CN1160095C - Antisanility health-care cream and its preparing process - Google Patents
Antisanility health-care cream and its preparing process Download PDFInfo
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- CN1160095C CN1160095C CNB011143177A CN01114317A CN1160095C CN 1160095 C CN1160095 C CN 1160095C CN B011143177 A CNB011143177 A CN B011143177A CN 01114317 A CN01114317 A CN 01114317A CN 1160095 C CN1160095 C CN 1160095C
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- paeoniae alba
- rhizoma atractylodis
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to anti-aging health preservation ointment which belongs to the technical field of producing health food prepared by using plants as raw materials. The anti-aging health preservation ointment is prepared from 10 medicinal materials including ginseng, white atractylodes rhizome, astragalus root, eucommia bark, mulberry fruit seed, donkey-hide gelatin, Chinese wolfberry, radix paeoniae alba, coix seed, licorice and the supplementary material of mutton fat, crystal sugar and Tween-80, and the method for preparing the anti-aging health preservation ointment comprises the following steps: pretreatment, extractum preparation of the ginseng and the coix seed, extraction of the volatile oil of the white atractylodes rhizome and the radix paeoniae alba, manufacture of seven medicines, such as the mulberry fruit seeds, the white atractylodes rhizome, etc., by mixing and decocting, manufacture of a solution of the donkey-hide gelatin and supplementary materials, addition of the Tween-80 and even mixing, split charging, sterization and packaging. The anti-aging health preservation ointment has the functions for body building and aging delaying, and has the advantages of medium mouth feelings, convenient taking, design and manufacture according to national standards, safety and reliability. The anti-aging health preservation ointment is proved to have no toxic side action according to experiments and tests, and is effective health food.
Description
Antisanility health-care cream has another name called " Yongkang health preserving cream ", belongs to the anti-aging health care technical field of food preparation that is made of vegetable material.
Known to the applicant, present disclosed anti-ageing healthcare medicine is more, for this reason, has carried out the Searches of Patent Literature, reflects that the file of these background technologies has: " defying age Chinese patent medicine " (application number: 94112748); " Antisenile medicine and preparation method thereof " (application number: 93100177); " compounded " (application number: 96115394); " Antisenile medicine and preparation method thereof " (application number: 92112368); " Antisenile medicine " (application number: 96104129); " a kind of antidotal Chinese medicine " (application number: 00110320) or the like.The applicant thinks: above-mentioned antiaging agent has identical purpose and function with the present patent application technical scheme, but the technological means that is adopted is variant, is fully inequality as product component and preparation technology.The applicant once did market survey, also found no product on market the public offering identical with preparing process with this product component.In addition, also there is not the people developing phase antisenescence health product roughly the same therewith according to the multidate information that the applicant grasped.
The purpose of invention is, provides a kind of no side effects to society, and effective component is stable, has health food---the Antisanility health-care cream of benefiting QI and nourishing blood, building body, deferring senility.
The technical scheme of claimed invention is as follows:
Antisanility health-care cream is made of the plant material and the adjuvant of following weight ratio: Radix Ginseng 10 weight portions, the Rhizoma Atractylodis Macrocephalae 14 weight portions, the Radix Astragali 14 weight portions, the Cortex Eucommiae 10 weight portions, Fructus Mori 10 weight portions, Colla Corii Asini 10 weight portions, Fructus Lycii 10 weight portions, the Radix Paeoniae Alba 8 weight portions, Semen Coicis 8 weight portions, Radix Glycyrrhizae 6 weight portions, Adeps caprae seu ovis 30 weight portions, crystal sugar 300 weight portions, tween 80 11 weight portions.
