CN1096699A - Anti-caries chewing gum and preparation method thereof - Google Patents
Anti-caries chewing gum and preparation method thereof Download PDFInfo
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- CN1096699A CN1096699A CN 94110006 CN94110006A CN1096699A CN 1096699 A CN1096699 A CN 1096699A CN 94110006 CN94110006 CN 94110006 CN 94110006 A CN94110006 A CN 94110006A CN 1096699 A CN1096699 A CN 1096699A
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- magnoliae officinalis
- cortex magnoliae
- stevioside
- chewing gum
- extract
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- 229940112822 chewing gum Drugs 0.000 title claims abstract description 40
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 40
- 230000000675 anti-caries Effects 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 25
- 229940013618 stevioside Drugs 0.000 claims abstract description 25
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- 235000019202 steviosides Nutrition 0.000 claims abstract description 25
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- 239000002994 raw material Substances 0.000 claims abstract description 11
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
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- 208000032139 Halitosis Diseases 0.000 description 2
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 description 2
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- 230000004054 inflammatory process Effects 0.000 description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
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- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
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- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- Confectionery (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of anti-caries chewing gum and preparation method thereof, raw materials used Chinese medicine Cortex Magnoliae Officinalis extract, stevioside microcapsule, plant cellulose, oils and fats, gum base and adjuvant etc. are put into the blender mixing, are kneaded, rolling stripping and slicing, and packing is finished product.Easy, the instant of its preparation method except that the advantage with general chewing gum, also has the sterilization of cleaning the teeth, anti-caries effect outstanding feature.
Description
The present invention relates to a kind of chewing gum that contains Chinese medicine, particularly a kind of main control dental caries, have cleaning oral cavity concurrently, eliminate halitosis and multiple oral inflammation is played the anti-caries chewing gum of auxiliary treatment effect.
Dental caries is department of stomatology commonly encountered diseases, frequently-occurring disease.According to The World Health Organization's statistics, dental caries jeopardizes health and is only second to and cardiovascular diseases and cancer.Have 56.6% to suffer from dental caries among China 1-13 year child, also have many eurodonticuses among adult and the old people.Therefore the control of strengthening dental caries causes medical worker's concern day by day.The generation of dental caries mainly is by the pathogenic bacterium in the bacterial plaque that adheres to dental surface, and the pathogenic bacterium of generally acknowledging are Streptococcus mutans at present.To this more existing prevent and treat the drug research of dental caries, though antibiotics commonly used such as penicillin, erythromycin, tetracycline etc. can effectively be prevented and treated dental caries, can cause that oral cavity and intestinal microbial population take place out of proportion and give rise to diseases.Since chewing gum (claiming chewing gum or chewing gum again) came out, people were always as the health food that improves oral hygiene.Because of its chewiness is strong, has certain viscosity, so in the process of chewing, can rub or glue tartar and the bacterial plaque of falling to be attached on the tooth, its gum base plays by the effect of comforting gingiva, the health that helps periodontal tissue plays teeth consolidating, promotes the effect that facial muscle are grown up healthy and sound, and is loved by the people.Added certain cleaning agent, biocide in the existing commercially available chewing gum gum base,, also can reach the effect that suppresses oral inflammation, eliminates halitosis as hibitane.Hibitane is the wide spectrum cationic disinfectant, various bacteria there are inhibition and killing action, but it is insensitive to cariogenic bacteria Streptococcus mutans and lactobacillus, long-term and unrestricted the application, then can cause various such as oral mucosa peel, fester, side effect such as tongue, tooth and the silicate fillers variable color of tooth section.Mainly make sweeting agent with sucrose, glucose in the chewing gum gum base in addition, the cariogenic bacteria in the dental surface bacterial plaque can make carbohydrate fermentation produce organic acid such as lactic acid, progressively makes the dental tissue decalcification and forms cavity, is easy to again simultaneously produce and infects, the infringement health.
The purpose of this invention is to provide a kind of anti-caries chewing gum that contains Chinese medicine, easy, the instant of its preparation method, except that advantages such as the teeth consolidating with general chewing gum, health care, also have clean the teeth, sterilization, anti-caries effect outstanding feature.
