CN1088555C - 含有n－(2,6－二溴－4－三氟甲氧基苯基)－2－甲基－4－三氟甲基－5－噻唑羧酰胺的农药组合物 - Google Patents
含有n－(2,6－二溴－4－三氟甲氧基苯基)－2－甲基－4－三氟甲基－5－噻唑羧酰胺的农药组合物 Download PDFInfo
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- CN1088555C CN1088555C CN97100023A CN97100023A CN1088555C CN 1088555 C CN1088555 C CN 1088555C CN 97100023 A CN97100023 A CN 97100023A CN 97100023 A CN97100023 A CN 97100023A CN 1088555 C CN1088555 C CN 1088555C
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- bacterium azoles
- fluorine bacterium
- bromine fluorine
- bromine
- water
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- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N Tetraethylene glycol, Natural products OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
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- PZYDAVFRVJXFHS-UHFFFAOYSA-N n-cyclohexyl-2-pyrrolidone Chemical compound O=C1CCCN1C1CCCCC1 PZYDAVFRVJXFHS-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
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- TVDSBUOJIPERQY-UHFFFAOYSA-N prop-2-yn-1-ol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 1
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- CIBMHJPPKCXONB-UHFFFAOYSA-N propane-2,2-diol Chemical compound CC(C)(O)O CIBMHJPPKCXONB-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 229920005552 sodium lignosulfonate Polymers 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本发明提供含有用活性炭处理的溴氟菌唑作为有效成分的农药组合物。这些组合物提供溴氟菌唑在水中的增加释放。
Description
本发明涉及含有在水中释放性能改善的N-(2，6-二溴-4-三氟甲氧基苯基)-2-甲基-4-三氟甲基-5-噻唑羧酰胺(通用名：溴氟菌唑，英文名称为thifluzamide)的农药组合物。
溴氟菌唑是一种对稻纹枯病有高的农药活性的化合物。因为在水稻栽培中使用抗稻纹枯病的药品是在水稻田中的水量较少的时候，有效成分的溶解/扩散率可以明显影响铲除效果。然而，由于溴氟菌唑在水中的溶解度极低，大约为1.6mg/l(20℃)，因此希望开发出一种可以增加它在水中释放率且改善其效力的方法。
我们发现，含有用活性炭处理的溴氟菌唑作为有效成分的农药组合物，溴氟菌唑在水中释放的性能得到了改善，从而实现了本发明。
因此，本发明是包含用活性炭处理过的溴氟菌唑的农药组合物。
本发明的另一实施方案是一种农药组合物，其中活性成分是通过将溴氟菌唑溶于有机溶剂并将所得的溶液用活性炭处理而获得的溴氟菌唑。
本发明的第三种实施方案是制备在水中释放性能改善的溴氟菌唑的方法，该方法包含：将溴氟菌唑溶于有机溶剂中，加入活性炭，除去活性炭，蒸馏除去有机溶剂，并结晶溴氟菌唑。
本发明中所用的活性炭可以是任何形状和形式的，只要它是通常采用的如颗粒和粉状的活性炭。对于意欲加入的量，无特殊的限制。对溶液中每重量份的溴氟菌唑，意欲加入的活性炭量优选是0.0001-0.5重量份，更优选0.001-0.5重量份。