Antisanility health-care cream is prepared according to following technological process: (1) raw material gives processing, learn from else's experience screening, Radix Ginseng, the Cortex Eucommiae, Fructus Mori, each 10 weight portion of Fructus Lycii after purifying, the Rhizoma Atractylodis Macrocephalae, each 14 weight portion of the Radix Astragali, the Radix Paeoniae Alba, each 8 weight portion of Semen Coicis, Radix Glycyrrhizae 6 weight portions, cut into 2～3 fens long fragments or section, standby; (2) Radix Ginseng, Semen Coicis extractum preparation is got Radix Ginseng, Semen Coicis is produced extractum according to percolation; Make solvent, dipping after 24 hours with 60% ethanol of 10 times of amounts, carry out percolation with the speed of per minute 1～3ml; Abandon medicinal residues; Collect percolate, decompression recycling ethanol makes concentrated solution be the thick paste shape, and when temperature was 80 ℃, relative density is 1.1 8～1.2, and was standby; (3) extract the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba volatile oil, get volatile oil through distillation in 6 hours; After its medicinal residues water decoction filtration in 1 hour, get decocting liquid and medicinal residues, branch is deposited standby; (4) Fructus Mori, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Glycyrrhizae and the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba medicinal residues decocting liquid produces, with latter's medicinal residues incorporate in the preceding 5 flavor raw materials, the decocting that adds 2 times of amounts boils 3 times, each 1 hour, get decocting liquid, abandon medicinal residues, again this decocting liquid and the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba decocting liquid are merged, filter, concentrate, make 7 flavor medicine mixing decocting liquids, the ethanol that adds 2 times of amounts 95% again, leave standstill more than 12 hours, filter, decompression recycling ethanol to concentrated solution is the thick paste shape; (5) get Colla Corii Asini 10 weight portions, Adeps caprae seu ovis 30 weight portions, crystal sugar 300 weight portions and add water and heat and be lysate, standby; (6) with Radix Ginseng, Semen Coicis concentrated solution, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba volatile oil, Fructus Mori, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba decocting liquid concentrated solution, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Colla Corii Asini, Adeps caprae seu ovis, crystal sugar dissolving liquid phase mixing; And take the dish out of the pot at extractum and to add tween 80 11 weight portions in preceding 15 minutes; (7) packing, sterilization, packing.
Can draw the technological process of production figure of Antisanility health-care cream according to above-mentioned technological process, as shown in drawings.
Formulation data that technique scheme is given and preparation method be implement of the present invention one typical
Embodiment.
The pharmacology of Antisanility health-care paste formulation is according to being: Chinese medicine thinks that deficient (being asthenia) is that with the internal organs loss, the negative and positive of qi and blood deficiency is the general name of the multiple slow weak sign of main pathogenesis due to the multiple reason.We are that to decrease at spleen kidney two deficiency of five ZANG-organs be main and insufficiency of vital energy and blood is established, and Ming Dynasty Wang Qi stone is paid attention to the importance of lung spleen in deficient, and it is shown " reason nihility mirror, controlling void has this " and points out that " controlling void has originally, and lung, spleen, kidney are also.Lung is a source of vital essence of five ZANG-organs, and spleen is the mother of bones of the body collectively, and kidney is the root of life, controls lung, controls spleen, controls kidney, controls the road of void and finishes." because our to control the spleen kidney, the kidney spleen is the congenital the foundation of acquired constitution of life, so the effect of life lengthening is arranged.
According to " Chinese antiaging agent " record with " Chinese medicinal herb compilation ", Radix Ginseng, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, the Cortex Eucommiae etc. are the traditional medication of prolonging life of the traditional Chinese medical science in this prescription.Modern medicine and pharmacological research prove, Radix Ginseng can improve cell survival, has the free radical resisting Oxidation, improve ability of learning and memory and old people's adaptive capacity, enhancing human body immunity function, stimulation hemopoietic function of bone marrow and liver detoxification function, and have cardiotonic, strengthen blood fluidity, anticoagulant fibrinolytic effect, therefore to improving tissue perfusion, reduce thrombosis, blood fat reducing and prevent and treat atherosclerosis and also play an important role.
Lycium barbarum polysaccharide has enhancing immunity function, blood fat reducing, blood sugar lowering, promotion hemopoietic function, liver function protecting, and has the testosterone of raising level to play strong effect.
The Rhizoma Atractylodis Macrocephalae has effects such as building body, blood sugar lowering, raise immunity, antitumor, the liver protecting, adjusting function of intestinal canal.
The Radix Astragali can strengthen immune function of human body, promotes nucleic acid and protein synthesis, makes vigorous, the life-saving of cell growth, and the process that prevents and palliate a disease is improved the adaptive capacity to environment.
The Cortex Eucommiae has blood pressure lowering, promotes immunity and diuresis.
Removing uncle's cloud according to Anhui medical university and studies show that its drug effect of the Radix Paeoniae Alba in the prescription can match in excellence or beauty with Radix Ginseng, and have analgesia, protect the liver, improve function such as sleep, is one of medicine that the employing frequency is the highest in the successive dynasties proved recipe.
Immunologic function can be regulated and promote to Fructus Mori.
The chromocor compound of Radix Glycyrrhizae has tangible antioxidation.
Semen Coicis has significant antitumaous effect.
The growth effect that Colla Corii Asini has improvement calcium balance effect and quickens cell and hemoglobin.
Above-mentioned showing, this prescription has benefiting QI and nourishing blood, building body, deferring senility.
In order to ensure the quality of Antisanility health-care cream product, the applicant is according to national regulation, and the specification requirement of having worked out product is as follows:
(1) raw material and adjuvant, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, the Cortex Eucommiae, Fructus Mori, Colla Corii Asini, Fructus Lycii, the Radix Paeoniae Alba, Semen Coicis, Radix Glycyrrhizae should meet the pertinent regulations of the Pharmacopoeia of the People's Republic of China.Free from insect pests, nothing are gone mouldy.
