CN1111984A - Bath lotion series with anti-inflammatory, antipruritic and antibiotic functions - Google Patents
Bath lotion series with anti-inflammatory, antipruritic and antibiotic functions Download PDFInfo
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- CN1111984A CN1111984A CN 95104681 CN95104681A CN1111984A CN 1111984 A CN1111984 A CN 1111984A CN 95104681 CN95104681 CN 95104681 CN 95104681 A CN95104681 A CN 95104681A CN 1111984 A CN1111984 A CN 1111984A
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- prescription
- antipruritic
- antiinflammatory
- mentholum
- alumen
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- 239000006210 lotion Substances 0.000 title claims abstract description 11
- 230000006870 function Effects 0.000 title abstract description 5
- 230000003115 biocidal effect Effects 0.000 title abstract description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 20
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- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 12
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- 229960004889 salicylic acid Drugs 0.000 claims abstract description 10
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- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims 5
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The bath lotion in different prescriptions for curing skin diseases such as eczema, itching, dermatitis, urethritis, scrotitis, vulvitis, gonorrhea, psoriasis, tinea, urticaria, etc. is prepared with menthol, alum, salicylic acid, powdered sulfur, boric acid, calamine and resorcin and has anti-inflammatory, antipruritic and antibiotic functions.
Description
A kind of external-use bathing lotion with antiinflammatory, antipruritic, antibacterial action, be applicable to antipruritic, antiinflammatory, the antibacterial therapy of clinical dermatosis, particularly to skin lesion widely disease such as subacute or chronic eczema, general scratch where it itches disease, fill the air rubescent dermatitis or eczema, psoriasis etc., this bath agent has splendid curative effect.
In motherland's medical science, soak or all kinds of dermatosiss of treatment of taking a shower existing long history with Chinese medicine back to boil water.Modern medicine also proves, adding some drugs in bath water can have certain therapeutical effect, can have a bath with the potassium permanganate weak solution as the pemphigus vulgaris patient, can deodorization and sterilization; When having suppurative the infringement, hand can wash one's hands with the sulfated compound copper solution of dilution; There is the patient of erosive tinea pedis also can use it always and comes foot bath; The subacute widely or chronic eczema patient of skin lesion can carry out tar bath, promptly be in bath water, to add an amount of liquor carbonis detergens, can alleviate tickle and itch immediately, make patient feel comfortable, rubescent desquamation of whole skin and the erythroderma patient of itching can carry out alkaline bath, promptly in bath water, add sodium bicarbonate, symptom is temporarily alleviated; General scratch where it itches disease, fill the air rubescent dermatitis or eczema, the psoriasis patient can carry out starch bath, promptly be starch to be boiled into scattered paste shape pour in the bath water, the rice water of cooking also can, but above-mentioned various dipping, because the dipping time is short, drug level is low, therapeutic effect is little, some medicine is Diazolidinyl Urea or sensitization also, can cause the danger that whole body is poisoned through a large amount of absorption of skin even, therefore, seek the externally applied anti-inflammation of some high-efficiency low-toxicities, antipruritic, antiseptic bath agent, be clinical medical personnel heat subject anxious to be solved always.
Purpose of the present invention, be to provide a kind of to have antipruritic, antiinflammatory and antibacterial action is arranged, the external-use bathing lotion that dermal toxicity is low, this bath agent can be used for treating various dermopathic prurituss and all kinds of eczema, dermatitis, antibacterial, fungal infection also there is splendid curative effect, for dermopathic control provides a new therapy and preparation.
The object of the present invention is achieved like this, and the Mentholum that adopts the Chinese medicine Herba Menthae or purify and obtain from Herba Menthae is formed compound preparation with Alumen again.This two medicine is ground to form powdery, mixed being distributed into 30～50g, one bag by 1: 30, face with before, it is dissolved among 50～60 ℃ the hot water, the affected part that is used for the dipping bath patient slightly after the cold can be received antiinflammatory, curative effect such as antipruritic, antibiotic, thus all kinds of dermopathic effects of performance treatment.
