CN102293625B - Intelligent detection system for gastrointestinal hemorrhage - Google Patents
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Abstract
本发明公开了一种医疗器械技术领域的胃肠道出血智能检测系统,包括微型胃肠道血液颜色检测装置、出血点定位装置、体外数据存储装置、胃肠道出血诊断分析系统。微型胃肠道血液颜色检测装置经口服进入胃肠道,无创检测和无线发射胃肠道出血量信息。出血点定位装置检测微型胃肠道血液颜色检测装置在体内的位置信息,并通过导线传输到体外数据存储装置;所述体外数据存储装置接收和存储微型胃肠道血液颜色检测装置发射的胃肠道出血量信息和出血点定位装置传输的位置信息;胃肠道出血诊断分析系统用于读取并处理体外数据存储装置中存储的数据。本发明检测时无痛、无创、无须清肠,人体胃肠道pH、压力等生理参数对检测结果无影响。
The invention discloses an intelligent detection system for gastrointestinal bleeding in the technical field of medical equipment, comprising a miniature gastrointestinal blood color detection device, a bleeding point positioning device, an in vitro data storage device, and a gastrointestinal bleeding diagnosis and analysis system. The miniature gastrointestinal tract blood color detection device enters the gastrointestinal tract through oral administration, non-invasively detects and wirelessly transmits the bleeding volume information of the gastrointestinal tract. The bleeding point positioning device detects the position information of the miniature gastrointestinal tract blood color detection device in the body, and transmits it to the in vitro data storage device through a wire; the in vitro data storage device receives and stores the gastrointestinal tract blood color detection device emitted Tract bleeding volume information and location information transmitted by the bleeding point positioning device; the gastrointestinal bleeding diagnosis and analysis system is used to read and process the data stored in the external data storage device. The detection of the present invention is painless, non-invasive, and does not require bowel cleansing, and physiological parameters such as pH and pressure of the human gastrointestinal tract have no influence on the detection results.
Description
技术领域: Technical field:
本发明涉及一种肠道出血智能检测系统,用于胃肠道出血无创检测。The invention relates to an intelligent detection system for intestinal bleeding, which is used for non-invasive detection of gastrointestinal bleeding.
背景技术: Background technique:
肠道出血是临床常见的消化道疾病,严重的肠道出血可导致急性贫血及出血性休克,甚至危及患者生命。在对肠道出血进行治疗之前,对出血部位进行准确的定位是关键,只有准确定位出血部位,才能进行有效地后续治疗。人体肠道生理结构复杂,尤其是小肠段,长度大,弯曲多,致使患者在诊断过程中常因得不到及时准确的治疗而导致严重后果。因此研制能有效检测肠道出血并准确定位出血点的检测装置,对于提高医疗水平,保护患者生命具有很重要的意义。Intestinal bleeding is a common gastrointestinal disease in clinical practice. Severe intestinal bleeding can lead to acute anemia and hemorrhagic shock, and even endanger the lives of patients. Before treating intestinal bleeding, accurate positioning of the bleeding site is the key. Only by accurately locating the bleeding site can effective follow-up treatment be carried out. The physiological structure of the human intestinal tract is complex, especially the small intestine, which is long and has many bends. As a result, patients often fail to receive timely and accurate treatment during the diagnosis process, resulting in serious consequences. Therefore, the development of a detection device that can effectively detect intestinal bleeding and accurately locate the bleeding point is of great significance for improving the medical level and protecting the lives of patients.
目前临床所用的肠道出血检测及定位的方式主要有:肠镜检查、核素扫描、血管造影、胶囊内镜等。肠镜检查是消化道出血灶检查中应用最广泛的手段,肠镜一般可深入空肠近端和回肠末端的50至80cm处,从而对介入肠段部分的出血灶进行定位探查。但是,肠镜检查是一种高侵入性检查方式,其操作难度高,且检查过程中肠镜的介入很容易使病人受到创伤,同时承受因检查带来的痛苦。肠镜检查还增加了因检查而产生的并发症,提高了死亡率。核素扫描常用于小肠出血的检查。该方法的不足之处在于其不能用于定性诊断,同时也难以用于出血点的准确定位。血管造影多用于活动性出血且出血量大的病人,对出血缓慢且出血量少的情况检查效果不好。Currently, the clinical methods for detecting and locating intestinal bleeding mainly include colonoscopy, radionuclide scanning, angiography, and capsule endoscopy. Colonoscopy is the most widely used method in the examination of gastrointestinal bleeding. Generally, colonoscopy can go deep into the proximal jejunum and the terminal ileum 50 to 80 cm, so as to locate and explore the bleeding focus of the intervening intestinal segment. However, colonoscopy is a highly invasive examination method, and its operation is difficult, and the intervention of colonoscopy during the examination is easy to traumatize the patient and bear the pain caused by the examination. Colonoscopy also increases the complications caused by the examination and increases the mortality rate. Nuclide scans are often used to detect small bowel bleeding. The disadvantage of this method is that it cannot be used for qualitative diagnosis, and it is also difficult to be used for accurate location of bleeding points. Angiography is mostly used for patients with active bleeding and a large amount of bleeding, but it is not effective for patients with slow bleeding and a small amount of bleeding.
