CN101803947A - Cold and hot probe device for tumor cold and hot combined treatment - Google Patents

Abstract

The invention discloses a cold and hot probe device, in particular to a cold and hot combined therapy probe device using electric heating and liquid nitrogen refrigeration, which is suitable for treating various solid tumors. The cold and hot probe device includes: cryogenic pressure vessel, cryogenic working medium, booster, cryogenic fluid valve, cryogenic working medium transmission pipe, handle, probe rod, probe head, electric heating element, temperature sensor, data acquisition/control Units, DC power modules, and computers, etc. The invention can conveniently realize the cooling and heating of the probe head, so as to implement combined cold and heat treatment, and can also prevent normal tissues around the probe shaft from being damaged by freezing during the cooling process. The invention has the advantages of simple structure, low cost, good controllability, high safety and convenient use.

Description

A cold and hot probe device for combined cold and hot treatment of tumors

technical field

The present invention relates to a cold and heat treatment probe used in combined cold and heat treatment of tumors, in particular to a cold and hot probe device for combined cold and heat treatment of tumors which is heated by an electric heating element; The electric heating element inside or on the surface of the probe, on the one hand, can prevent the normal tissue along the way caused by the heat leakage of the probe rod during the freezing process, and on the other hand, can quickly heat the tumor tissue after the cryotherapy stops.

Background technique

Technological research around tumor treatment has always been one of the major topics of concern to the biomedical engineering circles at home and abroad. In this regard, minimally invasive interventional physical therapy is becoming the forefront of developments in the field of medical devices. Among various minimally invasive treatment techniques for tumors, cryotherapy and hyperthermia are two physical therapies that have developed rapidly in recent years. The two have obvious advantages such as definite curative effect and strong orientation, so they have attracted extensive attention in the medical field. In particular, these two types of tumor treatment technologies have won the reputation of "green therapy" in tumor clinical practice because of their side effects are far lower than conventional radiotherapy and chemotherapy. However, a single cryotherapy or hyperthermia is difficult to achieve the best killing effect and prognosis in clinical practice. The reason is that traditional cryotherapy may cause tumor cells to remain and then recur due to incomplete cooling or cryopreservation effect, while the enhanced blood circulation caused by high temperature heating may promote the spread of tumor cells to other parts of the body.

Studies have shown that combining cryotherapy and hyperthermia at the same time can significantly enhance the tumor killing effect, and can also overcome the shortcomings of a single freezing or heating treatment mode. Therefore, the combination of freezing and heating has become a new mode of tumor treatment, which is expected to play an important role in the clinical treatment of tumors. The first patent for the new treatment mode of cold and heat combined therapy is "a probe-type tumor treatment device that alternately transports high and low temperature working fluids to achieve sudden temperature rise and fall" (Liu Jing, Zhou Yixin, Yu Tianhua, Alternate Transport Probe-type tumor therapeutic apparatus with high and low temperature working fluid to realize sudden temperature rise and fall, patent number: 01268378.7), this therapeutic apparatus uses high and low temperature working fluid to implement heating and freezing respectively. Since then, there have been some new patent applications in succession, in which the cryogenic working medium (liquid nitrogen) is still used for freezing, and the heating uses radio frequency or laser heating principles (Liu Jing, Rao Wei, cold and hot probe therapy system, application number: 200710098735.2). In the above-mentioned patents, the heating technologies involved, such as high-temperature fluid heating, radio frequency heating, and laser heating, are relatively complicated in terms of equipment implementation on the one hand, and on the other hand, there are certain difficulties in preventing normal tissue freezing damage along the way. In fact, electric heating, as a simple and effective heating method, is expected to replace the above-mentioned heating techniques in combined cold and heat therapy, thus providing a more controllable and safer solution for combined cold and heat therapy.

Based on the above considerations, the present invention will provide a cold and hot probe device for combined cold and hot therapy of tumors, which uses cryogenic working medium (such as liquid nitrogen) to implement cryotherapy , using electric heating to implement high-temperature hyperthermia, and electric heating can also effectively prevent the probe rod from freezing damage to normal tissues along the way during cryotherapy.

