CN108338789B - Intelligent capsule - Google Patents
Intelligent capsule Download PDFInfo
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- CN108338789B CN108338789B CN201810316600.7A CN201810316600A CN108338789B CN 108338789 B CN108338789 B CN 108338789B CN 201810316600 A CN201810316600 A CN 201810316600A CN 108338789 B CN108338789 B CN 108338789B
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- 239000002775 capsule Substances 0.000 title claims abstract description 103
- 239000003814 drug Substances 0.000 claims abstract description 80
- 229940079593 drug Drugs 0.000 claims abstract description 30
- 238000012545 processing Methods 0.000 claims abstract description 13
- 238000010897 surface acoustic wave method Methods 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000002195 soluble material Substances 0.000 claims description 4
- 238000005259 measurement Methods 0.000 abstract description 7
- 238000011282 treatment Methods 0.000 abstract description 7
- 238000012544 monitoring process Methods 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 239000011257 shell material Substances 0.000 description 20
- 238000000034 method Methods 0.000 description 10
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 8
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 8
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 8
- 208000028017 Psychotic disease Diseases 0.000 description 6
- 210000004211 gastric acid Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000009747 swallowing Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 241000167880 Hirundinidae Species 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000003090 exacerbative effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000000698 schizophrenic effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6861—Capsules, e.g. for swallowing or implanting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6871—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention relates to the field of intelligent medical treatment, in particular to an intelligent capsule. The intelligent capsule includes: the capsule shell, capsule shell one side sets up an acid-soluble lid, includes in the capsule shell: the medicine storage bin is provided with an acid-soluble cover at one side and a piston at the other side, and the medicine storage bin, the acid-soluble cover and the piston form a closed space together for storing powdery or liquid medicines; one side of the piston, which is away from the medicine storage bin, is connected with a spiral antenna, and the spiral antenna has a target working frequency; the processing chip is connected with one side of the spiral antenna, which is not connected with the piston; the sensor is fixed on the inner wall of the capsule shell, and one surface of the processing chip, which is back to the spiral antenna, is connected to the sensor; the sensor also communicates with an external reader through a helical antenna. The invention is based on the surface acoustic wave sensor technology, increases the reliability of wireless inquiry of the intelligent capsule, combines external environment parameter measurement, is beneficial to stable monitoring of the compliance of the patient medicine, and reduces the medicine cost.
Description
Technical Field
The invention relates to the field of intelligent medical treatment, in particular to an intelligent capsule.
Background
Because many chronic patients (such as schizophrenia) have great defects in behavior normalization and behavior pattern development capability, the feasibility of the pure artificial training is often poor. In order to ensure that patients can take medicines in a quantitative manner on time according to medical orders, some medicine administration supervision products are generated.
The intelligent medicine box is a precursor product in the intelligent medical field. Smart kits also have a significant limitation. For example, intelligent kits can only determine whether a medication is removed from the kit and cannot determine whether a patient has taken the medication. For schizophrenic patients, their non-compliance with drugs results to some extent from the contradiction of drugs by their side effects or from the fear of the addition of hazards from relatives and medical staff. When they are required to take the medicine, they may have the medicine hidden in the body and not taken. For this situation, it is difficult for the intelligent kit to determine whether the patient is taking the medicine, thereby delaying the treatment process and exacerbating the patient's condition.
In this context, the emerging concept of "smart tablets" emerges. Smart tablets can monitor where the drug is located by the differences that the tablet exhibits under different circumstances. Smart tablets produced by the us protein company, which is currently the mainstream, trigger the built-in chip with gastric acid, so as to transmit signals. The appearance of the intelligent tablet greatly improves the defects of high misjudgment rate and poor supervision of the intelligent medicine box, provides convenience for doctors to supervise the medicine taking condition of patients in real time, and realizes 'accurate medical treatment'.
However, by analyzing the solutions currently available, almost all smart tablets require a built-in power supply for power and are costly. Because the market of the intelligent tablet is positioned for patients afflicted with chronic diseases to take every day, the cost rise caused by the complex structure is likely to be unfavorable for the popularization of the intelligent tablet among the patients, and the principle of general medical treatment is violated. In addition, intervention of a power supply can bring a certain influence to the reliability and the service life of the intelligent tablet, and is not beneficial to stable monitoring of the compliance of the patient.
Disclosure of Invention
The invention aims to provide an intelligent capsule, which is based on the surface acoustic wave sensor technology, does not need power supply, has an antenna structure which is released only in gastric acid environment, and increases the reliability of wireless inquiry of the intelligent capsule. And the external environment parameter measurement is combined, so that the stable monitoring of the drug compliance of a patient is facilitated, and the drug cost is reduced.
