴童面霜的制备方法具体包括以下步骤:16. The preparation method of the soothing baby face cream according to claim 10, wherein the preparation method of the soothing baby face cream specifically comprises the following steps: (1)将溶剂小麦胚芽提取物、增稠剂和保湿剂在80-90℃下进行水相混合搅拌,得到水相混合液;将乳化剂、润肤剂和修复组分B在75-85℃下进行油相混合搅拌,得到油相混合液;(1) Mix and stir the aqueous phase of the solvent wheat germ extract, thickener and moisturizing agent at 80-90° C. to obtain an aqueous phase mixture; mix the emulsifier, emollient and repair component B at 75-85° C. The oil phase is mixed and stirred at ℃ to obtain an oil phase mixed solution; (2)将步骤(1)得到的水相混合液和油相混合液在80-82℃下混合均质,得到均质液;(2) mixing and homogeneously mixing the water-phase mixed solution and the oil-phase mixed solution obtained in step (1) at 80-82° C. to obtain a homogeneous solution; (3)降温至55-65℃后,向步骤(2)得到的均质液中加入pH调节剂调节pH,再降温至40-45℃后,加入修复组分A混合,得到所述舒缓婴童面霜。(3) After cooling to 55-65°C, adding a pH adjuster to the homogeneous solution obtained in step (2) to adjust pH, and then cooling to 40-45°C, adding repairing component A and mixing to obtain the soothing baby Children's Cream.
CN202010169726.3A 2020-03-12 2020-03-12 Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof Active CN111228196B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010169726.3A CN111228196B (en) 2020-03-12 2020-03-12 Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010169726.3A CN111228196B (en) 2020-03-12 2020-03-12 Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof

Publications (2)

Publication Number Publication Date
CN111228196A CN111228196A (en) 2020-06-05
CN111228196B true CN111228196B (en) 2022-05-27

Family

ID=70876888

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010169726.3A Active CN111228196B (en) 2020-03-12 2020-03-12 Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof

Country Status (1)

Country Link
CN (1) CN111228196B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494377A (en) * 2020-09-22 2021-03-16 福建省梦娇兰日用化学品有限公司 Infant repair cream containing rape-derived phytosterol and preparation method thereof
CN112386556B (en) * 2020-11-23 2022-08-26 浙江孕町母婴用品有限公司 Seven-weight relieving composition for relieving and treating eczematous dermatitis of skin sensitive people and preparation method thereof
CN113893206A (en) * 2021-10-25 2022-01-07 福建省梦娇兰日用化学品有限公司 Soothing skin cream suitable for sensitive skin for infants and preparation method thereof
CN115813834A (en) * 2021-12-09 2023-03-21 浙江孕町母婴用品有限公司 Skin-soothing and moisturizing composition containing German chamomile for infants and children and application of skin-soothing and moisturizing composition
CN114259437A (en) * 2021-12-14 2022-04-01 广州杨森药业有限公司 Plant fresh-raising dew soothing and repairing composition and preparation method and application thereof
CN114668684A (en) * 2022-04-26 2022-06-28 凡可化妆品研究开发(广州)有限公司 Composition containing bluecopper peptide and essence thereof
CN118001188B (en) * 2024-02-03 2025-01-24 北京一轻日用化学有限公司 Facial skin care composition simulating native vernix caseosa of infants and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379213A (en) * 2016-12-14 2018-08-10 天津强微特生物科技有限公司 A kind of moisture-keeping crease-shedding hand lotion
RU2663910C1 (en) * 2017-11-27 2018-08-13 Акционерное общество "Косметическое объединение "СВОБОДА" (АО "СВОБОДА") Cosmetic cream for baby skin protection against wind and weather
CN108969446A (en) * 2018-10-10 2018-12-11 福建省梦娇兰日用化学品有限公司 It is a kind of enhance skin barrier function infant prevent chapped skin care compositions and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9770480B2 (en) * 2007-08-13 2017-09-26 Shantel Medical Supply Corp. Producing a topical solution coposition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379213A (en) * 2016-12-14 2018-08-10 天津强微特生物科技有限公司 A kind of moisture-keeping crease-shedding hand lotion
RU2663910C1 (en) * 2017-11-27 2018-08-13 Акционерное общество "Косметическое объединение "СВОБОДА" (АО "СВОБОДА") Cosmetic cream for baby skin protection against wind and weather
CN108969446A (en) * 2018-10-10 2018-12-11 福建省梦娇兰日用化学品有限公司 It is a kind of enhance skin barrier function infant prevent chapped skin care compositions and preparation method thereof

