CN1095659C - A set of external baths with anti-inflammatory, anti-itch and anti-bacterial effects - Google Patents

Abstract

The bath agent is suitable for the itching relieving, inflammation diminishing and antibacterial treatment of various clinical skin diseases, and especially has good curative effects on diseases with wide skin lesions, such as subacute or chronic eczema, systemic pruritus, diffuse reddish dermatitis or eczema, pruritus, drug eruption, prurigo, pityriasis rosea, urethritis, scrotitis, vulvitis, gonorrhea, non-gonococcal infection, perianal dermatitis, perineal dermatitis, eczema and the like, and the stable stage and the regression stage of psoriasis. The invention also discloses a novel bath agent prescription which is prepared by adding certain external drugs such as salicylic acid, sulfur powder, boric acid, calamine and resorcinol on the basis of the formula, and the novel prescription also has better treatment effect on certain skin diseases which are difficult to treat such as various tinea, urticaria and the like.

Description

A set of external baths with anti-inflammatory, anti-itch and anti-bacterial effects

An external bath agent with anti-inflammatory, anti-itching and anti-bacterial effects, suitable for anti-itching, anti-inflammatory and anti-bacterial treatment of clinical skin diseases, especially for diseases with extensive skin lesions such as subacute or chronic eczema, generalized pruritus, diffuse For reddened dermatitis, eczema, psoriasis, etc., this bath has excellent curative effect.

In traditional Chinese medicine, it has a long history to use traditional Chinese medicine to boil water and then soak or bathe to treat various skin diseases. Modern medicine has also proved that adding certain drugs to the bath water can have a certain therapeutic effect. For example, patients with pemphigus vulgaris can take a bath with a dilute solution of potassium permanganate, which can sterilize and deodorize; Wash your hands with compound copper sulfate solution; patients with erosive tinea pedis can also use it to soak their feet; patients with subacute or chronic eczema with extensive skin lesions can take a tar bath, that is, add an appropriate amount of coal tar solution to the bath water, and immediately Relieve itching and make patients feel comfortable. Erythroderma patients with red, desquamated and itchy skin can take alkaline baths, that is, adding sodium bicarbonate to the bath water can also temporarily relieve symptoms; generalized pruritus, diffuse Patients with red dermatitis, eczema, and psoriasis can take starch bath, that is, boil starch into a thin paste and pour it into bath water, or rice soup for cooking. The concentration is low, the therapeutic effect is not great, and some drugs can also irritate the skin or sensitize, and even cause the danger of systemic poisoning due to the large amount of absorption through the skin. It has always been a hot topic that clinical medical workers urgently need to solve.

The purpose of the present invention is to provide a bath agent for external use with antipruritic, anti-inflammatory, antibacterial and low skin toxicity. , fungal infection also has an excellent curative effect, providing a new therapy and preparation for the prevention and treatment of skin diseases.

The object of the present invention is achieved by adopting traditional Chinese medicine Peppermint or menthol purified from Peppermint, and then forming a compound preparation with alum. Grind these two medicines into powder, mix them according to 1:30, and pack them into 30-50g packs. Before use, dissolve them in hot water at 50-60°C, and use them for bathing patients after cooling slightly. The affected area can receive anti-inflammatory, antipruritic, antibacterial and other curative effects, so as to play the role of treating various skin diseases.