Alumen is a kind of conventional Chinese medicine, in treating skin disease often it as astringent and protective agent, because of it has vasoconstrictive and bring into play " antiinflammatory " effect, suppress sebaceous gland and sweat gland secretion and inflammation secretions is reduced and bring into play " convergence " and act on.Modern pharmacological research proves, Alumen has significant antibacterial action, golden Portugal bacterium and Bacillus proteus there is inhibitory action (test tube method), to escherichia coli, bacillus pyocyaneus, anthrax bacillus, dysentery bacterium, Bacillus typhi, paratyphoid fever bacillus, Bacillus proteus, and staphylococcus, Candida albicans etc. also have obvious suppression to render a service (paper dish, flat band method), and are the strongest to viridans streptococci, Hemolytic streptococcus, streptococcus pneumoniae, diphtheria corynebacterium effect; Cattle type Brucella, bordetella pertussis, meningococcus effect are taken second place, hemophilus influenza is not had effect (paper disk method), the high concentration alum steep is to human-like (H
37RV) and bacillus tuberculosis bovis inhibitory action is also arranged, research also shows, Alumen also has tangible anti-trichomonas vaginitis effect (Chinese medicine voluminous dictionary, P680), this mechanism of action of Alumen is commonly considered as because it has the effect of intensive solidifying protein, is suppressed even death thereby bacterial growth is grown.Herba Menthae or its extract Mentholum are classified as pruritus to it in treating skin disease, its blood circulation promoting and antiinflammatory, antipruritic etc. acts on now generally acknowledged.Clinical practice in antiinflammatory, antipruritic, pain relieving, alleviate edema etc., studies show that Mentholum is applied to skin because the tip sensor that excites nerve at first produces cold sensation, the sense of burning of slight thorn is arranged subsequently.This moment, skin temperature did not reduce, even slightly raise, and can slowly penetrate Intradermal, cause long hyperemia, and reflexive causes that the deep blood vessel changes, adjust the function of blood vessel, and reach therapeutical effect (Chinese medicine modern study and clinical practice, P683), experiment in vitro also confirms, Herba Menthae is to staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, the enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli, Bacillus proteus, Candida albicans all has antibacterial action, research also shows, Herba Menthae is to herpes simplex virus, vaccinia virus, Semliki forest virus and mumps virus all have inhibitory action (Chinese medicine modern study and clinical practice, P683), research in recent years also shows, the Herba Menthae decoct, Mentholum is to dermatophytes such as trichophyton, trichophyton gypseum, acrothesium floccosums etc. all have inhibitory action, wherein Oleum menthae, Mentholum still has bactericidal action preferably.In addition, Oleum menthae, Mentholum also have killing action [Hu Lifang, sterilization and sterilization, 1989,6(1): 10] to Candida albicans.Herba Menthae or its extract and Alumen are formed compound preparation, and its antibacterial action is strengthened mutually, and antimicrobial spectrum increases, and is used for treating for skin disease, and antiphlogistic effects and antipruritic effect are obvious especially, and we are very sure through the clinical observation curative effect.
On above-mentioned basic side's basis, can increase more following medicines, make it bring into play better therapeutical effect to some dermatosis:
1, on the basis of above-mentioned prescription＜1 〉, add 3～5 parts of boric acid again and form prescription＜2 〉, prepare by preceding method, the antibacterial and anti-inflammation functions of can strengthen writing out a prescription＜1 〉, to dermopathic erosion, exudative infringement curative effect is better.
2, on the basis of above-mentioned prescription＜2 〉, add 2～4 parts of Cosans again, by the preparation of preceding method with use, the skin lesion to due to scabies, acne, seborrheic dermatitis, neurodermatitis, all kinds of ringworms etc. has splendid curative effect.We also can also can obtain same curative effect to dermatosiss such as some ringworms directly with its powder varnish affected part.
