CN1188800A - Wine with liver protective function and making method thereof - Google Patents
Wine with liver protective function and making method thereof Download PDFInfo
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- CN1188800A CN1188800A CN97105640A CN97105640A CN1188800A CN 1188800 A CN1188800 A CN 1188800A CN 97105640 A CN97105640 A CN 97105640A CN 97105640 A CN97105640 A CN 97105640A CN 1188800 A CN1188800 A CN 1188800A
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- Prior art keywords
- wine
- protective function
- elaboration
- silymarin
- liver
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- 210000004185 liver Anatomy 0.000 title claims abstract description 27
- 230000009993 protective function Effects 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 4
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 claims abstract description 20
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 claims abstract description 20
- 229960004245 silymarin Drugs 0.000 claims abstract description 20
- 235000017700 silymarin Nutrition 0.000 claims abstract description 20
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- 235000020072 grain neutral spirit Nutrition 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 238000004587 chromatography analysis Methods 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000000741 silica gel Substances 0.000 claims description 9
- 229910002027 silica gel Inorganic materials 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000012046 mixed solvent Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- 229920002554 vinyl polymer Polymers 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012452 mother liquor Substances 0.000 claims description 5
- SEBFKMXJBCUCAI-DBMPWETRSA-N silybin Chemical compound C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-DBMPWETRSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 238000005238 degreasing Methods 0.000 claims description 3
- 238000010790 dilution Methods 0.000 claims description 3
- 239000012895 dilution Substances 0.000 claims description 3
- 239000003208 petroleum Substances 0.000 claims description 3
- -1 polyoxyethylene Polymers 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 238000001953 recrystallisation Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000009736 wetting Methods 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 150000002632 lipids Chemical class 0.000 abstract description 2
- LBEZAAAVJBINPH-UHFFFAOYSA-N mucronatine Natural products CN1C(OC)=NC(N)=C2N=CN=C21 LBEZAAAVJBINPH-UHFFFAOYSA-N 0.000 abstract description 2
- BCJMNZRQJAVDLD-FXGRWVCYSA-N usaramine Chemical compound O1C(=O)C(=C/C)/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3[C@H]2[C@H]1CC3 BCJMNZRQJAVDLD-FXGRWVCYSA-N 0.000 abstract description 2
- KPKZJLCSROULON-QKGLWVMZSA-N Phalloidin Chemical compound N1C(=O)[C@@H]([C@@H](O)C)NC(=O)[C@H](C)NC(=O)[C@H](C[C@@](C)(O)CO)NC(=O)[C@H](C2)NC(=O)[C@H](C)NC(=O)[C@@H]3C[C@H](O)CN3C(=O)[C@@H]1CSC1=C2C2=CC=CC=C2N1 KPKZJLCSROULON-QKGLWVMZSA-N 0.000 abstract 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 abstract 1
- 108010009711 Phalloidine Proteins 0.000 abstract 1
- 244000272459 Silybum marianum Species 0.000 abstract 1
- 102000003929 Transaminases Human genes 0.000 abstract 1
- 108090000340 Transaminases Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 230000004224 protection Effects 0.000 description 5
- 230000036541 health Effects 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 231100000753 hepatic injury Toxicity 0.000 description 2
- 231100000334 hepatotoxic Toxicity 0.000 description 2
- 230000003082 hepatotoxic effect Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000002075 anti-alcohol Effects 0.000 description 1
- 230000003035 anti-peroxidant effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000005987 sulfurization reaction Methods 0.000 description 1
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A liver-protecting wine as grains spirit is made up of silymarin extracted from its plant silybum marianum, and can serves to prevent over-oxidization of lipid, remove free radicals, promote synthesis of protein and increase the activity of SOD, so preventing and curing the damage of liver caused by alcohol, thioacetylamine, toxin of toxic mushroom, phalloidine and mucronatine and inhibiting the raise of transaminase.
Description
The invention belongs to healthcare products, particularly be that Silymarin is added wine with liver protective function and the production method thereof that makes in the food-drink.
Drinking amount is a lot of in social interaction now, amusement and the daily life, but long-term excessive consumption of alcohol can cause a series of hepar damnifications such as alcoholic liver poisoning, fatty liver, drinking, not to be harmful to the health or to be harmful to the health less be necessary, though antialcoholism tea, antialcoholic drug are arranged, but just relieve the effect of alcohol, along with Chinese economic development, the people's life improves very fast, to protective foods, the beverage of human body also require higher, the function that can play prevention, treatment, health care three unification with food-drink is people's yearning, so can not only drink, and the health promoting wine that can protect liver again is our striving direction.
