CN1141138C - Medicine composition for curing coronary heart disease - Google Patents
Medicine composition for curing coronary heart disease Download PDFInfo
- Publication number
- CN1141138C CN1141138C CNB021173044A CN02117304A CN1141138C CN 1141138 C CN1141138 C CN 1141138C CN B021173044 A CNB021173044 A CN B021173044A CN 02117304 A CN02117304 A CN 02117304A CN 1141138 C CN1141138 C CN 1141138C
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- rhizoma
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- 208000029078 coronary artery disease Diseases 0.000 title claims abstract description 11
- 239000003814 drug Substances 0.000 title abstract description 8
- 239000000203 mixture Substances 0.000 title abstract description 3
- 229940079593 drug Drugs 0.000 title description 4
- 241000305492 Gastrodia Species 0.000 claims abstract description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 241000756943 Codonopsis Species 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 5
- 241000283956 Manis Species 0.000 claims description 5
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- 235000005903 Dioscorea Nutrition 0.000 claims description 2
- 241000234273 Dioscorea Species 0.000 claims description 2
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 2
- 241000202807 Glycyrrhiza Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 235000004879 dioscorea Nutrition 0.000 claims description 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 9
- 206010003210 Arteriosclerosis Diseases 0.000 abstract description 3
- 206010020772 Hypertension Diseases 0.000 abstract description 3
- 208000001407 Vascular Headaches Diseases 0.000 abstract description 3
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 3
- 244000233890 Alisma plantago Species 0.000 abstract 1
- 235000017300 Alisma plantago Nutrition 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 240000007890 Leonurus cardiaca Species 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 241001448421 Ophiopogon jaburan Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000283966 Pholidota <mammal> Species 0.000 abstract 1
- 235000006751 Platycodon Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 241000756042 Polygonatum Species 0.000 abstract 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 229930189914 platycodon Natural products 0.000 abstract 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 3
- 239000000006 Nitroglycerin Substances 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229960003711 glyceryl trinitrate Drugs 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine composition for treating coronary disease, which is mainly composed of pangolin, motherwort, white atractylodes rhizome, lilyturf root, cowherb seed, Chinese angelica, water plantain, orange peel, licorice root, cortex moutan, pilose asiabell root, red peony root, safflower, trichosanthis, platycodon root, rehmannia root, fleeceflower root, solomonseal rhizome, aurantii immaturus Chinese yam and gastrodia tuber. The present invention has good effects on treating coronary disease, angina pectoris, high blood pressure, vascular headache, arteriosclerosis, etc.
Description
Technical field:
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of coronary heart disease, angina pectoris, hypertension, vascular headache, arteriosclerosis etc.
Background technology:
Coronary atherosclerotic heart disease, be called for short coronary heart disease, its cause of disease is because some can not infilter blood-lipoids material such as cholesterol, the triglyceride etc. of arterial wall, be deposited on and form " atheromatous plaque " back on the endarterium because of calmness calcareous in the liquid, make original whippy tremulous pulse hardening, along with the atheromatous plaque scope on the endarterium strengthens, cause lumen of vessels to narrow down even block, cause myocardial ischemia, anoxia or necrosis; At present, the medicament categories of treatment coronary heart disease is various, but these medicines all are to pass through blood vessel dilating on pharmacology, temporarily solve the blood supply problem, so short term efficacy is in various degree all arranged, but late result is relatively poor, does not reach the purpose of healing, and takes drug resistance and the toxic and side effects that all has in various degree for a long time.
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of coronary heart disease, angina pectoris, hypertension, vascular headache, arteriosclerosis etc.