The technical scheme of the invention is as follows:
a smart capsule, wherein: the intelligent capsule includes:
the capsule shell, capsule shell one side sets up an acid-soluble lid, include in the capsule shell:
the medicine storage bin is characterized in that one side of the medicine storage bin is provided with the acid-soluble cover, the other side of the medicine storage bin is provided with a piston, and the medicine storage bin, the acid-soluble cover and the piston form a closed space together and are used for storing powdery or liquid medicines in the closed space;
one side of the piston, which is away from the medicine storage bin, is connected with a spiral antenna, and the spiral antenna has a preset target working frequency;
the processing chip is connected with one side of the spiral antenna, which is not connected with the piston;
the sensor is fixed on the inner wall of the capsule shell, and one surface of the processing chip, which faces away from the spiral antenna, is connected to the sensor; the sensor is also communicated with an external reader through the spiral antenna, and the reader is used for receiving sensor information output by the sensor;
when the medicine storage bin is filled with the medicine, the spiral antenna is compressed, the current working frequency of the spiral antenna deviates from the target working frequency, and the reader cannot receive the sensor information output by the sensor;
when all the openings formed after the medicine in the medicine storage bin is dissolved through the acid-soluble cover are released, the spiral antenna recovers the original length, the current working frequency of the spiral antenna is equal to the target working frequency, and the reader receives the sensor information output by the sensor.
Preferably, the above intelligent capsule, wherein: the spiral antenna is attached to the inner wall of the capsule shell.
Preferably, the above intelligent capsule, wherein: the sensor is a surface acoustic wave sensor.
Preferably, the above intelligent capsule, wherein: the acid-soluble cover is a cylinder, the diameter of the acid-soluble cover is smaller than that of the capsule shell, and the acid-soluble cover is arranged on the surface of the capsule shell and closes the opening arranged on the surface of the capsule shell.
Preferably, the above intelligent capsule, wherein: the acid-soluble cover is made of acid-soluble materials.
Preferably, the intelligent capsule is characterized in that a temperature sensor is further arranged on the processing chip and used for detecting the real-time temperature inside the intelligent capsule;
the real-time temperature is included in the sensor information.
Preferably, the intelligent capsule is characterized in that the sensor information comprises the serial number information of the intelligent capsule.
Preferably, the smart capsules are characterized in that each of said smart capsules has said numbering information uniquely identified.
The invention has the beneficial effects that:
the intelligent capsule is based on the surface acoustic wave sensor technology, does not need power supply, has an antenna structure which is released in the gastric acid environment, increases the reliability of wireless inquiry of the intelligent capsule, combines external environment parameter measurement, is favorable for stable monitoring of the compliance of the patient, and reduces the cost of the medicine.
Drawings
FIG. 1 is a schematic diagram of the structure of a smart capsule of the present invention;
FIG. 2 is a schematic diagram of a capsule housing structure of an intelligent capsule according to the present invention;
FIG. 3 is a diagram of the piston structure of an intelligent capsule of the present invention;
fig. 4 is a schematic diagram of a wireless wave sensor workflow of a smart capsule according to the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
The invention is further described below with reference to the drawings and specific examples, which are not intended to be limiting.
As shown in fig. 1, the present invention provides a smart capsule comprising:
the capsule shell 1 is of a cylindrical structure, the length is not more than 35mm, the diameter is not more than 15mm, and the smoothness and good surface process of the capsule shell are ensured when the shell structure is designed. When the auxiliary drug release products enter the digestive system of a human body, the auxiliary drug release products are usually discharged after 1-2 days, and the auxiliary drug release products basically do not harm to the digestive system of the human body. However, if the capsule housing 1 is not smooth enough, it will affect the patient's swallowing comfort and gastrointestinal motility. Therefore, the material of the capsule shell 1 should be chosen to ensure the desired biocompatibility. The acrylonitrile-butadiene-styrene copolymer (ABS) has stable mechanical and chemical properties at the temperature of-25-60 ℃, and the processed product has smooth surface and can slide flexibly relative to the inner wall of the capsule. In addition, the ABS material has excellent surface hardness and impact strength so as to ensure that the piston 4 does not deform seriously in the process of pushing the piston 4 to the bottom of the capsule. Meanwhile, the nontoxic and corrosion-resistant stable chemical property of ABS also makes the ABS an ideal choice for shell materials. The shell is prepared from acrylonitrile-butadiene-styrene copolymer serving as a manufacturing material. The acrylonitrile-butadiene-styrene copolymer is a high molecular material with high strength, high toughness and high thermoplasticity, has the density close to that of water of about 1.04-1.06g/cm < 3 >, and meets the light weight requirement of the capsule shell 1.
An acid soluble cover 3 is provided on the side of the cover capsule housing 1. In order to make patients feel less uncomfortable when swallowing and gastrointestinal peristalsis, the invention selects a streamline cylindrical shell with the length of 26mm, the diameter of 11mm and the thickness of 0.5mm and the upper and lower bottom surfaces with 10mm rounded corners when the shell is selected for modeling; the acid-soluble cover 3 is glued with a bottom surface of the capsule shell 1 and is a cylinder with the diameter of 8mm and the thickness of 0.5 mm. For the acid soluble cover 3, it is intended to use hydroxypropyl methylcellulose (HPMC), a common gastric soluble material, to allow the smart capsule to be rapidly dissolved by gastric acid after entering the stomach of a patient, thereby releasing the drug. The capsule housing 1 is structured as shown in fig. 2.
The capsule housing 1 includes:
the medicine storage bin 2 is used for placing medicines, one side of the medicine storage bin 2 is provided with the acid-soluble cover 3, and the other side of the medicine storage bin 2 is provided with a piston 4. The medicine storage bin 2, the acid soluble cover 3 and the piston 4 together form a closed space, and the closed space is used for storing powdery or liquid medicines. As shown in fig. 3, the piston 4 is of cylindrical structure and has the same diameter as the inner wall of the capsule housing. The piston 4 should also be made of acrylonitrile-butadiene-styrene copolymer. Depending on the size of the capsule housing 1, the piston 4 selects a cylinder with a radius of 5.0mm and a thickness of 1.7mm, and a portion thereof connected to the helical antenna 5 has a radius of 0.5mm and a depth of 1.5 mm. The side of the piston 4 facing away from the medicine storage bin 2 is connected with a spiral antenna 5.
Since the smart capsule is essentially a passive measurement system, the quality factor of the sensor itself, the impedance matching and the gain of the helical antenna 5 all affect the sensing distance of the sensor 6, thereby affecting the operation performance of the capsule. There is a high requirement for the kind and specification of the helical antenna 5. The normal mode spiral antenna not only has excellent radiation capability and considerable gain, but also can be used as an antenna model of the design because the shape of the normal mode spiral antenna is high in fit with the capsule shell 1 and the shape of the normal mode spiral antenna is easy to change through compression or stretching and the like so as to change the receiving effect. Meanwhile, the normal mode spiral antenna 5 has the dual functions of an effector and an indicator, so that an additional indicating unit and a compliance judging mechanism are omitted, and the medicine storage space and the manufacturing cost are saved.
In the invention, considering the comprehensive assembly scheme of the sensor 6, the processing chip 7, the spiral antenna 5 and the piston 4, the length of the spiral part of the antenna to be designed is L=23 mm, the length of the feeder line part is 1.8mm, and the antenna is wound by adopting a memory shape alloy material with the wire diameter d=1.0 mm. In order to ensure the convenience of the assembly of the antenna and the capsule, the spiral outer diameter of the antenna is designed to be D=9.8mm. The number of turns N of the antenna is about 8.3 turns under 433MHz working frequency. I.e. the helical antenna 5 has a preset target operating frequency of 433MHz.
The processing chip 7 is connected to the side of the spiral antenna 5 to which the piston 4 is not connected. The processing chip 7 in the invention can be pasted on a printed circuit board or can be made of a single chip.
The sensor 6 is fixed on the inner wall of the capsule shell 1 and is connected with the processing chip 7, and the sensor 6 is a passive sensor. The surface acoustic wave (Surface Acoustic Wave SAW) sensor has longer service life and ideal anti-interference capability, and can be used as an ideal choice of an intelligent capsule sensor system. The SAW resonator has a stronger energy storage capability than the delay device and a more excellent remote measurement capability, so that the resonance SAW temperature sensor is selected as the sensor in the capsule. The SAW wireless sensor system consists of a reader and an SAW sensor.
