CN1092055C - Chinese medicine preparation - Google Patents
Chinese medicine preparation Download PDFInfo
- Publication number
- CN1092055C CN1092055C CN00108022A CN00108022A CN1092055C CN 1092055 C CN1092055 C CN 1092055C CN 00108022 A CN00108022 A CN 00108022A CN 00108022 A CN00108022 A CN 00108022A CN 1092055 C CN1092055 C CN 1092055C
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- CN
- China
- Prior art keywords
- medicine
- chinese medicine
- fructus
- radix
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 25
- 201000002364 leukopenia Diseases 0.000 claims abstract description 12
- 231100001022 leukopenia Toxicity 0.000 claims description 11
- 241000756943 Codonopsis Species 0.000 claims description 4
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 235000013399 edible fruits Nutrition 0.000 abstract 3
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000207901 Cuscuta Species 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 240000001659 Oldenlandia diffusa Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 239000002775 capsule Substances 0.000 description 13
- 239000003292 glue Substances 0.000 description 11
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 7
- 210000000265 leukocyte Anatomy 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 210000001185 bone marrow Anatomy 0.000 description 4
- 229960004397 cyclophosphamide Drugs 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000009874 shenqi Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XDBMTQVSHNQIFU-UHFFFAOYSA-N 2-(2-ethoxy-2-oxo-1-phenylethyl)-1,3-thiazolidin-3-ium-4-carboxylate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)C1NC(C(O)=O)CS1 XDBMTQVSHNQIFU-UHFFFAOYSA-N 0.000 description 1
- 208000001395 Acute radiation syndrome Diseases 0.000 description 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- 241000608867 Leucogenes Species 0.000 description 1
- 206010068142 Radiation sickness syndrome Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 229960003513 batilol Drugs 0.000 description 1
- 210000002960 bfu-e Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
- 210000003013 erythroid precursor cell Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 230000000388 leucogen effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a traditional Chinese medicine preparation for treating leucopenia, which is composed of acanthopanax root, cuscuta seed, schisandra fruit, pilose asiabell root, barbary wolfberry fruit, white atractylodes rhizome, indian bread, giant knotweed, spreading hedyotis herb, glossy privet fruit, etc.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation for the treatment of leukopenia.
The leukopenia ownership is at " asthenia " and " blood deficiency " card category of the traditional Chinese medical science.Chinese medicine is to the existing many-sided research of its treatment in recent years, and wherein reporting maximum has SHENQI PIAN, sets upright and rise plain soup, SHENGXUE WAN, BUZHONG YIQI TANG, SHENGBAI PIAN and single medicine Herba Apocyni veneti, Radix Rubiae, Herb Gynostemmae Pentaphylli, Radix Rubiae Yunnanensis etc.But the clinical and pharmacological research of above compound recipe and single medicine transits directly to the SHENQI PIAN of having only of new drug research.In view of leukopenia is a common clinical disease, bone marrow transplant patient and acute radiation sickness are also seen this disease more, although doctor trained in Western medicine has the treatment of medicines such as GM-CSF, leucogen, batilol, inosine, VitB4, VitB6 to this, and occupy certain advantage, but many patient's leukocyte counts often fall rapidly after drug withdrawal, and some medicine costs an arm and a leg, and is difficult to be accepted extensively by society.And that Chinese medicine has toxicity is little, the late result height, and characteristics such as inexpensive make this research become very important work.
The purpose of this invention is to provide a kind of nontoxic, effect of paying, late result is good, industrial cost's price is lower and can effectively treats the Chinese medicine preparation of leukopenia.
Technical scheme of the present invention is by the medicine of selecting effective science and proportioning thereof, makes medicine according to conventional formulation technology and realizes.The selected crude drug of the present invention is (by weight):
Radix Et Caulis Acanthopanacis Senticosi 10-90 Semen Cuscutae 6-60 Fructus Schisandrae Chinensis 2-15
Radix Codonopsis 5-45 Fructus Lycii 5-45 Rhizoma Atractylodis Macrocephalae 5-45
Poria 5-45 Rhizoma Polygoni Cuspidati 3-27 Herba Hedyotidis Diffusae 6-60
Fructus Ligustri Lucidi 5-45
According to the prepared capsule of technical solution of the present invention (thorn white glues capsule), confirm that through pharmacodynamic experiment leukopenia is had the good curing effect.The inventor is by right
60The hemopoietic function of Canis familiaris L. leukopenia changes after leukopenia of Co γ line total irradiation mice and the cyclophosphamide administration, observes the therapeutical effect of thorn white glues capsule to leukopenia, and the result is as follows:
1, mice is after the total irradiation of 7.0Gy γ line, and leukocyte is reduced to about 10% of normal value, and thorn white glues capsule can alleviate its degree of injury, and its peripheral white blood cell is compared P＜0.01 with simple irradiation group; Promote the formation of CFU-S; Recover the bone marrow nucleated cell number; The most obvious with the big or middle dosage group of thorn white glues capsule effect, compare P＜0.01 or P＜0.001 with simple irradiation group.
