CN1188158C - Medicines composition for raising body's immunity and its prepn - Google Patents
Medicines composition for raising body's immunity and its prepn Download PDFInfo
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- CN1188158C CN1188158C CNB021465711A CN02146571A CN1188158C CN 1188158 C CN1188158 C CN 1188158C CN B021465711 A CNB021465711 A CN B021465711A CN 02146571 A CN02146571 A CN 02146571A CN 1188158 C CN1188158 C CN 1188158C
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Abstract
The present invention uses the theory of supporting healthy energy and eliminating evil in Chinese medicine to provide a medicine composition for improving body immune function, strengthening the spleen and invigorating the kidney, thereby achieving the purposes of resolving the current problems and eliminating the root causes. The medicine composition is prepared from the components of the following weight proportion: 130 to 390 portions of astragali, 105 to 315 portions of glossy privet fruit, 39 to 117 portions of ginseng, 40 to 120 portions of ganoderma, 79 to 327 portions of zedoary, 157 to 473 portions of fiveleaf gynostemma herb, 40 to 120 portions of sauted white atractylodes rhizome, 40 to 120 portions of tuckahoe, 5 to 15 portions of cordyceps sinensis, 79 to 237 portions of paniculate swallowwort root, 40 to 120 portions of ground beetle, 13 to 39 portions of notoginseng, 79 to 237 portions of spreading hedyotis herb, 79 to 237 portions of barbed skullcap herb and 25 to 75 portions of sauted medicated leaven. The pharmacological test research of the traditional Chinese medicine college in Hebei medical university shows that the medicine composition capsule of the present invention has obvious inhibiting effect on the sarcomatous growth of a mouse S180 and extends the survival days of a mouse with ehrlich ascites tumor, and the medicine composition capsule has obvious synergistic inhibiting effect on sarcoma of the mouse S180 by combining with cyclophosphamide of chemotherapeutics medicines.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of human body immunity improving function, belong to the Chinese herbal and crude drugs preparations technical field, be particularly useful for treating clinically deficiency of spleen and stomach such as tumor, hepatitis, liver cirrhosis, diseases such as emaciated physique, fatigue and asthenia, distension and fullness in the abdomen due to the combined symptoms in the stasis of blood poison.
Background technology
" deficient " category of diseases genus motherland medical science such as emaciated physique, fatigue and asthenia, distension and fullness in the abdomen due to the combined symptoms in the deficiency of spleen and stomach such as tumor, hepatitis, liver cirrhosis, stasis of blood poison.At present, the Chinese medicine preparation of treatment immunocompromised, as Radix codonopsis pilosulae's soft extract (invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting), Polysaccharide-peptide capsule (nourishing the essence and strengthening QI, invigorating spleen and nourishing heart), ten flavor body-strengthening granules (benefiting vital QI and blood, warming YANG and strengthening the spleen), SHENQI FUZHENG ZHUSHEYE (QI invigorating is set upright), ginseng one capsule (element culturing fixed folder, benefiting vital QI and blood), they are partial to mend more, and are too unilateral.It is considered herein that diseases such as emaciated physique that immunocompromised disease occurs, fatigue and asthenia, spiritlessness and sparing of words, poor appetite lack of appetite, distension and fullness in the abdomen are deficiency of spleen and stomach, tie in the stasis of blood poison and cause, card for deficiency in origin and excess in superficiality, so with strengthening spleen, tonifying kidney, dissolving blood stasis and detoxication is the rule of treatment, starts with from treating both the principal and secondary aspects of a disease, can obviously improve body fluid and cellular immunization function, thereby enhancing resistance against diseases, but and physical strength reinforcing.
Summary of the invention
The present invention provides a kind of with the human body immunity improving function with traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors theory, and the pharmaceutical composition of strengthening spleen, tonifying kidney reaches treating both the principal and secondary aspects of a disease.