The present invention seeks to be achieved through the following technical solutions: choose crude drug
Squama Manis 100-200 weight portion Herba Leonuri 100-300 weight portion
Rhizoma Atractylodis Macrocephalae 100-300 weight portion 100-300 Radix Ophiopogonis weight portion
Semen Vaccariae 100-300 weight portion Radix Angelicae Sinensis 100-300 weight portion
Rhizoma Alismatis 100-300 weight portion Pericarpium Citri Reticulatae 50-200 weight portion
Radix Glycyrrhizae 50-200 weight portion Cortex Moutan 100-300 weight portion
Radix Codonopsis 100-300 weight portion Radix Paeoniae Rubra 100-300 weight portion
Flos Carthami 100-300 weight portion Fructus Trichosanthis 100-300 weight portion
Radix Platycodonis 100-300 weight portion Radix Rehmanniae 100-300 weight portion
Radix Polygoni Multiflori 100-300 weight portion Rhizoma Polygonati 100-300 weight portion
Fructus Aurantii Immaturus 100-300 weight portion Rhizoma Dioscoreae 100-300 weight portion
Rhizoma Gastrodiae 100-200 weight portion
The present invention most preferably proportioning is:
The Squama Manis 150 weight portion Herba Leonuris 250 weight portion Rhizoma Atractylodis Macrocephalaes 250 weight portions
Radix Ophiopogonis 200 weight portion Semen Vaccariae, 200 weight portion Radix Angelicae Sinensis, 200 weight portions
Rhizoma Alismatis 200 weight portion Pericarpium Citri Reticulataes 100 weight portion Radix Glycyrrhizaes 100 weight portions
Cortex Moutan 200 weight portion Radix Codonopsis 200 weight portion Radix Paeoniae Rubra 200 weight portions
Flos Carthami 200 weight portion Fructus Trichosanthis 250 weight portion Radix Platycodoniss 100 weight portions
The Radix Rehmanniae 200 weight portion Radixs Polygoni Multiflori 200 weight portion Rhizoma Polygonatis 200 weight portions
Fructus Aurantii Immaturus 200 weight portion Rhizoma Dioscoreaes 200 weight portion Rhizoma Gastrodiaes 150 weight portions
The present composition can be made into acceptable forms clinically according to common process.Once obey suitable crude drug in whole 150g, twice on the one.
The present invention treats coronary heart disease (angina pectoris) 210 routine observation of curative effect:
This organizes 210 examples, male's 120 examples, and women's 90 property, minimal ages 50 years old at maximum 80 years old age, is all made a definite diagnosis typing through hospital above county level according to " clinical disease diagnosis is according to curing the improvement standard " and " up-to-date domestic and international medical diagnosis on disease standard ".
Criterion of therapeutical effect and therapeutic outcome;
Produce effects (the basic healing): 1, the angina pectoris symptom classification of exertional angina pectoris treatment back reduces two-stage or disappearance, originally be that I, the angina pectoris of II level disappear (promptly also not occurring angina pectoris substantially in the heavier physical exertion that surpasses daily routines) substantially, without nitroglycerin; 2, noneffort angina transference cure or basic the disappearance, no more than 2 times of angina pectoris week is substantially without nitroglycerin.
Invalid: symptom and nitroglycerin consumption do not have change, though or reduce the improvement degree that do not reach to some extent.
The ECG curative effect evaluation criteria:
Produce effects: electrocardiogram returns to normally during rest, and double 2-step exercise test transfers feminine gender to by the positive; Inferior maximum dose graded exercise test feminine gender, or exercise tolerance occurs positive than the preceding rising secondary of treatment.
Do not have and change: be basic identical before electrocardiogram or exercise test and the treatment during rest; Though or have and improve but do not reach above-mentioned regulation.
This group treatment observation patient with angina pectoris 210 examples, except that the no changers of 4 examples, all the other all obviously alleviate in the north day back symptom of taking medicine, pain, reach produce effects and cure with basic in 60-90 days.The also synchronous produce effects of Electrocardiographic curative effect.The shortest observation is 1 year after the drug withdrawal, and is the longest 5 years, the bullet phenomenon do not occur returning.
Embodiment:
Squama Manis 150g Herba Leonuri 250g Rhizoma Atractylodis Macrocephalae 250g 200g Radix Ophiopogonis
Semen Vaccariae 200g Radix Angelicae Sinensis 200g Rhizoma Alismatis 200g Pericarpium Citri Reticulatae 100g
Radix Glycyrrhizae 100g Cortex Moutan 200g Radix Codonopsis 200g Radix Paeoniae Rubra 200g
Flos Carthami 200g Fructus Trichosanthis 250g Radix Platycodonis 100g Radix Rehmanniae 200g
Radix Polygoni Multiflori 200g Rhizoma Polygonati 200g Fructus Aurantii Immaturus 200g is by medicine 200g
Rhizoma Gastrodiae 150g
Technology is made 1000 of capsules routinely.