胶囊内镜是一种新兴的小肠出血检查手段。自从以色列Given Imaging Ltd推出消化道可视化胶囊内镜Pillcam以来,胶囊内镜就因其完全无创而得到人们关注。在Pillcam之后,日本的RF System Lab和OLYMPUS分别推出Norika系列和Endocapsule系列胶囊内窥镜产品。中国金山公司的OMOM胶囊内镜也在临床上得到大量应用。韩国、德国、意大利和比利时学者也分别提出了关于胶囊内窥镜的技术设想。胶囊内镜用于消化道出血检查也存在不足,它对消化道褶襞和弯曲处的检查效果不好。此外,胶囊内镜检查是将图像传输至体外,需要医生阅读大量的图像并根据经验判断肠道出血状况,导致医生的工作量非常大。即使发现了肠道有出血征状,医生仅仅根据图像无法得到出血区域的具体位置,进行针对性的治疗。Capsule endoscopy is an emerging method for the detection of small intestinal bleeding. Since Israel's Given Imaging Ltd launched the digestive tract visualization capsule endoscope Pillcam, capsule endoscopy has attracted people's attention because it is completely non-invasive. After Pillcam, Japan's RF System Lab and OLYMPUS launched the Norika series and Endocapsule series of capsule endoscope products respectively. The OMOM capsule endoscope of China Jinshan Company has also been widely used in clinical practice. Scholars from South Korea, Germany, Italy and Belgium have also proposed technical assumptions about capsule endoscopy. Capsule endoscopy is also insufficient for the examination of gastrointestinal bleeding, and its effect on the inspection of gastrointestinal folds and bends is not good. In addition, capsule endoscopy is to transmit images outside the body, requiring doctors to read a large number of images and judge intestinal bleeding based on experience, resulting in a very heavy workload for doctors. Even if symptoms of intestinal bleeding are found, doctors cannot get the specific location of the bleeding area based on the image alone, so they can carry out targeted treatment.
在中国专利CN200710045625.X中公开了一种利用血红蛋白传感器检测胃肠道出血的装置。该装置包括一个内置血红蛋白传感器的微型血红蛋白检测装置、出血点定位装置、记录存储装置、胃肠诊断分析系统。该血红蛋白检测装置从口腔进入胃肠道,借助胃肠道生理蠕动在胃肠道中运动,血红蛋白传感器可检测胃肠道中血红蛋白浓度并将数据发送至体外。出血点定位装置通过检测微型血红蛋白检测装置中的永磁铁在出血点定位装置中产生的磁场大小来推算微型血红蛋白检测装置在体内的位置,实验检测数据与肠段的对应关系。记录存储装置用于无线接收和存储微型血红蛋白检测装置发射的检测数据。胃肠诊断分析系统用于读取和处理记录存储装置内的数据,获得胃肠道出血状况。In Chinese patent CN200710045625.X, a device for detecting gastrointestinal bleeding using a hemoglobin sensor is disclosed. The device includes a micro-hemoglobin detection device with a built-in hemoglobin sensor, a bleeding point location device, a record storage device, and a gastrointestinal diagnosis and analysis system. The hemoglobin detection device enters the gastrointestinal tract from the oral cavity, and moves in the gastrointestinal tract by means of the physiological peristalsis of the gastrointestinal tract. The hemoglobin sensor can detect the concentration of hemoglobin in the gastrointestinal tract and send the data to the outside of the body. The bleeding point positioning device calculates the position of the micro-hemoglobin detection device in the body by detecting the magnetic field generated by the permanent magnet in the micro-hemoglobin detection device in the bleeding point positioning device, and the corresponding relationship between the experimental detection data and the intestinal segment. The record storage device is used for wirelessly receiving and storing the detection data emitted by the micro-hemoglobin detection device. The gastrointestinal diagnosis and analysis system is used to read and process the data in the record storage device to obtain the gastrointestinal bleeding status.
上述发明存在以下缺点:该发明所述的微型血红蛋白检测装置中所用的血红蛋白传感器中需要将传感器电极与胃肠道内容物接触,胃肠道内容物会污染传感器电极,使传感器检测结果不稳定。The above invention has the following disadvantages: the hemoglobin sensor used in the miniature hemoglobin detection device described in this invention needs to contact the sensor electrodes with the contents of the gastrointestinal tract, and the contents of the gastrointestinal tract will contaminate the sensor electrodes, making the sensor detection results unstable.
发明内容: Invention content:
本发明的目的是克服现有技术的不足,提供一种胃肠道出血检测装置,以检测血液颜色特征来判断肠道出血征状,包括出血量大小、出血位置,从而对肠道出血疾病进行定量诊断与治疗。The purpose of the present invention is to overcome the deficiencies of the prior art, to provide a gastrointestinal bleeding detection device, to detect the blood color characteristics to judge the symptoms of intestinal bleeding, including bleeding volume, bleeding location, so as to diagnose intestinal bleeding diseases Quantitative diagnosis and treatment.
本发明的技术方案是:胃肠道出血智能检测系统,包括微型胃肠道血液颜色检测装置、出血点定位装置、体外数据存储装置、胃肠道出血诊断分析系统。所述微型胃肠道血液颜色检测装置通过口服进入胃肠道,随着胃肠道的生理蠕动而通过整个胃肠道,无创检测胃肠道出血征状,包括出血量大小信息,检测信息通过无线方式发送至体外。出血点定位装置在体表通过检测微型胃肠道血液颜色检测装置中的永磁体在出血点处所产生的磁场特征来计算微型胃肠道血液检测装置在体内的位置,从而得到出血点的位置,并通过导线传输到体外数据存储装置,体外数据存储装置配置于体表,用于无线接收并存储微型胃肠道血液颜色检测装置发射的数据,同时用于启动出血点定位装置进行出血点定位检测、有线接收并存储出血点定位装置所检测到的永磁体在出血点处所产生的磁场特征数据,肠道出血诊断分析系统在体外,用于读取和处理体外数据存储装置中的数据,得到肠道内出血点的状况,包括出血量大小和出血点位置。The technical scheme of the present invention is: an intelligent detection system for gastrointestinal bleeding, including a miniature gastrointestinal blood color detection device, a bleeding point positioning device, an in vitro data storage device, and a gastrointestinal bleeding diagnosis and analysis system. The miniature gastrointestinal tract blood color detection device enters the gastrointestinal tract through oral administration, passes through the entire gastrointestinal tract along with the physiological peristalsis of the gastrointestinal tract, and non-invasively detects symptoms of gastrointestinal bleeding, including information on the amount of bleeding, and the detection information is passed through It is sent wirelessly to the outside of the body. The bleeding point positioning device calculates the position of the miniature gastrointestinal blood detection device in the body by detecting the magnetic field characteristics generated by the permanent magnet in the micro-gastrointestinal blood color detection device at the bleeding point on the body surface, thereby obtaining the position of the bleeding point, And transmit to the in vitro data storage device through wires, the in vitro data storage device is configured on the body surface, used to wirelessly receive and store the data emitted by the micro-gastrointestinal blood color detection device, and at the same time used to start the bleeding point location device to perform bleeding point location detection , receive and store the characteristic data of the magnetic field generated by the permanent magnet at the bleeding point detected by the bleeding point positioning device by cable, and the intestinal bleeding diagnosis and analysis system is in vitro, used to read and process the data in the external data storage device to obtain intestinal The condition of the bleeding point in the tract, including the amount of bleeding and the location of the bleeding point.
所述的微型胃肠道血液颜色检测装置包括微型胃肠道血液颜色检测传感器外壳、透明涂片盖板、胃肠液涂片台、引流孔、颜色检测模块、微型胃肠道血液颜色检测传感器外壳开口端、微型胃肠道血液颜色检测装置外壳、微型电池、磁控开关、微处理芯片、信号无线发射功能模块、发射天线、永磁体。其中微型胃肠道血液颜色检测传感器外壳、透明涂片盖板、胃肠液涂片台、引流孔、颜色检测模块、微型胃肠道血液颜色检测传感器外壳开口端共同组成微型胃肠道血液颜色检测传感器。透明涂片盖板是一个厚度为0.2mm至1.0mm之间的透明的圆形透明薄片,粘接在微型胃肠道血液颜色检测传感器外壳内壁。胃肠液涂片台是一个白色的不透明反光圆台,反光圆台和透明涂片盖板之间的间距为2.0mm至5.0mm之间。透明涂片盖板和胃肠液涂片台所用材料均对人体无毒无害。胃肠液涂片台和透明涂片盖板之间可以形成肠液涂片区。引流孔的作用是让肠液进出涂片区,引流孔的大小和数量主要取决于肠液的粘性和保证微型胃肠道血液颜色检测传感器外壳结构牢固性的需要。在透明涂片盖板的另外一侧是颜色检测模块。颜色检测模块可提供白色光源,白色光透过透明涂片盖板照射在肠液涂片区内肠液上,其反射的彩色光被颜色检测模块检测。颜色检测模块检测到彩色光后,将该彩色光的颜色信息转变为频率电压信号输出。微型电池、磁控开关、微处理芯片、信号无线发射功能模块、发射天线和永磁体封装于微型胃肠道血液颜色检测装置外壳之内,微型胃肠道血液颜色检测装置外壳一端封闭另一端开口,该开口端与血液颜色检测传感器封装外壳开口端无缝粘合。所述的胃肠道血液颜色检测传感器以设定的时间间隔检测肠道内血液颜色特征,并输出具有血液颜色特征的频率电压信号,微处理芯片的输入端接收血液检测传感器所输出的频率电压信号,微处理芯片根据所输入的频率电压信号计算出血量大小并将出血量大小信息输出到无线发射功能模块的输入端,信号无线发射功能模块的输出端连接到天线,信号无线发射模块控制天线将出血量大小信息无线发送到体外,微型电池通过磁控开关对胃肠道血液颜色检测传感器、微处理芯片、信号无线发射功能模块进行供电。The miniature gastrointestinal tract blood color detection device comprises a miniature gastrointestinal tract blood color detection sensor housing, a transparent smear cover, a gastrointestinal fluid smear table, drainage holes, a color detection module, and a miniature gastrointestinal blood color detection sensor The open end of the casing, the casing of the miniature gastrointestinal tract blood color detection device, a microbattery, a magnetic control switch, a microprocessing chip, a wireless signal transmitting function module, a transmitting antenna, and a permanent magnet. Among them, the housing of the miniature gastrointestinal blood color detection sensor, the transparent smear cover, the gastrointestinal fluid