The purpose of this invention is to provide a kind of is that raw material extracts the silymarin elaboration with Silymarin, is dissolved in scientific approach and makes wine with liver protective function and the production method thereof that has anti-liver alcoholism, protects physiologically actives such as liver in the grain neutral spirit.
The object of the present invention is achieved like this, is described as follows: a kind of combination formula of wine with liver protective function is: the moisture silibin elaboration 140-200 milligram that flies in per 500 milliliters of grain neutral spirits.
The production method of above-mentioned wine with liver protective function is:
1. it is standby to weigh up 20 milliliters of grain neutral spirits;
2. water intaking flies silibin elaboration 280-400 milligram and places glass beaker, adding 8-12 milliliter polyoxyethylene glycol-400 (being DEG-400) heats to 30-40 ℃ and makes its dissolving, be cooled to room temperature then, under whipped state, join again in the grain neutral spirit of having got ready, behind the mixing mother liquor;
3. get above-mentioned mother liquor with 50 times of grain neutral spirit dilutions, become 1000 milliliters of cubic capacitys, stir, again through filtering packing, wine with liver protective function.
In the production method of above-mentioned wine with liver protective function, used grain neutral spirit is the liquor of Luzhou-flavor preferably.
The process for purification of used silymarin elaboration is in the above-mentioned wine with liver protective function production method:
1. after the Silymarin seed being pulverized, use petroleum ether degreasing, extracted at least 8 hours continuously with vinyl acetic monomer then, reclaim vinyl acetic monomer then and obtain dense thick extract, add sherwood oil again and grind, obtain yellow powder;
2. get above-mentioned yellow powder and add that acetone is wetting to be mixed thoroughly, add the chromatographic silica gel mixing again, make the acetone solution composition all be adsorbed onto on the silica gel, go up chromatography column then and carry out chromatography (sample: silica gel=1: 3-5 is advisable), again with chloroform: mixed solvent wash-out methyl alcohol=100: 1), collect elutriant again with chloroform: methyl alcohol=100: 3 mixed solvent wash-outs, collecting elutriant checks with TLC, merge identical elutriant, reclaim solvent, get micro-yellow powder;
3. the powder behind the chromatography is carried out recrystallization in acetone, after to be crystallized the separating out, the filtering and washing crystallization promptly gets the silymarin elaboration.
Above-mentioned silymarin is the flavonoid compound that extracts by in the composite family Silymarin seed; has anti peroxidation of lipid; eliminate free radical; promote protein synthesis; improve the effects such as activity of superoxide dismutase (SOD); can protect significantly and stable liver plasma membrane; to ethanol; tetracol phenixin; thioacetamide; the poisonous fungus element; phallodine; the various liver injuries that hepatotoxic agents such as mucronatine cause have protection and therapeutic action in various degree; and the increasing of Alanine transaminase that tetracol phenixin causes there is certain interception; compare with the silymarin crude extract liver protection effect that records on the existing pharmacopeia, the silymarin elaboration liver protection effect that the present invention extracts is more remarkable.
Embodiment 1, combination formula are:
The prescription of wine with liver protective function is: in 500 milliliters of the scape wine in spring of Luzhou-flavor, contain 150 milligrams of Silymarin poison elaboration respectively, and 170 milligrams, the wine with liver protective function of three kinds of models such as 190 milligrams of grades.
The production method of embodiment 2, wine with liver protective function is:
Water intaking flies the silibin elaboration and inserts in the beaker for 340 milligrams, adds 10 milliliters and be heated to 35 ℃ of dissolvings simultaneously in cup, reduces to room temperature then, adds 20 milliliters of five-Grain Liquor liquor mixings then under constantly stirring, the wine with liver protective function mother liquor; With 50 times of five-Grain Liquor liquor dilutions, become 1000 milliliters of cubic capacitys then, stir, be distributed into 500 milliliters every bottle, include 170 milligrams of silymarin elaboration.Wine with liver protective function.