Contents of the invention

The purpose of the present invention is to overcome the shortcomings of the existing cold and heat combination therapy probe system, which is complex in structure and difficult to prevent freezing damage to normal tissues along the probe, so as to provide a safer and more efficient cold and heat combination therapy for tumors. Probe device; it can not only carry out alternating cold and heat therapy on tumors very conveniently, but also can effectively prevent freezing damage to normal tissues around the probe rod in the process of cryotherapy; moreover, the present invention has simple structure, and can reduce temperature, heat up and prevent frostbite. It is easy to implement, and has the advantages of good controllability, high safety and convenient use, and is suitable for the treatment of various solid tumors.

Technical scheme of the present invention is as follows:

The cold and hot probe device for combined cold and hot treatment of tumors provided by the present invention includes:

A low-temperature pressure vessel 1 with a booster 3 inside and a low-temperature working medium 2 inside;

One end is placed in the low-temperature working medium 2 in the low-temperature pressure vessel 1. The low-temperature working medium transmission pipe 5; The first heat-insulating lumen 51 on the outer wall; the first heat-insulating lumen 51 is a vacuum lumen or a lumen with a built-in heat-insulating material; A cryogenic fluid valve 4 is installed in the lumen;

A probe rod 7 connected to the other end of the low-temperature working medium transmission pipe 5; , the second heat-insulating lumen 73 set on the outer wall of the first return pipe 72 and the first electric heating element 74 set on the outer wall of the second heat-insulating lumen 73; the second heat-insulating lumen 73 is a vacuum lumen or a lumen with a built-in heat insulating material; the outer wall of the connection between the probe rod 7 and the low-temperature working medium transmission tube 5 is covered with a heat-insulating handle 6; the first electric heating element of the probe rod 7 Temperature sensors are evenly distributed on the 74;

A probe head 8 connected to the front end of the probe rod 7; the probe head 8 is composed of a third incoming flow pipe 81 and a second heating element 83 surrounding the third incoming flow pipe 81; the The second electric heating element 83 is composed of a circular tube-shaped rear part at the rear and a conical front part with an arcuate front end integrated with the circular tube-shaped rear part; the second electric heating element 83 and The space left between the third incoming flow pipes 81 is the second return flow pipe 82; the front end of the inner cavity of the second electric heating element 83 is equipped with a temperature sensor; the first incoming flow pipe 52, the second incoming flow pipe The flow pipe 72 communicates with the third incoming flow pipe 81; the first return pipe 72 communicates with the second return pipe 82; open exhaust port;

A DC power supply module 12; the DC power supply module 12 is electrically connected with the first heating element 74, the second heating element 83 and the booster 3 respectively to heat them; the voltage of the DC power supply module 12 1~36V;

A data acquisition and control module 10 and a computer 11; the data acquisition and control module 10 is connected with the computer 11 by a data line; the data acquisition channel of the data acquisition and control module 10 is connected with the temperature sensor; the data The control channels of the acquisition and control module 10 are respectively connected to the cryogenic fluid valve 4 and the DC power supply module 12; the computer 11 controls the opening and closing of the cryogenic fluid valve 4 through the data acquisition and control module 10; Described data acquisition and control module 10 is connected with described temperature sensor to collect the temperature of described temperature sensor in real time, and the temperature sensor temperature of collection is sent to computer (11); Described computer 11 is controlled by data acquisition and control module 10 The heating power of the DC power supply module 12 controls the heating temperatures of the first heating element 74 and the second heating element 83 .

The cold and hot probe device for combined cold and hot therapy of tumors has a separate structure: at the low temperature working medium transmission tube 5 close to the handle 6, the low temperature working medium transmission tube 5 is divided into two parts, and passed through a quick joint 13 The two parts of the cryogenic working medium transmission pipe 5 are connected into a whole.

The resistance value of the first electric heating element 74 and the resistance value of the second electric heating element 83 are between 1Ω-100Ω; their outer surfaces are sprayed with an insulating paint layer.

The low-temperature pressure vessel 1 is an electrically heated pressure vessel or a self-pressurized pressure vessel.

The first heating element 74 and the second heating element 83 are constantan wires, nickel wires, thin film resistors, semiconductor resistors or positive temperature coefficient resistors.

The inner wall of the hollow cavity at the conical front part of the probe head 8 is an inner fin structure.