2, Canis familiaris L. with continuous five days oral cyclophosphamide of 5mg/kg body weight after, reduce to minimum in the 9th day leukocyte count, be about about 30% of normal value.And behind the oral thorn white glues of the Canis familiaris L. capsule, its minimum level increases, and is about 45% of normal value; Leukocyte count is lower than persistent period of 50% obviously to be shortened, and simple ring phosphamide matched group is 10.0 ± 3.3 days, and the large and small dosage group of thorn white glues capsule was respectively 2.0 ± 1.6 days and 3.3 ± 1.2 days; Sting white Capsules group leukocyte and be higher than that the time of occurrence of value 50% obviously shifts to an earlier date before the medicine, the cyclophosphamide group is 16.5 ± 2.3 days behind the medicine, stings the large and small dosage group of white glues capsule and is respectively 7.8 ± 5.3 days and 10.5 ± 3.0 days.
3, the Canis familiaris L. of oral cyclophosphamide, the propagation of bone marrow nucleated cell is suppressed, and thorn white glues capsule can recover the bone marrow nucleated cell number, wherein stings the heavy dose of group of white glues capsule and compares P＜0.05 with the cyclophosphamide group; More obviously improve CFU-GM, CFU-E and BFU-E productive rate, the large and small dosage group of thorn white glues capsule and cyclophosphamide group ratio, P＜0.001.
Above result shows: thorn white glues capsule to the leukopenia of 7.0Gy γ line total irradiation mice and cyclophosphamide administration after the Canis familiaris L. leukopenia to a certain degree therapeutical effect is all arranged.
Embodiment: take by weighing following proportion raw material medicine:
Radix Et Caulis Acanthopanacis Senticosi 30g Semen Cuscutae 20g Fructus Schisandrae Chinensis 5g
Radix Codonopsis 15g Fructus Lycii 15g Rhizoma Atractylodis Macrocephalae 15g
Poria 15g Rhizoma Polygoni Cuspidati 9g Herba Hedyotidis Diffusae 20g
Fructus Ligustri Lucidi 15g
Above-mentioned raw materials medicated powder is broken into fine powder, crosses 200 mesh sieves, encapsulated, promptly.
Claims (2)
1, a kind of medicine for the treatment of leukopenia is characterized in that this medicine made by following raw medicaments in portion by weight:
Radix Et Caulis Acanthopanacis Senticosi 10-90 Semen Cuscutae 6-60 Fructus Schisandrae Chinensis 2-15
Radix Codonopsis 5-45 Fructus Lycii 5-45 Rhizoma Atractylodis Macrocephalae 5-45
Poria 5-45 Rhizoma Polygoni Cuspidati 3-27 Herba Hedyotidis Diffusae 6-60
Fructus Ligustri Lucidi 5-45
2, medicine as claimed in claim 1 is characterized in that this medicine made by following raw medicaments in portion by weight:
Radix Et Caulis Acanthopanacis Senticosi 30 Semen Cuscutae 20 Fructus Schisandrae Chinensis 5
Radix Codonopsis 15 Fructus Lycii 15 Rhizoma Atractylodis Macrocephalaes 15
Poria 15 Rhizoma Polygoni Cuspidati 9 Herba Hedyotidis Diffusaes 20
Fructus Ligustri Lucidi 15
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00108022A CN1092055C (en) | 2000-06-09 | 2000-06-09 | Chinese medicine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00108022A CN1092055C (en) | 2000-06-09 | 2000-06-09 | Chinese medicine preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1277034A CN1277034A (en) | 2000-12-20 |
| CN1092055C true CN1092055C (en) | 2002-10-09 |
Family
ID=4579092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00108022A Expired - Fee Related CN1092055C (en) | 2000-06-09 | 2000-06-09 | Chinese medicine preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1092055C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102461892A (en) * | 2010-11-11 | 2012-05-23 | 卢卫红 | Formula and preparation method of portable functional food for stress after disaster |
| CN102048902B (en) * | 2010-12-22 | 2012-05-09 | 中国人民解放军第三○二医院 | A traditional Chinese medicine composition, extract, preparation method, application and dosage form for treating hepatitis |
| CN106491838A (en) * | 2016-12-15 | 2017-03-15 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Thorn white glue capsule and its application in treatment leukopenia |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081901A (en) * | 1993-04-28 | 1994-02-16 | 贵阳中药厂 | Paste for increasing leukocyte |
| CN1085801A (en) * | 1992-10-17 | 1994-04-27 | 北京市凯祥生物制品公司 | Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof |
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN1170584A (en) * | 1996-07-11 | 1998-01-21 | 刘毅斌 | Preparation method of medicine Kangfubiyin |
-
2000
- 2000-06-09 CN CN00108022A patent/CN1092055C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085801A (en) * | 1992-10-17 | 1994-04-27 | 北京市凯祥生物制品公司 | Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof |
| CN1081901A (en) * | 1993-04-28 | 1994-02-16 | 贵阳中药厂 | Paste for increasing leukocyte |
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN1170584A (en) * | 1996-07-11 | 1998-01-21 | 刘毅斌 | Preparation method of medicine Kangfubiyin |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1277034A (en) | 2000-12-20 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |