CN1233343C - Prescription and preparing process for compound spanishneedles ointment - Google Patents
Prescription and preparing process for compound spanishneedles ointment Download PDFInfo
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- CN1233343C CN1233343C CN 02110272 CN02110272A CN1233343C CN 1233343 C CN1233343 C CN 1233343C CN 02110272 CN02110272 CN 02110272 CN 02110272 A CN02110272 A CN 02110272A CN 1233343 C CN1233343 C CN 1233343C
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Abstract
The present invention relates to a preparing process for compound spanishneedles ointment of a Chinese drug preparation, which uses a medicinal material of spanishneedles herb of a Taishan Mount special product as main medicine. Scutellaria root, coptis, phellodendron, earthworm and sesame oil serve as substrate in an auxiliary mode, and beeswax serves as excipient. The spanishneedles herb is boiled by adding water, and decoction liquid is concentrated. After sesame oil is refined, other medicinal materials are added and heated by soft fire, and dregs of decoction is discarded after filtration to obtain filtering oil. The compound spanishneedles ointment is made through the processes of merging decoction liquid, heating the filtering oil by soft fire until no water exists, homogenizing by adding beeswax, etc. The present invention has the advantages of rich medicinal herbs resource, low cost, easy acquirement and simple manufacturing process. The present invention is widely used for treating diseases of burn and scald, open type skin injury, bedsore, chronic infection wounds, body surface or mucosa chronic canker, etc. The present invention has combined curative effect of promoting blood circulation for removing blood stasis, clearing heat, removing toxicity, eliminating slough and promoting granulation.
Description
Invention field:
The present invention relates to a kind of medicine for the treatment of the burn disease, is the Chinese patent medicine of feedstock production with Chinese herbal medicine such as Mount Taishan special product Herba Bidentis Bipinnatae medical materials specifically, the invention still further relates to the preparation technology of this medicine.
Background of invention:
The traditional Chinese medical science thinks that the morbidity of burn disease is (cause of disease+disease position)+symptom.The cause of disease, sick position are that body is subjected to exopathogen invasion and attack suddenly and causes qi depression to blood stasis, and qi depression to blood stasis is then obstructed, stagnation of QI and blood may bring about pain, and general rule is wet long-pending, and wet long-pending then mildew mouldly then becomes rotten, and corruption is fire-toxin then, and fire-toxin is skin ulcer then, and skin ulcer is the slough pus and blood then.Common sympton such as pain, infection, necrosis progrediens, leave over cicatrix etc.Burn skin infection external treatment medicaments such as at present existing tincture, film former, spray agent, gauze agent, aerosol come out, but in application or because of function singleness, or unsound because of the preparation theory, preparation is lack of standardization, the usage disunity, and can not be applied smoothly.
Goal of the invention:
The object of the present invention is to provide a kind of blood circulation promoting and blood stasis dispelling that has, heat-clearing and toxic substances removing, the medicine of removing the necrotic tissue and promoting granulation effect, and make unformed wound-surface cover, reach preserve moisture, skin moistening, unfold pain relieving, porous is to slough inside and intercellular substance, reach adequate drainage, make the solid slough softening, loosening, finally become liquid substance and get rid of, safeguard the microenvironment of cells survival simultaneously, promote the damaged skin histology organ of Regeneration and Repair.
Another object of the present invention provides the preparation method of burn Remedies for diseases in association.
Summary of the invention:
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to the burn disease pathogenesis, achieve with reference to modern pharmacological research, from motherland's medicine and pharmacology treasure-house, filter out the relieving the exterior syndrome heat clearing away, the detoxifcation dissipating blood stasis, the natural plant of the body resistance strengthening and constitution consolidating is according to Chinese medicine and pharmacy monarch, minister, assistant, make compatibility theory, take efficacy of drugs into account and cure mainly, return effect characteristics prescription through, four natures and five flavors of drug and medicine itself.
Medicine of the present invention is that following each the composition combination in mountain is made:
Herba Bidentis Bipinnatae 60～100g, Radix Scutellariae 20～45g, Rhizoma Coptidis 20～45g, Cortex Phellodendri 20～45g, Pheretima 20～35g, Oleum Sesami 1000g, Cera Flava 45～55g.
