CN1028151C - 胶囊充填设备 - Google Patents
胶囊充填设备 Download PDFInfo
- Publication number
- CN1028151C CN1028151C CN92101007.9A CN92101007A CN1028151C CN 1028151 C CN1028151 C CN 1028151C CN 92101007 A CN92101007 A CN 92101007A CN 1028151 C CN1028151 C CN 1028151C
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- Prior art keywords
- capsule
- blank
- filling
- blanks
- helical spring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Basic Packing Technique (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Formation And Processing Of Food Products (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Endoscopes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
Abstract
一种胶囊药物充填设备，该设备将硅酮塑料管料上切断以制成胶囊坯料，该坯料排成数个坯料一行的行列，对在坯料行中胶囊充填以药物并封闭之。投配材料通过装料漏斗向胶囊输送，该漏斗中穿以一个起着进料螺旋作用的旋转螺旋弹簧，该弹簧还伸入待充填材料的胶囊。
Description
本发明涉及在胶囊中充填基本为粉状药物的设备，该胶囊用于植入皮下，其中药物透过囊壁扩散到血液循环中。预期使用目的可为诸如避孕激素以及安塔布司剂等的投配。
在胶囊生产中，其起点是用以形成胶囊壳体的管料，用以制造管料的适当材料为硅酮塑料。制造激素胶囊的管料，其直径为1.5mm。输送到胶囊生产线的管料以绵长的管料方式从适当的设备中送出。在胶囊生产线的起点，将管料切成适当长度的胶囊坯料，其长度例如约为34mm。
然后将该胶囊坯料排成数个一行的行列。例如一行可有12个坯料。将一个这种行列连在一起较为有利，以便形成各后续工序的处理单元。为连接该处理单元行列，可以使用一个装置，以保持该坯料在其预定位置上。借助该装置可将该处理单元行列从一个工序转移到另一工序，也可在每一工序中将其定位。所述装置以具夹爪结构的夹盒较为有利。该夹爪以共同弹簧加载作夹紧接触，在夹爪的接触表面上形成共同互相配合的凹槽，以便形成容纳胶囊坯料的通孔。
在各后续的工序中，将材料的投配量从每一投配装置投放到在盘表面上制成的、起着振动运送器作用的相应的输送槽中。投配的材料量在振动运送器中继续前进，进入装料漏斗中，待充填的胶囊坯料早已由夹爪夹盒载送而转移到该装料漏斗之下方。为加速材料流入胶囊坯料中，采用一种特别的螺旋进料器。所述进料器有一个直径小于胶囊坯料的内径的螺旋弹簧，其中有一条直的金属引导线。弹簧按其螺旋向前推进的方向旋转。
就送料过程本身而言，在该工序进行过程中，螺旋弹簧先插入胶囊坯料内，然后使之旋转。在开始作旋转动作的同时，也开始从胶囊坯料中提高该螺旋弹簧。当旋转方向如上文所述时，该螺旋弹簧起着螺旋送料器的作用。在进行胶囊坯料充填过程中，将螺旋弹簧边旋转边从胶囊料坯中抽出。在所述各操作阶段中，继续保持装料漏斗不停振动。当螺旋弹簧头升到所述要求的材料充填高度时，上升动作停止，但弹簧的振动及旋转动作继续进行。于是螺旋弹簧便决定充填入胶囊的材料柱的高度。
充填阶段之后，应将胶囊坯料开口端的内表面清理，清除粘附的充填材料，以保证坯料端的封闭不出问题。可用旋转铲刮心轴或相应的帚刷在胶囊料坯口的内部进行清理工作。胶囊坯料端采用与上述关于胶囊坯料第一端封闭相似的步骤进行封闭。密封过程中所用的胶剂硬化后，同样地可以将其密封部分的一部分切除以便精整胶囊的端部。
经过这些工序阶段后，将制成的胶囊输送通过本身为已知的工序，从而将胶囊清洗、干燥、检查、包装及消毒等直至制成备用的制品。
下文中将参照附图对本发明进行叙述，其中：
图1为投配及充填设备的三向投影图;
图2示出进料漏斗区域中的放大细节。
将批量投配到槽盘21上的材料。输送到成横行放置在槽盘21后缘下方的装料漏斗23中。在这些装料漏斗的下方，有一行由夹爪夹盒6载送的胶囊坯料7，该胶囊坯料的下端已封闭且以该下端已作精整为有利。
充填器24包括进料器，其数目与装料漏斗23的数目相同。每一进料器有一个旋转电机25、一根转轴26和安装在该转轴下端上的螺旋送料器。为使该螺旋送料器能在待充填的胶囊那种小尺寸所决定的条件下工作，该装料螺旋由细螺旋弹簧制成。为便于控制螺纹弹簧的动作，在弹簧内放置着另一条直的引导金属线，该金属线基本沿螺旋弹簧的全部长度上伸展。
由螺旋弹簧制成的进料螺旋27被导引穿过装漏斗23而达到其下面的胶囊坯料，并使之旋转。旋转动作必然选择螺旋弹簧的送料方向。进料螺旋在胶囊坯料中旋转，将供入装料漏斗中的材料有效地送入胶囊坯料中。为防止材料在胶囊料坯中发生不必要的压实，在进行充填的过程中提高送料螺旋。在投配批量完全输送后，进料螺旋也已完全从胶囊坯料中提出，然后转移坯料，以将之封闭。在
封闭前可以将开口区的内部清理以便清除存留的任何充填材料。用胶剂进行密封，其方法与充填前密封坯料另一端相同。
密封后，可通过剪切精整已充填好的胶囊端。精整后，将制成的胶囊从其相应的夹爪夹盒中取出，然后按上面简单讨论过的先有技术进行个别加工。
Claims (1)
1、用以将一预定剂量的药物填充入一胶囊的充填设备，该胶囊以下端封闭和上端开口的方式安排成垂直放置，且包含某一数目的胶囊的行列，该设备中每一个胶囊有一个用以接收该预定剂量药物的装料漏斗，其特征在于，每一个装料漏斗有一旋转螺旋弹簧装置，该弹簧装置可穿过该装料漏斗而插入胶囊坯料内。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FIPCT/FI91/00091 | 1991-03-28 | ||