(2) organoleptic indicator
The outward appearance thickness is moderate, exquisiteness, free from admixture, no sand feeling
The pale brown color of color and luster is to brownish black
Sweet, the little hardship of flavour flavor
The peculiar fragrance of abnormal smells from the patient
(3) function slow down aging
(4) physical and chemical index
Every bottle of net content 200 ± 9g of weight
Saponin (%) 〉=0.15
PH value (25 ℃) 4.0～6.0
Moisture content (%)≤25
(5) sanitary index
Poisonous metal is limited the quantity of
Plumbous mg/kg≤0.5
Arsenic mg/kg≤0.3
Copper mg/kg≤5.0
Microorganism is limited the quantity of
Total number of bacteria cfu/g≤1000
Coliform number MPN/100g≤30
Mycete cfu/g≤25
Yeast cfu/g≤25
Pathogenic bacterium must not detect
(6) 18 months shelf-lifves
For the reliability of verifying present design and the quality of product, according to relevant rules and above-mentioned standard, the applicant had once done following test and detection to this product, and was existing that its process and brief introduction as a result is as follows:
1. animal experiment is a subjects with Kunming kind white mice, selects each 10 of male and female, and body weight is 18～22 grams, irritates stomach with the Antisanility health-care cream (being the dark brown paste) of 10g/kg, bw dosage, observes continuously 14 days.According to the acute toxicity classification, prove the Antisanility health-care cream avirulence.Other three genetic toxicity tests, i.e. Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test, the result is all negative.
2. feeding trial, the sample thief Antisanility health-care cream is the dark brown paste, and experimental animal is the Sprague-Dawleg rat, selects 80 of body weight 72～80 gram ablactation rats for use, be divided into matched group and 3 at random and organized by examination, 20 every group, male and female half and half.Matched group is fed to the arm's length basis feedstuff, be subjected to examination group per os irritate stomach give various dose (be 2500mg/kg, bw, 1250mg/kg, bw, 625mg/kg bw) are tried thing, free diet writes down rats eating amount, body weight, observes continuously 30 days.Observation index is: the general behavior of animal, body weight, food utilization, routine blood test and biochemical indicator, pathological anatomy.Result proves by statistics: each dosage treated animal growth promoter is good; Body weight gain, food utilization and matched group do not have significant difference; Every blood parameters and hematological indices are all in range of normal value; Each dosage group internal organs histopathology is observed and is not seen significant pathological change.
3. rat tertogenicity test, getting the Antisanility health-care cream test specimen, is experimental animal with the Wistar rat, optional ripe rat, male and female are by mating copulation at 1: 1, with pregnant Mus be divided at random a matched group different with 3 dosage (be 2500mg/kg, bw, 625mg/kg, bw, 156mg/kg, the examination group that is subjected to bw) is contrast with the distilled water, is tried thing and disposes desired concn with distilled water.In the 7th～16 day that becomes pregnant, every day, per os gave the thing that tried of various dose.Each dosage treated animal has a net increase of body weight and is lower than matched group, but there was no significant difference; Each dosage group and matched group all have the breastbone hypoevolutism, but difference does not have significance, do not see tire Os Mus bone deformity and internal organs deformity, no teratogenesis.
4. delaying senility function test.Laboratory animal is a Drosophila melanogaster, adopts flat cultivation vial to cultivate, and 25 of every pipes place 25 ℃, and relative humidity is in 65% the dark incubator, changes a subculture in four days.Collect virgin fly, the treated grouping of hatching in the 10h, male and female are divided and are supported, and mix by 0.05%, 0.20% and 1.0% dosage in basal medium and are tried thing, and establish matched group.Result of the test shows: (1) low, middle dosage group can obviously prolong the average life of male drosophila, and middle dosage group can obviously prolong average life and the maximum life span of female fruit bat, with matched group significant difference is arranged relatively.
Be experimental animal in addition, also basic, normal, high group and matched group be set and test that the result shows: compare with aged matched group, high dose group can obviously reduce by 10% liver homogenate with various dose with 12 monthly age BALB/C female mices; Low, middle dosage group can obviously reduce Serum LPO content, and is remarkable with aged matched group comparing difference; Low, the middle dosage group activity of SOD in serum that can obviously raise, the low dose group 1% liver homogenate SOD activity that can obviously raise is remarkable with aged matched group comparing difference.
5. stability test.It is 37 ℃ that tested Antisanility health-care cream sample is placed temperature, and relative humidity 75% is incubated 3 months.Detect once before the insulation, detected once continuous three months in later every month.Detection shows that the every detection index after the insulation all do not have change.