The object of the present invention is achieved like this: the contained raw material composition of this anti-caries chewing gum is respectively Cortex Magnoliae Officinalis extract 0.02-7.72 part, plant cellulose 10-70 part, oils and fats 0.2-3 part, stevioside microcapsule 0.16-2 part, gum base 15-26 part; Preferentially select for use raw material to form and be respectively 0.14 part of Cortex Magnoliae Officinalis extract, 30 parts of plant celluloses, 2.5 parts of oils and fatss, 0.8 part of stevioside microcapsule, 25 parts of gum base.
Its preparation method is as follows: after ready-formed each raw material is taken by weighing by above-mentioned recipe quantity, in blender, put into gum base, plant cellulose, oils and fats mixing, add Cortex Magnoliae Officinalis extract, stevioside microcapsule again and produce fragrant mouthful of sugar auxiliary materials and mixing commonly used, rolling stripping and slicing, packing are finished product.
Because the chewing gum base that anti-caries chewing gum of the present invention adopts people to like is a carrier, so improve the health-care effect of oral hygiene except that having chewing gum, also because of stevioside microcapsule and the alternative part Icing Sugar of plant cellulose, improved the sense of taste of chewing gum, be anticariogenic agent to add the Chinese medicine Cortex Magnoliae Officinalis extract simultaneously, be substituted with the preventing decayed tooth medicine of side effect, as antibiolics and hibitane etc., so effectively overcome the side effect that existing chewing gum exists.Although Cortex Magnoliae Officinalis is not also used as anticariogenic agent in practice, show that through laboratory research its main active magnolol and honokiol Streptococcus mutans is had efficient quick sterilization effect, and oral toxicity are very little.Insensitive to escherichia coli, so long-term eating can not caused the intestinal microbial population disorder.The two minimum inhibitory concentration (MIC) of magnolol and honokiol is 6.3 μ g/ml, and the shortest sterilizing time is 5 minutes, and minimum bactericidal concentration (MBC) is 50-75 μ g/ml.Stevioside is a kind of natural sweetener of high sugariness, is a kind of ideal sucrose succedaneum, reduces the consumption of sucrose, can prevent to produce the infringement of too much organic acid to dental tissue because of saccharide under the cariogenic bacteria effect.Experimental results show that stevioside can not can not be utilized by antibacterial and produce acid or generate insoluble polysaccharide as the carbon source of Streptococcus mutans, can strengthen the anticaries action effect so be used in the chewing gum of the present invention.Stevioside is made microencapsulated form to add in the gum base, the stevioside microcapsule was slowly discharged at 5-10 minute, prolong chewing gum chewing the time in the oral cavity, to overcome after the existing chewing gum time of chewing in the oral cavity surpasses 2 minutes, the shortcoming that the sense of taste is poor, mouthfeel is bad can appear, thus make chewing gum of the present invention have fragrant and sweet, mouthfeel good, long persistent outstanding feature.Plant cellulose is water-swellable in the oral cavity, increases itself and the contacting of tooth face as abrasivus, can work in coordination with the adhesive attraction of gum base, more helps removing tartar and bacterial plaque, and then improves the effect that cleans the teeth.Icing Sugar in the gum base because of the existence of plant cellulose, does not also have and is utilized the beyond thought effect of producing acid by antibacterial simultaneously.
Anti-caries chewing gum of the present invention is checked and through clinical observation through Liaoning Province's Food Hygiene Surveillance check, and the result shows that this anti-caries chewing gum takes safety and have no side effect the anti-caries effect highly significant.Its structure is as follows:
One, safety
1, acute toxicity test (large and small Mus)
Median lethal dose(LD 50) (LD50) g/kg＞21.50 belong to nontoxic;
2, rat cumulative toxicity test
Contamination is 28 days continuously, and animal all survives, no poisoning symptom, and accumulate a little less than the genus K＞5;
3, mouse bone marrow cells micronucleus test: being tried thing does not have mutagenicity;
4, mouse sperm distortion test: being tried thing does not have mutagenicity;
5, salmonella/microsomes test mutagenicity test: negative result.
Two, effectiveness
Anti-caries chewing gum is 0.05g/ml to the minimum inhibitory concentration of mutans streptococcus;
Anti-caries chewing gum is 0.25g/ml to the minimum bactericidal concentration of mutans streptococcus.