Claims (2)
1, a kind of pharmaceutical composition for the treatment of coronary heart disease is characterized in that this pharmaceutical composition is to be made by following materials of weight proportions:
Squama Manis 100-200 weight portion Herba Leonuri 100-300 weight portion
Rhizoma Atractylodis Macrocephalae 100-300 weight portion 100-300 Radix Ophiopogonis weight portion
Semen Vaccariae 100-300 weight portion Radix Angelicae Sinensis 100-300 weight portion
Rhizoma Alismatis 100-300 weight portion Pericarpium Citri Reticulatae 50-200 weight portion
Radix Glycyrrhizae 50-200 weight portion Cortex Moutan 100-300 weight portion
Radix Codonopsis 100-300 weight portion Radix Paeoniae Rubra 100-300 weight portion
Flos Carthami 100-300 weight portion Fructus Trichosanthis 100-300 weight portion
Radix Platycodonis 100-300 weight portion Radix Rehmanniae 100-300 weight portion
Radix Polygoni Multiflori 100-300 weight portion Rhizoma Polygonati 100-300 weight portion
Fructus Aurantii Immaturus 100-300 weight portion Rhizoma Dioscoreae 100-300 weight portion
Rhizoma Gastrodiae 100-200 weight portion.
2, the pharmaceutical composition with treatment coronary heart disease as claimed in claim 1 is characterized in that this pharmaceutical composition is to be made by following materials of weight proportions:
The Squama Manis 150 weight portion Herba Leonuris 250 weight portion Rhizoma Atractylodis Macrocephalaes 250 weight portions
Radix Ophiopogonis 200 weight portion Semen Vaccariae, 200 weight portion Radix Angelicae Sinensis, 200 weight portions
Rhizoma Alismatis 200 weight portion Pericarpium Citri Reticulataes 100 weight portion Radix Glycyrrhizaes 100 weight portions
Cortex Moutan 200 weight portion Radix Codonopsis 200 weight portion Radix Paeoniae Rubra 200 weight portions
Flos Carthami 200 weight portion Fructus Trichosanthis 250 weight portion Radix Platycodoniss 100 weight portions
The Radix Rehmanniae 200 weight portion Radixs Polygoni Multiflori 200 weight portion Rhizoma Polygonatis 200 weight portions
Fructus Aurantii Immaturus 200 weight portion Rhizoma Dioscoreaes 200 weight portion Rhizoma Gastrodiaes 150 weight portions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021173044A CN1141138C (en) | 2002-04-17 | 2002-04-17 | Medicine composition for curing coronary heart disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021173044A CN1141138C (en) | 2002-04-17 | 2002-04-17 | Medicine composition for curing coronary heart disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1380088A CN1380088A (en) | 2002-11-20 |
| CN1141138C true CN1141138C (en) | 2004-03-10 |
Family
ID=4744383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021173044A Expired - Fee Related CN1141138C (en) | 2002-04-17 | 2002-04-17 | Medicine composition for curing coronary heart disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1141138C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101417042B (en) * | 2008-05-04 | 2011-11-09 | 庄明增 | Medical composition capable of treating hypertension |
| CN101530556B (en) * | 2009-04-17 | 2011-05-11 | 河北惟祥福中药科技开发有限公司 | Chinese traditional medicine preparation used for curing angina |
| CN101874887B (en) * | 2010-04-23 | 2011-12-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating angina and preparation method thereof |
| CN103948832A (en) * | 2014-05-29 | 2014-07-30 | 张军 | Traditional Chinese medicine preparation for lowering blood pressure |
| CN104887954A (en) * | 2015-05-29 | 2015-09-09 | 吴优 | Medicine for treating latent coronary heart diseases and preparation method thereof |
-
2002
- 2002-04-17 CN CNB021173044A patent/CN1141138C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1380088A (en) | 2002-11-20 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |