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CN111228196A - A kind of composition based on wheat germ extract, soothing baby face cream and preparation method thereof - Google Patents

A kind of composition based on wheat germ extract, soothing baby face cream and preparation method thereof Download PDF

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CN111228196A
CN111228196A CN202010169726.3A CN202010169726A CN111228196A CN 111228196 A CN111228196 A CN 111228196A CN 202010169726 A CN202010169726 A CN 202010169726A CN 111228196 A CN111228196 A CN 111228196A
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CN111228196B (en
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陈伟阶
孙永
潘美红
徐小建
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Guangdong Kangaroo Mama Group Co.,Ltd.
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Guangdong Kangaroo Mommy Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

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Abstract

The invention provides a composition based on a wheat germ extracting solution, a soothing baby cream and a preparation method thereof. The composition comprises: a repairing component A, a repairing component B and a solvent wheat germ extract; the repair component A comprises wheat ceramide, plant anti-allergy agent, chlorphenamine maleate, purslane extract, kakakadu extract, hydrolyzed wheat protein and plant composition; the repair component B comprises olive oil, shea butter, coconut oil, Defu and tocopherol. The composition has good nutrition and soothing effects on fragile, sensitive and highly reactive skin, and has effects of nourishing and regenerating skin, resisting water loss, and removing dryness of skin. The baby soothing cream prepared by adding the composition based on the wheat germ extracting solution can achieve the effect of strengthening protection from the inner skin bottom layer, and the external part is soothing and moist, so that the skin is soft, moist and healthy.

Description

一种基于小麦胚芽提取液的组合物、舒缓婴童面霜及其制备 方法A kind of composition based on wheat germ extract, soothing baby face cream and preparation thereof method

技术领域technical field

本发明属于化妆品技术领域,具体涉及一种基于小麦胚芽提取液的组合物、舒缓婴童面霜及其制备方法。The invention belongs to the technical field of cosmetics, and in particular relates to a composition based on a wheat germ extract, a soothing baby face cream and a preparation method thereof.

背景技术Background technique

婴幼儿肌肤在结构、成分、功能上都与成分有明显的不同,其中就皮肤基本结构来说,婴幼儿角质层和表皮厚度均比成人薄20-30%,角质细胞中更加小且其脂质含量在与母体分离后迅速的下降,所以药物分子经婴幼儿皮肤渗透将比成人更加直接、容易,其系统吸收也比成人多,因此,对有害物质和过敏物质反应也更加强烈,则婴儿外用功效性添加剂要非常小心,最好使用专门的护肤品,避免香精酒精、色素、等刺激性物质的危害。The skin of infants and young children is significantly different from the composition in terms of structure, composition and function. In terms of the basic structure of the skin, the thickness of the stratum corneum and epidermis of infants and young children is 20-30% thinner than that of adults. The substance content of the drug drops rapidly after being separated from the mother, so the penetration of drug molecules through the skin of infants and young children will be more direct and easier than that of adults, and its systemic absorption will be more than that of adults. Therefore, the reaction to harmful substances and allergic substances is also stronger. Be very careful with external use of functional additives. It is best to use special skin care products to avoid the harm of flavor alcohol, pigments, and other irritating substances.

婴幼儿的比成人吸收水分快,能够维持比成人高的水分含量,但是其肌肤屏障功能并未发育完全,所以丢失水分速度也更快,经皮失水率(TEWL)即角质层皮肤渗透性和皮肤水合度的数据,能分析出皮肤屏障功能的强弱,有数据表明婴幼儿的TEWL和成人有明显差异。Infants and young children absorb water faster than adults and can maintain a higher water content than adults, but their skin barrier function is not fully developed, so they lose water faster. Transepidermal water loss rate (TEWL) And skin hydration data, can analyze the strength of skin barrier function, data show that infants and young children's TEWL and adults are significantly different.

目前市面上婴幼儿保湿产品以简单天然来源为主要宣称,功效多是保湿润肤,在不能加强肌肤屏障的基础上,大多是通过加强皮肤表层的保湿度或者添加舒缓原料,只能降低肌肤的受损炎症或者让皮肤表层暂时水润,并不能从根本上解决婴幼儿肌肤屏障不完全,脂质含量低的情况。At present, infant moisturizing products on the market are mainly claimed to be of simple natural origin. Most of them are moisturizing and moisturizing. On the basis of not strengthening the skin barrier, most of them can only reduce the moisturizing degree of the skin surface or add soothing ingredients. Damaged inflammation or temporarily moisturizing the skin surface cannot fundamentally solve the situation of infants and young children with incomplete skin barrier and low lipid content.

CN109925245A公开了一种甜睡婴儿润肤露及其制备方法,其组分中包含辛酸/癸酸甘油三酯3~5份、牛油果树果脂油3~5份、角鲨烷2~5份、小麦胚芽油0.1~0.3份、透明质酸钠0.01~0.3份、精氨酸0.01~0.3份、小麦谷蛋白0.1~1份、母菊提取物0.1~1份、聚二甲基硅氧烷1~3份、乳化剂2~11份、多元醇类保湿剂1~6份,还可以包括生育酚乙酸酯、增稠剂等。本发明的配方含有多种保湿和滋润作用的植物油脂和植物提取液易于人体吸收,对皮肤起到很好保湿。CN109925245A discloses a sweet sleeping baby lotion and a preparation method thereof. The components include 3-5 parts of caprylic/capric triglyceride, 3-5 parts of shea butter, 2-5 parts of squalane, 0.1-0.3 part of wheat germ oil, 0.01-0.3 part of sodium hyaluronate, 0.01-0.3 part of arginine, 0.1-1 part of wheat gluten, 0.1-1 part of marigold extract, 1 part of polydimethylsiloxane ~3 parts, 2-11 parts of emulsifier, 1-6 parts of polyol-based moisturizing agent, and may also include tocopherol acetate, thickener and the like. The formula of the invention contains a variety of plant oils and plant extracts with moisturizing and moisturizing functions, which are easy to be absorbed by the human body, and have a good moisturizing effect on the skin.

CN109793688A公开一种保湿抗污染的婴幼儿清洁组合物及其制备方法,包含以下按重量百分比的组分组成:羧甲基脱乙酰壳多糖2~5%,透明质酸钠0.1~0.3%,小麦醇溶蛋白0.2~0.5%,乳木果油0.2~0.5%,迷迭香叶提取物1~4%,山茶花提取物7~9%,月桂醇醚硫酸铵7~10%,蓖麻醇酸酰胺丙基三甲基氯化铵0.3~0.5%等物质,本发明可有效地去除皮脂、汗渍、外部尘埃而不使皮肤干燥,同时能够保湿、舒缓肌肤的功效。CN109793688A discloses a moisturizing and anti-pollution cleaning composition for infants and young children and a preparation method thereof, comprising the following components by weight percentage: 2-5% of carboxymethyl chitosan, 0.1-0.3% of sodium hyaluronate, wheat Prolamin 0.2-0.5%, Shea Butter 0.2-0.5%, Rosemary Leaf Extract 1-4%, Camellia Extract 7-9%, Ammonium Laureth Sulfate 7-10%, Ricinoleic Acid Amidopropyl trimethyl ammonium chloride 0.3-0.5% and other substances, the present invention can effectively remove sebum, perspiration, external dust without drying the skin, and at the same time can moisturise and soothe the skin.

因此,开发一种能够能达到从婴幼儿内部肌肤底层加强防护作用,外部舒缓滋润,令肌肤柔润健康的护肤品是目前研究的重点。Therefore, the current research focus is to develop a skin care product that can strengthen the protective effect from the bottom layer of the inner skin of infants and young children, soothe and moisturize the outside, and make the skin soft and healthy.

发明内容SUMMARY OF THE INVENTION

本发明的目的在于提供一种基于小麦胚芽提取液的组合物、舒缓婴童面霜及其制备方法,所述组合物对于脆弱、敏感、反应性强的皮肤,具有很好的营养和舒缓功效,可令肌肤滋养和再生、抵御失水,使皮肤摆脱干燥等功效。添加本发明所述基于小麦胚芽提取液的组合物制得的舒缓婴童面霜能达到从内部肌肤底层加强防护作用,外部舒缓滋润,令肌肤柔润健康。The object of the present invention is to provide a wheat germ extract-based composition, a soothing cream for infants and a preparation method thereof, which have good nutritional and soothing effects on fragile, sensitive and highly reactive skin, Nourishes and regenerates the skin, resists dehydration and frees the skin from dryness. The soothing baby face cream prepared by adding the composition based on the wheat germ extract of the present invention can achieve a protective effect from the inner bottom layer of the skin, external soothing and moisturizing, and make the skin soft and healthy.

为达此目的,本发明采用以下技术方案:For this purpose, the present invention adopts the following technical solutions:

第一方面,本发明提供了一种基于小麦胚芽提取液的组合物,所述组合物包括:修复组分A、修复组分B和溶剂小麦胚芽提取物;In a first aspect, the present invention provides a composition based on a wheat germ extract, the composition comprising: a repair component A, a repair component B and a solvent wheat germ extract;

所述修复组分A包括小麦神经酰胺、植物抗敏剂、德敏舒、马齿苋提取物、卡卡杜里提取物、水解小麦蛋白和植物组合物;The repairing component A includes wheat ceramide, plant anti-allergic agent, Deminshu, purslane extract, kakaduli extract, hydrolyzed wheat protein and plant composition;

所述修复组分B包括西班牙橄榄油、乳木果油、椰果油、德肤修和生育酚。The repairing component B includes Spanish olive oil, shea butter, coconut oil, Defuxiu and tocopherol.

在本发明中,所述溶剂小麦胚芽提取物中所含小麦来源成分具有蛋白质和氨基酸、多种矿物质、寡聚和多聚糖、酚类复合物、生育酚等,具有结构重建和再生功能,舒缓和保护的作用。其所含天然维E、谷胱甘肽是出色的抗氧化剂,抗氧化机理是它能集中在不饱和脂肪酸过氧自由基周围,是一种有效的过氧自由基清除剂,阻止细胞中的过氧化反应。同时,维生素E能保持这些组织的联系,抑制脂质过氧化,能够使婴幼儿皮肤保持弹性,更加平滑、柔嫩、润泽,富有弹力。而且,基于婴幼儿皮肤脆弱、敏感、反应性强的特点,小麦胚芽能给肌肤补充营养,消除刺激。小麦胚芽大分子蛋白水解后的产物,能够为肌肤提供更多的营养成份,还能够迅速为肌肤表面形成透明的弹性生物膜,持久保湿并调理肌肤,令其光滑、细腻、柔韧。In the present invention, the wheat-derived components contained in the solvent wheat germ extract have proteins and amino acids, various minerals, oligomers and polysaccharides, phenolic complexes, tocopherols, etc., and have structural reconstruction and regeneration functions , soothing and protective effect. The natural vitamin E and glutathione contained in it are excellent antioxidants. The antioxidant mechanism is that it can concentrate around the peroxy radicals of unsaturated fatty acids. It is an effective peroxy radical scavenger, preventing the peroxidation reaction. At the same time, vitamin E can maintain the connection of these tissues, inhibit lipid peroxidation, and can keep the skin of infants and young children elastic, smoother, softer, moister, and elastic. Moreover, based on the characteristics of infants and young children's fragile, sensitive and highly reactive skin, wheat germ can nourish the skin and eliminate irritation. The proteolytic product of wheat germ macromolecules can provide more nutrients to the skin, and can quickly form a transparent elastic biofilm on the skin surface, lasting moisturizing and conditioning the skin, making it smooth, delicate and flexible.