The cold and hot probe device for combined cold and hot treatment of tumors of the present invention is provided with a booster 3 in the low temperature pressure vessel 1 (specifically, an electric heating pressure vessel or a self-pressurized pressure vessel can be used to heat the low temperature working medium 2 gasification, to realize the boost in the cryogenic vessel 1); one end of the cryogenic working medium transmission pipe 5 is immersed in the cryogenic working medium 2 in the cryogenic pressure vessel 1, and the other end passes through the first incoming flow pipe 52 and the probe rod 7 The second incoming flow pipeline 71 is connected; the low-temperature working medium transmission pipe 5 is provided with a low-temperature fluid valve 4 near the end of the low-temperature pressure vessel 1 (through the switch of the low-temperature fluid valve 4, the delivery and cut-off of the low-temperature working medium 2 are realized); Both the needle bar 7 and the probe head 8 are provided with an incoming flow channel and a return flow channel, and are respectively connected; the probe bar 7 and the probe head 8 also have electric heating elements; the probe bar 7 is provided with multiple independent control The first electric heating element, in the process of cryotherapy, is heated by electricity to prevent the normal tissue around the probe rod from being damaged by freezing, but at the same time, in order to avoid scalding the normal tissue caused by heating, the temperature sensor needs to monitor the temperature of the probe rod in real time during the heating process , and correspondingly control the electric heating power according to the temperature; the function of the second electric heating element in the probe head 8 is to perform heating treatment on the tumor tissue, and the heating power can be controlled in real time by monitoring the temperature inside the probe head during the heating process. To prevent carbonization or vaporization of tumor tissue; the outer surfaces of the electric heating elements in the probe rod 7 and the probe head 8 are all insulated; vacuum cavity or filled with insulating material), on the one hand, it can effectively prevent the surface temperature of the cryogenic working medium transmission pipe 5 and the probe rod 7 from being too low, and on the other hand, it can also reduce the loss of the low temperature working medium 2; the low temperature working medium transmission The end of the tube 5 connected to the probe rod 7 is provided with a handle 6 (made of heat insulating material, which is convenient for the doctor to operate during the operation); all electric heating elements are powered by a DC power supply module, and are controlled by the computer through the data acquisition and control module. 10. Precisely control the heating power. To ensure safety, all heating voltages are controlled within 1-36V.

In the above technical solution, one or more thin-wall thin metal tubes can be used for the incoming flow channel, and a single thin-walled metal tube can be used for the return flow channel, and it is located at the periphery of the incoming flow channel, and the incoming flow channel is wrapped in it; the probe rod The wall of the first return pipe 72 of 7 is provided with an exhaust port that communicates with the outside atmosphere;

In the above-mentioned technical scheme, the diameter of the circular tubular rear portion of the probe rod 7 is the same as that of the probe head 8, and its outer diameter is between 1mm and 10mm; The conical front part of the surface-shaped front end, the conical front part of the probe head 8 is a hollow cavity, and the inner wall of the cavity can be processed into an inner fin structure. Rapid gasification, thereby achieving rapid cooling of the target tissue; in addition, the outer wall of the probe head 8 is made of a metal material with high thermal conductivity.

In the above technical solution, after the low-temperature pressure vessel 1 is boosted to a sufficient pressure, the low-temperature working medium 2 can be input from the low-temperature pressure vessel into the first incoming flow pipe in the low-temperature working medium transmission pipe 5 through the control of the low-temperature fluid valve 4 52, then enter the hollow cavity at the conical front of the probe head through the second incoming flow pipe 71 of the probe rod 7 and the third incoming flow pipe 81 in the probe head 8 to absorb heat and gasify, and after gasification Pass through the second return pipe 82 of the probe head 8 and the first return pipe 72 of the probe rod 7, and finally discharge into the atmosphere; during cryotherapy, the first electric heating element 74 in the probe rod 7 can be controlled to prevent the probe The normal tissue around the needle shaft 7 is damaged by freezing; the cryotherapy can be stopped by closing the cryogenic fluid valve 4, and the tumor tissue can be heated and treated by the second electric heating element 83 in the probe head 8. In this way, alternate cold and heat treatment can be realized on tumor tissue.

The cold and hot probe device for combined cold and hot therapy of tumors provided by the present invention has the following advantages: the cold and hot probe device for combined cold and hot therapy of tumors of the present invention can not only perform cold and hot alternate therapy on tumors very conveniently, Moreover, it can effectively prevent freezing damage to normal tissues around the probe rod during cryotherapy; moreover, the present invention has a simple structure, and is easy to realize cooling, heating, and frostbite protection, and has the advantages of good controllability, high safety, and convenient use. , suitable for the treatment of various solid tumors.