smear table, the drainage hole, the color detection module, and the opening end of the miniature gastrointestinal blood color detection sensor housing together form the miniature gastrointestinal blood color Detect sensor. The transparent smear cover plate is a transparent circular transparent sheet with a thickness between 0.2mm and 1.0mm, which is bonded to the inner wall of the housing of the miniature gastrointestinal blood color detection sensor. The gastrointestinal juice smear table is a white opaque reflective round table, and the distance between the reflective round table and the transparent smear cover is between 2.0mm and 5.0mm. The materials used in the transparent smear cover plate and the gastrointestinal fluid smear table are non-toxic and harmless to the human body. An intestinal juice smear area can be formed between the gastrointestinal juice smear table and the transparent smear cover. The function of the drainage hole is to allow intestinal fluid to enter and exit the smear area. The size and quantity of the drainage hole mainly depend on the viscosity of the intestinal fluid and the need to ensure the firmness of the shell structure of the micro-gastrointestinal blood color detection sensor. On the other side of the clear smear cover is the color detection module. The color detection module can provide a white light source, and the white light shines through the transparent smear cover plate on the intestinal fluid in the intestinal fluid smear area, and the reflected colored light is detected by the color detection module. After the color detection module detects the colored light, it converts the color information of the colored light into a frequency voltage signal and outputs it. Micro-battery, magnetic control switch, micro-processing chip, signal wireless transmitting function module, transmitting antenna and permanent magnet are packaged in the shell of the miniature gastrointestinal blood color detection device, and one end of the shell of the micro-gastrointestinal blood color detection device is closed and the other end is open , the open end is seamlessly bonded to the open end of the blood color detection sensor packaging shell. The blood color detection sensor in the gastrointestinal tract detects the color characteristics of the blood in the intestinal tract at a set time interval, and outputs a frequency voltage signal with blood color characteristics, and the input terminal of the microprocessing chip receives the frequency voltage signal output by the blood detection sensor , the microprocessing chip calculates the amount of bleeding according to the input frequency and voltage signal and outputs the information of the amount of bleeding to the input terminal of the wireless transmitting function module, the output terminal of the signal wireless transmitting function module is connected to the antenna, and the signal wireless transmitting module controls the antenna to The bleeding volume information is sent to the body wirelessly, and the micro-battery supplies power to the gastrointestinal blood color detection sensor, micro-processing chip, and signal wireless transmission function module through the magnetic control switch.
所述微型胃肠道血液颜色检测装置为胶囊状体,微型胃肠道血液颜色检测装置外壳、血液颜色检测传感器的封装外壳、透明涂片盖板及胃肠液涂片台由对人体无毒害材料制成。微型胃肠道血液颜色检测装置工作时,微型胃肠道血液颜色检测装置外壳及血液颜色检测传感器封装外壳与胃肠道直接接触。The miniature gastrointestinal tract blood color detection device is in the form of a capsule, the casing of the miniature gastrointestinal tract blood color detection device, the encapsulation casing of the blood color detection sensor, the transparent smear cover plate and the gastrointestinal fluid smear station are non-toxic to the human body. material. When the miniature gastrointestinal tract blood color detection device is working, the shell of the miniature gastrointestinal tract blood color detection device and the packaging shell of the blood color detection sensor are in direct contact with the gastrointestinal tract.