本发明中,所述修复组分A为水相修复成分,其包括小麦神经酰胺、植物抗敏剂、德敏舒、马齿苋提取物、卡卡杜里提取物、水解小麦蛋白和植物组合物,各组分相互配合,具有协同增效的作用,可促进人体对小麦胚芽提取物中有效物质的吸收,还可以进一步提高滋润保湿效果,长期使用可增强肌肤防护屏障,更好的抵抗外界侵害。其中,小麦胚芽提取物中含有植物性神经酰胺,能够高效保湿,促进新生,其功效能够高效保湿以及对促进其他营养物质渗透,对皮肤有着较高的保湿效果。其中,德敏舒是德国德之馨的一款舒敏产品其商品名称为

Figure BDA0002408756770000031
德敏舒143535,含有丁二醇、1,2-戊二醇、羟苯基丙基酰胺苯甲酸,它能有效抑制组胺引起的皮肤红斑、瘙痒及过敏反应,在可以抑制肥大细胞的组胺释放时,抑制过敏反应,达到舒缓肌肤,及时止痒祛红。其中,马齿苋提取物防干燥老化、增加皮肤舒适度以及清除自由基,改善皮肤舒适感的综合性能。其中,卡卡杜里提取物天然维C含量是橙子的100倍,具有出色的保湿和抗氧化功效,同时富含维生素E、叶酸、锌、镁、钙等多种有价值的植物营养素。其中,水解小麦蛋白主要氨基酸麦醇溶蛋白(gliadin)和麦谷的蛋白,并含有丰富的胱氨酸,具有保湿、抗氧化作用及柔软细化皮肤。In the present invention, the repair component A is an aqueous repair component, which includes wheat ceramide, plant anti-allergic agent, Deminshu, purslane extract, kakaduli extract, hydrolyzed wheat protein and plant combination Each component cooperates with each other and has a synergistic effect, which can promote the human body to absorb the effective substances in the wheat germ extract, and can further improve the moisturizing effect. Long-term use can strengthen the skin's protective barrier and better resist the outside world. infringe. Among them, wheat germ extract contains phytoceramides, which can effectively moisturize and promote regeneration. Its effect can effectively moisturize and promote the penetration of other nutrients, and has a high moisturizing effect on the skin. Among them, Deminshu is a Shumin product of German Dezhixin, and its trade name is
Figure BDA0002408756770000031
Deminshu 143535, containing butanediol, 1,2-pentanediol, and hydroxyphenylpropyl amide benzoic acid, can effectively inhibit skin erythema, itching and allergic reactions caused by histamine. When the amine is released, it inhibits allergic reactions, soothes the skin, and relieves itching and redness in time. Among them, purslane extract has the comprehensive properties of preventing drying and aging, increasing skin comfort, scavenging free radicals, and improving skin comfort. Among them, the natural vitamin C content of Kakaduli extract is 100 times that of oranges, which has excellent moisturizing and antioxidant effects, and is rich in vitamin E, folic acid, zinc, magnesium, calcium and other valuable phytonutrients. Among them, the main amino acids of hydrolyzed wheat protein are gliadin and gluten protein, and it is rich in cystine, which has moisturizing, anti-oxidative effects, and softens and refines the skin.

在本发明中,所述修复组分B为油相修复成分,其包括西班牙橄榄油、乳木果油、椰果油、德肤修和生育酚,各组分相互配合,具有协同增效的作用,可促进人体对小麦胚芽提取物中有效物质的吸收,还可以进一步提高滋润保湿效果,长期使用可增强肌肤防护屏障,更好的抵抗外界侵害。其中,西班牙橄榄油富含不饱和脂肪酸以及各种维生素,橄榄油营养成分中人体不能合成的亚麻酸和亚油酸的比值和母乳相似,因此极易被婴幼儿皮肤吸收。其中,乳木果油含有大量的不皂化脂质,可为肌肤提供丰富的维他命A、D、E、F等,给肌肤补充足够的营养成分,更能够有效帮助细胞更生促进微血管循环,具有很好的的滋润补水功能,其中,德肤修是德之馨的一款原料,商品名为SymRelief德肤修153884,包含己基癸醇,十六烷基氢脯氨酸棕榈酰胺,硬脂酸,油菜甾醇类,a-红没药醇协同复配接近皮脂保护层的主要成份,己基癸醇、十六烷基羟脯氨酸棕榈酰胺、硬脂酸、油菜甾醇构成类似天然皮肤神经酰胺的皮肤角质层双分子模型,迅速重组类似皮肤自身的脂质双分子层,加上天然抗炎成分a-红没药醇,可快速修复并重建皮肤自我保护屏障功能。In the present invention, the repair component B is an oil phase repair component, which includes Spanish olive oil, shea butter, coconut oil, Defuxiu and tocopherol. It can promote the absorption of the effective substances in the wheat germ extract by the human body, and can further improve the moisturizing and moisturizing effect. Long-term use can strengthen the skin's protective barrier and better resist external aggressions. Among them, Spanish olive oil is rich in unsaturated fatty acids and various vitamins. The ratio of linolenic acid and linoleic acid that cannot be synthesized by the human body in olive oil nutrients is similar to that of breast milk, so it is easily absorbed by the skin of infants and young children. Among them, shea butter contains a large amount of unsaponifiable lipids, which can provide the skin with rich vitamins A, D, E, F, etc., supplement the skin with sufficient nutrients, and can effectively help cell regeneration and promote microvascular circulation. Good moisturizing and hydrating function, among them, Defuxiu is a raw material of Dezhixin, the trade name is SymRelief Defuxiu 153884, which contains hexyldecanol, cetylhydroproline palmitamide, stearic acid, Campesterols, α-bisabolol are synergistically compounded to be close to the main components of the sebum protective layer, hexyldecanol, cetyl hydroxyproline palmitamide, stearic acid, and campesterol form a skin similar to natural skin ceramides The stratum corneum bimolecular model rapidly reorganizes the lipid bilayer similar to the skin itself, plus a-bisabolol, a natural anti-inflammatory ingredient, which can quickly repair and rebuild the skin's self-protective barrier function.

优选地,所述修复组分A、修复组分B和溶剂小麦胚芽提取物的质量比为(3-8):(3-8):(50-80)。在此配比范围内,能够进一步提高所述组合物的舒缓功效,和令肌肤滋养和再生、抵御失水的能力,使皮肤从根本上摆脱干燥等功效。Preferably, the mass ratio of the repair component A, the repair component B and the solvent wheat germ extract is (3-8):(3-8):(50-80). Within this ratio range, the soothing effect of the composition can be further improved, and the skin's ability to nourish and regenerate, resist dehydration, and make the skin fundamentally free from dryness and other effects.

其中,“3-8”例如可以是3、3.5、4、4.5、5、5.5、6、6.5、7、7.5、8等。Wherein, "3-8" can be, for example, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, and the like.

其中,“50-80”例如可以是50、55、60、65、70、75、80、85、90等。Wherein, "50-80" can be, for example, 50, 55, 60, 65, 70, 75, 80, 85, 90 and so on.

优选地,所述修复组分A按重量份数计包括:小麦神经酰胺0.5-2份,植物抗敏剂1-5份、德敏舒0.1-0.5份、马齿苋提取物0.1-2份、卡卡杜里提取物0.1-1份、水解小麦蛋白0.1-0.5份和植物组合物0.05-0.2份。Preferably, the repairing component A includes in parts by weight: 0.5-2 parts of wheat ceramide, 1-5 parts of plant anti-allergic agent, 0.1-0.5 part of Deminshu, and 0.1-2 parts of purslane extract , Kakaduli extract 0.1-1 part, hydrolyzed wheat protein 0.1-0.5 part and plant composition 0.05-0.2 part.

本发明所述修复组分A中,小麦神经酰胺含量为0.5-2份,例如可以是0.5份、0.6份、0.7份、0.8份、0.9份、1份、1.2份、1.4份、1.6份、1.8份、2份等。In the repair component A of the present invention, the content of wheat ceramide is 0.5-2 parts, for example, it can be 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 part, 1.4 part, 1.6 part, 1.8 servings, 2 servings, etc.

本发明所述修复组分A中,植物抗敏剂含量为1-5份,例如可以是1份、1.5份、2份、2.5份、3份、3.5份、4份、4.5份、5份等。In the repair component A of the present invention, the content of the plant anti-sensitizer is 1-5 parts, for example, it can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts Wait.

本发明所述修复组分A中,德敏舒含量为0.1-0.5份,例如可以是0.1份、0.15份、0.2份、0.25份、0.3份、0.35份、0.4份、0.45份、0.5份等。In the repair component A of the present invention, the content of Deminshu is 0.1-0.5 part, for example, it can be 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, etc. .

本发明所述修复组分A中,马齿苋提取物含量为0.1-2份,例如可以是0.1份、0.2份、0.3份、0.4份、0.5份、0.6份、0.7份、0.8份、0.9份、1份、1.2份、1.4份、1.6份、1.8份、2份等。In the repair component A of the present invention, the content of purslane extract is 0.1-2 parts, for example, it can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part servings, 1 serving, 1.2 servings, 1.4 servings, 1.6 servings, 1.8 servings, 2 servings, etc.

本发明所述修复组分A中,卡卡杜里提取物含量为0.1-1份,例如可以是0.1份、0.2份、0.3份、0.4份、0.5份、0.6份、0.7份、0.8份、0.9份、1份等。In the repair component A of the present invention, the content of kakadu extract is 0.1-1 part, for example, it can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 servings, 1 serving, etc.

本发明所述修复组分A中,水解小麦蛋白含量为0.1-0.5份,例如可以是0.1份、0.15份、0.2份、0.25份、0.3份、0.35份、0.4份、0.45份、0.5份等。In the repair component A of the present invention, the content of hydrolyzed wheat protein is 0.1-0.5 part, for example, it can be 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, etc. .

本发明所述修复组分A中,植物组合物含量为0.05-0.2份,例如可以是0.05份、0.07份、0.09份、0.1份、0.12份、0.14份、0.18份、0.2份等。In the repair component A of the present invention, the content of the plant composition is 0.05-0.2 part, for example, it can be 0.05 part, 0.07 part, 0.09 part, 0.1 part, 0.12 part, 0.14 part, 0.18 part, 0.2 part, etc.

