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CN116137814A - 阿哌沙班的新型制造方法 - Google Patents

阿哌沙班的新型制造方法 Download PDF

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Publication number
CN116137814A
CN116137814A CN202180059664.3A CN202180059664A CN116137814A CN 116137814 A CN116137814 A CN 116137814A CN 202180059664 A CN202180059664 A CN 202180059664A CN 116137814 A CN116137814 A CN 116137814A
Authority
CN
China
Prior art keywords
apixaban
reaction
compound
formamide
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180059664.3A
Other languages
English (en)
Chinese (zh)
Inventor
堀瑶平
忠田悠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Da Tong Co ltd
Original Assignee
Da Tong Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Da Tong Co ltd filed Critical Da Tong Co ltd
Publication of CN116137814A publication Critical patent/CN116137814A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180059664.3A 2020-06-26 2021-05-28 阿哌沙班的新型制造方法 Pending CN116137814A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020110365A JP2022022550A (ja) 2020-06-26 2020-06-26 アピキサバンの新規製造方法
JP2020-110365 2020-06-26
PCT/JP2021/020478 WO2021261172A1 (fr) 2020-06-26 2021-05-28 Nouveau procédé de production d'apixaban

Publications (1)

Publication Number Publication Date
CN116137814A true CN116137814A (zh) 2023-05-19

Family

ID=79282492

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180059664.3A Pending CN116137814A (zh) 2020-06-26 2021-05-28 阿哌沙班的新型制造方法

Country Status (3)

Country Link
JP (1) JP2022022550A (fr)
CN (1) CN116137814A (fr)
WO (1) WO2021261172A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005511712A (ja) * 2001-12-10 2005-04-28 ブリストル−マイヤーズ　スクイブ　カンパニー ４，５−ジヒドロ−ピラゾロ［３，４−ｃ］ピリド−２−オンの合成
JP2008514712A (ja) * 2004-09-28 2008-05-08 ブリストル−マイヤーズ スクイブ カンパニー ４，５−ジヒドロ−ピラゾロ［３，４−ｃ］ピリド−２−オン類を製造する方法
CN104045637A (zh) * 2014-04-18 2014-09-17 河北科技大学 一种阿哌沙班的制备方法
CN104892601A (zh) * 2015-06-09 2015-09-09 江苏中邦制药有限公司 一种抗血栓药物阿哌沙班的制备方法
JP2017521437A (ja) * 2014-07-11 2017-08-03 ラボラトリオス、レスビ、ソシエダッド、リミターダＬａｂｏｒａｔｏｒｉｏｓ Ｌｅｓｖｉ，Ｓ．Ｌ． アピキサバンの製造方法
CN110615788A (zh) * 2019-10-17 2019-12-27 江西国药有限责任公司 一种高纯度阿哌沙班的制备工艺
CN110862389A (zh) * 2018-08-28 2020-03-06 江苏康缘药业股份有限公司 一种阿哌沙班晶型的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3666773A1 (fr) * 2018-12-11 2020-06-17 KRKA, D.D., Novo Mesto Procédé de préparation d'apixaban

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005511712A (ja) * 2001-12-10 2005-04-28 ブリストル−マイヤーズ　スクイブ　カンパニー ４，５−ジヒドロ−ピラゾロ［３，４−ｃ］ピリド−２−オンの合成
JP2008514712A (ja) * 2004-09-28 2008-05-08 ブリストル−マイヤーズ スクイブ カンパニー ４，５−ジヒドロ−ピラゾロ［３，４−ｃ］ピリド−２−オン類を製造する方法
CN104045637A (zh) * 2014-04-18 2014-09-17 河北科技大学 一种阿哌沙班的制备方法
JP2017521437A (ja) * 2014-07-11 2017-08-03 ラボラトリオス、レスビ、ソシエダッド、リミターダＬａｂｏｒａｔｏｒｉｏｓ Ｌｅｓｖｉ，Ｓ．Ｌ． アピキサバンの製造方法
CN104892601A (zh) * 2015-06-09 2015-09-09 江苏中邦制药有限公司 一种抗血栓药物阿哌沙班的制备方法
CN110862389A (zh) * 2018-08-28 2020-03-06 江苏康缘药业股份有限公司 一种阿哌沙班晶型的制备方法
CN110615788A (zh) * 2019-10-17 2019-12-27 江西国药有限责任公司 一种高纯度阿哌沙班的制备工艺

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YONG WANG等: ""Design, synthesis, and structure-activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1, 2, 4-triazole/pyrrole derivatives as P2 binding element"", 《BIOORGANIC & MEDICINAL CHEMISTRY》, 31 December 2016 (2016-12-31), pages 1 - 30 *

Also Published As

Publication number Publication date
JP2022022550A (ja) 2022-02-07
WO2021261172A1 (fr) 2021-12-30

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Application publication date: 20230519