Description of drawings

Fig. 1 is a structural schematic diagram of a cold and hot probe device for combined cold and hot treatment of tumors according to the present invention;

Fig. 1A is a schematic diagram of A-A section in Fig. 1;

Fig. 1 B is the B-B sectional schematic diagram in Fig. 1;

Fig. 2 is a schematic structural view of the probe rod 7 in the present invention (the arrow shows the flow direction of the cryogenic working medium);

Figure 2A is a schematic cross-sectional view of C-C in Figure 2;

Fig. 3 is a schematic structural view of the probe head 8 in the present invention (the arrow shows the flow direction of the cryogenic working medium);

Fig. 3 A is a schematic diagram of D-D section in Fig. 3;

Fig. 4 is a schematic structural diagram of another embodiment of the present invention.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

Example 1:

As shown in Figure 1, the present invention provides a cold and hot probe device for combined cold and hot treatment of tumors, its structure is as follows: it includes:

A low-temperature pressure vessel 1 with a booster 3 inside and a low-temperature working medium 2 inside;

One end is placed in the low-temperature working medium 2 in the low-temperature pressure vessel 1. The low-temperature working medium transmission pipe 5; The first heat-insulating lumen 51 on the outer wall; the first heat-insulating lumen 51 is a vacuum lumen or a lumen with a built-in heat-insulating material; A cryogenic fluid valve 4 is installed in the lumen;

A probe rod 7 connected to the other end of the low-temperature working medium transmission pipe 5; , the second heat-insulating lumen 73 set on the outer wall of the first return pipe 72 and the first electric heating element 74 set on the outer wall of the second heat-insulating lumen 73; the second heat-insulating lumen 73 is a vacuum lumen or a lumen with a built-in heat insulating material; the outer wall of the connection between the probe rod 7 and the low-temperature working medium transmission tube 5 is covered with a heat-insulating handle 6; the first electric heating element of the probe rod 7 Temperature sensors are evenly distributed on the 74;

A probe head 8 connected to the front end of the probe rod 7; the probe head 8 is composed of a third incoming flow pipe 81 and a second heating element 83 surrounding the third incoming flow pipe 81; the The second electric heating element 83 is composed of a circular tube-shaped rear part at the rear and a conical front part with an arcuate front end integrated with the circular tube-shaped rear part; the second electric heating element 83 and The space left between the third incoming flow pipes 81 is the second return flow pipe 82; the front end of the inner cavity of the second electric heating element 83 is equipped with a temperature sensor; the first incoming flow pipe 52, the second incoming flow pipe The flow pipe 72 communicates with the third incoming flow pipe 81; the first return pipe 72 communicates with the second return pipe 82; open exhaust port;

A DC power supply module 12; the DC power supply module 12 is electrically connected with the first heating element 74, the second heating element 83 and the booster 3 respectively to heat them; the voltage of the DC power supply module 12 1~36V;

A data acquisition and control module 10 and a computer 11; the data acquisition and control module 10 is connected with the computer 11 by a data line; the data acquisition channel of the data acquisition and control module 10 is connected with the temperature sensor; the data The control channels of the acquisition and control module 10 are respectively connected to the cryogenic fluid valve 4 and the DC power supply module 12; the computer 11 controls the opening and closing of the cryogenic fluid valve 4 through the data acquisition and control module 10; The data collection and control module 10 is connected with the temperature sensor to collect the temperature of the temperature sensor in real time, and the collected temperature sensor temperature is sent to the computer 11; the computer 11 controls the computer 11 through the data collection and control module 10 The heating power of the DC power supply module 12 controls the heating temperature of the first heating element 74 and the second heating element 83 .