Technical scheme of the present invention is achieved in that the pharmaceutical composition of this human body immunity improving function, and its proportion of composing (w/w) comprises Radix Astragali 130-390 part, Fructus Ligustri Lucidi 105-315 part, Radix Ginseng 39-117 part, Ganoderma 40-120 part, Rhizoma Curcumae 79-327 part, Herb Gynostemmae Pentaphylli 157-473 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 40-120 part, Poria 40-120 part, Cordyceps 5-15 part, Radix Cynanchi Paniculati 79-237 part, Eupolyphaga Seu Steleophaga 40-120 part, Radix Notoginseng 13-39 part, Herba Hedyotidis Diffusae 79-237 part, Herba Scutellariae Barbatae 79-237 part, Massa Medicata Fermentata (stir-fry) 25-75 part.
The pharmaceutical composition of described human body immunity improving function, its proportion of composing (w/w) comprise 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 78 parts of Radix Ginsengs, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 10 parts of Cordyceps, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 26 parts of Radix Notoginseng, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, 50 parts of Massa Medicata Fermentata (stir-fry).
The pharmaceutical composition of described human body immunity improving function, its form also can comprise Radix Codonopsis, Colla Plastri Testudinis, Fructus Psoraleae, rhizoma sparganic, Radix Ophiopogonis, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Radix Rehmanniae, the Rhizoma Anemarrhenae, Fructus Crataegi, Fructus Hordei Germinatus, the Cortex Eucommiae wherein one or more.
The preparation of drug combination method of above-mentioned human body immunity improving function comprises:
(1), 78 parts of Radix Ginsengs, 10 parts of Cordyceps, 26 parts of pulverize separately of Radix Notoginseng become fine powder, sieving for standby;
(2), 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, Massa Medicata Fermentata (stir-fry) decoct with water twice for 50 parts, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying, be ground into fine powder, with step (1) powder facing-up, the mixing that sieves, encapsulated.
The pharmaceutical composition of above-mentioned human body immunity improving function can also be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.
Pharmacological testing studies show that through the college of traditional Chinese medicine of Hebei Medical University, and medicament composition capsule of the present invention (trade name is for the strange capsule of China or join clever blue capsule) is to mice S
180The growth of sarcoma has obvious inhibitory action, can prolong ehrlich ascites tumor mice existence natural law, share mice S with the chemotherapeutics cyclophosphamide
180The inhibitory action of sarcoma has the notable synergistic effect, the mice serum hemolysin of caused by cyclophosphamide immunologic hypofunction is obviously raise, the splenocyte conversion ratio obviously increases, cyclophosphamide is caused the murine interleukin minimizing reverse effect, and cyclophosphamide is caused the minimizing of mice food-intake the increase effect.
Acute toxicity test in mice shows that the clinical consumption of capsule of the present invention is 6g/ day, and the oral maximum tolerated dose of mice is 20.0g/kg, 232.6 times of the clinical consumption that is equivalent to be grown up, animal Non Apparent Abnormality and death.Long term toxicity test shows: the present invention does not all have obvious influence to biochemical indicator such as the general situation of rat, body weight, hemogram and main organs coefficient, illustrates that the present invention does not have the overt toxicity reaction.See Appendix.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention.
Embodiment 1:
Radix Astragali 260g Fructus Ligustri Lucidi 210g Radix Ginseng 78g Ganoderma 80g Rhizoma Curcumae 158g
The Herb Gynostemmae Pentaphylli 315g Rhizoma Atractylodis Macrocephalae (stir-fry) 80g Poria 80g Cordyceps 10g
Radix Cynanchi Paniculati 158g Eupolyphaga Seu Steleophaga 80g Radix Notoginseng 26g Herba Hedyotidis Diffusae 158g
Herba Scutellariae Barbatae 158g Massa Medicata Fermentata (stir-fry) 50g
Preparation method:
(1), Radix Ginseng, Cordyceps, Radix Notoginseng pulverize separately become fine powder, sieving for standby;
(2), all the other medicines decoct with water twice, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying is ground into fine powder, and is with step (1) powder facing-up, the mixing that sieves, encapsulated.