所述的出血点定位装置包括腹部磁传感器阵列、背部磁传感器阵列、数据线、腹部磁传感器阵列固定装置、背部磁传感器阵列固定装置。腹部磁传感器阵列和背部磁传感器阵列分别通过腹部磁传感器阵列固定装置和背部磁传感器阵列固定装置固定于腹部和背部体表,用于检测微型胃肠道血液颜色检测装置中的永磁体在出血点处产生的磁场大小和方向,以实现对微型胃肠道血液颜色检测装置位置的检测。出血点定位装置与体外数据存储装置通过数据线连接。当体外数据存储装置接收到微型胃肠道血液颜色检测装置无线发射出的信号时,启动出血点位置检测程序对微型胃肠道血液颜色检测装置中的永磁体在出血点处产生的磁场大小和方向进行一次检测,并将检测结果存储于体外数据存储装置中。The bleeding point location device includes an abdominal magnetic sensor array, a back magnetic sensor array, a data line, an abdominal magnetic sensor array fixing device, and a back magnetic sensor array fixing device. The abdominal magnetic sensor array and the back magnetic sensor array are respectively fixed on the abdomen and the back body surface through the abdominal magnetic sensor array fixing device and the back magnetic sensor array fixing device, which are used to detect the bleeding point of the permanent magnet in the miniature gastrointestinal blood color detection device The magnitude and direction of the magnetic field generated at the place to realize the detection of the position of the miniature gastrointestinal blood color detection device. The bleeding point locating device is connected with the external data storage device through a data line. When the in vitro data storage device receives the wirelessly transmitted signal from the miniature gastrointestinal blood color detection device, start the bleeding point position detection program to check the magnetic field size and The direction is tested once, and the test result is stored in the in vitro data storage device.
所述的体外数据存储装置包括电池、电源开关、接收天线、信号无线接收功能模块、微处理模块、数据存储模块、数据接口、体外数据存储装置外壳。上述所有部件均安装在体外数据存储装置外壳内。体外数据存储装置外形不限,重量轻以便于使用者携带。体外接收报警器外壳材料由对人体无毒害材料制成。接收天线与信号无线接收功能模块连接,信号无线接收功能模块与微处理模块连接,实现对微型胃肠道血液颜色检测装置所检测到的出血量大小信息接收。体外数据存储装置的微处理模块通过数据线与出血点定位装置连接,以实现启动出血点位置检测程序并通过有线方式接收检测结果。体外数据存储装置的微处理模块与数据存储模块连接,微处理模块接收到信号无线接收功能模块所输入的出血量大小信息数据与出血点定位装置有线输入的永磁铁在出血点处产生的磁场大小和方向数据,并对这几组数据进行预处理后传输到数据存储模块存储。数据存储模块与数据接口连接,以实现所存储的数据向肠道出血诊断分析系统传输。电池与电源开关相连,并通过电源开关对信号无线接收功能模块、微处理模块、数据存储模块供电。The external data storage device includes a battery, a power switch, a receiving antenna, a wireless signal receiving function module, a micro-processing module, a data storage module, a data interface, and a shell of the external data storage device. All the above-mentioned components are installed in the outer casing of the data storage device outside the body. The shape of the external data storage device is not limited, and the weight is light so that users can carry it easily. The shell material of the external receiving alarm is made of non-toxic materials to the human body. The receiving antenna is connected with the signal wireless receiving function module, and the signal wireless receiving function module is connected with the micro-processing module, so as to realize the reception of the bleeding amount detected by the miniature gastrointestinal blood color detection device. The microprocessing module of the in vitro data storage device is connected with the bleeding point positioning device through a data line, so as to start the bleeding point position detection program and receive the detection result through a wired method. The micro-processing module of the in vitro data storage device is connected with the data storage module, and the micro-processing module receives the information data of the amount of bleeding input by the wireless receiving function module and the magnetic field generated by the permanent magnet wired into the bleeding point positioning device at the bleeding point. and direction data, and these sets of data are preprocessed and then transmitted to the data storage module for storage. The data storage module is connected with the data interface to realize the transmission of the stored data to the intestinal bleeding diagnosis and analysis system. The battery is connected with the power switch, and supplies power to the signal wireless receiving function module, the micro-processing module and the data storage module through the power switch.
所述的肠道出血诊断分析系统可通过数据接口下载体外数据存储装置所存储的数据,对体外数据存储装置所存储的数据进行处理,以定量获取肠道出血点位置及出血量大小。The intestinal bleeding diagnosis and analysis system can download the data stored in the in vitro data storage device through the data interface, and process the data stored in the in vitro data storage device to quantitatively obtain the position of the intestinal bleeding point and the amount of bleeding.
本微型胃肠道血液颜色检测装置不刺激胃肠道,进入胃肠道后随胃肠道的正常生理蠕动而前进。The miniature gastrointestinal tract blood color detection device does not stimulate the gastrointestinal tract, and advances with the normal physiological peristalsis of the gastrointestinal tract after entering the gastrointestinal tract.
本发明与现有技术相比,具有以下技术效果:Compared with the prior art, the present invention has the following technical effects:
1、操作简单,检测结果直观。1. Simple operation and intuitive detection results.
2、无须清肠,无创伤,无痛苦。2. No bowel cleansing, no trauma, no pain.
3、胃肠道内pH、压力等生理环境不稳定的情况对所检测的血液颜色特征完全没有影响,检测结果更稳定。3. The unstable physiological environment such as pH and pressure in the gastrointestinal tract has no effect on the detected blood color characteristics, and the detection results are more stable.
附图说明:Description of drawings:
图1是本发明的系统组成图。Fig. 1 is a system composition diagram of the present invention.