In this embodiment, the low-temperature working medium 2 is liquid nitrogen, and it is contained in the low-temperature pressure vessel 1. The low-temperature pressure vessel 1 can be purchased from the market or customized by relevant manufacturers. The low-temperature pressure vessel 1 is provided with a booster 3, which is an electric heating element, immersed in the low-temperature working medium 2, and when the booster 3 is heated by the DC power module 12, the low-temperature working medium 2 is quickly vaporized , so as to realize the pressure increase in the low-temperature pressure vessel 1; during the process of pressure increase, the pressure in the vessel can be read from the pressure gauge placed outside the low-temperature pressure vessel 1. The low-temperature working medium transmission pipe 5 can be made of stainless steel double-layer bellows, including a first heat-insulating lumen 51 and a first incoming flow pipe 52 (as shown in Figure 1A), wherein the first heat-insulating lumen 51 can be a vacuum chamber or filled with insulating material to achieve; one end of the low-temperature working medium transmission pipe 5 is immersed in the low-temperature working medium 2 in the low-temperature pressure vessel 1, and the other end passes through the first incoming flow pipe 52 and the second incoming flow pipe in the probe rod 7 71 are connected; the cryogenic fluid valve 4 is set at one end of the cryogenic working medium transmission pipe 5 close to the cryogenic pressure vessel 1, and a cryogenic solenoid valve or a cryogenic ball valve can be used; if a solenoid valve is used, the computer 11 can pass data during the operation. The acquisition and control module 10 implements automatic control of its circulation and closure; if a cryogenic ball valve is used, it is necessary to manually control the circulation and closure of the cryogenic fluid valve 4 during the operation; the cryogenic working medium can be easily realized by switching the cryogenic fluid valve 4. 2 and cut off; the end of the low-temperature working medium transmission tube 5 connected to the probe rod 7 is provided with a handle 6 (as shown in Figure 1 and Figure 1B), and the handle 6 is made of heat insulating material such as polytetrafluoroethylene, etc. It is convenient for the doctor to operate with the probe in hand during the operation; the probe rod 7 includes a second incoming flow conduit 71, a first return flow conduit 72, a second heat-insulating lumen 73, a first heating element 74 and a temperature sensor 9 (as shown in FIG. 2 and shown in Fig. 2A); Probe head 8 comprises the 3rd incoming flow pipe 81, the second return pipe 82, the second heating element 83 and temperature sensor 9 (as shown in Fig. 3 and Fig. 3A); Probe bar 7 And the temperature sensor 9 in the probe head 8 can be selected thermocouple or thermal resistance; The second incoming flow pipe 71 of the probe rod 7 is connected with the third incoming flow channel 81 of the probe head 8; The first return conduit 72 communicates with the second return conduit 82 of the probe head 8;

In this embodiment, a plurality of independently controllable first electric heating elements 74 are arranged inside the probe rod 7, and the first electric heating elements 74 are electrically connected to the DC power supply module 12, and electric heating can effectively prevent probe The normal tissue around the needle rod 7 is damaged by freezing; the second heat-insulating lumen 73 in the probe rod 7 can also be similar to that in order to prevent the heating of the probe rod 7 from causing burns to the normal tissue, and the temperature sensor 9 can be used during the heating process. Monitor the temperature of the probe rod 7 in real time, and control the heating power of each heating element according to the temperature;

The second electric heating element 83 in the probe head 8 is electrically connected to the DC power supply module 12, and its function is to implement heating treatment on the tumor tissue. During the heating process, the heating power can be controlled in real time by monitoring the temperature of the probe head 8 to prevent the tumor tissue from Carbonization or vaporization occurs when the temperature is too high;

The first electric heating element 74 in the probe rod 7 and the second electric heating element 83 in the probe head 8 can be made of constantan wire, nickel wire, thin film resistor, semiconductor resistor or positive temperature coefficient resistor, etc., and its resistance value is between between 1 Ω and 100 Ω; in addition, the outer surfaces of the first heating element 74 and the second heating element 83 need to be insulated. Specifically, an insulating paint layer can be sprayed on the mining surface. In order to ensure safety, all the first heating elements 74 and the heating voltage of the second heating element 83 are all controlled within 1-36V;

In this embodiment, the first heat-insulating lumen 51 and the second heat-insulating lumen 73 are respectively provided in the low-temperature working medium transmission pipe 5 and the probe rod 7. The purpose is to effectively prevent the low-temperature working medium transmission pipe 5 from The surface temperature of the probe rod 7 is too low, on the other hand, it can also reduce the loss of the cryogenic working medium 2 during the cryotherapy process;

