CN1111068C - Strong anti-oxidative composite capsule of grape seed extract OPC and its producing method - Google Patents
Strong anti-oxidative composite capsule of grape seed extract OPC and its producing method Download PDFInfo
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- CN1111068C CN1111068C CN00121388A CN00121388A CN1111068C CN 1111068 C CN1111068 C CN 1111068C CN 00121388 A CN00121388 A CN 00121388A CN 00121388 A CN00121388 A CN 00121388A CN 1111068 C CN1111068 C CN 1111068C
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- capsule
- vitis viniferae
- opc
- semen vitis
- vitamin
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- 229940087603 grape seed extract Drugs 0.000 title abstract description 6
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- 239000001717 vitis vinifera seed extract Substances 0.000 title abstract description 6
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a grape seed extract OPC strong antioxidant composite capsule and a manufacturing method thereof. Top quality grape seed extract OPC, gynostemma pentaphylla total glycosides, Ganderoma lucidum spore powder and vitamin C are taken as raw materials, and the capsule is manufactured through the processes of material inspection, sterilization, sifting, baking, weighing, three-dimensional total mixing, uniformity inspection, feeding materials vertically, capsule filling and separately loading, quality random inspection, packing sterilization, warehousing, etc. The capsule contains rich OPC polyphenols, saponins, polysaccharides, etc., has various effective oxidizing agents and various biologic active ingredients, and functionality tests prove that the capsule has health care functions of delaying aging, regulating body immune functions, etc.
Description
The present invention relates to a kind of medicinal preparation that contains the product of raw material or itself and not clear structure, relate in particular to a kind of medicine by plant and vitamin preparation.
Flavone in the medical evidence Semen Vitis viniferae is potent antioxidant; its oxidation resistance is 50 times of VE; 20 times of VC; its Oxidation also shows the attack of protecting the inside and outside biochemical composition of cell to avoid free radical; prolong cell survival, thereby can play the microcirculation improvement of defying age and vessel softening, reach cosmetology function; can also reduce erythrocytic aggregation, reduce the permeability of blood capillary.
Clinical trial has for many years been done in countries in the world, many medical and health-care products have been developed, " Lean, Portugal " and Canadian " getting precious element " that the U.S. is arranged on the Chinese market now, but these products are the price height not only, and health-care effect nutrition face is narrower, only play the high anti-oxidation effect, but can not play many-sided effects such as immunologic function, defying age, cholesterol reducing, blood pressure lowering, blood fat reducing.
The objective of the invention is to: develop a kind of high anti-oxidation, raise immunity, blood pressure lowering, blood fat reducing, improve cardiac function, slow down aging, promotion human body metabolism, suppress a kind of capsule new drug of tumor, stimulating appetite and resistance.
The present invention is achieved in that capsule is made up of following composition by weight percentage:
Grape seed extract OPC 10-20%
Herb Gynostemmae Pentaphylli total glycosides 10-30%
Ganoderma spore powder 20-40%
Vitamin C 20-40%
Its best is a Semen Vitis viniferae extract (OPC) 16%, Herb Gynostemmae Pentaphylli total glycosides 21%, Ganoderma spore powder 31.5%, vitamin C 31.5%.
Its production technology is: ingredient inspection (sample examination detects every index and will reach) is sterilized with Co-60 dosage 5GY radiation raw material one by one, and------------------------------pack---with Co-60 dosage 5GY radiation sterilization---puts in storage vertical material loading (evenly the back material loading reduces the material double differences) the check uniformity 15-30 minute three-dimensional total mixing the 80-100 order impurity that sieves in check in packing in capsule fillings in weighing (batching) in oven dry (make water content up to standard).
The present invention adopts the high-quality Semen Vitis viniferae, and through the elite (procyanidolic oligomers OPC) that modern science is extracted, Herb Gynostemmae Pentaphylli total glycosides, Ganoderma spore powder, vitamin C are that feed purification forms.Contain abundant OPC Polyphenols, Saponin class, polysaccharide etc., multiple effective antioxidant is arranged, health-care effects such as multiple biological activity functional trial (through a plurality of big mice animal experiments) confirms to have slow down aging, adjusting body's immunity, nontoxic pair of effect.The mechanism of curing the disease of several raw materials of above-mentioned this is as described below:
Semen Vitis viniferae extract among the present invention confirms through France, the U.S., Canada and some European big medical institutions: having one's own knack aspect the canceration of control cellularity, growth of cancer cells is inhibited and is avoiding the complication of various cancers.
Herb Gynostemmae Pentaphylli total glycosides is the good medicine of putative punish-old year chronic tracheitis, Herb Gynostemmae Pentaphylli has pharmacologically active widely because of it contains various chemical components, the confirmation that it is anticancer, defying age, resisting fatigue, antiulcer, analgesia, blood fat reducing, increase body hypoxia-bearing, the curative effect of paying aspects such as effect high temperature resistant and that prevent and treat diabetes, 17-hydroxy-11-dehydrocorticosterone have obtained the clinical research of pharmacological testing has been widely used in clinical improvements cardiac function, treatment mistake eye, headache, symptom such as nervous to the positive performance myodyamia effect of cardiac muscle and central nervous system's significant inhibitory effect.
Ganoderma spore powder: modern scientific research is found, on the Ganoderma fibre substrate, mycelium can be secreted a large amount of enzymes, wherein mainly contain lipase, maltase, laccase, saccharase, amylase, saccharifying enzyme, Chymosin, cellulase, half cellulase, emulsus enzyme, tannase, urine enzyme, the white egg enzyme of pancreas, lipopeptid enzyme etc., these enzymes participate in human body substance metabolism and energy metabolism widely.Material fully absorbs and conversion, and for energy metabolism provides material base, the energy that redox discharged again for substance metabolism provides energy needed, makes whole metabolism that the balance that can reach new all be arranged.Find also that in addition Ganoderma contains various trace elements, as silver, boron, calcium, ferrum, potassium, phosphorus, sodium, manganese, zinc, germanium, bismuth etc., these trace element play an important role to the immunity and the resistance against diseases of enhancing body.These trace element are again the synthetic essential elements of human endocrine hormone simultaneously, and these autacoids play very important regulatory role to the metabolism of body.
Vitamin c powder: play an important role in Cellular respiration, vitamin C participates in amino acid metabolism, neurotransmitter synthetic, matter is synthetic between collagen protein and histiocyte, can reduce the permeability of blood capillary, strengthen solidifying of blood, stimulate coagulation function, promote that ferrum absorbs at enteral, impel rate and blood-lipid decreased, increase resistance, participate in function of detoxification infecting, the effect that has antfhistamine effect and stop carcinogen (nitrosamine) to generate, clinical being used for: scorbutic prevention and treatment; Suitably replenishing of acute and chronic infectious disease with the enhancing body resistance, promotes sick the recovery and wound healing; Cardiogenic shock when taking place in Keshan disease patient, and available heavy dose is treated; Be used for liver cirrhosis, anxious quick dermatoses, aphtha, promotion wound healing etc., report in recent years: flu, some cancer, hyperlipidemia etc. are all had certain effect.
Vitamin C is for keeping one of indispensable vitamin of human body metabolism.Prevention vitamin C deficiency and treatment cause because of vitamin C is not enough that gingivitis, anemia, inappetence, malnutrition, resistance go down, growths stops and recovery after being ill etc., and are used for oral cavity, nose, kidney, uterus and other organ hemorrhages, various acute infectious disease etc.
Now with the high anti-oxidation of Semen Vitis viniferae extract (OPC) with increase the effect of immunologic function, the blood pressure lowering of Herb Gynostemmae Pentaphylli, blood fat reducing, improve cardiac function, function in delaying senility; The promotion human body metabolism of Ganoderma spore powder increases immunologic function, suppresses tumor; The nontoxic after testing pair effect of capsule of allocating development in one according to human needs is in proportion gathered in the effect of ascorbic appetite strengthening and resistance, the fullsized external product has stronger health-care effect in antioxidation, defying age, there is remarkable result aspects such as raise immunity and cholesterol reducing, blood pressure lowering, blood fat reducing.
In preparation during capsule: 1, get Semen Vitis viniferae extract, Herb Gynostemmae Pentaphylli total glycosides, Ganoderma spore powder, four kinds of raw material sample examinations of vitamin C (except the mushroom) qualified after, go its outer package to send between buffering with Co-60 dosage 5GY radiation sterilization, take out after disinfection by ultraviolet light 6-10 hour sieve (80-100 mesh sieve), sieve removes the solid impurity that may exist, the then oven drying if moisture content exceeds standard.
2, treat that the moisture content fast measuring is qualified after, weigh batching is gone into three-dimensional mixer mixing its uniformity of pick test after 15-30 minute, the filled capsules polishing of qualified back.
3, capsule subpackage: packing bottle closure film, go its outer package to enter between buffering, after the Burdick lamp irradiation, enter the inner packing operation and use (inner packing is checked before sealing, packing, every bottle capsule quantity difference positive and negative one), seal spiral cover after packing is qualified.
4, packing labeling, vanning, check are got the qualified back of 1-2 bottle joint sealing by every case, Co-60 dosage 5GY sterilization finished product warehouse-in.
5, working condition: production site should meet the pertinent regulations of " health food manufacturing enterprise GHP ".
6, process equipment: pulverizer, revolve the sieve that shakes, comminutor, drying bed, pelletizing machine, mixer, capsule filling machine, capsule, plastic bottle, sealing machine.
7, raw material production and quality standard: Semen Vitis viniferae extract, Herb Gynostemmae Pentaphylli total glycosides, Ganoderma spore powder are dry fine powder, vitamin c powder, medicinal raw material, white powder.
| Material name | Kind | Production unit | The standard code |
| Semen Vitis viniferae extract | Natural | Penglai City's marine biochemical industry company limited | Q/PSHO11-98 |
| Herb Gynostemmae Pentaphylli total glycosides | Natural | The safe and comfortable pharmaceutical factory of Beijing Medical University | Defend medicine Z-03 |
| Ganoderma spore powder | Cultivate | General biotechnology development company of China Science and Technology Exchange Centre Haier of the Department of Science and Technology | Medicine strong (96) 0082 is defended in the capital |
| Vitamin c powder | Synthetic | Hebei Weierkang Pharmaceutical Co., Ltd | Standards of pharmacopoeia |
| Capsule | Suzhou capsule factory | Standards of pharmacopoeia |
The present invention is also available other factories of raw material of the above-mentioned unit of usefulness, but the regulation of essential conformance with standard code.
Embodiment: (pressing the 100g weighing)
Form 1 and form 2 compositions, 3 compositions 4
Grape seed extract OPC 16 10 15 20
Herb Gynostemmae Pentaphylli total glycosides 21 10 25 10
Ganoderma spore powder 31.5 40 30 30
Vitamin C 31.5 40 30 40
Claims (3)
1, a kind of Semen Vitis viniferae extract procyanidolic oligomers strong anti-oxidative composite capsule is characterized in that: be made up of following composition by weight percentage:
Semen Vitis viniferae extract procyanidolic oligomers 10-20%
Herb Gynostemmae Pentaphylli total glycosides 10-30%
Ganoderma spore powder 20-40%
Vitamin C 20-40%.
2, a kind of Semen Vitis viniferae extract procyanidolic oligomers strong anti-oxidative composite capsule is characterized in that: be made up of following composition by weight percentage:
Semen Vitis viniferae extract procyanidolic oligomers 16%
Herb Gynostemmae Pentaphylli total glycosides 21%
Ganoderma spore powder 31.5%
Vitamin C 31.5%.
3, the manufacture method according to claim 1 or 2 Semen Vitis viniferae extract procyanidolic oligomers strong anti-oxidative composite capsules is characterized in that its operation is:
Ingredient inspection: sampling, chemical examination, the every index one of detection are with Co-60 dosage 5GY radiation
The raw material sterilization---sieve: the 80-100 order,---oven dry:---weighing---three-dimensional is always mixed:
15-30 minute,---the check uniformity---vertical material loading: material loading evenly---capsule
------check: sampling check for quality---packing---is with Co-60 dosage 5GY in packing in filling
Radiation sterilization---warehouse-in.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00121388A CN1111068C (en) | 2000-07-27 | 2000-07-27 | Strong anti-oxidative composite capsule of grape seed extract OPC and its producing method |
| PCT/CN2001/001203 WO2002011744A1 (en) | 2000-07-27 | 2001-07-25 | A strong antioxidant composite capsule containing grape seed extract opc and process for producing the same |
| AU2002214921A AU2002214921A1 (en) | 2000-07-27 | 2001-07-25 | A strong antioxidant composite capsule containing grape seed extract opc and process for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00121388A CN1111068C (en) | 2000-07-27 | 2000-07-27 | Strong anti-oxidative composite capsule of grape seed extract OPC and its producing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1280008A CN1280008A (en) | 2001-01-17 |