图2是本发明的微型胃肠道血液颜色检测装置Fig. 2 is the miniature gastrointestinal tract blood color detection device of the present invention
图3是本发明的微型胃肠道血液颜色检测传感器Fig. 3 is the miniature gastrointestinal tract blood color detection sensor of the present invention
图4是本发明的体外数据存储装置Fig. 4 is the in vitro data storage device of the present invention
图5是本发明的出血点定位装置Fig. 5 is the bleeding spot localization device of the present invention
在图1至图5中:In Figures 1 to 5:
1-微型胃肠道血液颜色检测传感器外壳,2-透明涂片盖板,3-胃肠液涂片台,4-引流孔,5-颜色检测模块,6-微型胃肠道血液颜色检测传感器外壳开口端,7-微型胃肠道血液颜色检测装置外壳开口端,8-微处理芯片,9-永磁体,10-微型胃肠道血液颜色检测装置外壳,11-磁控开关,12-微型电池,13-信号无线发射功能模块,14-发射天线,15-数据接口,16-电池,17-电源开关,18-接收天线,19-数据存储模块,20-微处理模块,21-信号无线接收功能模块,22-体外数据存储装置外壳,23-腹部磁传感器阵列,24-背部磁传感器阵列,25-数据线,26-腹部磁传感器阵列固定装置,27-背部磁传感器阵列固定装置。1-miniature gastrointestinal blood color detection sensor housing, 2-transparent smear cover, 3-gastrointestinal fluid smear table, 4-drainage hole, 5-color detection module, 6-miniature gastrointestinal blood color detection sensor The opening end of the housing, 7-the opening end of the housing of the miniature gastrointestinal blood color detection device, 8-the microprocessing chip, 9-the permanent magnet, 10-the housing of the miniature gastrointestinal blood color detection device, 11-magnetic control switch, 12-miniature Battery, 13-signal wireless transmitting function module, 14-transmitting antenna, 15-data interface, 16-battery, 17-power switch, 18-receiving antenna, 19-data storage module, 20-microprocessing module, 21-signal wireless Receiving function module, 22-external data storage device shell, 23-abdominal magnetic sensor array, 24-back magnetic sensor array, 25-data line, 26-abdominal magnetic sensor array fixing device, 27-back magnetic sensor array fixing device.
具体实施方式: Detailed ways:
下面结合附图对本发明的实施例作详细说明:本实施例在本发明技术方案为前提下进行实施,给出了详细的实施方式和具体的操作过程,但本发明的保护范围不限于下述的实施例。Below in conjunction with accompanying drawing, the embodiment of the present invention is described in detail: present embodiment implements under the premise of the technical scheme of the present invention, has provided detailed implementation mode and concrete operation process, but protection scope of the present invention is not limited to the following the embodiment.
如图1所示,本实施例由微型胃肠道血液颜色检测装置、体外数据存储装置、出血点定位装置、胃肠道出血诊断分析系统组成。微型胃肠道血液颜色检测装置通过口服进入胃肠道,实时、定量检测胃肠道出血状况,通过无线方式将检测数据发射至体外;出血点定位装置固定在体表,以探测微型胃肠道血液颜色检测装置在胃肠道中的位置;体外数据存储装置佩戴在体外,以接收存储微型胃肠道血液颜色检测装置发射的数据和出血点定位装置对微型胃肠道血液颜色检测装置的位置跟踪信息,也可以实时处理该信息;微型胃肠道血液颜色检测装置排出体外后,胃肠道出血诊断分析系统读取体外数据存储装置内的数据,定量获得胃肠道出血状况,包括出血量大小、出血点位置。As shown in Figure 1, this embodiment consists of a miniature gastrointestinal tract blood color detection device, an in vitro data storage device, a bleeding point location device, and a gastrointestinal bleeding diagnosis and analysis system. The miniature gastrointestinal blood color detection device enters the gastrointestinal tract through oral administration, real-time and quantitative detection of gastrointestinal bleeding, and transmits the detection data to the body through wireless means; the bleeding point positioning device is fixed on the body surface to detect the miniature gastrointestinal tract The position of the blood color detection device in the gastrointestinal tract; the in vitro data storage device is worn outside the body to receive and store the data emitted by the miniature gastrointestinal tract blood color detection device and the position tracking of the bleeding point positioning device to the miniature gastrointestinal blood color detection device The information can also be processed in real time; after the miniature gastrointestinal blood color detection device is discharged from the body, the gastrointestinal bleeding diagnosis and analysis system reads the data in the external data storage device, and quantitatively obtains the gastrointestinal bleeding status, including the amount of bleeding , The location of the bleeding point.