优选地,所述植物抗敏剂包括积雪草提取物、甘草提取物、母菊提取物、黄芩提取物、迷迭香提取物、茶叶提取物和虎杖提取物。其中,植物抗敏剂是韩国百鸥思特的一款植物来源的舒敏产品,含有积雪草提取物、甘草提取物、母菊提取物、黄芩提取物、迷迭香提取物、茶叶提取物、虎杖提取物,不仅能够修复因异位性皮炎引起的皮肤受损,对于敏感肌肤的抗敏、防敏以及激素依赖性皮炎的治疗都能起到很好的效果。Preferably, the plant anti-allergic agent includes Centella asiatica extract, licorice extract, Matricaria extract, Scutellaria baicalensis extract, rosemary extract, tea extract and Polygonum cuspidatum extract. Among them, the plant anti-allergic agent is a plant-derived soothing product from South Korea's Biost It can not only repair the skin damage caused by atopic dermatitis, but also have a good effect on the anti-allergy, anti-allergy and hormone-dependent dermatitis treatment of sensitive skin.

优选地,所述植物组合物包括苦橙花提取物、小苍兰提取物和玉兰花提取物。其中,植物组合物是广州合淼公司一款皮肤屏障改善剂,含有苦橙花提取物、小苍兰提取物、玉兰花提取物,能够增强细胞活性,改善肌肤微生态平衡。Preferably, the botanical composition comprises petitgrain extract, freesia extract and magnolia flower extract. Among them, the plant composition is a skin barrier improver of Guangzhou Hemiao Company, which contains bitter orange blossom extract, freesia extract, and magnolia flower extract, which can enhance cell activity and improve skin microecological balance.

优选地,所述修复组分B按重量份数计包括:西班牙橄榄油1-5份、乳木果油0.5-5份、椰果油0.5-5份、德肤修0.1-1份和生育酚0.1-1份。Preferably, the repairing component B comprises in parts by weight: 1-5 parts of Spanish olive oil, 0.5-5 parts of shea butter, 0.5-5 parts of coconut oil, 0.1-1 parts of Defuxiu and fertility Phenol 0.1-1 part.

本发明所述修复组分B中,西班牙橄榄油含量为1-5份,例如可以是1份、1.5份、2份、2.5份、3份、3.5份、4份、4.5份、5份等。In the repair component B of the present invention, the content of Spanish olive oil is 1-5 parts, such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc. .

本发明所述修复组分B中,乳木果油含量为0.5-5份,例如可以是0.5份、1份、1.5份、2份、2.5份、3份、3.5份、4份、4.5份、5份等。In the repair component B of the present invention, the content of shea butter is 0.5-5 parts, for example, it can be 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts , 5 copies, etc.

本发明所述修复组分B中,椰果油含量为0.5-5份,例如可以是0.5份、1份、1.5份、2份、2.5份、3份、3.5份、4份、4.5份、5份等。In the repairing component B of the present invention, the content of coconut oil is 0.5-5 parts, such as 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 servings etc.

本发明所述修复组分B中,德肤修含量为0.1-1份,例如可以是0.1份、0.2份、0.3份、0.4份、0.5份、0.6份、0.7份、0.8份、0.9份、1份等。In the repair component B of the present invention, the content of Defuxiu is 0.1-1 part, for example, it can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 serving etc.

本发明所述修复组分B中,生育酚含量为0.1-1份,例如可以是0.1份、0.2份、0.3份、0.4份、0.5份、0.6份、0.7份、0.8份、0.9份等。In the repair component B of the present invention, the content of tocopherol is 0.1-1 part, such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, etc.

第二方面,本发明提供了一种舒缓婴童面霜,所述舒缓婴童面霜按重量份数计包括:第一方面所述的基于小麦胚芽提取液的组合物60-90份、乳化剂0.5-2.5份、增稠剂0.8-2份、润肤剂3-10份、保湿剂3-10份、pH调节剂0.2-1份。In a second aspect, the present invention provides a soothing baby face cream, which includes, in parts by weight: 60-90 parts of the wheat germ extract-based composition described in the first aspect, 0.5 parts of an emulsifier -2.5 parts, thickener 0.8-2 parts, emollient 3-10 parts, moisturizing agent 3-10 parts, pH adjuster 0.2-1 part.

本发明舒缓婴童面霜中,所述基于小麦胚芽提取液的组合物的含量为60-90份,例如可以是60份、62份、64份、66份、68份、70份、72份、74份、76份、78份、80份、82份、84份、86份、88份、90份等。In the soothing baby face cream of the present invention, the content of the composition based on the wheat germ extract is 60-90 parts, such as 60 parts, 62 parts, 64 parts, 66 parts, 68 parts, 70 parts, 72 parts, 74, 76, 78, 80, 82, 84, 86, 88, 90, etc.

本发明舒缓婴童面霜中,所述乳化剂的含量为0.5-2.5份,例如可以是0.5份、0.6份、0.7份、0.8份、0.9份、1份、1.2份、1.4份、1.6份、1.8份、2份、2.2份、2.5份等。In the soothing baby face cream of the present invention, the content of the emulsifier is 0.5-2.5 parts, such as 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 part, 1.4 part, 1.6 part, 1.8 servings, 2 servings, 2.2 servings, 2.5 servings, etc.

本发明舒缓婴童面霜中,所述增稠剂的含量为0.8-2份,例如可以是0.8份、0.9份、1份、1.2份、1.4份、1.6份、1.8份、2份等。In the soothing baby face cream of the present invention, the content of the thickener is 0.8-2 parts, such as 0.8 parts, 0.9 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.

本发明舒缓婴童面霜中,所述润肤剂的含量为3-10份,例如可以是3份、4份、5份、6份、7份、8份、9份、10份等。In the soothing baby face cream of the present invention, the content of the emollient is 3-10 parts, such as 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc.

本发明舒缓婴童面霜中,所述pH调节剂的含量为0.2-1份,例如可以是0.2份、0.3份、0.4份、0.5份、0.6份、0.7份、0.8份、0.9份、1份等。In the soothing baby face cream of the present invention, the content of the pH adjuster is 0.2-1 part, for example, it can be 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part Wait.

优选地,所述乳化剂包括小麦乳化剂、EM-90、MON-L、A-165、M68、SP-60、单甘脂、1618醇、SSE-20或SS中的任意一种或至少两种的组合。Preferably, the emulsifier comprises any one or at least two of wheat emulsifier, EM-90, MON-L, A-165, M68, SP-60, monoglyceride, 1618 alcohol, SSE-20 or SS combination of species.

优选地,所述增稠剂包括卡波940、U21、2020、EG或汉生胶中的任意一种或至少两种的组合。Preferably, the thickener comprises any one or a combination of at least two of Carbo 940, U21, 2020, EG or Xanthan gum.

优选地,所述润肤剂包括2-EHP、GTCC、DC200/100cst或DC200/350cst中的任意一种或至少两种的组合。Preferably, the emollient comprises any one or a combination of at least two of 2-EHP, GTCC, DC200/100cst or DC200/350cst.

优选地,所述保湿剂包括甘油、丙二醇、丁二醇、己二醇、甜菜碱或戊二醇中的任意一种或至少两种的组合。Preferably, the humectant comprises any one or a combination of at least two of glycerol, propylene glycol, butylene glycol, hexylene glycol, betaine or pentylene glycol.

优选地,pH调节剂包括精氨酸、氨甲基丙醇、氢氧化钾或三乙醇胺中的任意一种或至少两种的组合。Preferably, the pH adjusting agent includes any one or a combination of at least two of arginine, aminomethyl propanol, potassium hydroxide or triethanolamine.

优选地,所述舒缓婴童面霜还包括螯合剂0.01-0.1份,例如可以是0.01份、0.02份、0.03份、0.04份、0.05份、0.06份、0.07份、0.08份、0.09份、0.1份等。Preferably, the soothing baby face cream further includes 0.01-0.1 part of a chelating agent, such as 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part, 0.1 part Wait.

优选地,所述螯合剂为EDTA-2Na。Preferably, the chelating agent is EDTA-2Na.

优选地,所述舒缓婴童面霜还包括防腐剂0.1-1份,例如可以是0.1份、0.2份、0.3份、0.4份、0.5份、0.6份、0.7份、0.8份、0.9份、1份等。Preferably, the soothing baby cream further includes 0.1-1 part of preservative, for example, it can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part Wait.

优选地,所述防腐剂为馨酰酮。Preferably, the preservative is cyanoyl ketone.

第三方面,本发明提供一种如第二方面所述的舒缓婴童面霜的制备方法,所述舒缓婴童面霜的制备方法为步骤:按配方量将如第一方面所述的基于小麦胚芽提取液的组合物、乳化剂、增稠剂、润肤剂、保湿剂和pH调节剂混合,制得所述舒缓婴童面霜。In a third aspect, the present invention provides a preparation method of the soothing baby face cream according to the second aspect. The composition of the extract, the emulsifier, the thickener, the emollient, the moisturizing agent and the pH adjusting agent are mixed to prepare the soothing baby face cream.

优选地,所述舒缓婴童面霜的制备方法具体包括以下步骤:Preferably, the preparation method of the soothing baby face cream specifically comprises the following steps:

(1)将溶剂小麦胚芽提取物、增稠剂和保湿剂进行水相混合搅拌,得到水相混合液;将乳化剂、润肤剂和修复组分B进行油相混合搅拌,得到油相混合液;(1) carry out water phase mixing and stirring with solvent wheat germ extract, thickener and moisturizing agent to obtain water phase mixed solution; emulsifier, emollient and repairing component B are carried out oil phase mixing and stirring to obtain oil phase mixing liquid;

(2)将步骤(1)得到的水相混合液和油相混合液混合均质,得到均质液;(2) mixing and homogeneously mixing the water-phase mixed solution and the oil-phase mixed solution obtained in step (1) to obtain a homogeneous solution;

(3)向步骤(2)得到的均质液中加入pH调节剂调节pH,再加入修复组分A混合,得到所述舒缓婴童面霜。(3) adding a pH adjuster to the homogeneous solution obtained in step (2) to adjust pH, and then adding repairing component A and mixing to obtain the soothing baby face cream.

优选地,步骤(1)所述水相混合搅拌的温度为80-90℃,例如可以是80℃、81℃、82℃、83℃、84℃、85℃、86℃、87℃、88℃、89℃、90℃等。Preferably, the temperature at which the water phase is mixed and stirred in step (1) is 80-90°C, for example, 80°C, 81°C, 82°C, 83°C, 84°C, 85°C, 86°C, 87°C, 88°C , 89℃, 90℃, etc.