| PCT/FI1991/000091 WO1992017149A1 (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
| HU9302744A HUT68494A (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
| CA002106986A CA2106986A1 (en) | 1991-03-28 | 1991-03-28 | A filling device for medicine capsules with a rotatable spiral spring means |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1065200A CN1065200A (zh) | 1992-10-14 |
| CN1028151C true CN1028151C (zh) | 1995-04-12 |
Family
ID=27169609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92101007.9A Expired - Fee Related CN1028151C (zh) | 1991-03-28 | 1992-02-12 | 胶囊充填设备 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0577593B1 (zh) |
| JP (1) | JPH06505885A (zh) |
| CN (1) | CN1028151C (zh) |
| AT (1) | ATE139686T1 (zh) |
| AU (1) | AU656317B2 (zh) |
| BR (1) | BR9201188A (zh) |
| CA (1) | CA2106986A1 (zh) |
| DE (1) | DE69120547T2 (zh) |
| DK (1) | DK0577593T3 (zh) |
| EE (1) | EE02956B1 (zh) |
| ES (1) | ES2090321T3 (zh) |
| FI (1) | FI934210A0 (zh) |
| GR (1) | GR3021181T3 (zh) |
| HU (1) | HUT68494A (zh) |
| LV (1) | LV10177B (zh) |
| MX (1) | MX9201401A (zh) |
| NO (1) | NO933408L (zh) |
| RU (1) | RU2103988C1 (zh) |
| WO (1) | WO1992017149A1 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400462D0 (sv) * | 1994-02-11 | 1994-02-11 | Astra Ab | Filling device |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| GB0616448D0 (en) * | 2006-08-18 | 2006-09-27 | Ici Plc | Methods of and apparatus for dispensing powder samples |
| IT1397610B1 (it) * | 2009-12-22 | 2013-01-18 | Mg 2 Srl | Macchina rotativa intermittente per il riempimento di capsule con prodotti farmaceutici. |
| JP5718766B2 (ja) * | 2011-08-12 | 2015-05-13 | 東洋自動機株式会社 | 被包装物充填装置及び方法 |
| CN104257274B (zh) * | 2014-09-23 | 2016-07-06 | 黄龙国 | 一种塑封胶囊机 |
| CN108455095B (zh) * | 2017-02-21 | 2023-07-14 | 李和伟 | 一种旋转式给药器 |
| CN107776920A (zh) * | 2017-11-23 | 2018-03-09 | 无锡鼎加弘思饮品科技有限公司 | 一种饮品胶囊灌装机构以及饮品胶囊的灌装方法 |
| CN112224545A (zh) * | 2020-10-09 | 2021-01-15 | 崔宝月 | 临床药学药剂调剂装置 |
| CN112722432A (zh) * | 2020-12-28 | 2021-04-30 | 广州水琴贸易有限公司 | 一种颗粒罐装机 |
| CN113335619B (zh) * | 2021-06-15 | 2022-10-14 | 重庆宏南科技股份有限公司 | 用于制药设备的药品自动定量分配装置 |
| CN113682506A (zh) * | 2021-08-18 | 2021-11-23 | 广州珐玛珈智能设备股份有限公司 | 多列条包机颗粒度量模块 |
| CN113955165A (zh) * | 2021-11-15 | 2022-01-21 | 江苏仅一联合智造有限公司 | 一种高速螺杆充填包装机 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1033874B (it) * | 1975-04-07 | 1979-08-10 | Zanasi Nigris Spa | Procedimento e dispositivo per il dosaggio di prodotti pastosi piu o meno densi,da immettere in un qualsivoglia contenitore |
| CA1259966A (en) * | 1985-02-27 | 1989-09-26 | Taizo Yamamoto | Capsule filling apparatus |