See by clinical effectiveness, select 186 of a child to be divided into test group and matched group at random, stipulate respectively to chew a slice anti-caries chewing gum after experimenter morning every day, noon, the late breakfast, lunch and dinner, chewed observation index 5-10 minute: newborn dental caries incidence rate, progress dental caries incidence rate at every turn.The newborn dental caries statistical table of result (1):
Group is observed the newborn dental caries incidence rates (%) of the newborn dental caries tooth of tooth number number
Experimental group 1,660 15 0.9
Matched group 1,810 248 13.7
Two groups of comparing difference highly significants (P＜0.01) anti-caries chewing gum can make newborn dental caries incidence rate reduce.
(2) progress dental caries statistical table:
Group is observed the newborn dental caries incidence rates (%) of the newborn dental caries tooth of tooth number number
Experimental group 417 13 3.11
Matched group 385 184 47.79
Two groups of comparing difference highly significants (P＜0.01), anti-caries chewing gum can make dental caries stop progress.
Three, quality control index
The project indicator
Arsenic (AS) mg/kg≤0.5
Plumbous (Pb) mg/kg≤1.0
Copper (Cu) mg/kg≤10.0
Total number of bacteria/g＜500
Coliform/100g＜30
Pathogenic bacterium must not detect
Medicament contg is in magnolol〉0.14%
The present invention is described in detail below in conjunction with embodiment.
The raw material that anti-caries chewing gum of the present invention adopts takes by weighing by recipe quantity after anticipating again, and its prefabricated process is as follows:
1, the preparation of Cortex Magnoliae Officinalis extract
Cortex Magnoliae Officinalis is pulverized and to be put into ethanol or methanol (concentration is selected for use as required, and it is 95% or 50% suitable generally selecting concentration), and heating and refluxing extraction promptly gets Cortex Magnoliae Officinalis extract after extracting solution cooling, filtering and concentrating, the drying.
1.2, Cortex Magnoliae Officinalis is pulverized through alkalization, is filtered, filtrate adds acid and carries out acidify, filters, taking precipitate is put into ethanol or dissolve with methanol (concentration is selected for use the same), filters, filtrate recycling ethanol or methanol concentrate, are drying to obtain the Cortex Magnoliae Officinalis extracting solution.
1.3, the Cortex Magnoliae Officinalis crushing and water-adding is decocted, Cortex Magnoliae Officinalis and water ratio are 1: (5-10), decoct twice, the Cortex Magnoliae Officinalis extracting solution is filtered, concentrates, is drying to obtain to merging secondary decoction liquor.
1.4, Cortex Magnoliae Officinalis extract can use replacements such as magnolia obovata extract, Rhizoma Coptidis extract, Galla Chinensis extract.
2, the preparation of stevioside microcapsule
Ethyl cellulose and stevioside are pressed (0.01-0.1): 1 ratio (preferentially selecting 0.02: 1 ratio for use) is put into and is warded off weight thinkling sound Sandwich pot (belt stirrer, cooler), add TPO encapsulation promoter for accelerating encystation, be heated to 75-85 ℃, the ethyl cellulose dissolving, and stir, be cooled to room temperature, leach the encapsulation stevioside,, promptly get the stevioside microcapsule through vacuum drying with cyclohexane extraction washing 2-3 time.
Add gum base again after also spice can being made microcapsule as required.
3, the pretreatment of plant cellulose
The granularity of plant cellulose has harsh feeling to be advisable not make the chewing gum that processes, so with after the plant cellulose pulverizing, be not less than 100 mesh sieves excessively and get final product.
4, the pretreatment of gum base
Gum base adopts the gum base of common chewing gum, stripping and slicing according to a conventional method, and softening back is standby.
5, greasy selecting for use
Add an amount of oils and fats and can prevent that plant cellulose from absorbing the very fast stripping of expanding after the saliva, makes chewing gum keep appropriate elasticity.Oils and fats is advisable to adopt vegetative grease, as 20-45 ℃ cocoa butter, Petiolus Trachycarpi oil, palm-kernel oil, cocos nucifera oil fat etc.
6, the preparation of adjuvant
The used adjuvant of the present invention is general chewing gum adjuvant, as adds a small amount of Icing Sugar, glucose syrup as binding agent, sweeting agent, and glycerol is as wetting agent, and spice is as correctives.