The process for purification of embodiment 3, silymarin elaboration is:
1. the Silymarin seed is pulverized, used petroleum ether degreasing again, extracted at least 10 hours continuously with vinyl acetic monomer again, reclaim vinyl acetic monomer again; Add again sherwood oil grind yellow powder; Mix thoroughly with acetone is wetting again; Add the chromatographic silica gel mixing again, make the composition of acetone solution all be adsorbed onto on the silica gel, go up chromatography column again and carry out chromatography (sample: silica gel=1: 4), with chloroform: methyl alcohol (100: 1) mixed solvent wash-out, again with chloroform: methyl alcohol (100: 3) mixed solvent wash-out, collect elutriant and check, remerge identical elutriant, reclaim solvent and get micro-yellow powder with TLC;
2. the micro-yellow powder behind the chromatography is carried out recrystallization in acetone, after to be crystallized the separating out, the filtering and washing crystallization promptly gets the silymarin elaboration.
Advantage of the present invention is a lot, and the preparation of wine with liver protective function science is because wherein containing the silymarin elaboration, through drink Significantly protection is arranged and stablize liver plasma membrane with experiment, to ethanol, carbon tetrachloride, sulfuration acetamide, poison Various hepatic injury tool protections and therapeutic action that the hepatotoxic agents such as gill fungus element cause are to increasing of glutamic-pyruvic transaminase Interception is arranged, and produce simple, easy to use, the effective popularization of being suitable for.
Claims (3)
1, a kind of wine with liver protective function is characterized in that: combination formula is: contain in 500 milliliters of grain neutral spirits and fly silibin elaboration 140-200 milligram.
2, a kind of production method of above-mentioned wine with liver protective function is characterized in that:
1. it is standby to weigh up 20 milliliters of grain neutral spirits;
2. water intaking flies silibin elaboration 280-400 milligram and places glass beaker, adding 8-12 milliliter polyoxyethylene glycol-400 (being DEG-400) heats to 30-40 ℃ and makes its dissolving, be cooled to room temperature then, under whipped state, join again in the grain neutral spirit of having got ready, behind the mixing mother liquor;
3. get above-mentioned mother liquor with 50 times of grain neutral spirit dilutions, become 1000 milliliters of cubic capacitys, stir, again through filtering packing, wine with liver protective function.
3, the production method of wine with liver protective function according to claim 2 is characterized in that: the process for purification of described silymarin elaboration is:
1. after the Silymarin seed being pulverized, use petroleum ether degreasing, extracted at least 8 hours continuously with vinyl acetic monomer then, reclaim vinyl acetic monomer then and obtain dense thick extract, add sherwood oil again and grind, obtain yellow powder;
2. get above-mentioned yellow powder and add that acetone is wetting to be mixed thoroughly, add the chromatographic silica gel mixing again, the acetone solution composition all is adsorbed onto on the silica gel, goes up chromatography column then and carry out chromatography, sample: silica gel=1: 3-5, again with chloroform: methyl alcohol=100: 1 mixed solvent wash-outs, collect elutriant again with chloroform: methyl alcohol=100: 3 mixed solvent wash-outs, collect elutriant and check with TLC, merge identical elutriant, reclaim solvent, get micro-yellow powder;
3. the powder behind the chromatography is carried out recrystallization in acetone, after to be crystallized the separating out, the filtering and washing crystallization promptly gets the silymarin elaboration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97105640A CN1188800A (en) | 1997-01-22 | 1997-01-22 | Wine with liver protective function and making method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97105640A CN1188800A (en) | 1997-01-22 | 1997-01-22 | Wine with liver protective function and making method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1188800A true CN1188800A (en) | 1998-07-29 |
Family
ID=5167957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97105640A Pending CN1188800A (en) | 1997-01-22 | 1997-01-22 | Wine with liver protective function and making method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1188800A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299694C (en) * | 2005-03-09 | 2007-02-14 | 董诗文 | Flavone composition for sobering and liver protection and its use |
| CN101961367A (en) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN101974398A (en) * | 2010-11-15 | 2011-02-16 | 宁蒗女儿珍生物工程有限公司 | Oleanolic acid health care wine |
| US9192638B2 (en) | 2009-10-28 | 2015-11-24 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
-
1997
- 1997-01-22 CN CN97105640A patent/CN1188800A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299694C (en) * | 2005-03-09 | 2007-02-14 | 董诗文 | Flavone composition for sobering and liver protection and its use |
| US9192638B2 (en) | 2009-10-28 | 2015-11-24 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| US9526753B2 (en) | 2009-10-28 | 2016-12-27 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| CN101961367A (en) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN101961367B (en) * | 2010-11-10 | 2012-05-23 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN101974398A (en) * | 2010-11-15 | 2011-02-16 | 宁蒗女儿珍生物工程有限公司 | Oleanolic acid health care wine |
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