The prescription compatibility is according to being: the lightly seasoned property of Herba Bidentis Bipinnatae is flat nontoxic, goes into lung, spleen, stomach, large intestine channel, and relieving the exterior syndrome heat-clearing and toxic substances removing dissipating blood stasis is a principal agent; Radix Scutellariae, bitter, cold, go into lung, gallbladder, liver, stomach, large intestine channel; Rhizoma Coptidis, bitter, cold, go into the heart, spleen, liver, kidney, gallbladder, large intestine channel; Cortex Phellodendri, bitter, tremble with fear, go into kidney, bladder, large intestine channel, three medicine heat-clearing and toxic substances removing, the pathogenic fire purging remuval of damp and hot is ministerial drug; Pheretima becomes, and cold, heat clearing away is relieving convulsion, detoxicating and resolving stagnation of pathogens, and removing the necrotic tissue and promoting granulation, relieving spasm to stop pain is an adjuvant drug; Cera Flava, sweet light, flat, Oleum sesami, sweet, dry in the air, go into meridian of Hand-YANG MING, two medicines detoxifcation removing dampness, is moisturized pain relieving at anticorrosion detumescence, and expelling pus and promoting granulation is a messenger drug.Full side supplements and complements each other, and compatibility is rigorous, and all medicines share, and medicine reaches disease institute, so can prove effective.
Advantage of the present invention:
The present invention is the ointment formulation of Wound treatings such as exploitation Herba Bidentis Bipinnatae medical material is used to burn, ulcer.Said preparation has effects such as blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, anti-inflammatory analgesic, removing the necrotic tissue and promoting granulation.Animal experiment and healthy application on human skin speckle are coated with test is not all had bad stimulation and anaphylaxis.It is faint yellow that said preparation is, and pH value is 7.0, and room temperature is semi-solid state down, leaves standstill not have in 5 years and separate phenomenons such as rotten.Said preparation is with low cost, makes simply, and implementation and operation is convenient, can bring bigger social benefit, economic benefit and technical benefits.
Description of drawings:
Fig. 1 is whole preparation technology's sketch map of the present invention.
Inventive embodiments:
Prescription is formed: Herba Bidentis Bipinnatae 60～100g, Radix Scutellariae 20～45g, Rhizoma Coptidis 20～45g, Cortex Phellodendri 20～45g, Pheretima 20～35g, Oleum Sesami 1000g, Cera Flava 45～55g.
Preparation technology:
1,100% Herba Bidentis Bipinnatae decocting liquid prepares: Herba Bidentis Bipinnatae Herba Bidentis Bipinnatae 60～100g is put add water to the medicine plane in the pot, slow fire, timing was 30 minutes after decoction was boiled, filter, medicinal residues are fried in shallow oil 2 times again, and every all over boiling back timing 20 minutes, decocting liquid is removed medicinal residues with 4,8,12 layers of filtered through gauze successively and merged three filtrates, again slow fire heating concentrate medicinal liquid 60～100ml, 100% Herba Bidentis Bipinnatae decocting liquid means the primary dried medicine decocting liquid 1ml of 1 gram.2, Oleum Sesami is practiced system: get Oleum Sesami and put in the stainless-steel pan slow fire and be heated to boil no oily foam and emit blue or green cigarette of oil, continue 20 again and boil, the filtration of ceasing fire.
3, medicine oil preparation: other medical material except that Herba Bidentis Bipinnatae is added in the appropriate Oleum Sesami of refining, and slow fire is heated to oil and boils, and heats while stirring, and ceases fire during acomia puckery sense during stirring, and it is to spend that medical material explodes withered to medicine.Abandon medicinal residues with 8 layers of filtered through gauze while hot and get oil strain.
4, finished product preparation: with the Herba Bidentis Bipinnatae decoction liquor, medicine oil merges slow fire again and is heated to and puts into the Cera Flava piece in the oil when anhydrous, be heated to wax stone while stirring and dissolve, promptly remove impurity, leave standstill that oil strain cold to 40～45 ° mould that box is cleaned, sterilization, packing, labeling be standby again with 8 layers of gauze pad filtered while hot.
Critical process condition: 1. select the high-quality medical material with preceding clean system; 2. get and add medical material again after Oleum Sesami heating 20 is boiled, control oil temperature, protection drug effect; 3. stir, filter 3 times; 4. put into Cera Flava piece heating 10 and boil and stir evenly, filter 1 time; 5. ointment 30000g, the packing of 40g/ box, make altogether 750 boxes/batch.