The passive surface acoustic wave sensor modules can be classified into a pulse query method based on a time domain and a frequency scanning method based on a frequency domain according to different measurement methods. Although the frequency domain method can obtain a longer measurement distance, the frequency domain method can easily confuse the transmitted and received signals in the same frequency band and influence the dynamic characteristics of echo signals. The time domain method utilizes the reader to emit pulse signals with the resonance frequency similar to that of the resonator to perform frequency searching on the full frequency band, and estimates the resonance frequency of the resonator according to different echo characteristics of different frequency components, so that the frequency searching time of the frequency sweeping method is saved. The design is intended to measure by using a pulse query method based on a time domain.
The SAW-based wireless measurement workflow is shown in fig. 4: the reader firstly transmits continuously excited short pulses to the resonator, the energy of the resonator gradually reaches a steady state, at the moment, the reader finishes pulse transmission, receives free decaying echo signals from the resonator through the duplex antenna, and finally carries out frequency estimation on the echo signals through the query unit to measure the resonant frequency of the resonator.
The sensor also communicates with an external reader through the helical antenna, which is used to receive the sensor 6 information, and a worker can determine whether the medication is being entered into the patient by looking at the reader.
When the medicine is not swallowed, the spiral antenna 5 is in a compressed state, and the medicine is placed in the medicine bin 2 formed inside the capsule. After the intelligent capsule enters the stomach of a human body, the cover made of acid-soluble materials is gradually melted due to corrosion of gastric acid, and after the release of powdery or liquid medicine in the digestive tract is finished, the capsule is recovered to be long due to the fact that the antenna 5 is out of constraint, and the piston 4 is pushed to enable the capsule to be resealed.
The working flow of the intelligent capsule can be simplified into three parts of a medicine storage standby stage, a medicine release stage and an in-vivo induction stage.
In the standby phase of the storage, the operating frequency of the helical antenna 5 will deviate from the target operating frequency (here assumed to be 433MHz for civil communication), and the reader cannot inquire about the information of the sensor 6 inside the capsule, since the helical antenna is compressed at this time.
After the patient takes the smart capsule, the capsule will pass through the esophagus and enter the stomach. Because the end of the capsule close to the medicine bin 2 is provided with an acid-soluble cover 3, the acid-soluble cover is gradually dissolved under the action of gastric acid in the stomach. When the dissolution of the acid soluble cover 3 is completed, the drug will contact the gastric juice and start to release, while the helical antenna 5 will start to resume its shape change due to the weakening of the restriction of the helical antenna 5. When the drug release is completed, the helical antenna 5 will resume its original length and the piston 4 is pushed to the bottom of the capsule.
At this point, the operating frequency of the helical antenna 5 is returned to the normal operating frequency (e.g., 443MHz or other predetermined operating frequency), and the sensor reader can be used to query the sensor information to determine that the capsule has been digested through the stomach. The medical care personnel can judge whether the patient takes medicine in a quantitative way according to the existence of the echo signal by inquiring the sensor in the patient through the reader.
The intelligent capsule can be used for monitoring patients who cannot or are unwilling to ingest medicines, so that the patients can ingest medicines on time, and the treatment effect is ensured.
Taking a psychotic patient as an example, the psychotic patient may have a certain degree of resistance to swallowing the drug, so that the drug is refused to be swallowed, or if the drug is swallowed, the drug is hidden or discarded, so that the effect of treating the psychosis cannot be guaranteed. The intelligent capsule can be used for monitoring the condition of a psychotic patient swallowing medicines. Specifically, after a psychotic takes a medicine, a reader of the present invention that is matched to a smart capsule may be used to attempt to receive sensor information at a location near the abdomen of the psychotic. Because the intelligent capsule can transmit the sensor information outwards only after the contained medicine is completely released and the antenna is restored to the original length, the reader can receive the sensor information only after the patient swallows the medicine and completely absorbs the medicine, and thus the situation that the patient is not required to swallow the medicine can be timely found and timely corrected, and the treatment effect is ensured.
Further, the sensor information may include number Information (ID) of the smart capsule, and the reader may determine whether the smart capsule is swallowed by the patient by receiving the ID number of the smart capsule.
Further, the number information of different intelligent capsules is different, i.e. each intelligent capsule has the number information of unique identification. The reader determines, based on the number of received numbered information, that the patient swallows several drugs at a time, and then compares the number with a predetermined treatment regimen to determine whether the patient has swallowed drugs in strict compliance with the treatment regimen.
Further, the sensor information may further include temperature information of the current inside of the smart capsule. Specifically, a temperature sensor (not shown) is also integrated in the processing chip 7, and is used for detecting the real-time temperature inside the intelligent capsule, and including the current real-time temperature in the sensor information.
The reader can analyze the real-time temperature contained in the sensor information after receiving the sensor information. Since the temperature in the patient is usually stabilized at about 37 ℃ and can be dynamically controlled by measuring the body temperature in advance, which is different from the outdoor temperature, the patient can be judged whether the drug has been swallowed by receiving the real-time temperature by the reader and judging whether the temperature corresponds to the body temperature of the patient.
The foregoing description is only illustrative of the preferred embodiments of the present invention and is not to be construed as limiting the scope of the invention, and it will be appreciated by those skilled in the art that equivalent substitutions and obvious variations may be made using the description and illustrations of the present invention, and are intended to be included within the scope of the present invention.
Claims (8)
1. An intelligent capsule, characterized in that: the intelligent capsule includes:
the capsule shell, capsule shell one side sets up an acid-soluble lid, include in the capsule shell:
the medicine storage bin is characterized in that one side of the medicine storage bin is provided with the acid-soluble cover, the other side of the medicine storage bin is provided with a piston, and the medicine storage bin, the acid-soluble cover and the piston form a closed space together and are used for storing powdery or liquid medicines in the closed space;
one side of the piston, which is away from the medicine storage bin, is connected with a spiral antenna, and the spiral antenna has a preset target working frequency;
the processing chip is connected with one side of the spiral antenna, which is not connected with the piston;
the sensor is fixed on the inner wall of the capsule shell, and one surface of the processing chip, which faces away from the spiral antenna, is connected to the sensor; the sensor is also communicated with an external reader through the spiral antenna, and the reader is used for receiving sensor information output by the sensor;
when the medicine storage bin is filled with the medicine, the spiral antenna is compressed, the current working frequency of the spiral antenna deviates from the target working frequency, and the reader cannot receive the sensor information output by the sensor;
when all the openings formed after the medicine in the medicine storage bin is dissolved through the acid-soluble cover are released, the spiral antenna recovers the original length, the current working frequency of the spiral antenna is equal to the target working frequency, and the reader receives the sensor information output by the sensor.
2. The smart capsule of claim 1, wherein: the spiral antenna is attached to the inner wall of the capsule shell.
3. The smart capsule of claim 1, wherein: the sensor is a surface acoustic wave sensor.
4. The smart capsule of claim 1, wherein: the acid-soluble cover is a cylinder, the diameter of the acid-soluble cover is smaller than that of the capsule shell, and the acid-soluble cover is arranged on the surface of the capsule shell and closes the opening arranged on the surface of the capsule shell.
5. The smart capsule of claim 4, wherein: the acid-soluble cover is made of acid-soluble materials.
6. The intelligent capsule of claim 1, wherein a temperature sensor is further provided on the processing chip for detecting a real-time temperature inside the intelligent capsule;
the real-time temperature is included in the sensor information.
7. The smart capsule of claim 1, wherein the sensor information includes numbering information of the smart capsule.
8. The smart capsule of claim 7, wherein each of the smart capsules has the number information uniquely identified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810316600.7A CN108338789B (en) | 2018-04-10 | 2018-04-10 | Intelligent capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810316600.7A CN108338789B (en) | 2018-04-10 | 2018-04-10 | Intelligent capsule |
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| Publication Number | Publication Date |
|---|---|
| CN108338789A CN108338789A (en) | 2018-07-31 |
| CN108338789B true CN108338789B (en) | 2023-12-19 |
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| CN201810316600.7A Active CN108338789B (en) | 2018-04-10 | 2018-04-10 | Intelligent capsule |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11786142B2 (en) * | 2019-01-11 | 2023-10-17 | Tokitae Llc | Ingestible RFID tag and reader system |
| CN113690574B (en) * | 2021-08-16 | 2024-07-02 | 维沃移动通信有限公司 | Antenna assembly, electronic device, and control method of antenna assembly |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9047746B1 (en) * | 2005-07-20 | 2015-06-02 | Neil Euliano | Electronic medication compliance monitoring system and associated methods |
| CN105050566A (en) * | 2012-10-09 | 2015-11-11 | 医学量度个性化药物输送公司 | Drug delivery capsules with external intelligence |
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| US9445711B2 (en) * | 2012-05-09 | 2016-09-20 | Carnegie Mellon University | System and method to magnetically actuate a capsule endoscopic robot for diagnosis and treatment |
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| US9047746B1 (en) * | 2005-07-20 | 2015-06-02 | Neil Euliano | Electronic medication compliance monitoring system and associated methods |
| CN105050566A (en) * | 2012-10-09 | 2015-11-11 | 医学量度个性化药物输送公司 | Drug delivery capsules with external intelligence |
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