对于意欲用于本发明中的有机溶剂无特殊的限制，只要它是一种可以溶解溴氟菌唑的普通溶剂。从工业的角度考虑，在20℃下每100ml溶剂可以溶解大于1.0g溴氟菌唑的有机溶剂是优选的。例如，可以提到的有下列溶剂，但不限于这些实例：(1)醇类如烯丙醇、异丁醇、异丙醇、乙醇、四氢糠醇、仲丁醇、叔丁醇、糠醇、炔丙醇、1-丙醇、甲醇、3-甲基-1-戊炔-3-醇、乙二醇、乙二醇二乙酸酯、乙二醇二缩水甘油醚、乙二醇单乙酸酯、乙二醇二甲基醚、乙二醇单乙基醚、乙二醇单乙基醚乙酸酯、乙二醇单丁基醚、乙二醇单甲基醚、乙二醇单乙基醚乙酸酯、乙二醇单甲氧基甲基醚、2-氯乙醇、甘油、甘油1，3-二甲基醚、2-氯-1，3-丙二醇、二乙二醇、二乙二醇乙基甲基醚、二乙二醇氯乙醇、二乙二醇二乙酸酯、二乙二醇二乙基醚、二乙二醇二甲基醚、二乙二醇单乙基醚、二乙二醇单乙基醚乙酸酯、二乙二醇单丁基醚、二乙二醇单乙基醚、二丙二醇、二丙二醇单乙基醚、二丙二醇单甲基醚、四甘醇、三甘醇、三甘醇单甲基醚、三乙二醇单甲基醚、亚丙基二醇、1，3-丁二醇、1，4-丁二醇、丙二醇、丙二醇单乙基醚、丙二醇单甲基醚和1，5-戊二醇；(2)醚类和缩醛类如乙醚、1，4-二 烷、二丙基醚、二甲醚、四氢吡喃、四氢呋喃、糠缩醛和甲缩醛；(3)酮类如丙酮、二丙酮醇和甲乙酮；(4)酯类如甲酸乙酯、甲酸甲酯、乙酸乙酯、乙酸甲酯、乳酸乙酯、乳酸甲酯和γ-丁内酯；(5)羧酸如异丁酸、甲酸、乙酸和二氯乙酸；(6)N-烷基吡咯烷酮如2-吡咯烷酮、N-甲基-2-吡咯烷酮、N-乙烯基-2-吡咯烷酮、N-乙基-2-吡咯烷酮、N-(2-羟乙基)-2-吡咯烷酮、N-环己基-2-吡咯烷酮、N-异丙基-2-吡咯烷酮、N-(正丁基)-2-吡咯烷酮、N-叔丁基-2-吡咯烷酮、N-(3-羟丙基)-2-吡咯烷酮、N-(2-甲氧基乙基)-2-吡咯烷酮和N-(3-甲氧基丙基)-2-吡咯烷酮；和(7)其它如烯丙胺、N-乙基乙醇胺、乙二胺、二乙胺、N，N-二甲基甲酰胺、N，N，N′，N′-四甲基乙二胺、三乙胺、三甲胺、2-甲基哌啶、哌啶、丙二胺、六甲基磷酰三胺、单乙醇胺、乙腈和二甲基亚砜。优选的溶剂是乙腈、甲醇、乙醇、四氢呋喃和丙酮。
虽然对本发明采用经活性炭处理的溴氟菌唑作为有效成分的农药组合物的药剂形式没有特殊的限制，但可以提到的形式例如有粉剂、可湿性粉剂、丸剂、片剂、可分散粒剂、悬浮剂等，且可以通过农药加工技术领域的技术人员已知的普通方法来制备各种制剂。对于除有效成分外的其它意欲加入到本发明的农药组合物中的添加剂也无特殊的限制。
除活性炭处理的溴氟菌唑外的其它有效成分也可以加入到本发明的农药组合物中。
本发明通过下列实施例和试验实施例作具体的描述。但本发明不限于这些实施例。顺带提一句，在下列实施例和对比实施例中“份”是指“重量份”。实施例1-用活性炭处理的溴氟菌唑
在室温下将10g溴氟菌唑溶于160ml乙腈后，加入3g活性炭粉。搅拌60分钟后，经1μm滤纸过滤。通过蒸发仪将乙腈从滤液中去除后，在减压下干燥，得溴氟菌唑。实施例2-用活性炭处理的溴氟菌唑
在室温下将10g溴氟菌唑溶于160ml乙腈后，加入0.5g活性炭粉。搅拌60分钟后，经1μm滤纸过滤。通过蒸发仪将乙腈从滤液中去除后，在减压下干燥，得溴氟菌唑。
实施例3-丸剂1
将实施例1中获得的溴氟菌唑用气流粉碎机(A-O Jet Mill，由Seishin Kigyo K.K.制造)粉碎。将此粉碎的材料2.0份、木素磺酸钠5.0份、烷基苯磺酸0.5份、聚丙烯酸钠1.0份、三聚磷酸钠2.0份、膨润土40份、碳酸钙49.5份和水16份在全能混合机(由Dalton K.K制造)中混合/掺合，并用装备有0.8mm孔筛的挤出型造丸机(BR-200，由Fuji Powdal K.K.制造)造丸。所造的丸在50℃干燥，得丸剂1。
实施例4-丸剂2
将实施例2中获得的溴氟菌唑进行与实施例3相似的工艺操作，得丸剂2。对比实施例1-对比丸剂
在室温下将10g溴氟菌唑溶于160ml乙腈后，搅拌60分钟，经1μm滤纸过滤。通过蒸发仪将乙腈从滤液中去除后，在减压下干燥，得溴氟菌唑。
由此得到的溴氟菌唑进行与实施例3相似的工艺操作，得对比丸剂。试验实施例-丸剂的释放试验
将丸剂1和2和对比丸剂各45毫克加入烧杯中，烧杯里含有1000ml保持在30℃水温的硬水(硬度＝10°)。静置7天后，将部分溶液从烧杯的中部取出，并分析溴氟菌唑的含量，被释放的溴氟菌唑的百分率用下列公式计算：
释放％＝A×100/B
A：释放入水中的溴氟菌唑的量(mg)
B：加入烧杯中的丸剂中的溴氟菌唑的含量(mg)
结果示于表1中。
表1
| 第7天的释放％ | |
| 丸剂1丸剂2对比丸剂 | 858558 |