优选地,步骤(1)所述油相混合搅拌的温度为75-85℃,例如可以是75℃、76℃、77℃、78℃、79℃、80℃、81℃、82℃、83℃、84℃、85℃等。Preferably, the temperature at which the oil phase is mixed and stirred in step (1) is 75-85°C, for example, it can be 75°C, 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C , 84℃, 85℃, etc.

优选地,步骤(2)所述混合均质的温度为80-82℃,例如可以是80℃、81℃、82℃等。Preferably, the temperature of the mixing and homogenizing in step (2) is 80-82°C, for example, 80°C, 81°C, 82°C, and the like.

优选地,步骤(3)所述调节pH的温度为55-65℃,例如可以是55℃、56℃、57℃、58℃、59℃、60℃、61℃、62℃、63℃、64℃、65℃等。Preferably, the temperature for adjusting pH in step (3) is 55-65°C, such as 55°C, 56°C, 57°C, 58°C, 59°C, 60°C, 61°C, 62°C, 63°C, 64°C °C, 65 °C, etc.

优选地,步骤(3)所述加入修复组分A混合的温度为40-45℃,例如可以是40℃、41℃、42℃、43℃、44℃、45℃等。Preferably, the temperature at which the repairing component A is added and mixed in step (3) is 40-45°C, such as 40°C, 41°C, 42°C, 43°C, 44°C, 45°C, and the like.

优选地,所述舒缓婴童面霜的制备方法具体包括以下步骤:Preferably, the preparation method of the soothing baby face cream specifically comprises the following steps:

(1)将溶剂小麦胚芽提取物、增稠剂和保湿剂在80-90℃下进行水相混合搅拌,得到水相混合液;将乳化剂、润肤剂和修复组分B在75-85℃下进行油相混合搅拌,得到油相混合液;(1) Mix and stir the aqueous phase of the solvent wheat germ extract, thickener and moisturizing agent at 80-90° C. to obtain an aqueous phase mixture; mix the emulsifier, emollient and repair component B at 75-85° C. The oil phase is mixed and stirred at ℃ to obtain an oil phase mixed solution;

(2)将步骤(1)得到的水相混合液和油相混合液在80-82℃下混合均质,得到均质液;(2) mixing and homogeneously mixing the water-phase mixed solution and the oil-phase mixed solution obtained in step (1) at 80-82° C. to obtain a homogeneous solution;

(3)降温至55-65℃后,向步骤(2)得到的均质液中加入pH调节剂调节pH,再降温至40-45℃后,加入修复组分A混合,得到所述舒缓婴童面霜。(3) After cooling to 55-65°C, adding a pH adjuster to the homogeneous solution obtained in step (2) to adjust pH, and then cooling to 40-45°C, adding repairing component A and mixing to obtain the soothing baby Children's Cream.

相对于现有技术,本发明具有以下有益效果:Compared with the prior art, the present invention has the following beneficial effects:

(1)本发明所述组合物各组分相互配合,具有协同增效的作用,对于脆弱、敏感、反应性强的皮肤,具有很好的营养和舒缓功效,可令肌肤滋养和再生、抵御失水,使皮肤摆脱干燥等功效。添加本发明所述基于小麦胚芽提取液的组合物制得的舒缓婴童面霜能达到从内部肌肤底层加强防护作用,外部舒缓滋润,令肌肤柔润健康。(1) The components of the composition of the present invention cooperate with each other, and have a synergistic effect. For fragile, sensitive and highly reactive skin, it has good nutrition and soothing effects, which can nourish and regenerate the skin, resist the Dehydration, make the skin get rid of dryness and other effects. The soothing baby face cream prepared by adding the composition based on the wheat germ extract of the present invention can achieve a protective effect from the inner bottom layer of the skin, external soothing and moisturizing, and make the skin soft and healthy.

(2)本发明的保湿霜自带植物微弱淡香,安全自然,温和无刺激,具有非常好的滋润保湿效果,长期使用可增强肌肤防护屏障,更好的抵抗外界侵害,为婴幼儿的成长路保驾护航。(2) The moisturizing cream of the present invention has its own weak and light fragrance of plants, is safe and natural, mild and non-irritating, has very good moisturizing and moisturizing effect, and can strengthen the skin protective barrier for long-term use, better resist external aggression, and is conducive to the growth of infants and young children. Road escort.

附图说明Description of drawings

图1为SDS模型皮肤完整度数据展示图。Figure 1 is a graph showing the skin integrity data of the SDS model.

具体实施方式Detailed ways

下面通过具体实施方式来进一步说明本发明的技术方案。本领域技术人员应该明了,所述实施例仅仅是帮助理解本发明,不应视为对本发明的具体限制。The technical solutions of the present invention are further described below through specific embodiments. It should be understood by those skilled in the art that the embodiments are only for helping the understanding of the present invention, and should not be regarded as a specific limitation of the present invention.

以下实施例舒缓婴童面霜中的各组分厂家及来源如下所述:植物抗敏剂是韩国百鸥思特的一款植物来源的舒敏产品,含有积雪草提取物、甘草提取物、母菊提取物、黄芩提取物、迷迭香提取物、茶叶提取物和虎杖提取物;德敏舒是德国德之馨的一款舒敏产品其商品名称为

Figure BDA0002408756770000102
德敏舒143535;德肤修是德之馨的一款原料,商品名为SymRelief德肤修153884;植物组合物是广州合淼公司一款皮肤屏障改善剂,含有苦橙花提取物、小苍兰提取物、玉兰花提取物。The manufacturers and sources of the components in the soothing baby face cream in the following examples are as follows: The plant anti-allergic agent is a plant-derived soothing product from BIOST, which contains Centella asiatica extract, licorice extract, Mother chrysanthemum extract, skullcap extract, rosemary extract, tea extract and knotweed extract; Deminshu is a soothing product of German Dezhixin, whose trade name is
Figure BDA0002408756770000102
Deminshu 143535; Defuxiu is a raw material of Dezhixin, and its trade name is SymRelief Defuxiu 153884; the botanical composition is a skin barrier improver of Guangzhou Hemiao Company, which contains bitter orange blossom extract, xiaocang Orchid Extract, Magnolia Flower Extract.

实施例1Example 1

本实施例提供一种舒缓婴童面霜,所述舒缓婴童面霜按重量份数计包括如下组分:The present embodiment provides a soothing baby face cream, which includes the following components in parts by weight:

Figure BDA0002408756770000101
Figure BDA0002408756770000101

Figure BDA0002408756770000111
Figure BDA0002408756770000111

本实施例提供的舒缓婴童面霜的制备方法具体包括以下步骤:The preparation method of the soothing baby face cream provided by this embodiment specifically includes the following steps:

(1)将溶剂小麦胚芽提取物、增稠剂(卡波940、汉生胶、EG)、保湿剂(甘油、丙二醇、甜菜碱、1,2-己二醇、尿囊素)和螯合剂在85℃下进行水相混合搅拌,得到水相混合液;将乳化剂(小麦乳化剂、MON-L、A-165、1618醇)、润肤剂(GTCC、DC200/100cst)和修复组分B在80℃下进行油相混合搅拌,得到油相混合液;(1) Combine the solvent wheat germ extract, thickener (Carbo 940, Xanthan gum, EG), humectant (glycerol, propylene glycol, betaine, 1,2-hexanediol, allantoin) and chelating agent The water phase was mixed and stirred at 85°C to obtain a water phase mixed solution; the emulsifier (wheat emulsifier, MON-L, A-165, 1618 alcohol), emollient (GTCC, DC200/100cst) and repair components B carries out oil phase mixing and stirring at 80°C to obtain an oil phase mixed solution;

(2)将步骤(1)得到的水相混合液和油相混合液在80℃下混合均质,得到均质液;(2) mixing the water-phase mixed solution and the oil-phase mixed solution obtained in step (1) at 80° C. to obtain a homogeneous solution;

(3)降温至60℃后,向步骤(2)得到的均质液中加入三乙醇胺调节pH,再降温至42℃后,加入修复组分A和防腐剂混合,得到所述舒缓婴童面霜。(3) After cooling to 60°C, add triethanolamine to the homogeneous solution obtained in step (2) to adjust pH, and then cool down to 42°C, add repair component A and preservatives and mix to obtain the soothing baby cream .

实施例2Example 2

本实施例提供一种舒缓婴童面霜,所述舒缓婴童面霜按重量份数计包括如下组分:The present embodiment provides a soothing baby face cream, which includes the following components in parts by weight:

Figure BDA0002408756770000112
Figure BDA0002408756770000112

Figure BDA0002408756770000121
Figure BDA0002408756770000121

本实施例提供的舒缓婴童面霜的制备方法具体包括以下步骤:The preparation method of the soothing baby face cream provided by this embodiment specifically includes the following steps:

(1)将溶剂小麦胚芽提取物、增稠剂(卡波940、汉生胶、EG)、保湿剂(甘油、丙二醇、甜菜碱、1,2-己二醇、尿囊素)和螯合剂在86℃下进行水相混合搅拌,得到水相混合液;将乳化剂(小麦乳化剂、MON-L、A-165、1618醇)、润肤剂(GTCC、DC200/100cst)和修复组分B在78℃下进行油相混合搅拌,得到油相混合液;(1) Combine the solvent wheat germ extract, thickener (Carbo 940, Xanthan gum, EG), humectant (glycerol, propylene glycol, betaine, 1,2-hexanediol, allantoin) and chelating agent The water phase was mixed and stirred at 86°C to obtain a water phase mixed solution; emulsifier (wheat emulsifier, MON-L, A-165, 1618 alcohol), emollient (GTCC, DC200/100cst) and repair components B carries out oil phase mixing and stirring at 78°C to obtain an oil phase mixed solution;

(2)将步骤(1)得到的水相混合液和油相混合液在81℃下混合均质,得到均质液;(2) mixing and homogeneously mixing the water-phase mixed solution and the oil-phase mixed solution obtained in step (1) at 81° C. to obtain a homogeneous solution;

(3)降温至62℃后,向步骤(2)得到的均质液中加入三乙醇胺调节pH,再降温至43℃后,加入修复组分A和防腐剂混合,得到所述舒缓婴童面霜。(3) after cooling to 62°C, adding triethanolamine to the homogeneous solution obtained in step (2) to adjust pH, and then cooling down to 43°C, adding repair component A and preservative and mixing to obtain the soothing baby cream .

实施例3Example 3

本实施例提供一种舒缓婴童面霜,所述舒缓婴童面霜按重量份数计包括如下组分:The present embodiment provides a soothing baby face cream, which includes the following components in parts by weight:

Figure BDA0002408756770000122
Figure BDA0002408756770000122

Figure BDA0002408756770000131
Figure BDA0002408756770000131

本实施例提供的舒缓婴童面霜的制备方法同实施例1。The preparation method of the soothing baby face cream provided in this example is the same as that in Example 1.