Alum is a commonly used traditional Chinese medicine. It is often used as an astringent and protective agent in the treatment of skin diseases. It has an "anti-inflammatory" effect by constricting blood vessels, and inhibits the secretion of sebaceous glands and sweat glands to reduce inflammatory secretions, thereby exerting an "astringent" effect. . Modern pharmacological studies have proved that alum has significant antibacterial effects, and has inhibitory effects on Staphylococcus aureus and Proteus (test tube method), and has antibacterial effects on Escherichia coli, Pseudomonas aeruginosa, Bacillus anthracis, Shigella, typhoid bacillus, paratyphi A, Proteus, as well as Staphylococcus, Candida albicans, etc. also have obvious inhibitory effect (paper plate, plate method), the strongest effect on Streptococcus viridans, Hemolytic Streptococcus, Pneumococcus, Bacillus diphtheria; on Brucella bovis , followed by pertussis bacillus and meningococcus, and has no effect on influenza bacilli (disc method). High-concentration alum liquid also has inhibitory effects on human type (H ₃₇ RV) and bovine type Mycobacterium tuberculosis. Research also shows that alum also has Obvious anti-trichomonas vaginalis effect (Dictionary of Traditional Chinese Medicine, P680), the mechanism of action of alum is generally believed to be due to its strong coagulation protein effect, thereby inhibiting the growth and development of bacteria or even death. Peppermint or its extract, menthol, is classified as an antipruritic agent in the treatment of skin diseases, and its effects of promoting blood circulation, anti-inflammatory, and antipruritic are now recognized. It is clinically used for anti-inflammatory, anti-itching, pain-relieving, reducing edema, etc. Studies have shown that when menthol is applied to the skin, due to the stimulation of nerve ending receptors, it first produces a cold sensation, followed by a slight tingling sensation. At this time, the skin temperature does not drop, or even rises slightly, and can slowly penetrate into the skin, causing long-term congestion, and reflexively causing changes in deep blood vessels, adjusting the function of blood vessels, and achieving therapeutic effects (modern research and clinical practice of traditional Chinese medicine) Application, P683), in vitro experiments also confirmed that peppermint has the effect on Staphylococcus aureus, Staphylococcus albus, Streptococcus type A, Streptococcus type B, catarrhal bacteria, enterococcus, Shigella flexneri, Bacillus anthracis, Bacillus diphtheria, typhoid fever Bacillus, Pseudomonas aeruginosa, Escherichia coli, Proteus, and Candida albicans all have antibacterial effects, and studies have also shown that mint herpes simplex virus, vaccinia virus, Semliki forest virus and mumps virus all have inhibitory effects (Modern Research on Chinese Medicine and Clinical application, P683), recent studies also show that peppermint decoction and menthol have inhibitory effects on skin fungi such as Trichophyton rubrum, Trichophyton gypsum, Epidermophyton flocculus, etc., wherein peppermint oil, menthol There is still a good bactericidal effect. In addition, peppermint oil and menthol also have a killing effect on Candida albicans [Hu Lifang, Disinfection and Sterilization, 1989, 6(1): 10]. Peppermint or its extracts and alum form a compound preparation, which can strengthen the antibacterial effect and increase the antibacterial spectrum. It is used for the treatment of skin diseases. The anti-inflammatory effect and antipruritic effect are particularly obvious. The curative effect of this prescription is very positive through clinical observation.

On the basis of the above basic prescription, some of the following drugs can be added to make it play a better role in the treatment of certain skin diseases:

1. On the basis of the above prescription <1>, add 3 to 5 parts of boric acid to form the prescription <2>, and prepare it according to the previous method, which can strengthen the antibacterial and anti-inflammatory effects of the prescription <1>, and has a good effect on the erosion and infiltration of skin diseases. Outgoing damage curative effect is better.

2. On the basis of the above prescription <2>, add 2 to 4 parts of sulfur powder, prepare and use according to the previous method, and treat scabies, acne, seborrheic dermatitis, neurodermatitis, various ringworms, etc. It has excellent curative effect on skin damage. This prescription can also be used directly on the affected area with its powder coating, and it can also achieve the same curative effect on some skin diseases such as ringworm.

3. On the basis of the above three groups of prescriptions, calamine can still be added to strengthen its astringent and antipruritic effects. Generally, calamine is added to any of the above prescriptions in a ratio of 2 to 5 parts. This prescription is effective for urticaria, Acute eczema, contact dermatitis, erythema multiforme and other skin lesions have better curative effect.

4. On the basis of the above four groups of prescriptions, salicylic acid can still be added to strengthen the antifungal effect of this prescription. Salicylic acid can be added to any of the above prescriptions at a ratio of 1 to 5 parts. Tinea versicolor, tinea corporis, tinea manus, pedis, and tinea imbricate have significant curative effects, and also have better curative effects on neurodermatitis, chronic eczema and prurigo nodularis.