3, on the basis of above-mentioned three groups of prescriptions, still can increase Calamina, strengthen its convergence and itching-relieving action, Calamina generally adds among above-mentioned arbitrary prescription in 2～5 parts of ratios, and this side has preferable curative effect to skin lesions such as urticaria, acute eczema, contact dermatitis, erythema multiformes.
4, on the basis of above-mentioned four groups of prescriptions, still can increase salicylic acid, strengthen we's antifungic action, salicylic acid can be added among above-mentioned arbitrary prescription in 1～5 part ratio, this prescription has significant curative effect to tinea versicolor, tinea corporis, tinea manus and pedis, tinea imbricata etc., and neurodermatitis, chronic eczema and prurigo nodularis etc. are also had preferable curative effect.
5, on the bases of above-mentioned five groups of prescriptions, still can increase resorcin, strengthen we's antifungic action, resorcin can be added among above-mentioned arbitrary prescription in 1～3 part ratio, and we are good to tinea corporis, tinea cruris, tinea versicolor, dermatocandidiasis curative effect spy.
Now introduce several examples of application:
Example one: prescription＜1 〉: Mentholum, Alumen are in 1～2: 30～40 ratio grinds to form powdery, be distributed into every bag 30～50g, face with before adding among 50 ℃～60 ℃ 5 kilograms of the hot water, stirring and dissolving, soak the affected part, can make affected part inflammation to secondary every day one, remission or disappearance such as scratch where it itches, effective percentage reaches 99%.
Example two: prescription＜2 〉: get 1 part of Mentholum, 3 parts of boric acid, 30 parts in Alumen grinds or is ground into fine powder respectively, is distributed into the 30g/ bag, face with before adding in 5 kilograms of 50 ℃～60 ℃ hot water, stirring and dissolving is soaked or the soak affected part, and every day one is to secondary, to dermopathic erosion, exudative infringement curative effect is better.Urethritis, vaginitis, vulvitis, perianal dermatitis, perineal position dermatitis etc. also there is preferable curative effect.
Example three: prescription＜3 〉: get 1 part of Mentholum, 3 parts of boric acid, 30 parts in Alumen, 3 parts of Cosans, grind or be ground into fine powder respectively, be distributed into the 30g/ bag, face with before adding in 50～60 ℃ of hot water stirring and dissolving, soak or the soak affected part, every day one, we dye acne, scabies, psoriasis, seborrheic dermatitis, neurodermatitis, drug eruption, prurigo, pityriasis rosea, gonorrhea and non-gonorrhea sexuality preferable curative effect, and all kinds of ringworms are also had certain effect to secondary.
Example four: prescription＜4 〉: get 1 part of Mentholum, 3 parts of boric acid, 3 parts of salicylic acid, 3 parts of Cosans, 30 parts in Alumen, grind or be ground into fine powder respectively, be distributed into the 30g/ bag, use by preceding method, we have preferable curative effect to urticaria, acute eczema, contact dermatitis, erythema multiforme etc.
Example five: prescription＜5 〉: get 1 part of Mentholum, 3 parts of boric acid, 3 parts of salicylic acid, 3 parts of Cosans, 30 parts in Alumen grinds or is ground into fine powder respectively, be distributed into the 30g/ bag, use by preceding method, we have significant curative effect to tinea versicolor, tinea corporis, tinea manus and pedis, tinea imbricata etc., and neurodermatitis, chronic eczema and prurigo nodularis are also had preferable curative effect.
Example six: prescription＜6 〉: get 1 part of Mentholum, 6 parts of salicylic acid, 5 parts of Cosans, 20 parts in Alumen grinds or is ground into fine powder respectively, is distributed into 30～50g/ bag, uses by preceding method, and we are to the quiet sick stable phase of silver and curative effect is preferably arranged paracmasis.