Embodiment one
Ready-formed each raw material is taken by weighing by recipe quantity: 0.14 kilogram of Cortex Magnoliae Officinalis extract, 30 kilograms of plant celluloses, 2.5 kilograms of oils and fatss, 0.8 kilogram of stevioside microcapsule, 25 kilograms of gum base, 31 kilograms of Icing Sugar, 7.86 kilograms of glucose syrups, 2 kilograms of glycerol, 0.7 kilogram of spice.Earlier gum base, plant cellulose, oils and fats are put into the blender mixing, add Cortex Magnoliae Officinalis extract, stevioside microcapsule and other adjuvant again and continue to knead, with the rolling stripping and slicing of pug mill, packing is finished product.
Embodiment two
Ready-formed each raw material is taken by weighing by recipe quantity: 0.25 kilogram of Cortex Magnoliae Officinalis extract, 40.3 kilograms of plant celluloses, 3 kilograms of oils and fatss, 1.2 kilograms of stevioside microcapsules, 25 kilograms of gum base, 18.3 kilograms of Icing Sugar, 10.15 kilograms of glucose syrups, 1 kilogram of glycerol, 0.8 kilogram in essence.All the other operating procedures are with embodiment one.
Embodiment three
Ready-formed each raw material is taken by weighing by recipe quantity: 1 kilogram of Cortex Magnoliae Officinalis extract, 63 kilograms of plant celluloses, 2.5 kilograms of oils and fatss, 2 kilograms of stevioside microcapsules, 20 kilograms of gum base, 8.5 kilograms of glucose syrups, 2 kilograms of glycerol, 1 kilogram of spice.All the other operating procedures are with embodiment one.
In the above-mentioned embodiment, every heavy 3-6 gram of the anti-caries chewing gum of making is advisable with every heavy 5 grams.When edible, edible after meal every day three times, in mouth, chewed 5-10 minute at every turn, also can suitably increase and decrease edible number of times as required.
Claims (10)
1, a kind of anti-caries chewing gum that contains Chinese medicine is characterized in that contained raw material composition is respectively Cortex Magnoliae Officinalis extract 0.02-7.72 part, plant cellulose 10-70 part, oils and fats 0.2-3 part, stevioside microcapsule 0.16-2 part, gum base 15-26 part.
2, preventing decayed tooth mouth according to claim 1 reaches, and it is characterized in that contained raw material composition is respectively 0.14 part of Cortex Magnoliae Officinalis extract, 30 parts of plant celluloses, 2.5 parts of oils and fatss, 0.8 part of stevioside microcapsule, 25 parts of gum base.
3, anti-caries chewing gum according to claim 1 and 2 is characterized in that used Cortex Magnoliae Officinalis extract can use magnolia obovata extract, Rhizoma Coptidis extract, Galla Chinensis extract to replace.
4, the preparation method of anti-caries chewing gum according to claim 1 and 2, it is characterized in that ready-formed each raw material is taken by weighing Cortex Magnoliae Officinalis extract 0.02-7.72 part, plant cellulose 10-70 part, oils and fats 0.2-3 part, stevioside microcapsule 0.16-2 part, gum base 15-26 part by above-mentioned recipe quantity, in blender, put into earlier gum base, plant cellulose, oils and fats mixing, add Cortex Magnoliae Officinalis extract, stevioside microcapsule again and produce fragrant mouthful of sugar auxiliary materials and mixing commonly used, rolling stripping and slicing, packing are finished product.
5, method according to claim 4 is characterized in that the technical process of prefabricated Cortex Magnoliae Officinalis extract is: Cortex Magnoliae Officinalis is pulverized put into ethanol or methanol, heating and refluxing extraction, is filtered, is concentrated, promptly gets Cortex Magnoliae Officinalis extract after the drying at the extracting solution cooling.
6, method according to claim 4, the technical process that it is characterized in that prefabricated Cortex Magnoliae Officinalis extract is: the Cortex Magnoliae Officinalis pulverizing is added acid through alkalization, filtration, filtrate carry out acidify, filtration, taking precipitate is put into ethanol or dissolve with methanol, filter, filtrate recycling ethanol or methanol concentrate, are drying to obtain Cortex Magnoliae Officinalis extract.
7, method according to claim 4, the technical process that it is characterized in that prefabricated Cortex Magnoliae Officinalis extract is: the Cortex Magnoliae Officinalis crushing and water-adding is decocted, and Cortex Magnoliae Officinalis and water ratio are 1: (5-10), decoct twice, merge the secondary decoction liquor, filter, concentrate, be drying to obtain Cortex Magnoliae Officinalis extract.