实施例4Example 4

本实施例提供一种舒缓婴童面霜,所述舒缓婴童面霜按重量份数计包括如下组分:The present embodiment provides a soothing baby face cream, which includes the following components in parts by weight:

Figure BDA0002408756770000132
Figure BDA0002408756770000132

Figure BDA0002408756770000141
Figure BDA0002408756770000141

本实施例提供的舒缓婴童面霜的制备方法同实施例1。The preparation method of the soothing baby face cream provided in this example is the same as that in Example 1.

实施例5Example 5

本实施例提供一种舒缓婴童面霜,与实施例1的区别在仅于,所述溶剂小麦胚芽提取物含量减至37.35份;修复组分A中:小麦神经酰胺增至3份,植物抗敏剂增至5份,德敏舒增至2.2份,马齿苋提取物增至3份,卡卡杜里提取物增至2.4份,水解小麦蛋白增至2.3份,植物组合物增至2.1份;修复组分B中:西班牙橄榄油增至4份,乳木果油增至3.5份,椰果油增至3份,德肤修增至2.5份,生育酚增至2.3份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This example provides a soothing baby cream, the difference from Example 1 is that the content of the solvent wheat germ extract is reduced to 37.35 parts; in repair component A: wheat ceramides are increased to 3 parts, plant anti-oxidants The sensitizer was increased to 5 parts, the Deminshu was increased to 2.2 parts, the purslane extract was increased to 3 parts, the kakaduli extract was increased to 2.4 parts, the hydrolyzed wheat protein was increased to 2.3 parts, and the plant composition was increased to 2.1 parts In the repair component B: Spanish olive oil increased to 4, shea butter increased to 3.5, coconut oil increased to 3, Defuxiu increased to 2.5, and tocopherol increased to 2.3. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

实施例6Example 6

本实施例提供一种舒缓婴童面霜,与实施例1的区别在仅于,所述溶剂小麦胚芽提取物含量增至62.45份;修复组分A中:小麦神经酰胺减至0.1份,植物抗敏剂减至0.1份,德敏舒减至0.1份,马齿苋提取物减至0.1份,卡卡杜里提取物减至0.1份,水解小麦蛋白减至0.1份,植物组合物仍为0.1份;修复组分B中:西班牙橄榄油增至2.86份,乳木果油增至2.36份,椰果油增至1.86份,德肤修增至1.36份,生育酚增至1.16份。本实施例提供的舒缓婴童面霜的制备方法同实施例1This example provides a soothing baby cream, the difference from Example 1 is that the content of the solvent wheat germ extract is increased to 62.45 parts; in repair component A: wheat ceramides are reduced to 0.1 parts, plant anti-oxidants Sensitizers are reduced to 0.1 parts, Deminshu is reduced to 0.1 parts, purslane extract is reduced to 0.1 parts, Kakaduli extract is reduced to 0.1 parts, hydrolyzed wheat protein is reduced to 0.1 parts, and plant composition is still 0.1 parts In the repair component B: Spanish olive oil increased to 2.86, shea butter increased to 2.36, coconut oil increased to 1.86, Defuxiu increased to 1.36, and tocopherol increased to 1.16. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

实施例7Example 7

本实施例提供一种舒缓婴童面霜,与实施例1的区别在仅于,所述溶剂小麦胚芽提取物含量增至62.05份;修复组分A中:小麦神经酰胺增至1.6份,植物抗敏剂增至3.6份,德敏舒增至0.8份,马齿苋提取物增至1.6份,卡卡杜里提取物增至1份,水解小麦蛋白增至0.9份,植物组合物增至0.7份;修复组分B中:西班牙橄榄油减至0.1份,乳木果油减至0.1份,椰果油减至0.1份,德肤修减至0.1份,生育酚减至0.1份。本实施例提供的舒缓婴童面霜的制备方法同实施例1This example provides a soothing baby cream, the difference from Example 1 is that the content of the solvent wheat germ extract is increased to 62.05 parts; in repair component A: wheat ceramides are increased to 1.6 parts, plant anti-oxidants Sensitizers increased to 3.6 parts, Deminsu to 0.8 parts, purslane extract to 1.6 parts, Kakaduli extract to 1 part, hydrolyzed wheat protein to 0.9 parts, and plant composition to 0.7 parts In the repair component B: Spanish olive oil was reduced to 0.1 part, shea butter to 0.1 part, coconut oil to 0.1 part, Deskin to 0.1 part, and tocopherol to 0.1 part. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例1Comparative Example 1

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,将61.45份溶剂小麦胚芽提取物替换为61.45份去离子水,其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, which differs from Example 1 in that 61.45 parts of solvent wheat germ extract is replaced with 61.45 parts of deionized water, and the contents and preparation methods of other components are the same as those of Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例2Comparative Example 2

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,所述舒缓婴童面霜中不添加修复组分A;所述溶剂小麦胚芽提取物含量增至62.45份;修复组分B中:西班牙橄榄油增至3份,乳木果油增至2.5份,椰果油增至2份,德肤修增至1.5份,生育酚增至1.3份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby face cream, which is different from Example 1 in that the repair component A is not added to the soothing baby face cream; the content of the solvent wheat germ extract is increased to 62.45 parts; the repair group In point B: Spanish olive oil increased to 3, shea butter increased to 2.5, coconut oil increased to 2, Defuxiu increased to 1.5, and tocopherol increased to 1.3. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例3Comparative Example 3

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,所述舒缓婴童面霜中不添加修复组分B,溶剂小麦胚芽提取物含量增至63.25份;修复组分A中:小麦神经酰胺增至1.5份,植物抗敏剂增至3.5份,德敏舒增至0.7份,马齿苋提取物增至1.5份,卡卡杜里提取物增至0.9份,水解小麦蛋白增至0.8份,植物组合物增至0.6份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby face cream, which is different from Example 1 in that the repairing component B is not added to the soothing baby face cream, and the content of the solvent wheat germ extract is increased to 63.25 parts; the repairing component A is Middle: wheat ceramides increased to 1.5 parts, plant anti-sensitizers increased to 3.5 parts, Deminsol increased to 0.7 parts, purslane extract increased to 1.5 parts, kakaduli extract increased to 0.9 parts, hydrolyzed wheat The protein was increased to 0.8 parts, and the vegetable composition was increased to 0.6 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例4Comparative Example 4

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加小麦神经酰胺,植物抗敏剂增至3.2份,德敏舒增至0.36份,马齿苋提取物增至1.16份,卡卡杜里提取物增至0.46份,水解小麦蛋白增至0.36份,植物组合物增至0.16份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, the difference from Example 1 is that wheat ceramide is not added to the repair component A, the plant anti-sensitizer is increased to 3.2 parts, the Deminshu is increased to 0.36 parts, and the horse Amaranth extract increased to 1.16 parts, kakaduli extract increased to 0.46 parts, hydrolyzed wheat protein increased to 0.36 parts, and plant composition increased to 0.16 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例5Comparative Example 5

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加植物抗敏剂,小麦神经酰胺增至1.5份,德敏舒增至0.7份,马齿苋提取物增至1.5份,卡卡杜里提取物增至0.9份,水解小麦蛋白增至0.8份,植物组合物增至0.6份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby face cream, the only difference from Example 1 is that no plant anti-allergic agent is added in the repair component A, the wheat ceramide is increased to 1.5 parts, the Deminshu is increased to 0.7 parts, and the horse ceramide is increased to 0.7. Amaranth extract was increased to 1.5 parts, Kakaduli extract was increased to 0.9 parts, hydrolyzed wheat protein was increased to 0.8 parts, and plant composition was increased to 0.6 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例6Comparative Example 6

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加德敏舒,小麦神经酰胺增至1.04份,植物抗敏剂增至3.04份,马齿苋提取物增至1.04份,卡卡杜里提取物增至0.44份,水解小麦蛋白增至0.34份,植物组合物仍为0.1份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, which differs from Example 1 in that no Deminshu is added to the repair component A, the amount of wheat ceramide is increased to 1.04, the amount of plant anti-sensitizer is increased to 3.04, and the The extract of S. amaranth was increased to 1.04 part, the extract of kakaduli was increased to 0.44 part, the hydrolyzed wheat protein was increased to 0.34 part, and the plant composition was still 0.1 part. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例7Comparative Example 7

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加马齿苋提取物,小麦神经酰胺增至1.2份,植物抗敏剂增至3.1份,德敏舒增至0.4份,卡卡杜里提取物增至0.6份,水解小麦蛋白增至0.5份,植物组合物增至0.2份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1。This comparative example provides a soothing baby face cream, the difference from Example 1 is that no purslane extract is added to the repair component A, the amount of wheat ceramide is increased to 1.2, and the amount of plant anti-sensitizer is increased to 3.1 , Deminshu increased to 0.4, Kakaduli extract increased to 0.6, hydrolyzed wheat protein increased to 0.5, and plant composition increased to 0.2. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided in this example is the same as that in Example 1.

对比例8Comparative Example 8

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加卡卡杜里提取物,小麦神经酰胺增至1.03份,植物抗敏剂增至3.07份,德敏舒增至0.27份,马齿苋提取物增至1.00份,水解小麦蛋白增至0.37份,植物组合物增至0.15份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1。This comparative example provides a soothing baby cream, which differs from Example 1 only in that no kakaduri extract is added to the repair component A, the amount of wheat ceramides is increased to 1.03, and the amount of plant anti-sensitizers is increased to 3.07 1 part, Deminshu was increased to 0.27 part, purslane extract was increased to 1.00 part, hydrolyzed wheat protein was increased to 0.37 part, and plant composition was increased to 0.15 part. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided in this example is the same as that in Example 1.