Also Published As

Publication number Publication date
CN111228196A (en) 2020-06-05

Similar Documents

Publication Publication Date Title
CN111228196B (en) Composition based on wheat germ extracting solution, soothing infant cream and preparation method thereof
CN108969446B (en) Infant anti-chap skin care composition for enhancing skin barrier function and preparation method thereof
US11571373B2 (en) Skin care preparations for babies
CN105106098B (en) It is a kind of to be used to prepare composition of camel milk facial mask and preparation method thereof
CN103520051B (en) Hair and body shampoo
CN108542870B (en) Mild soothing infant face cream
CN102908304B (en) Anti-ageing wrinkle reduction toning lotion enriched with active peptide, and preparation method thereof
CN103976906B (en) A kind of plant extract liquid mixture with moisturizing antiinflammation
CN106619337A (en) Crowfoot crack resistant cream for infants and a preparing method thereof
CN113398016A (en) Skin soothing and repairing composition and cosmetic composition
CN109010115A (en) Allergy-relieving cream with anti-inflammatory effect
CN111374924A (en) Baby wheat fresh extract raw pulp hip-protecting cream and preparation method thereof
EP3976205A1 (en) Skin treatment composition and preservation system
CN110801412B (en) Sebum bionic composition, application thereof and cosmetics
CN106580732A (en) Emulsion and preparation method thereof
AU2025259962A1 (en) Certified natural skin care products
CN115501158A (en) A cosmetic preparation containing radix astragali extract and its preparation method
CN106137805A (en) A kind of pharmaceutical composition for skin moisture-keeping and preparation method thereof
CN111228154A (en) Fresh wheat extract protoplasm milk for infants and preparation method thereof
CN111297789A (en) Antiallergic cosmetic composition for pregnant and lying-in women and preparation method and application thereof
EP3509706B1 (en) Method for increasing lipolysis using a composition comprising bioactive nelumbo nucifera (lotus) extract
CN112220705B (en) Moisturizing cosmetic with pure natural components
CN116035982A (en) Marine biological activity repair cream
CN114259443A (en) Skin lotion and preparation method thereof
JP2005298503A (en) Moisture-retention cosmetic composition containing pulverized polygonatum offcinale

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20230914

Address after: 511300 No. 2, environmental protection Third Road, Xintang Town, Zengcheng District, Guangzhou City, Guangdong Province (office building B1)

Patentee after: Guangzhou natural state Biotechnology Co.,Ltd.

Address before: 511340 Room 101, No. 1, Yonghe Yushan international Rongjing 1st Road, Xintang, Zengcheng, Guangzhou, Guangdong

Patentee before: GUANGDONG KANGAROO MOMMY BIOTECHNOLOGY CO.,LTD.

CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: No.2, environmental protection Third Road, Xintang Town, Zengcheng District, Guangzhou City, Guangdong Province (office building B1)

Patentee after: Guangdong Kangaroo Mama Group Co.,Ltd.

Country or region after: China

Address before: No.2, environmental protection Third Road, Xintang Town, Zengcheng District, Guangzhou City, Guangdong Province (office building B1)

Patentee before: Guangzhou natural state Biotechnology Co.,Ltd.

Country or region before: China