Claims (9)
1, a kind of antiinflammatory, antipruritic, antimicrobial external-use bathing lotion, it is characterized in that this prescription is made up of Mentholum and Alumen, the ratio of Mentholum and Alumen is 1: 30, and this bath agent can be distributed into 30～50g/ bag, facing the time spent is dissolved in it among 5 kilograms of hot water again, soaks affected part or shower whole body;
2, antiinflammatory as claimed in claim 1, antipruritic, antimicrobial external-use bathing lotion, it is characterized in that to increase boric acid in the prescription of this bath agent, boric acid can be added in 3～5 parts ratio, forms new prescription, and the optimal proportion of this prescription is that Mentholum, boric acid, Alumen were respectively 1: 3: 30;
3, as claim 1,2 described antiinflammatory, antipruritic, antimicrobial external-use bathing lotion, it is characterized in that to increase Cosan in the prescription of this bath agent, Cosan can be added in 2～4 parts ratio, form new prescription, the optimal proportion of this prescription is that Mentholum, boric acid, Cosan, Alumen were respectively 1: 3: 3: 30;
4, as claim 1,2,3 described antiinflammatory, antipruritic, antimicrobial external-use bathing lotion, it is characterized in that can increasing Calamina in the prescription of this bath agent, Calamina can be added among above-mentioned arbitrary prescription in 2～5 parts of ratios;
5, as the described antiinflammatory of claim 1～4, antipruritic, antimicrobial external-use bathing lotion, it is characterized in that can increasing salicylic acid in the prescription of this bath agent, salicylic acid can be added among above-mentioned arbitrary prescription in 1～5 part ratio;
6, as the described antiinflammatory of claim 1～5, antipruritic, antimicrobial external-use bathing lotion, it is characterized in that can increasing resorcin in the prescription of this bath agent, resorcin can be added among above-mentioned arbitrary prescription in 1～3 part ratio;
7, antiinflammatory as claimed in claim 4, antipruritic, antiphlogistic externally applied liniment is characterized in that the ratio of its optimum formula Mentholum, boric acid, Calamina, Alumen was respectively 1: 3: 5: 25;
8, antiinflammatory as claimed in claim 5, antipruritic, antiphlogistic externally applied liniment is characterized in that the ratio of its optimum formula Mentholum, boric acid, salicylic acid, Cosan, Alumen was respectively 1: 3: 3: 3: 30;
9, antiinflammatory as claimed in claim 5, antipruritic, antiphlogistic externally applied liniment is characterized in that the ratio of its optimum formula Mentholum, salicylic acid, Cosan, Alumen was respectively 1: 6: 5: 20.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95104681A CN1095659C (en) | 1995-04-26 | 1995-04-26 | A set of external baths with anti-inflammatory, anti-itch and anti-bacterial effects |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95104681A CN1095659C (en) | 1995-04-26 | 1995-04-26 | A set of external baths with anti-inflammatory, anti-itch and anti-bacterial effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1111984A true CN1111984A (en) | 1995-11-22 |
| CN1095659C CN1095659C (en) | 2002-12-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95104681A Expired - Fee Related CN1095659C (en) | 1995-04-26 | 1995-04-26 | A set of external baths with anti-inflammatory, anti-itch and anti-bacterial effects |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1095659C (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479058B1 (en) | 1999-09-02 | 2002-11-12 | Mccadden Michael E. | Composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| US6656928B1 (en) * | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| EP1206269A4 (en) * | 1999-06-30 | 2007-09-12 | Don H Girvan | Compositions and methods for the treatment of skin disorders |
| CN101167855B (en) * | 2007-11-01 | 2010-09-08 | 郑瑞 | Medicine for treating tinea pedis and tinea manuum |
| CN104042462A (en) * | 2013-03-16 | 2014-09-17 | 李江水 | Preparation and production of sulfurous spring powdery bath salt |
