CN1188800A - 护肝酒及其生产方法 - Google Patents
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Abstract
本发明护肝酒是粮食白酒中用科学的方法加入由植物水飞蓟中提取水飞蓟素精品制得的,酒后饮此护肝酒具有抗脂质过氧化、清除自由基、促进蛋白质合成,提高超氧化物岐化酶的活性等作用,能明显地保护及稳定肝细胞膜对乙醇、硫代乙酰胺、毒蕈素、鬼笔碱、猪屎豆碱等肝脏毒物引起的各种肝损伤具保护和治疗作用,并对四氯化碳引起的谷丙转氨酶的增高有阻止作用。且生产容易,使用方便,效果好,易推广。
Description
本发明属于保健品，特别涉及的是将水飞蓟加入食品饮料中制得的护肝酒及其生产方法。
现在社会交往、娱乐及日常生活中饮酒量很多，但长期过量饮酒可导致酒精肝中毒、脂肪肝等一系列肝脏损伤，喝酒不伤身或少伤身是必要的，虽有解酒茶、解酒药，但只是解酒，随着我国经济的发展，人民的生活提高很快，对人体的保健食品、饮料也要求的更高，用食品饮料能起预防、治疗、保健三者合一的功用是人们的向往，所以不仅能饮酒，而且又能护肝的保健酒是我们的努力方向。
本发明的目的是提供一种用水飞蓟为原料提取水飞蓟素精品，用科学方法溶于粮食白酒中制成具有抗肝脏酒精中毒、保护肝脏等生理活性的护肝酒及其生产方法。
本发明的目的是这样实现的，说明如下：一种护肝酒的组合配方为：每500毫升粮食白酒中含水飞蓟素精品140-200毫克。
上述护肝酒的生产方法为：
①称出粮食白酒20毫升备用；
②取水飞蓟素精品280-400毫克置于玻璃烧杯中，加入8-12毫升聚乙二醇-400(即DEG-400)加温至30-40℃使其溶解，然后降温至室温，再在搅拌状态之下加入到已备好的粮食白酒中，混匀后即成母液；
③取上述母液用粮食白酒稀释50倍，成总容积1000毫升，搅拌均匀，再经滤过分装，即成护肝酒。
上述护肝酒的生产方法中，所用的粮食白酒最好是浓香型的白酒。
上述护肝酒生产方法中所用水飞蓟素精品的精制方法为：
①将水飞蓟种子粉碎后，用石油醚脱脂，然后用醋酸乙酯连续提取至少8小时，然后回收醋酸乙酯得到浓稠的提取物，再加石油醚研磨，得到黄色粉末；
②取上述黄色粉末加丙酮润湿拌匀，再加层析硅胶混匀，使丙酮溶解成分全部吸附到硅胶上，然后上层析柱进行层析(样品∶硅胶＝1∶3-5为宜)，再以氯仿∶甲醇＝100∶1)混合溶剂洗脱，收集洗脱液再以氯仿∶甲醇＝100∶3混合溶剂洗脱，收集洗脱液用TLC检查，合并相同洗脱液，回收溶剂，得微黄色粉末；
③将层析后的粉末在丙酮中进行重结晶，待结晶析出后，抽滤洗涤结晶，即得水飞蓟素精品。
上述水飞蓟素是由菊科水飞蓟种子中提取的黄酮类化合物，具有抗脂质过氧化，消除自由基，促进蛋白质合成，提高超氧化物岐化酶(SOD)的活性等作用，能明显地保护及稳定肝细胞膜，对乙醇、四氯化碳、硫代乙酰胺、毒蕈素、鬼笔碱、猪屎豆碱等肝脏毒物引起的各种肝损伤具有不同程度的保护和治疗作用，并对四氯化碳引起的谷一丙转氨酶的增高有一定的阻止作用，与现有药典上收载的水飞蓟素粗提物护肝作用相比，本发明提取的水飞蓟素精品护肝作用更加显著。
实施例1、组合配方为：
护肝酒的配方为：在浓香型的景阳春酒500毫升中分别含有水飞蓟毒精品150毫克，170毫克，190毫克等三种型号的护肝酒。
实施例2、护肝酒的生产方法为：
取水飞蓟素精品340毫克置入烧杯中，在杯中加入10毫升同时加热至35℃溶解，然后降至室温，然后在不断搅拌下加入20毫升五粮液白酒混匀，即成护肝酒母液；然后用五粮液白酒稀释50倍，成总容积1000毫升，搅拌均匀、分装成每瓶500毫升，内含水飞蓟素精品170毫克。即成护肝酒。
实施例3、水飞蓟素精品的精制方法为：
①将水飞蓟种子粉碎，再用石油醚脱脂，再用醋酸乙酯连续提取至少10小时，再回收醋酸乙酯；再加石油醚研磨得黄色粉末；再用丙酮润湿拌匀；再加层析硅胶混匀，使丙酮溶解的成分全部吸附到硅胶上，再上层析柱进行层析(样品∶硅胶＝1∶4)，以氯仿∶甲醇(100∶1)混合溶剂洗脱，再以氯仿∶甲醇(100∶3)混合溶剂洗脱，收集洗脱液用TLC检查，再合并相同洗脱液，回收溶剂得微黄色粉末；
②将层析后的微黄色粉末在丙酮中进行重结晶，待结晶析出后，抽滤洗涤结晶，即得水飞蓟素精品。
本发明的优点很多，护肝酒科学配制，因其中含有水飞蓟素精品，经饮用实验有明显地保护及稳定肝细胞膜，对乙醇、四氯化碳、硫化乙酰胺、毒蕈素等肝脏毒物引起的各种肝损伤具保护和治疗作用，对谷丙转氨酶的增高有阻止作用，且生产简单、使用方便、效果好宜于推广。
Claims (3)