In this embodiment, the first incoming flow pipe 52, the second incoming flow pipe 71 and the third incoming flow pipe 81 can be made of one or more thin-walled fine metal tubes; the first return flow pipe 72 and the second return flow pipe 82 are all made of a single thin-walled metal tube, and are respectively located at the periphery of the incoming flow channels 71 and 81 to wrap them inside; Vent to atmosphere; probe rod 7 has the same diameter as the cylindrical rear part of probe head 8, between 1 mm and 10 mm; probe head 8 has a conical front part which is a hollow Cavity (as shown in Figure 3), in order to enhance the heat transfer coefficient, the inner wall of the conical front group can adopt an inner fin structure; the low-temperature working fluid 2 passes through the first incoming flow pipe 52, The second incoming flow pipe 71 of the probe rod 7 and the third incoming flow pipe 81 of the probe head 8 flow into the conical front part of the front end of the probe head 8, and the cavity of the conical front part absorbs a large amount of heat quickly. gasification, so as to achieve rapid cooling of the target tissue; after the cryogenic working medium 2 is gasified in the conical front cavity of the probe head 8, it passes through the second return pipe 82 of the probe head 8 and the probe The first return pipe 72 of the rod 7 is exhausted to the atmosphere at last. Considering the clinical requirements on the nuclear magnetic compatibility of the therapeutic probes that intervene in the human body, and the requirements on the heat exchange performance of the probes during the thermal treatment process, the probes It should be made of materials with both low magnetic susceptibility and high thermal conductivity (such as stainless steel or titanium).

In this embodiment, the cryogenic working medium 2 (such as liquid nitrogen) is contained in the cryogenic pressure vessel 1, and the vessel 1 is equipped with a booster (that is, an electric heating element), and the liquid nitrogen in it can be heated and vaporized after being energized. , due to the expansion of the gas, the pressure in the airtight container 1 rises, and when it rises to a certain size, the cryogenic fluid valve 4 can be opened, and the cryogenic working medium 2 passes through the first flow pipe 52 and the second flow pipe 52 from the container 1 in turn. The flow pipe 71 and the third incoming flow pipe 81 are transported to the hollow cavity at the conical front of the probe head 8, so that the tissue can be cryotherapy; the low-temperature working medium 2 absorbs heat and then gasifies, and then passes through the The second return pipe 82 and the first return pipe 72 are finally discharged into the atmosphere; the cryotherapy can be stopped by closing the cryogenic fluid valve 4; Heat treatment. In this way, the combination of cold and heat treatment for tumor tissue is realized, and this combination of cold and heat treatment can repeat multiple cycles of cold and heat according to needs.

Example 2:

Fig. 4 is a schematic structural diagram of a cold and hot probe device used in combined cold and hot therapy for tumors according to this embodiment.

The structure of this embodiment is basically the same as that of Example 1, the difference is that the cold and hot probe device used in this embodiment for the combination therapy of tumors adopts a detachable design; in clinical practice, for deep tumors, based on intervention Minimally invasive surgery performed by human probes generally requires percutaneous puncture; if the probe adopts a detachable design, it will undoubtedly greatly increase the flexibility of the doctor's operation during the puncture process, and facilitate more accurate surgery; this implementation In this example, it is only necessary to divide the low-temperature working medium transmission tube 5 into two parts near the handle 6 , and then connect them through the quick connector 13 . Pipeline quick connectors are a mature technology that can be purchased from the market or customized by relevant manufacturers. Except for the above changes, the positions and structures of other components are the same as those in Embodiment 1. In this embodiment, all other components have been explained in depth in Embodiment 1, so details are not repeated in this embodiment.

Example 3:

The structure of this embodiment is basically the same as that of Embodiment 1; the difference between the two is that in this embodiment, the low-temperature pressure vessel 1 no longer uses electric heating to boost the pressure, but uses a self-pressurized low-temperature pressure vessel;

Self-boosting low-temperature pressure vessels (such as self-boosting liquid nitrogen tanks) are available on the market. The boosting principle is to draw part of the liquid nitrogen from the liquid nitrogen tank through a side pipe, and exchange heat with air through a coil heat exchanger, and then Vaporization, thereby increasing the pressure in the container; Compared with the electric heating boost method, the advantage of the self-pressurization method is that it will not increase the temperature of the liquid nitrogen in the container, so that on the one hand, it can obtain the lowest temperature closer to the liquid nitrogen temperature. Cryotherapy temperature, on the other hand, can significantly reduce the consumption of liquid nitrogen during treatment.