如图2所示,所述的微型胃肠道血液颜色检测装置包括:微型胃肠道血液颜色检测传感器外壳1、透明涂片盖板2、胃肠液涂片台3、引流孔4、颜色检测模块5、微型胃肠道血液颜色检测传感器外壳开口端6、微型胃肠道血液颜色检测装置外壳开口端7、微处理芯片8、永磁体9、微型胃肠道血液颜色检测装置外壳10、磁控开关11、微型电池12、信号无线发射功能模块13、发射天线14。其中微型胃肠道血液颜色检测传感器外壳1、透明涂片盖板2、胃肠液涂片台3、引流孔4、颜色检测模块5、微型胃肠道血液颜色检测传感器外壳开口端6共同组成微型胃肠道血液颜色检测传感器。微处理芯片8接收颜色检测模块5所输出的频率电压信号并对其进行处理,将处理结果输出到信号无线发射功能模块13。信号无线发射功能模块13输出端连接到发射天线14,发射天线14将上述处理结果数据向体外发射。微型电池12通过磁控开关11对颜色检测模块5、微处理芯片8、信号无线发射功能模块13进行供电,以保证整个系统正常运行。As shown in Figure 2, the described miniature gastrointestinal blood color detection device includes: a miniature gastrointestinal blood color detection sensor housing 1, a transparent
微型胃肠道血液颜色检测传感器外壳开口端6和微型胃肠道血液颜色检测装置外壳开口端7进行无缝粘合以保证胃肠道内容物无法进入微型胃肠道血液颜色检测装置内部而影响其内部电路运行。The open end 6 of the housing of the miniature gastrointestinal blood color detection sensor and the open end 7 of the housing of the miniature gastrointestinal blood color detection device are seamlessly bonded to ensure that the contents of the gastrointestinal tract cannot enter the interior of the miniature gastrointestinal blood color detection device and affect the Its internal circuitry operates.
如图3所示,所述的微型胃肠道血液颜色检测传感器包括:微型胃肠道血液颜色检测传感器外壳1、透明涂片盖板2、胃肠液涂片台3、引流孔4、颜色检测模块5、微型胃肠道血液颜色检测传感器外壳开口端6组成。透明涂片盖板2是一个厚度为0.2mm的透明的圆形聚碳酸酯薄片,粘接在微型胃肠道血液颜色检测传感器外壳1内壁。胃肠液涂片台3是一个白色的不透明聚乙烯反光圆台,反光圆台3和透明涂片盖板2之间的间距为2.0mm。透明涂片盖板2和胃肠液涂片台3所用材料均对人体无毒无害。胃肠液涂片台3和透明涂片盖板2之间可以形成肠液涂片区。引流孔4的作用是让肠液进出涂片区,引流孔4的大小和数量主要取决于肠液的粘性和保证微型胃肠道血液颜色检测传感器外壳1结构牢固性的需要。在透明涂片盖板2的另外一侧是颜色检测模块5。颜色检测模块5可提供白色光源,白色光透过透明涂片盖板2照射在肠液涂片区内肠液上,其反射的彩色光被颜色检测模块5检测。颜色检测模块检5测到彩色光后,将该彩色光的颜色信息转变为频率电压信号输出。As shown in Figure 3, the described miniature gastrointestinal blood color detection sensor includes: a miniature gastrointestinal blood color detection sensor housing 1, a transparent
如图4所示,所述的体外数据存储装置包括:包括数据接口15、电池16、电源开关17、接收天线18、数据存储模块19、微处理模块20、信号无线接收功能模块21、体外数据存储装置外壳22。上述所有部件均安装在体外数据存储装置外壳22内。体外数据存储装置外形不限,重量轻以便于使用者携带。体外数据存储装置外壳材料22由对人体无毒害材料制成。接收天线18与信号无线接收功能模块21连接,实现对微型胃肠道血液颜色检测装置所发射的信号进行接收。信号无线接收功能模块21与微处理模块20连接,以将所接收到的无线信号传输到微处理模块20。体外数据存储装置的微处理模块20通过数据线与出血点定位装置连接,以实现启动出血点位置检测程序并通过有线方式接收检测结果。体外数据存储装置的微处理模块20与数据存储模块19连接,微处理模块20接收到信号无线接收功能模块21所输入的数据与出血点定位装置有线输入的永磁铁在出血点处产生的磁场大小和方向数据,并对这几组数据进行预处理后传输到数据存储模块存储。数据存储模块19与数据接口15连接,以实现所存储的数据向肠道出血诊断分析系统传输。As shown in Figure 4, described extracorporeal data storage device comprises:
如图5所示,所述的出血点定位装置包括:腹部磁传感器阵列23、背部磁传感器阵列24、数据线25、腹部磁传感器阵列固定装置26、背部磁传感器阵列固定装置27。腹部磁传感器阵列23固定在腹部磁传感器阵列固定装置26上,背部磁传感器阵列24固定在背部磁传感器阵列固定装置27上,腹部磁传感器阵列固定装置26、背部磁传感器阵列固定装置27固定在体表。腹部磁传感器阵列23和背部磁传感器阵列24检测微型胃肠道血液颜色检测装置中永磁体9的磁场信息并将检测结果通过数据线25传输到体外数据存储装置。As shown in FIG. 5 , the bleeding point localization device includes: an abdominal
所述的肠道出血诊断分析系统可通过数据接口15下载体外数据存储装置所存储的数据,对体外数据存储装置所存储的数据进行处理,以定量获取肠道出血点位置及出血量大小。The intestinal bleeding diagnosis and analysis system can download the data stored in the in vitro data storage device through the
