CN102145096B - 用于治疗幽门螺杆菌相关性胃炎的汤剂 - Google Patents
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Abstract
本发明涉及中药配方领域，具体地说是一种用于治疗幽门螺杆菌相关性胃炎的汤剂，采用黄连、制半夏、黄芩、蒲公英、佛手、荷叶、厚朴、炒白术、甘草为原料制备而成，将上述原料加水浸泡，然后煎熬，去渣得滤液，其特征是原料组成以重量百分比计为：黄连4～6％、制半夏7～9％、黄芩8～10％、蒲公英12～25％、佛手12～16％、荷叶10～14％、厚朴10～12％、炒白术12～22％、甘草6～8％。本发明原料成本低，依从性好，无毒副作用，可抗菌消炎，增强防护因子，调节抗体免疫功能，能有效治疗幽门螺杆菌相关性胃炎。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种用于治疗幽门螺杆菌相关性胃炎的汤剂。
背景技术
众所周知，幽门螺杆菌是微需氧的革兰氏阴性杆菌，全球人群感染率高达50％，目前已确定幽门螺杆菌与胃肠道疾病中的慢性胃炎、消化性溃疡、胃癌和胃粘膜相关淋巴组织淋巴瘤4种疾病关系密切，并且认为根除幽门螺杆菌对上述4种疾病的治疗极为重要。幽门螺杆菌感染是引起慢性活动性胃炎及消化性溃疡发生和复发的重要原因。幽门螺杆菌感染的治疗一直是幽门螺杆菌研究领域的重点和热点。根除幽门螺杆菌现代医学主要采用一种质子泵抑制或一种胶体泌剂加上克拉霉素、阿莫西林或四环素、甲硝唑(或替硝唑)3种抗菌药物中的两种，组成三联疗法。但随着幽门螺杆菌耐菌菌株的增加，标准的7日或10日三联疗法的幽门螺杆菌根除率逐渐下降，在一些地区已降至80％以下。同时应用西药耐药性的产生，药物的毒性和不良反应的发生明显增加，且病情复发率高。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种用于治疗幽门螺杆菌相关性胃炎的汤剂，原料成本低，依从性好，无毒副作用，可抗菌消炎，增强防护因子，调节抗体免疫功能，能有效治疗幽门螺杆菌相关性胃炎。
本发明解决上述技术问题采用的技术方案是：一种用于治疗幽门螺杆菌相关性胃炎的汤剂，采用黄连、制半夏、黄芩、蒲公英、佛手、荷叶、厚朴、炒白术、甘草为原料制备而成，将上述原料加水浸泡，然后煎熬，去渣得滤液，其特征是原料组成以重量百分比计为：黄连4～6％、制半夏7～9％、黄芩8～10％、蒲公英12～25％、佛手12～16％、荷叶10～14％、厚朴10～12％、炒白术12～22％、甘草6～8％。
本发明原料成本低，依从性好，无毒副作用，可抗菌消炎，增强防护因子，调节抗体免疫功能，能有效治疗幽门螺杆菌相关性胃炎。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例一：采用黄连、制半夏、黄芩、蒲公英、佛手、荷叶、厚朴、炒白术、甘草为原料制备而成，其组分(重量％)为黄连5、制半夏8、黄芩8、蒲公英17、佛手12、荷叶12、厚朴12、炒白术20、甘草6，取上述9种原料总重量为181克，在室温下将12种中草药加水至800～1000ml，浸泡3～5分钟，然后用武火煮沸文火煎熬90～100分钟左右，去渣得滤液200ml，药渣再加水250～300ml，煎熬30～40分钟，去渣得滤液100ml，共得300ml左右药汁，即制得用于治疗幽门螺杆菌相关性胃炎的汤剂。装入无菌玻璃瓶内，密封瓶盖备用，每日1剂分2次口服，每次空腹口服150ml左右，服用后临床症状体征消失，再巩固疗效服用1周。