这些数据表明，可以通过使用活性炭处理的溴氟菌唑作为有效成分的农药组合物来增加溴氟菌唑在水中的释放率。
Claims (6)
1.一种农药组合物，它包含用活性炭处理过的溴氟菌唑。
2.权利要求1的农药组合物，其中溴氟菌唑是通过将溴氟菌唑溶于有机溶剂并将所得的溶液用活性炭处理而得到的。
3.权利要求2的农药组合物，其中溴氟菌唑在有机溶剂中的溶解度在20℃下至少为1.0g/100ml。
4.权利要求2的农药组合物，其中对应于在溶液中的每重量份的溴氟菌唑，活性炭的量是0.0001-0.5重量份。
5.制备用活性炭处理的溴氟菌唑的方法，包括：
a)将溴氟菌唑溶于有机溶剂，
b)加入活性炭，
c)去除活性炭，
d)蒸馏去除有机溶剂，和
e)将溴氟菌唑结晶。
6.权利要求5的方法，其中对应于在溶剂中的每重量份的溴氟菌唑，活性炭的量是0.0001-0.5重量份。
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| Application Number | Priority Date | Filing Date | Title |
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| JP96/65139 | 1996-02-28 | ||
| JP8065139A JPH09227313A (ja) | 1996-02-28 | 1996-02-28 | 水中溶出性が向上したチフルザミド農薬組成物 |
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| JP (1) | JPH09227313A (zh) |
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| AU (1) | AU725559B2 (zh) |
| BR (1) | BR9701089A (zh) |
| CA (1) | CA2198429A1 (zh) |
| DE (1) | DE69700038T2 (zh) |
| IL (1) | IL120323A0 (zh) |
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| CN1086909C (zh) * | 1999-04-30 | 2002-07-03 | 湖南农业大学 | 一种防治作物纹枯病杀菌剂的配制方法 |
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| EP0371950A2 (en) * | 1988-11-29 | 1990-06-06 | Monsanto Company | Substituted thiazoles and their use as fungicides |
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| Title |
|---|
| BRIGHTON CROP .PROT.CONF.-PESTS DIS NO.1,1992, 1992.1.1 "MON 24000:A NOVEL FUMGICIDE WITH DROAD -SPTRUM DISEASE CONT NOL"O'REILLY等人 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL120323A0 (en) | 1997-06-10 |
| US5723478A (en) | 1998-03-03 |
| DE69700038T2 (de) | 1999-07-01 |
| ZA971705B (en) | 1997-09-03 |
| BR9701089A (pt) | 1998-12-15 |
| CA2198429A1 (en) | 1997-08-28 |
| TW336155B (en) | 1998-07-11 |
| AU1476897A (en) | 1997-09-04 |
| AU725559B2 (en) | 2000-10-12 |
| DE69700038D1 (de) | 1998-11-26 |
| MX9701518A (es) | 1998-07-31 |
| EP0792582A1 (en) | 1997-09-03 |
| JPH09227313A (ja) | 1997-09-02 |
| EP0792582B1 (en) | 1998-10-21 |
| CN1160482A (zh) | 1997-10-01 |
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