| CN107375452A (en) * | 2017-09-29 | 2017-11-24 | 梁正文 | Tinea medicinal powder and its preparation and application |
| CN108014182A (en) * | 2018-02-06 | 2018-05-11 | 威海惠高生物科技有限公司 | A kind of Chinese medicine composition and production method for being used to treat pruitus |
| CN108126173A (en) * | 2017-12-30 | 2018-06-08 | 湖南三五二环保科技有限公司 | A kind of composition of medicine for treating fungal dermatopathy and preparation method thereof |
| CN108853410A (en) * | 2018-09-07 | 2018-11-23 | 陕西省万安药业有限公司 | A kind of Chinese drugs agentia and its preparation method and application for preventing and treating gynecological disease |
| CN109010100A (en) * | 2018-09-06 | 2018-12-18 | 黄犟兵 | A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition |
| CN109316552A (en) * | 2018-11-30 | 2019-02-12 | 无锡福祈制药有限公司 | A kind of pharmaceutical composition for treating tinea pedis |
| CN110179956A (en) * | 2019-05-09 | 2019-08-30 | 重庆医药高等专科学校 | The Chinese medicine external use lotion for treating hidrosis erosive beriberi |
| CN117018101A (en) * | 2023-08-30 | 2023-11-10 | 华南农业大学 | An external Chinese medicinal lotion for treating equine mite disease and its preparation method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087830A (en) * | 1992-12-10 | 1994-06-15 | 段亿昕 | A kind of deodorant shoe powder |
| CN1044443C (en) * | 1993-01-11 | 1999-08-04 | 绵竹县中医医院 | Fumigant for curing anal and intestinal disease |
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1995
- 1995-04-26 CN CN95104681A patent/CN1095659C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1206269A4 (en) * | 1999-06-30 | 2007-09-12 | Don H Girvan | Compositions and methods for the treatment of skin disorders |
| US6479058B1 (en) | 1999-09-02 | 2002-11-12 | Mccadden Michael E. | Composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| US6656928B1 (en) * | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| US6890544B2 (en) | 1999-09-02 | 2005-05-10 | Mccadden Michael E. | Gel composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| CN101167855B (en) * | 2007-11-01 | 2010-09-08 | 郑瑞 | Medicine for treating tinea pedis and tinea manuum |
| CN104042462A (en) * | 2013-03-16 | 2014-09-17 | 李江水 | Preparation and production of sulfurous spring powdery bath salt |
| CN107375452A (en) * | 2017-09-29 | 2017-11-24 | 梁正文 | Tinea medicinal powder and its preparation and application |
| CN108126173A (en) * | 2017-12-30 | 2018-06-08 | 湖南三五二环保科技有限公司 | A kind of composition of medicine for treating fungal dermatopathy and preparation method thereof |
| CN108014182A (en) * | 2018-02-06 | 2018-05-11 | 威海惠高生物科技有限公司 | A kind of Chinese medicine composition and production method for being used to treat pruitus |
| CN109010100A (en) * | 2018-09-06 | 2018-12-18 | 黄犟兵 | A kind of acne-removing composition and anti-acne antiallergic cream and preparation method containing the composition |
| CN108853410A (en) * | 2018-09-07 | 2018-11-23 | 陕西省万安药业有限公司 | A kind of Chinese drugs agentia and its preparation method and application for preventing and treating gynecological disease |
| CN108853410B (en) * | 2018-09-07 | 2021-02-05 | 陕西省万安药业有限公司 | Traditional Chinese medicine medicament for preventing and treating gynecological diseases and preparation method and application thereof |
| CN109316552A (en) * | 2018-11-30 | 2019-02-12 | 无锡福祈制药有限公司 | A kind of pharmaceutical composition for treating tinea pedis |
| CN110179956A (en) * | 2019-05-09 | 2019-08-30 | 重庆医药高等专科学校 | The Chinese medicine external use lotion for treating hidrosis erosive beriberi |
| CN110179956B (en) * | 2019-05-09 | 2021-07-20 | 重庆医药高等专科学校 | Traditional Chinese medicine external lotion for treating hyperhidrosis and erosive athlete's foot |
| CN117018101A (en) * | 2023-08-30 | 2023-11-10 | 华南农业大学 | An external Chinese medicinal lotion for treating equine mite disease and its preparation method |
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| CN1095659C (en) | 2002-12-11 |
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