In this embodiment, all other components have been explained in depth in Embodiment 1, so details are not repeated in this embodiment.

Claims (6)

1. cold and hot probe device that is used for cold and hot combination therapy of tumor, it comprises:

One intracavity is provided with the low-temperature pressure container (1) of the interior dress cryogenic fluid (2) of booster (3);

End places the cryogenic fluid transfer tube (5) among the interior cryogenic fluid of low-temperature pressure container (1) (2) one by one; Described cryogenic fluid transfer tube (5) is made up of the first incoming flow pipeline (52) and the first heat insulation tube chamber (51) that is set on this first incoming flow pipeline (52) outer wall; The described first heat insulation tube chamber (51) is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; In the tube chamber of described cryogenic fluid transfer tube (5) near described low-temperature pressure container (1) end cryogen valve (4) is housed;

One is connected in the probe rod (7) of described cryogenic fluid transfer tube (5) other end; Described probe rod (7) by the second incoming flow pipeline (71), be set in first reflux line (72) on this second incoming flow pipeline (71) outer wall, be set in the second heat insulation tube chamber (73) on described first reflux line (72) outer wall and first heating (74) that is set on described second heat insulation tube chamber (73) outer wall is formed; The described second heat insulation tube chamber (73) is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; Be set with heat insulation bat-handle (6) on described probe rod (7) and described cryogenic fluid transfer tube (5) the junction outer wall; Be distributed with temperature sensor equably on first heating (74) of described probe rod (7);

One is connected in the probe (8) of described probe rod (7) front end; Described probe (8) is formed by the 3rd incoming flow pipeline (81) with second heating (83) that described the 3rd incoming flow pipeline (81) surrounds wherein; Described second heating (83) is formed by the tubular rear portion that is positioned at the rear portion with into a single integrated structure the conical anterior of arc surfaced front end that have in described tubular rear portion; The space of leaving between described second heating (83) and described the 3rd incoming flow pipeline (81) is second reflux line (82); Described second heating (83) inner chamber front end is equipped with temperature sensor; The described first incoming flow pipeline (52), the described second incoming flow pipeline (72) and described the 3rd incoming flow pipeline (81) are connected; Described first reflux line (72) is connected with described second reflux line (82); The tube wall of described first reflux line (72) is provided with the air vent that is connected with outside atmosphere;

One direct current power module (12); Described DC power supplier (12) is electrically connected so that they are heated with described first heating (74), second heating (83) and described booster (3) respectively; The voltage of described DC power supplier (12) is 1～36V;

One data acquisition and control module (10) and a computer (11); Described data acquisition links to each other by data wire with computer (11) with control module (10); The data acquisition channel of described data acquisition and control module (10) links to each other with described temperature sensor; The control channel of described data acquisition and control module (10) links to each other with described DC power supplier (12) with described cryogen valve (4) respectively; Described computer (11) is by the open and close of described data acquisition and control module (10) the described cryogen valve of control (4); Described data acquisition links to each other with the temperature of the described temperature sensor of real-time collection with described temperature sensor with control module (10), and the temperature sensing actuator temperature of gathering is sent to computer (11); Described computer (11) is controlled the heating power of described DC power supplier (12) by data acquisition and control module (10), thereby controls the heating-up temperature of described first heating (74), second heating (83).

2. by the described cold and hot probe device that is used for cold and hot combination therapy of tumor of claim 1, it is characterized in that: the described cold and hot probe device that is used for cold and hot combination therapy of tumor is a separate type: locate at the cryogenic fluid transfer tube (5) near handle (6), with cryogenic fluid transfer tube (5) difference two parts, and by a fast joint (13) that two parts connection of described cryogenic fluid transfer tube (5) is in aggregates.

3. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that described first heating (74) resistance value and second heating (83) resistance value are between 1 Ω～100 Ω; All be coated with the insulation enamelled coating on its outer surface.

4. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that: described low-temperature pressure container (1) is for the electrical heating pressure vessel or from the boost pressure container.

5. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that: described first heating (74) and described second heating (83) are constantan wire, nickel wire, film resistor, semiconductor resistor or positive temperature coefficient resistor.

6. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that: the conical forward hollow cavity inner wall of described probe (8) is the inner fin structure.

Images