对比例9Comparative Example 9

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加水解小麦蛋白,小麦神经酰胺增至1.05份,植物抗敏剂增至3.05份,德敏舒增至0.25份,卡卡杜里提取物增至0.45份,马齿苋提取物增至1.05份,植物组合物增至0.15份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, the difference from Example 1 is that no hydrolyzed wheat protein is added to the repair component A, the wheat ceramide is increased to 1.05 parts, the plant anti-sensitizer is increased to 3.05 parts, and the German Minsu increased to 0.25 parts, kakaduli extract to 0.45 parts, purslane extract to 1.05 parts, and botanical composition to 0.15 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例10Comparative Example 10

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分A中不添加植物组合物,小麦神经酰胺增至1.02份,植物抗敏剂增至3.02份,德敏舒增至0.22份,卡卡杜里提取物增至0.42份,马齿苋提取物增至1.01份,水解小麦蛋白增至0.11份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream. The only difference from Example 1 is that no plant composition is added to the repair component A, the amount of wheat ceramide is increased to 1.02, and the amount of plant anti-sensitizer is increased to 3.02. Minsu increased to 0.22 parts, kakaduli extract to 0.42 parts, purslane extract to 1.01 parts, and hydrolyzed wheat protein to 0.11 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例11Comparative Example 11

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分B中不添加西班牙橄榄油,乳木果油增至2份,椰果油增至1.5份,德肤修增至1份,生育酚增至0.8份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, the difference from Example 1 is that no Spanish olive oil is added to the repair component B, the shea butter is increased to 2 parts, the coconut oil is increased to 1.5 parts, and the The skin repair was increased to 1 part, and the tocopherol was increased to 0.8 part. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例12Comparative Example 12

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分B中不添加乳木果油,西班牙橄榄油增至2.3份,椰果油增至1.4份,德肤修增至0.9份,生育酚增至0.7份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, the difference from Example 1 is that no shea butter is added to the repair component B, the amount of Spanish olive oil is increased to 2.3, the amount of coconut oil is increased to 1.4, and the The skin repair was increased to 0.9, and the tocopherol was increased to 0.7. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例13Comparative Example 13

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分B中不添加椰果油,西班牙橄榄油增至2.25份,乳木果油增至1.75份,德肤修增至0.75份,生育酚增至0.55份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing cream for babies and children. The difference from Example 1 is that no coconut oil is added to the repair component B, the number of Spanish olive oil is increased to 2.25, and the amount of shea butter is increased to 1.75. The skin repair was increased to 0.75, and the tocopherol was increased to 0.55. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例14Comparative Example 14

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分B中不添加德肤修,西班牙橄榄油增至2.2份,乳木果油增至1.6份,椰果油增至1.1份,生育酚增至0.4份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, the difference from Example 1 is that Defuxiu is not added in the repair component B, the Spanish olive oil is increased to 2.2 parts, the shea butter is increased to 1.6 parts, and coconut oil is increased to 1.6 parts. Fruit oil increased to 1.1 parts, and tocopherols increased to 0.4 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

对比例15Comparative Example 15

本对比例提供一种舒缓婴童面霜,与实施例1的区别在仅于,修复组分B中不添加生育酚,西班牙橄榄油增至2.075份,乳木果油增至1.575份,椰果油增至1.075份,德肤修增至0.575份。其他组分含量及制备方法同实施例1。本实施例提供的舒缓婴童面霜的制备方法同实施例1This comparative example provides a soothing baby cream, the difference from Example 1 is that no tocopherol is added to the repairing component B, the Spanish olive oil is increased to 2.075 parts, the shea butter is increased to 1.575 parts, and the coconut fruit is increased to 2.075 parts. The oil was increased to 1.075 parts, and the de skin repair was increased to 0.575 parts. The content of other components and the preparation method are the same as those in Example 1. The preparation method of the soothing baby face cream provided by the present embodiment is the same as that of embodiment 1

试验例1Test Example 1

安全性能测试Safety performance test

对实施例1提供的舒缓婴童面霜和对比例1提供的舒缓婴童面霜进行安全性能测试,方法如下:The safety performance test was carried out to the soothing baby face cream provided by Example 1 and the soothing baby face cream provided by Comparative Example 1, and the method is as follows:

测试项目:急性皮肤刺激性试验Test item: acute skin irritation test

测试方法:《化妆品安全技术规范》(2015年版)第六章毒理学试验方法4、皮肤刺激性/腐蚀性试验Test method: "Safety Technical Specification for Cosmetics" (2015 Edition) Chapter VI Toxicology Test Method 4. Skin irritation/corrosion test

检测环境:普通级动物房;室温21~23℃,相对湿度55~65%。Testing environment: ordinary animal room; room temperature 21-23 ℃, relative humidity 55-65%.

实验动物:采用普通级新西兰白色家兔,由广东省医学实验动物中心(三水基地)(实验动物生产许可证编号:SCXK(粵)2019-0035)提供。实验动物体重2.3~2.5kg。Experimental animals: Ordinary New Zealand white rabbits were used, which were provided by the Guangdong Provincial Medical Laboratory Animal Center (Sanshui Base) (experimental animal production license number: SCXK (Guangdong) 2019-0035). The experimental animals weighed 2.3 to 2.5 kg.

实验动物数量/性别:4只/♂:♀=2:2Number of experimental animals/sex: 4/♂:♀=2:2

样品处理:直接取样品原液作为受试物。Sample processing: directly take the sample solution as the test substance.

观察时点:清除受试物后的1、24、48和72h观察给予受试物部位的皮肤反应。Observation time point: 1, 24, 48 and 72 hours after removing the test substance to observe the skin reaction at the site where the test substance was administered.

试验步骤:(1)分别选用选4只健康成年新西兰兔。试验前24h,将实验动物背部脊柱两侧毛剃掉,准备2块去毛区域(每一去毛范围各约3cmx3cm),确认动物皮肤完好无损后进行试验。(2)取实施例1,0.5mL均匀涂抹于左侧去毛区域2.5cmx2.5cm大小的皮肤上,用斑贴覆盖,然后用无刺激性胶布和绷带加以固定。同样的右侧去毛区域取对比例1斑贴覆盖作为对照。贴敷4h后用温水清除残留受试物。于清除受试物后的1h、24h、48h和72h观察受试部位皮肤反应并按方法中表1“皮肤刺激反应评分”进行皮肤刺激反应评分,记录每一观察时点的皮肤反应分值,计算受试动物积分的平均值,根据1h、24h、48h和72h各观察时点最高积分均值,按方法表2“皮肤刺激强度分级”判定皮肤刺激强度。Test steps: (1) 4 healthy adult New Zealand rabbits were selected respectively. Twenty-four hours before the test, the hairs on both sides of the back spine of the experimental animal were shaved, and two depilation areas were prepared (each depilation area was about 3cmx3cm), and the test was carried out after confirming that the animal's skin was intact. (2) Take 0.5 mL of Example 1 and evenly apply it to the 2.5cmx2.5cm skin in the left hair removal area, cover it with a patch, and then fix it with a non-irritating tape and bandage. The same depilated area on the right side was covered with the patch of Comparative Example 1 as a control. After 4 hours of sticking, the residual test substance was removed with warm water. 1h, 24h, 48h and 72h after removing the test substance, observe the skin reaction of the test site and carry out the skin irritation reaction score according to Table 1 "Skin irritation reaction score" in the method, record the skin reaction score at each observation time point, Calculate the average score of the tested animals, and determine the skin irritation intensity according to the highest average score at each observation time point of 1h, 24h, 48h and 72h, and according to the method Table 2 "Skin irritation intensity classification".

表1Table 1

Figure BDA0002408756770000201
Figure BDA0002408756770000201

表2皮肤刺激强度分级Table 2 Skin irritation intensity classification

Figure BDA0002408756770000202
Figure BDA0002408756770000202

Figure BDA0002408756770000211
Figure BDA0002408756770000211

试验结果表明,在1h观察时点观察到该受试物实施例1对家兔皮肤造成红斑刺激反应。24h、48h和72h各观察时点最高积分均值为0.00,在0~<0.5无刺激的范围内,由此表明本发明中的实施例1中由以小麦胚芽提取液为基质,多种植物修复成分为主的婴儿保湿面霜在动物刺激性试验中具有无刺激反应,小麦胚芽提取液的多种天然成分温和安全,多种修复组分更是以多方面的舒缓修复为主。在1h、24h、48h和72h观察时点观察到该受试物对比例1分别对家兔皮肤造成红斑、水肿等刺激反应。24h、48h和72h各观察时点最高积分均值为0.87,在0.5~<2.0轻刺激性的范围内。The test results showed that the test substance Example 1 was observed to cause erythema irritation to the skin of rabbits at the observation time point of 1 h. The highest integral mean value at each observation time point of 24h, 48h and 72h is 0.00, which is in the range of 0~<0.5 without stimulation, which shows that in Example 1 of the present invention, the wheat germ extract is used as the matrix, and a variety of phytoremediation The ingredient-based baby moisturizing cream has no irritating reaction in the animal irritation test. The various natural ingredients of the wheat germ extract are mild and safe, and the various repairing ingredients are mainly for various soothing and repairing purposes. At the observation time points of 1h, 24h, 48h and 72h, it was observed that the test substance Comparative Example 1 caused erythema, edema and other irritating reactions to the rabbit skin respectively. The mean value of the highest integral at each observation time point of 24h, 48h and 72h was 0.87, which was in the range of 0.5~<2.0 mild irritation.

试验例2Test Example 2

化妆品性能测试Cosmetic performance test

对实施例1-7提供的舒缓婴童面霜和对比例1-15提供的舒缓婴童面霜进行化妆品各项基础性能测试,方法如下:Various basic performance tests of cosmetics were carried out on the soothing baby face cream provided by Example 1-7 and the soothing baby face cream provided by Comparative Example 1-15, and the methods were as follows:

(1)性状:采用目测法。(1) Characters: using visual inspection method.

(2)pH值:按照GBT 13531.1-2008化妆品通用检验方法pH值的测定;(2) pH value: Determination of pH value according to GBT 13531.1-2008 General Cosmetics Inspection Method;

(3)粘度:按照GB-T 10247-1988粘度测试方法,测试仪器为博勒飞LVDV-S+15-2000000cP型电子旋转式粘度计;(3) Viscosity: According to GB-T 10247-1988 viscosity test method, the test instrument is Brookfield LVDV-S+15-2000000cP electronic rotational viscometer;

(4)稳定性:按照GBT 34857-2017国家标准,对实施例1的保湿面霜进行取样,将其封装于透明化妆品瓶以及测试样品瓶中,分别置于-18℃、25℃、45℃、48℃实验条件下,对外观、香味、pH值、粘度以及其他项目进行为期30天的持续测试,观察是否出现析水、分层、分离、沉淀、变色、异味、破乳等不良现象;(4) Stability: According to the national standard of GBT 34857-2017, the moisturizing cream of Example 1 was sampled, packaged in a transparent cosmetic bottle and a test sample bottle, and placed at -18°C, 25°C, 45°C, Under the experimental conditions of 48 °C, the appearance, fragrance, pH value, viscosity and other items were continuously tested for 30 days to observe whether there were any undesirable phenomena such as water separation, stratification, separation, precipitation, discoloration, peculiar smell, and demulsification;

上述化妆品各项基础性能测试的测试结果如下表3所示:The test results of the above-mentioned cosmetic basic performance tests are shown in Table 3 below:

表3table 3

Figure BDA0002408756770000221
Figure BDA0002408756770000221

Figure BDA0002408756770000231
Figure BDA0002408756770000231

由表3的化妆品各项基础性能测试结果可知,本发明实施例1-7提供的舒缓婴童面霜外观为乳白色膏霜,均匀无颗粒,稳定性好,气味自然清淡,pH值(25℃)为5.0-7.0,保湿面霜的的粘度(25℃)在90000mpa·s以上,说明本发明所述的舒缓婴童面霜均具有温和无刺激的特点,30天内均未出现析水、分层、分离、沉淀、变色、异味、破乳等不良现象,表明稳定性良好。It can be seen from the test results of the basic properties of cosmetics in Table 3 that the soothing baby face creams provided in Examples 1-7 of the present invention are milky white creams, uniform without particles, good stability, natural and light smell, pH value (25°C) It is 5.0-7.0, and the viscosity (25° C.) of the moisturizing cream is above 90,000 mpa·s, indicating that the soothing baby face cream of the present invention is mild and non-irritating, and there is no water separation, stratification or separation within 30 days. , precipitation, discoloration, odor, demulsification and other undesirable phenomena, indicating good stability.

试验例3Test Example 3

皮肤屏障功能测试skin barrier function test

分别对75位5-12岁肌肤无过敏史、健康的测试者分批进行测试评价,皮肤的TEWL值越低,降低的变化率越大,说明防止水分散失的屏障功能越强。TEWL值的变化率为:75 5-12-year-old skin testers with no history of allergy and healthy skin were tested and evaluated in batches. The lower the TEWL value of the skin, the greater the reduction rate, indicating that the barrier function to prevent water loss is stronger. The rate of change of the TEWL value is:

TEWL变化率=(测量值-空白对照值)/空白对照值*100%TEWL rate of change = (measured value - blank control value) / blank control value * 100%

采用设备

Figure BDA0002408756770000232
dual MPA 580,探头Tewameter TM300经表皮水分散失测试仪进行测试。以受试者两前臂内侧各取3个3cm2大小的区域为测试区,受试者测试之前应以清水清洗手臂测试区域并在恒温独立环境(22±1℃),相对湿度50±5%的环境中静坐30-60分钟。之后使用移液枪按2.0mg样品/cm2的用量,用乳胶手套将样品均匀涂抹于测试区域内,分别测试初始值空白对照值、5min、2h、4h的TEWL值,并计算第四小时的TEWL变化率,结果如下表4所示:Adopt equipment
Figure BDA0002408756770000232
Dual MPA 580, Probe Tewameter TM300 Transepidermal Water Loss Tester for testing. Take three 3cm 2 areas on the inner sides of the subjects' two forearms as the test area. Before the test, the subjects should clean the arm test area with clean water and keep it in a constant temperature independent environment (22±1℃) with a relative humidity of 50±5% Sit quietly for 30-60 minutes. Afterwards, use a pipette to apply 2.0 mg of sample/cm 2 to the test area, and use latex gloves to spread the sample evenly in the test area, test the initial value of the blank control value, the TEWL value of 5min, 2h, and 4h, and calculate the TEWL value of the fourth hour. TEWL rate of change, the results are shown in Table 4 below:

表4Table 4

Figure BDA0002408756770000241
Figure BDA0002408756770000241

Figure BDA0002408756770000251
Figure BDA0002408756770000251

由表4的实验结果可知,本发明实施例1-7制得的舒缓婴童面霜的水合度变化率在第四小时的减少差异大于-54.69%以内,说明本发明所述基于小麦胚芽提取液的组合物的各成分配伍科学合理,协同增效,所述组合物对于脆弱、敏感、反应性强的皮肤,具有很好的营养和舒缓功效。其中,可以得出使用在实施例1的舒缓保湿面霜后肌肤的水合度变化率在四小时内的减少差异较大,而对比例1(不添加溶剂小麦胚芽提取物)的水合度变化率小,防止水分散失的屏障功能较差,而实施例1添加本发明所述基于小麦胚芽提取液的组合物制得的舒缓婴童面霜能达到从内部肌肤底层加强防护作用,有效提高水分散失的屏障功能,外部舒缓滋润,令肌肤柔润健康。From the experimental results in Table 4, it can be seen that the hydration rate change rate of the soothing baby creams prepared in Examples 1-7 of the present invention has a decrease difference of less than -54.69% in the fourth hour, indicating that the present invention is based on the wheat germ extract. The ingredients of the composition are scientifically reasonable and synergistically synergistic, and the composition has good nutritional and soothing effects on fragile, sensitive and highly reactive skin. Among them, it can be concluded that after using the soothing moisturizing cream of Example 1, the change rate of hydration degree of the skin has a large difference in the reduction within four hours, while the change rate of hydration degree of Comparative Example 1 (without adding solvent wheat germ extract) is small. , the barrier function of preventing water loss is poor, and the soothing baby cream prepared by adding the composition based on the wheat germ extract of the present invention in Example 1 can achieve a strengthening protective effect from the inner skin bottom layer and effectively improve the barrier of water loss. Function, external soothing and moisturizing, leaving skin soft and healthy.

试验例4Test Example 4

保湿性功效测试Moisturizing Efficacy Test

依据化妆品行业标准《化妆品保湿功效评价指南》,选取30名志愿者,按随机分批在其双前臂分别使用实施例1-7提供的舒缓婴童面霜和对比例1-15提供的舒缓婴童面霜,于涂抹前、涂抹后5min和涂抹后2h时、4h时进行皮肤含水量测量,从而对产品在皮肤表层的保湿功效进行评估。水分值变化情况结果如下表5所示:According to the cosmetic industry standard "Guidelines for the Evaluation of Moisturizing Efficacy of Cosmetics", 30 volunteers were selected to use the soothing baby cream provided in Examples 1-7 and the soothing baby cream provided in Comparative Examples 1-15 on their forearms in random batches. For the face cream, the skin moisture content was measured before application, 5 minutes after application, 2 hours and 4 hours after application, so as to evaluate the moisturizing effect of the product on the skin surface. The results of the change of moisture value are shown in Table 5 below:

表5table 5

Figure BDA0002408756770000252
Figure BDA0002408756770000252

Figure BDA0002408756770000261
Figure BDA0002408756770000261

由表5的实验结果可知,本发明实施例1-7制得的舒缓婴童面霜的水分值在62.00以上,说明本发明所述基于小麦胚芽提取液的组合物的各成分配伍科学合理,协同增效,对于脆弱、敏感、反应性强的皮肤,具有很好的营养和舒缓功效,可令肌肤滋养和再生、抵御失水,使皮肤摆脱干燥等功效。From the experimental results in Table 5, it can be seen that the moisture value of the soothing baby face cream prepared in Examples 1-7 of the present invention is above 62.00, which shows that the composition of the present invention based on the wheat germ extract is scientific and reasonable. Synergistic, nourishing and soothing for fragile, sensitive, reactive skin, nourishing and regenerating, resisting dehydration, and getting rid of dryness.

试验例5Test Example 5

感官评价试验Sensory evaluation test

依据化妆品行业内感官分析法,选取实施例1-7提供的舒缓婴童面霜和对比例1-15提供的舒缓婴童面霜,进行肤感评估。According to the sensory analysis method in the cosmetic industry, the soothing baby creams provided in Examples 1-7 and the soothing baby creams provided in Comparative Examples 1-15 were selected for skin feel evaluation.

1、评价项目:铺展性,吸收性,温和性,整体感受。1. Evaluation items: spreadability, absorption, mildness, overall feeling.

2、评分制度:分值为1~10分,总分值越高该项目指标特征性越强。2. Scoring system: The score ranges from 1 to 10 points. The higher the total score, the stronger the characteristic of the item.

3、实验方案:选取75位受过培训的评估人员,女性,年龄20-30岁。在恒温独立环境(22±1℃),相对湿度50±5%,休息静坐30-60分钟后进行,结果见表6。3. Experimental protocol: 75 trained evaluators, female, aged 20-30 years, were selected. In a constant temperature independent environment (22±1°C), relative humidity 50±5%, rest and sit for 30-60 minutes, and the results are shown in Table 6.

表6Table 6

测试样品testing sample 铺展性Spreadability 吸收性Absorbency 温和性mildness 保湿性moisturizing 整体感受overall feeling 总得分Total Score 实施例1Example 1 9.29.2 9.59.5 1010 9.59.5 1010 48.248.2 实施例2Example 2 9.09.0 9.49.4 9.09.0 9.09.0 9.09.0 45.445.4 实施例3Example 3 8.38.3 8.28.2 9.59.5 8.08.0 9.39.3 43.043.0 实施例4Example 4 8.08.0 8.08.0 9.09.0 9.29.2 9.09.0 43.243.2 实施例5Example 5 9.19.1 9.59.5 9.49.4 9.79.7 9.89.8 47.047.0 实施例6Example 6 9.39.3 9.29.2 9.09.0 9.29.2 9.39.3 46.046.0 实施例7Example 7 9.49.4 9.09.0 9.19.1 9.69.6 9.09.0 46.146.1 对比例1Comparative Example 1 7.07.0 7.27.2 7.57.5 7.87.8 7.07.0 28.928.9 对比例2Comparative Example 2 6.76.7 6.76.7 5.05.0 5.55.5 6.16.1 30.030.0 对比例3Comparative Example 3 5.25.2 6.06.0 6.56.5 5.05.0 6.36.3 29.029.0 对比例4Comparative Example 4 4.84.8 5.55.5 6.06.0 5.55.5 6.26.2 28.028.0 对比例5Comparative Example 5 5.05.0 5.85.8 5.95.9 6.06.0 6.66.6 29.329.3 对比例6Comparative Example 6 5.05.0 5.55.5 5.85.8 5.85.8 6.06.0 28.128.1 对比例7Comparative Example 7 5.15.1 5.75.7 5.85.8 5.75.7 5.85.8 28.128.1 对比例8Comparative Example 8 5.05.0 5.25.2 5.25.2 5.55.5 6.06.0 26.926.9 对比例9Comparative Example 9 5.55.5 6.06.0 5.55.5 5.25.2 5.65.6 27.827.8 对比例10Comparative Example 10 5.65.6 5.65.6 5.45.4 5.45.4 5.55.5 27.527.5 对比例11Comparative Example 11 6.36.3 5.05.0 5.55.5 6.06.0 5.75.7 28.528.5 对比例12Comparative Example 12 4.84.8 5.25.2 5.85.8 5.55.5 5.75.7 27.027.0 对比例13Comparative Example 13 4.74.7 5.55.5 6.46.4 5.45.4 5.35.3 27.327.3 对比例14Comparative Example 14 6.06.0 6.36.3 5.35.3 5.25.2 6.06.0 28.828.8 对比例15Comparative Example 15 5.65.6 6.16.1 5.85.8 5.75.7 5.35.3 28.528.5

由表6的实验结果可知,本发明实施例1-7制得的舒缓婴童面霜的感官评价试验测试中,铺展性得分在8.0以上,吸收性得分在8.0以上,温和性得分在9.0以上,保湿性得分在8.0以上,整体感受得分在9.0以上,整体的总得分在43.0以上;而对比例1-15制得的舒缓婴童面霜的感官评价测试中,铺展性得分在7.0以下,吸收性得分在7.5以下,温和性得分在7.5以下,保湿性得分在8.0以下,整体感受得分在7.0以下,整体的总得分在30.0以下。这充分说明本发明所述组合物对于脆弱、敏感、反应性强的皮肤,具有很好的营养和舒缓功效,可令肌肤滋养和再生、抵御失水,使皮肤摆脱干燥等功效。添加本发明所述基于小麦胚芽提取液的组合物制得的舒缓婴童面霜能达到从内部肌肤底层加强防护作用,外部舒缓滋润,令肌肤柔润健康。From the experimental results in Table 6, it can be seen that in the sensory evaluation test test of the soothing baby creams prepared in Examples 1-7 of the present invention, the spreadability score is above 8.0, the absorption score is above 8.0, and the mildness score is above 9.0. The moisturizing score is above 8.0, the overall feeling score is above 9.0, and the overall total score is above 43.0. In the sensory evaluation test of the soothing baby cream prepared in Comparative Examples 1-15, the spreadability score is below 7.0, and the absorption is below 7.0. The score is below 7.5, the mildness score is below 7.5, the moisturizing score is below 8.0, the overall feeling score is below 7.0, and the overall overall score is below 30.0. This fully shows that the composition of the present invention has good nutritional and soothing effects on fragile, sensitive and highly reactive skin, and can nourish and regenerate the skin, resist dehydration, and free the skin from dryness. The soothing baby face cream prepared by adding the composition based on the wheat germ extract of the present invention can achieve a protective effect from the inner bottom layer of the skin, external soothing and moisturizing, and make the skin soft and healthy.