1、一种护肝酒，其特征在于：组合配方为：在500毫升粮食白酒中含有飞蓟素精品140-200毫克。
2、一种上述护肝酒的生产方法，其特征在于：
①称出粮食白酒20毫升备用；
②取水飞蓟素精品280-400毫克置于玻璃烧杯中，加入8-12毫升聚乙二醇-400(即DEG-400)加温至30-40℃使其溶解，然后降温至室温，再在搅拌状态之下加入到已备好的粮食白酒中，混匀后即成母液；
③取上述母液用粮食白酒稀释50倍，成总容积1000毫升，搅拌均匀，再经滤过分装，即成护肝酒。
3、根据权利要求2所述的护肝酒的生产方法，其特征在于：所述的水飞蓟素精品的精制方法为：
①将水飞蓟种子粉碎后，用石油醚脱脂，然后用醋酸乙酯连续提取至少8小时，然后回收醋酸乙酯得到浓稠的提取物，再加石油醚研磨，得到黄色粉末；
②取上述黄色粉末加丙酮润湿拌匀，再加层析硅胶混匀，使丙酮溶解成分全部吸附到硅胶上，然后上层析柱进行层析，样品∶硅胶＝1∶3-5，再以氯仿∶甲醇＝100∶1混合溶剂洗脱，收集洗脱液再以氯仿∶甲醇＝100∶3混合溶剂洗脱，收集洗脱液用TLC检查，合并相同洗脱液，回收溶剂，得微黄色粉末；
③将层析后的粉末在丙酮中进行重结晶，待结晶析出后，抽滤洗涤结晶，即得水飞蓟素精品。
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| CN97105640A CN1188800A (zh) | 1997-01-22 | 1997-01-22 | 护肝酒及其生产方法 |
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| CN97105640A CN1188800A (zh) | 1997-01-22 | 1997-01-22 | 护肝酒及其生产方法 |
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| CN1188800A true CN1188800A (zh) | 1998-07-29 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299694C (zh) * | 2005-03-09 | 2007-02-14 | 董诗文 | 一种解酒保肝的黄酮组合物及其用途 |
| CN101961367A (zh) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | 一种预防酒精性肝损伤的中药组合物 |
| CN101974398A (zh) * | 2010-11-15 | 2011-02-16 | 宁蒗女儿珍生物工程有限公司 | 一种齐墩果酸保健酒 |
| US9192638B2 (en) | 2009-10-28 | 2015-11-24 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
-
1997
- 1997-01-22 CN CN97105640A patent/CN1188800A/zh active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299694C (zh) * | 2005-03-09 | 2007-02-14 | 董诗文 | 一种解酒保肝的黄酮组合物及其用途 |
| US9192638B2 (en) | 2009-10-28 | 2015-11-24 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| US9526753B2 (en) | 2009-10-28 | 2016-12-27 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| CN101961367A (zh) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | 一种预防酒精性肝损伤的中药组合物 |
| CN101961367B (zh) * | 2010-11-10 | 2012-05-23 | 江苏省奥康生物科技有限公司 | 一种预防酒精性肝损伤的中药组合物 |
| CN101974398A (zh) * | 2010-11-15 | 2011-02-16 | 宁蒗女儿珍生物工程有限公司 | 一种齐墩果酸保健酒 |
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