Preparation character, stability, quality control standard are with former tentative standard.
Using method:
During clinical treatment burn wound surface, get the present invention slightly with spatula, the directly outer wound surface≤1mm that is applied to is thick, changes dressings once in per 6～8 hours, exposes treatment, until wound healing.Clinical application research and conclusion are applied to burn wound's treatment, see that all the said preparation decrustation is fast, form one deck oiliness thin film jointly with the wound surface exudate, and flap coverage has played barrier action, and dark II ° of wound healing do not stay cicatrix, and newborn skin function is good.
The use prospect:
Herba Bidentis Bipinnatae of the present invention is the annual herb plant, and the medicine beginning is stated from supplement to the Herbal, all herbal medicine.Has heat-clearing and toxic substances removing, expelling wind and activating blood circulation, effects such as antidiarrheal.Studies confirm that Herba Bidentis Bipinnatae contains total flavones, coumarin, alkaloid, sulphur, carotene, several amino acids.In recent years research data shows that Herba Bidentis Bipinnatae has blood circulation promoting and blood stasis dispelling, relievings asthma, heart tonifying, stable, blood pressure lowering, sets upright, and effect such as consolidates.It is introduced and tangible reduction lipoprotein, cholesterol are arranged, the effect of blood viscosity lowering by Herba Bidentis Bipinnatae extractum.Wherein, it is the highest to contain aminoacid in the spanishneedles herb leaf, and its content is equivalent to 5 times of milk, 1 of egg.38 times, 20 times of Fructus Citri tangerinae, 30 times of Fructus Mali pumilae.Herba Bidentis Bipinnatae in the wasteland, roadside, river shoal, woodland, limit, ditch self-sow be dense, abundant information shows according to Tai'an natural resources of Chinese medicinal materials generaI investigation statistics, about 500,000 kilograms of whole city's Herba Bidentis Bipinnatae reserves year, but year application quantity is few.If change this data advantage into the commodity advantage, comprehensive exploitation Herba Bidentis Bipinnatae herb resource fully improves its medical value, brings benefit to the mankind, and for saving food and other resource, promotes that the agricultural modernization development is useful.
Claims (1)
1, a kind of Chinese medicine composition for the treatment of wound infections disease, it is characterized in that forming by Herba Bidentis Bipinnatae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Pheretima, Oleum Sesami and Cera Flava, the parts by weight proportioning of described each composition is: Herba Bidentis Bipinnatae 60～100g, Radix Scutellariae 20～45g, Rhizoma Coptidis 20～45g, Cortex Phellodendri 20～45g, Pheretima 20～35g, Oleum Sesami 1000g, Cera Flava 45～55g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02110272 CN1233343C (en) | 2002-04-18 | 2002-04-18 | Prescription and preparing process for compound spanishneedles ointment |
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| CN 02110272 CN1233343C (en) | 2002-04-18 | 2002-04-18 | Prescription and preparing process for compound spanishneedles ointment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872218A (en) * | 2012-10-05 | 2013-01-16 | 鞠发军 | Chinese herba preparation for treating acute radiation skin injury |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7282226B2 (en) | 2003-08-11 | 2007-10-16 | I-Hung Chu | Vapor fraction from seeds of Glycine max (L.) Merr. and composition thereof |
| DE60316681T2 (en) * | 2003-08-11 | 2008-07-17 | Chu, I-Hung, Chiao-Tou | Vapor fraction of Glycine max (L.) merr. Seeds and corresponding composition |
| US7112344B2 (en) | 2003-08-11 | 2006-09-26 | I-Hung Chu | Vapor fraction from seeds of Glycine max (L.)Merr. and composition thereof |
| CN101491626B (en) * | 2008-11-27 | 2012-04-25 | 北京宏泰康达医药科技有限公司 | A Chinese medicinal composition for treating skin injury and suppurative infection |
| DE102015102020A1 (en) * | 2015-02-12 | 2016-08-18 | Renate Wilmanowicz | Immunologically active phytogen mixture and its use in prevention and in a process for the treatment of efflorescences |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102872218A (en) * | 2012-10-05 | 2013-01-16 | 鞠发军 | Chinese herba preparation for treating acute radiation skin injury |
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