6. hygiology detects.Testing result meets above-mentioned specification requirement.
By as seen above-mentioned, to compare with background technology, prescription of this product and production technology are more reasonable and advanced, thereby have the function of benefiting QI and nourishing blood, building body, slow down aging preferably.Secondly, carried out many-sided test of toxicity safety, health care, stability and hygiology and detection according to national regulation and company standard, the result proves that the specification requirement of this product all reaches design standard, meets national regulation.The 3rd, facts have proved that invented food person has obtained good effect, amount and eating method: solar eclipse once, each 3 grams, early or evening edible on an empty stomach best.
Claims (2)
1. Antisanility health-care cream is characterized in that being made by the plant material and the adjuvant of following weight ratio:
The Radix Ginseng 10 weight portion Rhizoma Atractylodis Macrocephalaes 14 weight portion Radixs Astragali 14 weight portions
The Cortex Eucommiae 10 weight portion Fructus Mori 10 weight portion Colla Corii Asini 10 weight portions
The Fructus Lycii 10 weight portion Radix Paeoniae Albas 8 weight portion Semen Coiciss 8 weight portions
Radix Glycyrrhizae 6 weight portion Adeps caprae seu ovis 30 weight portion crystal sugar 300 weight portions
Tween 80 11 weight portions.
2. the preparation method of an Antisanility health-care cream is characterized in that being prepared according to following technological process:
(1) raw material gives processing, the screening of learning from else's experience, Radix Ginseng, the Cortex Eucommiae, Fructus Mori, each 10 weight portion of Fructus Lycii after purifying, and the Rhizoma Atractylodis Macrocephalae, each 14 weight portion of the Radix Astragali, the Radix Paeoniae Alba, each 8 weight portion of Semen Coicis, Radix Glycyrrhizae 6 weight portions cut into 2～3 fens long fragments or section, and are standby;
(2) Radix Ginseng, Semen Coicis extractum preparation is got Radix Ginseng, Semen Coicis is produced extractum according to percolation; Make solvent, dipping after 24 hours with 60% ethanol of 10 times of amounts, carry out percolation with the speed of per minute 1～3ml; Abandon medicinal residues; Collect percolate, decompression recycling ethanol makes concentrated solution be the thick paste shape, and when temperature was 80 ℃, relative density is 1.18～1.2, and was standby;
(3) extract the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba volatile oil, get volatile oil through distillation in 6 hours; After its medicinal residues water decoction filtration in 1 hour, get decocting liquid and medicinal residues, branch is deposited standby;
(4) Fructus Mori, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Glycyrrhizae and the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba medicinal residues decocting liquid produces, with latter's medicinal residues incorporate in the preceding 5 flavor raw materials, the decocting that adds 2 times of amounts boils 3 times, each 1 hour, get decocting liquid, abandon medicinal residues, again this decocting liquid and the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba decocting liquid are merged, filter, concentrate, make 7 flavor medicine mixing decocting liquids, after add 2 times of amount ethanol of 95% again, leave standstill more than 12 hours, filter, decompression recycling ethanol to concentrated solution is the thick paste shape;
(5) get Colla Corii Asini 10 weight portions, Adeps caprae seu ovis 30 weight portions, crystal sugar 300 weight portions and add water and heat and be lysate, standby;
(6) with Radix Ginseng, Semen Coicis concentrated solution, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Mori, the Cortex Eucommiae, the Radix Astragali, Fructus Lycii, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba decocting liquid concentrated solution, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba volatile oil, Colla Corii Asini, Adeps caprae seu ovis, crystal sugar dissolving liquid phase mixing; And take the dish out of the pot at extractum and to add tween 80 11 weight portions in preceding 15 minutes.
(7) packing, sterilization, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011143177A CN1160095C (en) | 2001-06-26 | 2001-06-26 | Antisanility health-care cream and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011143177A CN1160095C (en) | 2001-06-26 | 2001-06-26 | Antisanility health-care cream and its preparing process |
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| Publication Number | Publication Date |
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| CN1393231A CN1393231A (en) | 2003-01-29 |
| CN1160095C true CN1160095C (en) | 2004-08-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011143177A Expired - Fee Related CN1160095C (en) | 2001-06-26 | 2001-06-26 | Antisanility health-care cream and its preparing process |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314352C (en) * | 2005-06-16 | 2007-05-09 | 云南德林海生物科技有限公司 | Life-cultivating paste nourishing agent and its processing method |
| CN104256006A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Yin-enriching, beautifying, ageing-resisting and life-nourishing tea and preparation method thereof |
| CN109247571A (en) * | 2018-10-31 | 2019-01-22 | 吉林省恒实传食品科技发展有限公司 | A kind of anti-aging health preserving health-care food and preparation method thereof |
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2001
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