| GB2237258B (en) * | 1989-10-26 | 1993-10-20 | American Cyanamid Co | Apparatus and method for manufacturing soft shell capsules |
-
1991
- 1991-03-28 JP JP3506898A patent/JPH06505885A/ja active Pending
- 1991-03-28 WO PCT/FI1991/000091 patent/WO1992017149A1/en not_active Ceased
- 1991-03-28 RU RU93057752A patent/RU2103988C1/ru active
- 1991-03-28 AU AU75690/91A patent/AU656317B2/en not_active Ceased
- 1991-03-28 DE DE69120547T patent/DE69120547T2/de not_active Expired - Fee Related
- 1991-03-28 MX MX9201401A patent/MX9201401A/es not_active IP Right Cessation
- 1991-03-28 HU HU9302744A patent/HUT68494A/hu unknown
- 1991-03-28 AT AT91906873T patent/ATE139686T1/de not_active IP Right Cessation
- 1991-03-28 EP EP91906873A patent/EP0577593B1/en not_active Expired - Lifetime
- 1991-03-28 FI FI934210A patent/FI934210A0/fi not_active Application Discontinuation
- 1991-03-28 CA CA002106986A patent/CA2106986A1/en not_active Abandoned
- 1991-03-28 ES ES91906873T patent/ES2090321T3/es not_active Expired - Lifetime
- 1991-03-28 DK DK91906873.4T patent/DK0577593T3/da active
-
1992
- 1992-02-12 CN CN92101007.9A patent/CN1028151C/zh not_active Expired - Fee Related
- 1992-03-27 BR BR929201188A patent/BR9201188A/pt not_active Application Discontinuation
-
1993
- 1993-09-10 LV LVP-93-1066A patent/LV10177B/en unknown
- 1993-09-24 NO NO93933408A patent/NO933408L/no unknown
-
1994
- 1994-10-13 EE EE9400113A patent/EE02956B1/xx unknown
-
1996
- 1996-09-26 GR GR960402533T patent/GR3021181T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2103988C1 (ru) | 1998-02-10 |
| ATE139686T1 (de) | 1996-07-15 |
| FI934210A7 (fi) | 1993-09-24 |
| FI934210L (fi) | 1993-09-24 |
| MX9201401A (es) | 1993-01-01 |
| EP0577593A1 (en) | 1994-01-12 |
| LV10177B (en) | 1995-04-20 |
| NO933408D0 (no) | 1993-09-24 |
| GR3021181T3 (en) | 1996-12-31 |
| WO1992017149A1 (en) | 1992-10-15 |
| LV10177A (lv) | 1994-10-20 |
| DE69120547T2 (de) | 1997-02-13 |
| HUT68494A (en) | 1995-06-28 |
| CA2106986A1 (en) | 1992-09-29 |
| DK0577593T3 (da) | 1996-10-14 |
| FI934210A0 (fi) | 1993-09-24 |
| AU656317B2 (en) | 1995-02-02 |
| ES2090321T3 (es) | 1996-10-16 |
| DE69120547D1 (de) | 1996-08-01 |
| JPH06505885A (ja) | 1994-07-07 |
| EE02956B1 (et) | 1997-02-17 |
| CN1065200A (zh) | 1992-10-14 |
| EP0577593B1 (en) | 1996-06-26 |
| AU7569091A (en) | 1992-11-02 |
| NO933408L (no) | 1993-09-24 |
| BR9201188A (pt) | 1992-09-15 |
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Address after: Turku, Finland Applicant after: Leiras L Oy Address before: Helsinki, Finland Applicant before: Huhtamaeki OY |
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