| CN1111068C true CN1111068C (en) | 2003-06-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00121388A Expired - Fee Related CN1111068C (en) | 2000-07-27 | 2000-07-27 | Strong anti-oxidative composite capsule of grape seed extract OPC and its producing method |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1111068C (en) |
| AU (1) | AU2002214921A1 (en) |
| WO (1) | WO2002011744A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893641B2 (en) | 1999-10-12 | 2005-05-17 | Chee-Keung Chung | Ganoderma lucidum spores for treatment of autoimmune diseases |
| US6908614B2 (en) | 1999-10-12 | 2005-06-21 | Chee-Keung Chung | Anti-aging/menopause symptoms relief using ganoderma lucidum spores |
| US7037535B2 (en) | 2002-11-19 | 2006-05-02 | Kimberly-Clark Worldwide, Inc. | Method and composition for neutralizing house dust mite feces |
| US7585518B2 (en) | 2002-11-19 | 2009-09-08 | Kimberly-Clark Worldwide, Inc. | Products and methods for maintaining or increasing ceramide levels in skin |
| US20050019379A1 (en) | 2003-07-22 | 2005-01-27 | Kimberly-Clark Worldwide, Inc. | Wipe and methods for improving skin health |
| CN100420391C (en) * | 2006-12-18 | 2008-09-24 | 东北虎药业股份有限公司 | Health-care food with anti-oxidation and lowering weight functions |
| CN102511826A (en) * | 2011-12-29 | 2012-06-27 | 苏州爱斯欧蒂生物科技有限公司 | Lipid-lowering health care product and preparation method thereof |
| CN103156878A (en) * | 2013-04-11 | 2013-06-19 | 天津市园艺工程研究所 | Phellinus baumii polysaccharide and OPC (Oligomeric Proantho Cyanidins) slow-release micro-capsules |
| CN105475999A (en) * | 2015-11-27 | 2016-04-13 | 杭州海王生物工程有限公司 | Composition with effects of resisting oxidation, improving liver damage and improving immunity |
| CN109007833A (en) * | 2018-08-22 | 2018-12-18 | 广州市顺芝堂生物科技有限公司 | It is a kind of to adjust the composition of immune function of human body, capsule and preparation method thereof |
| CN115444894B (en) * | 2022-09-24 | 2024-06-04 | 北京东方红航天生物技术股份有限公司 | Composition for early intervention of liver fibrosis, preparation method and preparation thereof |
| CN117618527B (en) * | 2023-12-04 | 2024-10-25 | 山东益衡元健康科技有限公司 | Composition for improving male hormone level and male sexual ability, preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241623A (en) * | 1999-08-18 | 2000-01-19 | 孙传经 | Supercritical carbon dioxide extraction process of grape seed oil and cyanine oligomer |
| CN1268891A (en) * | 1997-08-06 | 2000-10-04 | 麦莱琉卡有限公司 | A food additive containing natural ingredients |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61104772A (en) * | 1984-10-27 | 1986-05-23 | Osaka Chem Lab | Tea-like refreshing drink containing 'amachazuru' and its production |
| CN1083387A (en) * | 1993-05-31 | 1994-03-09 | 季永高 | " glossy ganoderma-gynostemma pentaphyllum " oral liquid |
| US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
| AU1944599A (en) * | 1997-12-24 | 1999-07-19 | Shaklee Corporation | Composition with high efficiency skin protection from damaging effects of ultraviolet light |
| KR20000034037A (en) * | 1998-11-27 | 2000-06-15 | 박인배 | Grape Seed Extract as a Tyrosinase Inhibitor |
-
2000
- 2000-07-27 CN CN00121388A patent/CN1111068C/en not_active Expired - Fee Related
-
2001
- 2001-07-25 WO PCT/CN2001/001203 patent/WO2002011744A1/en not_active Ceased
- 2001-07-25 AU AU2002214921A patent/AU2002214921A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1268891A (en) * | 1997-08-06 | 2000-10-04 | 麦莱琉卡有限公司 | A food additive containing natural ingredients |
| CN1241623A (en) * | 1999-08-18 | 2000-01-19 | 孙传经 | Supercritical carbon dioxide extraction process of grape seed oil and cyanine oligomer |
Non-Patent Citations (2)
| Title |
|---|
| 沙棘2000,13(1) 2000-01-31 刘朵花等沙棘和葡萄籽中原药青素的对比研究 * |
| 衡阳医学院学报1995,23(1) 1995-01-31 张秋菊等绞股蓝总皂甙和维生素E对实验性动脉粥样硬化兔的肝脏和心肌中SOD及LPO含量的影响 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1280008A (en) | 2001-01-17 |
| WO2002011744A1 (en) | 2002-02-14 |
| AU2002214921A1 (en) | 2002-02-18 |
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