5. On the basis of the above five groups of prescriptions, resuoxin can still be added to strengthen the antifungal effect of this prescription. Resuoxin can be added to any of the above prescriptions at a ratio of 1 to 3 parts. Ringworm, jock itch, tinea versicolor, and skin candidiasis are particularly effective.

Here are a few application examples;

Example 1: Prescription <1>: Grind menthol and alum into powder at a ratio of 1～2:40～, pack into 30～50g per pack, add 5kg of hot water at 50℃～60℃ before use Among them, stirring and dissolving, soaking the affected area once or twice a day can relieve or disappear symptoms such as inflammation and itching in the affected area, with an effective rate of 99%.

Example 2: Prescription <2>: 1 part of menthol, 3 parts of boric acid, 30 parts of alum, grind or pulverize into fine powder respectively, pack into 30g/bag, add hot water at 50°C to 60°C before use 5 In kilograms, stir to dissolve, soak or wet compress the affected area, one to two times a day, it is better for skin erosion and exudative damage, and for urethritis, vaginitis, vulvitis, perianal dermatitis, perineal dermatitis etc. also have better curative effect.

Example 3: Prescription <3>: Take 1 part of menthol, 3 parts of boric acid, 30 parts of alum, and 3 parts of sulfur powder, grind or pulverize them into fine powders respectively, pack them into 30g/bag, and add them at 50℃~ Stir and dissolve in hot water at 60°C, soak or wet compress the affected area, once or twice a day, this prescription is effective for acne, scabies, psoriasis, seborrheic dermatitis, neurodermatitis, drug eruption, prurigo, pityriasis rosea, gonorrhea And non-gonococcal infection has better curative effect, also has a certain effect on all kinds of ringworm.

Example 4: Prescription <4>: 1 part of menthol, 3 parts of boric acid, 3 parts of salicylic acid, 3 parts of sulfur powder, 30 parts of alum, grind or pulverize into fine powder respectively, pack into 30g/bag, according to the previous method Application, this prescription has better curative effect on urticaria, acute eczema, contact dermatitis, erythema multiforme, etc.

Example 5: Prescription <5>: 1 part of menthol, 3 parts of boric acid, 3 parts of salicylic acid, 3 parts of sulfur powder, 30 parts of alum, respectively ground or crushed into fine powder, divided into 30g/bag, according to the previous method Application, this prescription has significant curative effect on tinea versicolor, tinea corporis, tinea manuum, tinea imbricate, etc., and also has better curative effect on neurodermatitis, chronic eczema and prurigo nodularis.

Example 6: Prescription <6>: 1 part of menthol, 6 parts of salicylic acid, 5 parts of sulfur powder, 20 parts of alum, grind or pulverize into fine powder respectively, pack into 30-50g/bag, apply according to the previous method, This prescription has a good curative effect on the stable and regressing stages of psoriasis.

Claims (3)

1, a kind of antiinflammatory, antipruritic, antimicrobial external-use bathing lotion is characterized in that this prescription is made up of Mentholum and Alumen, and the proportion of composing of Mentholum and Alumen is 1: 30; This bath agent can be packed as fractional pack, faces with preceding it is dissolved in the hot water, soaks affected part or shower whole body.

2, a kind of antiinflammatory, antipruritic, antimicrobial external-use bathing lotion is characterized in that this prescription is made up of Mentholum, boric acid and Alumen, and the proportion of composing of Mentholum, boric acid and Alumen is 1: 3: 30; This bath agent can be packed as fractional pack, faces with preceding it is dissolved in the hot water, soaks affected part or shower whole body.

3, a kind of antiinflammatory, antipruritic, antimicrobial external-use bathing lotion is characterized in that this prescription is made up of Mentholum, boric acid, Cosan and Alumen, and the proportion of composing of Mentholum, boric acid, Cosan and Alumen is 1: 3: 3: 30; This bath agent can be packed as fractional pack, faces with preceding it is dissolved in the hot water, soaks affected part or shower whole body.