本发明的工作过程为:(1)在志愿者、或者患者体表安置出血点定位装置。(2)为志愿者、或者患者配带数据存储装置。(3)启动微型胃肠道血液颜色检测装置和体外数据存储装置。(4)志愿者、或者患者口服微型胃肠道血液颜色检测装置,微型胃肠道血液颜色检测装置进入胃肠道,随着胃肠道的生理蠕动而通过整个胃肠道,胃肠道内的胃液或者肠液或者胃液与血液的混合液或者肠液与血液的混合液通过引流孔4进入胃肠液涂片台3和透明涂片盖板2之间形成的胃肠液涂片区。颜色检测模块5提供白色光源,白色光透过透明涂片盖板2照射在胃肠液涂片区内液体上,其反射的彩色光被颜色检测模块5检测。颜色检测模块5检测到彩色光后,将该彩色光的颜色信息转变为频率电压信号输出。微处理芯片8接收颜色检测模块5所输出的频率电压信号并对其进行处理得到出血量大小,将处理结果输出到信号无线发射功能模块13。信号无线发射功能模块13输出端连接到发射天线14,发射天线14将上述处理结果数据向体外发射。(5)接收天线18和信号无线接收功能模块21接收发射天线14所发射的无线信号并将接收的数据输入到体外数据存储装置的微处理模块20,体外数据存储装置的微处理模块20启动出血点定位装置对微型胃肠道血液颜色检测装置进行定位信息检测,出血点定位装置通过数据线25将定位信息检测结果传输到体外数据存储装置的微处理模块20,体外数据存储装置的微处理模块20将所接收到的出血量大小信息和定位信息存储到体外数据存储装置的数据存储模块19。(6)随着胃肠道的自然蠕动,微型胃肠道血液颜色检测装置完成对胃肠道的全段检测并排出体外。(7)胃肠道出血诊断分析系统通过数据接口15读出体外数据存储装置存储的数据并进行计算处理,根据需要对处理结果进行输出。The working process of the present invention is as follows: (1) Place the bleeding point localization device on the body surface of a volunteer or a patient. (2) Equipping volunteers or patients with data storage devices. (3) Start the miniature gastrointestinal tract blood color detection device and the in vitro data storage device. (4) Volunteers or patients take the miniature gastrointestinal blood color detection device orally. The miniature gastrointestinal blood color detection device enters the gastrointestinal tract and passes through the entire gastrointestinal tract with the physiological peristalsis of the gastrointestinal tract. Gastric juice or intestinal juice or a mixture of gastric juice and blood or a mixture of intestinal juice and blood enters the gastrointestinal juice smear area formed between the gastrointestinal juice smear table 3 and the transparent
由上述检测过程可见该检测过程无痛、无创、无须清肠,胃肠道内pH、压力等生理环境不稳定的情况对所检测的血液颜色特征完全没有影响,检测结果更稳定。From the above detection process, it can be seen that the detection process is painless, non-invasive, and does not require bowel cleansing, and the unstable pH, pressure and other physiological environments in the gastrointestinal tract have no effect on the detected blood color characteristics, and the detection results are more stable.
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CN102631183A (en) * | 2012-05-03 | 2012-08-15 | 重庆大学 | Novel intellectual detection system of gastric fluid occult blood |
RU2566730C1 (en) * | 2014-06-17 | 2015-10-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Diagnostic technique for colonic injuries |
CN104971423B (en) * | 2015-05-07 | 2018-05-18 | 北京邮电大学 | A kind of physiological parameter radio pill |
CN106137099A (en) * | 2016-09-27 | 2016-11-23 | 重庆大学 | Intelligent capsule detecting system based on cloud service |
CN106618640A (en) * | 2017-02-24 | 2017-05-10 | 北京汇影互联科技有限公司 | Tracer and system for assisting to obtain intestinal ultrasound image and transmission speed |
CN108968924A (en) * | 2018-05-28 | 2018-12-11 | 重庆大学 | A kind of bleeding medicine releasing capsule |
CN108784632A (en) * | 2018-05-28 | 2018-11-13 | 重庆大学 | A kind of bleeding detection capsule system |
CN112274115A (en) * | 2020-07-03 | 2021-01-29 | 母宗军 | Integrated gastric environment detection platform and method |
CN117158919B (en) * | 2023-10-25 | 2024-03-15 | 深圳大学 | Bleeding point detection device and computer-readable storage medium |
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CN100534381C (en) * | 2007-09-06 | 2009-09-02 | 上海交通大学 | Gastrointestinal tract hemorrhage non-invasive monitoring system |
WO2010143692A1 (en) * | 2009-06-10 | 2010-12-16 | オリンパスメディカルシステムズ株式会社 | Capsule type endoscope device |
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