试验例6Test Example 6

皮肤敏感性测试(SDS模型)Skin Sensitivity Test (SDS Model)

对比测试实施例1提供的舒缓婴童面霜和对比例1、7、11、14提供的舒缓婴童面霜的屏障修复能力,选取30名肌肤健康、无过敏史的志愿者,分批在受试者两前臂内侧各取3个3cm2大小的区域为测试区,应用2%的SDS*24h破坏肌肤屏障的(封闭环境),之后去除残余的SDS溶液,每天对应的区域应用两次实施例产品和对比例产品(2mg/cm2),应用SDS处理,并在处理9天得出的数据后,节选部分对比例与实施例1的最终皮肤屏障完整度的数据进行分析。选取实施例1,对比例1、7、11、14的肌肤屏障完整度的数据展示图如图1所示。The barrier repair ability of the soothing baby cream provided in Example 1 and the soothing baby cream provided in Comparative Examples 1, 7, 11, and 14 were compared and tested. 30 volunteers with healthy skin and no history of allergies were selected and tested in batches. Take three 3cm 2 areas on the inner side of the two forearms as the test area, apply 2% SDS*24h to destroy the skin barrier (closed environment), then remove the residual SDS solution, and apply the product of the embodiment twice a day to the corresponding area and the comparative example product (2 mg/cm 2 ), treated with SDS, and after 9 days of processing the data, an excerpt of the comparative example and the final skin barrier integrity data of Example 1 were analyzed. Example 1 is selected, and the data presentation diagram of the skin barrier integrity of Comparative Examples 1, 7, 11, and 14 is shown in FIG. 1 .

由实验结果可知,本发明实施例1制得的舒缓婴童面霜能更好的修复还原肌肤本身的完整程度最高,几乎接近未损伤前的肌肤状态。这充分说明本发明所述组合物对本发明的选择了以小麦胚芽提取物液为溶剂,添加以两种修复组分包含了马齿苋、德敏舒、积雪草、橄榄果、椰子果、牛油果等等,小麦胚芽提取液能皮肤重建结构物给皮肤补充天然营养成分,如氨基酸,矿物质和寡糖,帮助皮肤重建结构,刺激皮肤细胞,物带给皮肤营养,促进皮肤结构再生,重获新生的同时,小麦胚芽提取液具有真实可见的成膜功效可以在皮肤上形成一层屏障,这层膜会保护皮肤的表皮层免受外界侵害,添加2组修复组份能与小麦胚芽提取液协同增效,最终能得到维持肌肤水分充盈,水合度平衡,降低TEWL值的舒缓保湿面霜。It can be seen from the experimental results that the soothing baby face cream prepared in Example 1 of the present invention can better restore and restore the integrity of the skin itself, which is almost close to the skin state before damage. This fully shows that the composition of the present invention uses the wheat germ extract liquid as the solvent, and adds two repair components including purslane, Deminshu, Centella asiatica, olive fruit, coconut fruit, Avocado, etc., wheat germ extract can rebuild the skin structure and supplement the skin with natural nutrients, such as amino acids, minerals and oligosaccharides, help the skin rebuild its structure, stimulate skin cells, bring nutrients to the skin, and promote skin structure regeneration. At the same time of rebirth, wheat germ extract has a real and visible film-forming effect, which can form a barrier on the skin. This film will protect the epidermis of the skin from external aggression. Adding 2 groups of repair components can be extracted with wheat germ. The synergistic effect of the liquid can finally be obtained to maintain the skin's moisture filling, hydration balance, and reduce the TEWL value of the soothing moisturizing cream.

申请人声明,本发明通过上述实施例来说明本发明的基于小麦胚芽提取液的组合物、舒缓婴童面霜及其制备方法,但本发明并不局限于上述详细方法,即不意味着本发明必须依赖上述详细方法才能实施。所属技术领域的技术人员应该明了,对本发明的任何改进,对本发明产品各原料的等效替换及辅助成分的添加、具体方式的选择等,均落在本发明的保护范围和公开范围之内。The applicant declares that the present invention illustrates the wheat germ extract-based composition, the soothing baby face cream and the preparation method thereof through the above examples, but the present invention is not limited to the above detailed methods, that is, it does not mean the present invention Implementation must rely on the methods detailed above. Those skilled in the art should understand that any improvement of the present invention, the equivalent replacement of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims (10)

1. A composition based on wheat germ extract, characterized in that it comprises: a repairing component A, a repairing component B and a solvent wheat germ extract;
the repair component A comprises wheat ceramide, plant anti-allergy agent, chlorphenamine maleate, purslane extract, kakakadu extract, hydrolyzed wheat protein and plant composition;
the repair component B comprises olive oil, shea butter, coconut oil, Defu and tocopherol.
2. The wheat germ extract-based composition according to claim 1, wherein the mass ratio of the repairing component A, the repairing component B and the solvent wheat germ extract is (3-8): (50-80).
3. The wheat germ extract-based composition according to claim 1 or 2, wherein the repair component A comprises, in parts by weight: 0.5-2 parts of wheat ceramide, 1-5 parts of plant anti-allergy agent, 0.1-0.5 part of chlorpheniramine maleate, 0.1-2 parts of purslane extract, 0.1-1 part of kakadu extract, 0.1-0.5 part of hydrolyzed wheat protein and 0.05-0.2 part of plant composition;
preferably, the plant anti-allergic agent comprises centella asiatica extract, licorice extract, chamomile extract, scutellaria baicalensis extract, rosemary extract, tea extract, and polygonum cuspidatum extract;
preferably, the botanical composition comprises neroli extract, freesia cubeba extract and magnolia extract;
preferably, the repair component B comprises the following components in parts by weight: 1-5 parts of spanish olive oil, 0.5-5 parts of shea butter, 0.5-5 parts of coconut oil, 0.1-1 part of Defu and 0.1-1 part of tocopherol.
4. The soothing infant cream is characterized by comprising the following components in parts by weight: 60-90 parts of a wheat germ extract-based composition according to any one of claims 1-3, 0.5-2.5 parts of an emulsifier, 0.8-2 parts of a thickener, 3-10 parts of an emollient, 3-10 parts of a humectant, and 0.2-1 part of a pH regulator.
5. A soothing baby cream as claimed in claim 4, wherein the emulsifier comprises any one of wheat emulsifier, EM-90, MON-L, A-165, M68, SP-60, monoglyceride, 1618 alcohol, SSE-20 or SS or a combination of at least two thereof;
preferably, the thickener comprises any one of U21, 2020, EG or xanthan gum or a combination of at least two thereof.
6. A soothing baby cream as claimed in claim 4 or 5, wherein the emollient comprises any one or combination of at least two of 2-EHP, GTCC, DC200/100cst or DC200/350 cst;
preferably, the humectant comprises any one or a combination of at least two of glycerin, propylene glycol, butylene glycol, hexylene glycol, betaine, pentanediol, or allantoin;
preferably, the pH adjusting agent comprises any one of arginine, aminomethyl propanol, potassium hydroxide, or triethanolamine, or a combination of at least two thereof;
preferably, the baby soothing cream further comprises 0.01-0.1 part of a chelating agent;
preferably, the chelating agent is EDTA-2 Na;
preferably, the baby soothing cream further comprises 0.1-1 part of preservative;
preferably, the preservative is jasmonate.
7. The preparation method of the soothing baby cream according to claims 4-6, wherein the preparation method of the soothing baby cream comprises the following steps: the baby soothing cream is prepared by mixing the wheat germ extract-based composition according to any one of claims 1 to 3, an emulsifier, a thickener, an emollient, a humectant and a pH regulator in formula amounts.
8. The preparation method of the soothing baby cream according to claim 7, wherein the preparation method of the soothing baby cream specifically comprises the following steps:
(1) mixing and stirring wheat germ extract, thickening agent and humectant to obtain water phase mixed solution; mixing and stirring the emulsifier, the emollient and the repairing component B in an oil phase to obtain an oil phase mixed solution;
(2) mixing the water phase mixed liquor and the oil phase mixed liquor obtained in the step (1) and homogenizing to obtain homogenized liquor;
(3) and (3) adding a pH regulator into the homogenized liquid obtained in the step (2) to regulate the pH, and then adding a repairing component A for mixing to obtain the soothing baby cream.
9. The method for preparing a soothing baby cream according to claim 8, wherein the temperature of the water phase mixing and stirring in the step (1) is 80-90 ℃;
preferably, the temperature for mixing and stirring the oil phase in the step (1) is 75-85 ℃;
preferably, the temperature for mixing and homogenizing in the step (2) is 80-82 ℃;
preferably, the temperature for adjusting the pH in the step (3) is 55-65 ℃;
preferably, the temperature for adding the repairing component A in the step (3) is 40-45 ℃.
10. The preparation method of the soothing infant face cream according to claim 8 or 9, wherein the preparation method of the soothing infant face cream specifically comprises the following steps:
(1) mixing wheat germ extract, thickener and humectant at 80-90 deg.C with water, and stirring to obtain water phase mixture; mixing emulsifier, emollient and repairing component B at 75-85 deg.C under stirring to obtain oil phase mixed solution;
(2) mixing the water phase mixed liquor and the oil phase mixed liquor obtained in the step (1) at 80-82 ℃ for homogenization to obtain a homogenized liquor;
(3) and (3) cooling to 55-65 ℃, adding a pH regulator into the homogenized liquid obtained in the step (2) to regulate the pH, cooling to 40-45 ℃, adding a repairing component A, and mixing to obtain the soothing baby cream.
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