Embodiment 2:
Radix Astragali 150g Fructus Ligustri Lucidi 100g Radix Ginseng 40g Ganoderma 80g Rhizoma Curcumae 80g
The Herb Gynostemmae Pentaphylli 150g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Poria 80g Cordyceps 10g
Radix Cynanchi Paniculati 158g Eupolyphaga Seu Steleophaga 40g Radix Notoginseng 15g Herba Hedyotidis Diffusae 158g
Herba Scutellariae Barbatae 80g Fructus Crataegi (stir-fry) 50g
Embodiment 3:
Radix Astragali 500g Fructus Ligustri Lucidi 400g Radix Ginseng 150g Ganoderma 80g Rhizoma Curcumae 320g
The Herb Gynostemmae Pentaphylli 600g Rhizoma Atractylodis Macrocephalae (stir-fry) 40g Poria 80g Cordyceps 10g
Radix Cynanchi Paniculati 158g Eupolyphaga Seu Steleophaga 160g Radix Notoginseng 50g Herba Hedyotidis Diffusae 158g
Herba Scutellariae Barbatae 300g Fructus Hordei Germinatus (stir-fry) 50g
Embodiment 4:
The Radix Astragali 500g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Radix Ginseng 150g Poria 160g rhizoma sparganic 320g
Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Rhizoma Dioscoreae 250g
Arillus Longan 150g Fructus Lycii 150g Radix Polygoni Multiflori Preparata 86g Caulis Spatholobi 89g Radix Glycyrrhizae 90g
Embodiment 5:
The red Radix Paeoniae Alba of the Radix Astragali 500g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Radix Ginseng 150g each 120
Rhizoma sparganic 320g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g
Fructus Ligustri Lucidi 210g 160g Radix Ophiopogonis Fructus Lycii 150g Radix Angelicae Sinensis 89g
Colla Plastri Testudinis 86g Fructus Crataegi 100g
Embodiment 6:
Radix Astragali 450g 220g Radix Ophiopogonis Radix Scrophulariae 120g Rhizoma dioscoreae 89g
Fructus Lycii 90g Rhizoma Anemarrhenae 67g Rhizoma Polygonati Odorati 68g Herb Gynostemmae Pentaphylli 600g
Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Fructus Schisandrae Chinensis 45g Radix Trichosanthis 68
Embodiment 7:
Radix Astragali 450g Radix Ginseng 150g Radix Aconiti Lateralis Preparata 45g Herba Epimedii 68g
Rhizoma Curculiginis 35g Fructus Psoraleae 89g Cordyceps 10g Cortex Eucommiae 86g
Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g 150g Radix Ophiopogonis Radix Rehmanniae 150g
Radix Glycyrrhizae 90g
Embodiment 8:
Radix Codonopsis 220g Radix Astragali 250g Rhizoma Atractylodis Macrocephalae 180g Rhizoma dioscoreae 98g
Stir-fried kidney beans 120g Poria 150g Rhizoma Curcumae 158g Herb Gynostemmae Pentaphylli 315g
Herba Scutellariae Barbatae 158g gives birth to Semen Coicis 86g Pericarpium Citri Reticulatae 68g Radix Glycyrrhizae 90g
Embodiment 9:
Radix Codonopsis 450g Radix Astragali 250g Rhizoma Atractylodis Macrocephalae 120g Rhizoma dioscoreae 68g
Poria 76g Rhizoma Alismatis 35g Cortex Cinnamomi 86g Semen Cuscutae 120g
Fructus Ligustri Lucidi 210g Fructus Corni 86g Radix Rehmanniae 86g Fructus Psoraleae 98g
Fructus Lycii 68g Pericarpium Citri Reticulatae 98g Radix Cyathulae 68
Embodiment 10:
The Radix Astragali (processing) 450g Rhizoma Atractylodis Macrocephalae 220g Fructus Ligustri Lucidi 210g Poria 80g
Herba Scutellariae Barbatae 158g Rhizoma Curcumae 158g Cortex Magnoliae Officinalis 65g Fructus Aurantii Immaturus 56g
Pericarpium Citri Reticulatae 98g Fructus Lycii 86g FLOS MUME 50g Radix Ginseng 45g
Massa Medicata Fermentata (stir-fry) 45g Radix Glycyrrhizae 90gg
Embodiment 11:
Radix Astragali 450g Rhizoma Atractylodis Macrocephalae 220g Radix Angelicae Sinensis 35g Radix Rehmanniae Preparata 150g
Each 86g rhizoma sparganic 180g Eupolyphaga Seu Steleophaga 80g Radix Notoginseng 26g of the red Radix Paeoniae Alba
Radix Polygoni Multiflori Preparata 86g Radix Salviae Miltiorrhizae 110g Poria 86g Rhizoma Dioscoreae 86g
Radix Cyathulae 120g Flos Carthami 86g Radix Glycyrrhizae 90g
The preparation method of embodiment 2-11 and embodiment 1 are basic identical.
