CN1038919A - A kind of new liuyangmycin compound preparation - Google Patents

Abstract

The invention provides an agricultural acaricide and insecticide compound preparation with macro tetralide antibiotics and triphenyl phosphate or triphenyl phosphite as active ingredients. It has no environmental pollution effect, low cost and excellent effect, providing a good example for the use of pollution-free pesticides.

Description

The present invention has the following chemical structural formula

(where R ₁ , R ₂ , R ₃ and R ₄ are lower alkyl groups) a compound preparation of macro tetralide antibiotics and non-chemical pesticides.

The antibiotics represented by the above structural formulas may produce several stereoisomers with slightly different physical and chemical properties due to their different manufacturing methods and extraction and purification methods. However, since these isomers have no great difference in acaricidal and insecticidal activities, they can generally be regarded as the same substance. In the present invention, the above-mentioned isomers are also regarded as the same substance.

In the past, two or more different pesticides were used in combination, mostly for the purpose of reducing the frequency of application and saving labor. Later, more and more compound preparations with synergistic effects were gradually developed, but most of them were still limited to the compounding of pesticides. Compounding Liuyangmycin antibiotics (hereinafter referred to as Liuyangmycin) with various organophosphorus pesticides (Zhao 45-71417), organochlorine pesticides (Zhao 48-24726), and carbamate pesticides (Zhao 48-25488) There have been many reports on the preparation of a certain synergistic effect, but it is the first time that non-chemical pesticides and Liuyangmycin are compounded into a preparation with obvious synergistic effect as described in the present invention.

The object of the present invention is to provide an agricultural acaricide and insecticide compound preparation without chemical pesticides, so as to gradually replace the use of chemical pesticides and reduce environmental pollution.

The present invention will be described in detail below.

Liuyangmycin is almost non-toxic to warm-blooded animals, and has no teratogenic and carcinogenic effects, while triphenyl phosphate and triphenyl phosphite are less toxic to warm-blooded animals than Liuyangmycin, and they are not irritating to the skin and are not easy to pass through. The skin absorbs.

Compounding liuyangmycin with triphenyl phosphate or triphenyl phosphite at different weight ratios from 1:1 to 1:7, the results all have different degrees of synergistic effect, especially 1:3 is the most good.

Using liuyangmycin (industrial product, content 88.7%) and triphenyl phosphate (chemically pure) as test agents, the synergistic coefficient of spider mite was determined, and the results are shown in Table 2.

^* LC ₅₀ is the 50% lethal concentration

Synergy coefficient = (Liuyangmycin LC ₅₀ )/(Liuyangmycin + Triphenylphosphate LC ₅₀ ) = 14.07

The compound preparation of the present invention can be formulated into various preparations according to different application purposes and needs, among which emulsion is more commonly used.

The solvent used in the formulation of the emulsion may be benzene, toluene or xylene. Emulsifier can choose to use 0201, 0203 or 0204.

The drug efficacy test effect of the compound preparation of the present invention on acaricide and insecticide is described in the following list, and the compound Liuyangmycin (compound preparation of Liuyangmycin and dimethoate) containing chemical pesticides commonly used, Dicofol and other agents for comparison.

In summary, the new compound preparation of liuyangmycin antibiotics provided by the present invention not only does not contain chemical pesticides, is safe for humans, animals and natural enemy insects, has no environmental pollution risk, can be widely used in edible and medicinal crops, and kills The mite insecticidal effect is excellent, the residual effect is long, it is not easy to induce resistance, and the price is cheap. The compound formulation of the invention provides a good model for using pollution-free pesticides.

Embodiment 1 The formula of 20% liuyangmycin, triphenyl phosphate emulsion

Liuyangmycin 5%

Triphenyl Phosphate 15%

Xylene 70%

0201 Emulsifier 10%

Example 2 The formula of 40% liuyangmycin and triphenyl phosphite emulsion

Liuyangmycin 10%

Triphenyl phosphite 30%

Xylene 50%

0201 Emulsifier 10%

Claims (3)

1, a kind of general expression is

(R in the formula ₁, R ₂, R ₃And R ₄Be low alkyl group) macro tetrolide (macrotetrolide) class antibiotic and the complex preparation of other compounds, it is characterized in that described other compounds are triphenyl phosphate or triphenyl phosphite.

2, complex preparation as claimed in claim 1, the weight ratio that it is characterized in that liuyangmycin antibiotics and triphenyl phosphate or triphenyl phosphite were the best with 1: 3 wherein between 1: 1 to 1: 7.

3, a kind of agriculture and garden is characterized in that with killing mite, insecticide contained effective ingredient is the compound of liuyangmycin antibiotics and triphenyl phosphate or triphenyl phosphite.