本发明的治疗原则：幽门螺杆菌相关性胃炎以胃烷灼热疼痛、胃脘痞闷、口苦口臭、纳呆、尿黄、渴不欲饮、便溏等为临床表现，属祖国医学“胃脘痛”“痞满”范畴。湿热为本病的外在主要病因，又是病理产物，是决定本病发生、发展、转归的重要因素。脾胃虚弱是本病的内在病因，提示本病正气不足，免疫功能下降，本病病变在胃，与脾关系密切，湿热内蕴，脾胃虚弱为关键，根据“虚则补之，实则泻之”的治疗原则，本病虚实夹杂，宜采用清热利湿，健脾益胃的基本治法，方中黄连味苦性寒，能“深除肠、胃、脾三家之湿热”，现代药理研究具有抗微生物及抗原虫的作用，其抗菌谱广，对幽门螺杆菌的抑制作用最强，还能增强白细胞的吞噬能力，又有解热、镇静、镇痛、松弛胃肠道路血管平滑肌等作用，为君药；配半夏味辛性温，能行能散，其体滑质润，能疏通隔间气机，降逆止呕，现代药理研究有显著的解毒作用，可抑制呕吐中枢而止呕；与黄芩相伍，黄芩有清热利湿泻火、凉血解毒止血之功，现代药理研究，黄芩苷能抑制受幽门螺杆菌感染的胃上皮细胞中核因子-KB的P50亚基，具有对幽门螺杆菌所致的胃炎有抗炎和胃保护作用，半夏与黄芩为臣药；蒲公英性味甘苦，清热解毒，具有较强的抑菌、健胃作用，佛手辛温，理气和中，疏肝解郁；荷叶其质轻清，其气芳香，功擅芳香化浊，升发脾胃清阳之气；厚朴辛苦性温，辛而能发，温而能行，能下气除满，行气祛湿；炒白术性味苦甘温，归脾胃经，具有补气健脾，燥湿之功，其为佐药；甘草调和药性，减轻药物副作用，又可调和脾胃，为使药。方中荷叶轻清上达，厚朴药势下趋，佛手旋于中焦，使本方动静相因，纳运相合，补泻兼施，脾胃升降复常。诸药合用，共奏清热化湿理气，湿祛热清，脾健胃和，本发明具有抗幽门螺杆菌、抗炎、促进胃肠运动、削弱损伤因子、减少对胃粘膜的损害、增强防护因子、加强胃粘膜屏障作用、调整免疫功能等作用，临床应用治疗幽门螺杆菌相关性胃炎取得很好疗效。
本发明各原料还可按下表所列比例(重量百分比)混合的实施例来实现，其煎熬程序、口服方法与实施例1相同，其含量如下表所示。
下面结合我院，即山东省威海市文登中心医院进行的临床试验对本发明作进一步、详细地描述：
1.病例选择：本组84例，男41例，女43例，年龄20-68岁，平均年龄40±2岁，病程2月至35年，平均8±1.2年。
2.诊断标准：慢性浅表性胃炎幽门螺杆菌相关性胃炎“诊断标准参照2006年上海中华医学会消化病学会中国慢性胃炎参考意见”拟定。全部病例均经上消化道钡餐透视或电子胃镜检查及胃黏膜活检诊断为慢性浅表性胃炎，实验室HP检测均阳性，临床表现不同程度消化不良，厌食，与进食有关的上腹部疼痛，病程迁延。体征：可伴有上腹部轻度压痛。中医辨证标准：依据《中药新药临床研究指导原则》的标准制定。主症：胃脘疼痛，胃脘痞胀，纳呆；次症：口苦或口臭或口粘，大便溏，渴不欲饮，舌质淡，苔黄腻，脉弦涩或弦滑。具备主症1项，次症2项和相应舌脉即可诊断。
2.病例排除标准：1、胃及十二指肠溃疡、胃黏膜有异型增生或疑有恶性病变。2、消化道出血或胃肠手术后者。3、恶性肿瘤患者。
3.疗效标准：参照《中药新药临床研究指导原则》制定。痊愈：临床症状消失，HP检测阴性，胃镜和组织管检查提示，活动性炎症消失，粘膜可有轻度慢性炎症；显效：临床症状基本消失，HP检测阴性，胃镜和组织学检查提示活动性炎症基本消失，粘膜慢性炎症下降一个等级；有效：主要症状减轻，HP检测弱阳性或阳性，胃镜和组织学检查提示活动性炎症无明显改变；无效：无变化或恶化者。
4.治疗方法：每次服用本发明汤剂150ml，每日早晚各一次，空腹温服，服用十天为一疗程，连续服用本发明三个疗程。
5.治疗结果：本发明治疗84例，服药三个疗程，临床治愈18例(21.43％)，显效44例(52.38％)，有效18例(21.43％)，无效4例(4.76％)总有效率为95.24％。
Claims (1)
1.一种用于治疗幽门螺杆菌相关性胃炎的汤剂，采用黄连、制半夏、黄芩、蒲公英、佛手、荷叶、厚朴、炒白术、甘草为原料制备而成，将上述原料加水浸泡，然后煎熬，去渣得滤液，其特征是：原料组成以重量百分比计为：黄连4～6％、制半夏7～9％、黄芩8～10％、蒲公英12～25％、佛手12～16％、荷叶10～14％、厚朴10～12％、炒白术12～22％、甘草6～8％。
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| CN103751609A (zh) * | 2014-01-01 | 2014-04-30 | 肖辉丽 | 治疗慢性浅表性胃炎幽门螺杆菌相关性胃炎的中药 |
| CN113057235A (zh) * | 2020-01-02 | 2021-07-02 | 于宝淇 | 一种有效去除幽门螺旋杆菌引起的口臭的保健茶 |
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