The mixture that the preparation method of the foregoing description is made can be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.
Pharmaceutical composition of the present invention is monarch with the Radix Astragali, Fructus Ligustri Lucidi, with Radix Ginseng, Ganoderma, Rhizoma Curcumae, Herb Gynostemmae Pentaphylli is ministerial drug, the Rhizoma Atractylodis Macrocephalae, Poria, Cordyceps, Radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Herba Hedyotidis Diffusae are adjuvant drug altogether, Herba Scutellariae Barbatae, Massa Medicata Fermentata are for making, the tumor that causes for immunologic hypofunction, hepatitis, liver cirrhosis etc. all can be used as the treatment ancillary drug and use, but physical strength reinforcing is resisted exopathogen, makes the body early recovery.
Claims (3)
1, a kind of pharmaceutical composition of human body immunity improving function is characterized in that being made by following raw medicaments in portion by weight: Radix Astragali 130-390 part, Fructus Ligustri Lucidi 105-315 part, Radix Ginseng 39-117 part, Ganoderma 40-120 part, Rhizoma Curcumae 79-327 part, Herb Gynostemmae Pentaphylli 157-473 part, Rhizoma Atractylodis Macrocephalae (parched) 40-120 part, Poria 40-120 part, Cordyceps 5-15 part, Radix Cynanchi Paniculati 79-237 part, Eupolyphaga Seu Steleophaga 40-120 part, Radix Notoginseng 13-39 part, Herba Hedyotidis Diffusae 79-237 part, Herba Scutellariae Barbatae 79-237 part, Massa Medicata Fermentata preparata 25-75 part.
2, the pharmaceutical composition of human body immunity improving function according to claim 1 is characterized in that being made by following raw medicaments in portion by weight: 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 78 parts of Radix Ginsengs, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 80 parts in Poria, 10 parts of Cordyceps, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 26 parts of Radix Notoginseng, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, 50 parts of Massa Medicata Fermentata preparatas.
3, the preparation of drug combination method of human body immunity improving function according to claim 1 and 2 is:
(1), 78 parts of Radix Ginsengs, 10 parts of Cordyceps, 26 parts of pulverize separately of Radix Notoginseng become fine powder, sieving for standby;
(2), 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 80 parts in Poria, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, Massa Medicata Fermentata preparata decoct with water twice for 50 parts, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying, be ground into fine powder, with step (1) powder facing-up, the mixing that sieves, encapsulated.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB021465711A CN1188158C (en) | 2002-10-24 | 2002-10-24 | Medicines composition for raising body's immunity and its prepn |
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| CNB021465711A CN1188158C (en) | 2002-10-24 | 2002-10-24 | Medicines composition for raising body's immunity and its prepn |
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| CN1403147A CN1403147A (en) | 2003-03-19 |
| CN1188158C true CN1188158C (en) | 2005-02-09 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101607059B (en) * | 2008-06-20 | 2012-06-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating and preventing radiation injury |
| CN101607058B (en) * | 2008-06-20 | 2012-06-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating chronic nephritis |
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