8, method according to claim 4, the technical process that it is characterized in that prefabricated stevioside microcapsule is: ethyl cellulose and stevioside are pressed (0.01-0.1): 1 ratio, put into sugared enamel Sandwich pot heated and stirred, be heated to 75-85 ℃, the ethyl cellulose dissolving is cooled to room temperature, leaches the encapsulation stevioside, with cyclohexane extraction washing 2-3 time, promptly get the stevioside microcapsule through vacuum drying.
9, method according to claim 4 is characterized in that the technical process of prefabricated plant cellulose is: plant cellulose is pulverized, crossed and be not less than 100 mesh sieves promptly.
10, method according to claim 4 is characterized in that used gum base is common gum base for chewing gum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94110006 CN1096699A (en) | 1994-01-07 | 1994-01-07 | Anti-caries chewing gum and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94110006 CN1096699A (en) | 1994-01-07 | 1994-01-07 | Anti-caries chewing gum and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1096699A true CN1096699A (en) | 1994-12-28 |
Family
ID=5033999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94110006 Pending CN1096699A (en) | 1994-01-07 | 1994-01-07 | Anti-caries chewing gum and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1096699A (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500409B1 (en) * | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| US6703000B2 (en) | 2001-05-15 | 2004-03-09 | The Procter & Gamble Co. | Confectionery compositions |
| US6706256B2 (en) | 2001-05-15 | 2004-03-16 | The Procter & Gamble Co. | Oral care compositions |
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7470442B2 (en) | 2005-12-02 | 2008-12-30 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| CN107319090A (en) * | 2017-06-16 | 2017-11-07 | 司和平 | A kind of feature natural plant fibre chewing gum and preparation method thereof |
| CN107333993A (en) * | 2017-08-30 | 2017-11-10 | 贵港正邦农牧科技有限公司 | A kind of feedstuff for live pigs additive and preparation method thereof |
| CN107439815A (en) * | 2017-08-30 | 2017-12-08 | 贵港正邦农牧科技有限公司 | A kind of efficiently feedstuff for live pigs and preparation method thereof |
| AU2017228332B2 (en) * | 2016-03-01 | 2020-01-16 | Wm. Wrigley Jr. Company | Long-lasting sweetener formulations |
| CN115154501A (en) * | 2022-06-20 | 2022-10-11 | 云南白药集团股份有限公司 | Composition for oral cavity repair, gel preparation prepared from composition and application of gel preparation |
| CN118902887A (en) * | 2024-09-12 | 2024-11-08 | 南宁兴景科技有限公司 | Preparation method of stevioside and magnolol for preventing dental caries |
-
1994
- 1994-01-07 CN CN 94110006 patent/CN1096699A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500409B1 (en) * | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| US6703000B2 (en) | 2001-05-15 | 2004-03-09 | The Procter & Gamble Co. | Confectionery compositions |
| US6706256B2 (en) | 2001-05-15 | 2004-03-16 | The Procter & Gamble Co. | Oral care compositions |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7470442B2 (en) | 2005-12-02 | 2008-12-30 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| AU2017228332B2 (en) * | 2016-03-01 | 2020-01-16 | Wm. Wrigley Jr. Company | Long-lasting sweetener formulations |
| CN107319090A (en) * | 2017-06-16 | 2017-11-07 | 司和平 | A kind of feature natural plant fibre chewing gum and preparation method thereof |
| CN107333993A (en) * | 2017-08-30 | 2017-11-10 | 贵港正邦农牧科技有限公司 | A kind of feedstuff for live pigs additive and preparation method thereof |
| CN107439815A (en) * | 2017-08-30 | 2017-12-08 | 贵港正邦农牧科技有限公司 | A kind of efficiently feedstuff for live pigs and preparation method thereof |
| CN115154501A (en) * | 2022-06-20 | 2022-10-11 | 云南白药集团股份有限公司 | Composition for oral cavity repair, gel preparation prepared from composition and application of gel preparation |
| CN118902887A (en) * | 2024-09-12 | 2024-11-08 | 南宁兴景科技有限公司 | Preparation method of stevioside and magnolol for preventing dental caries |
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