CN1073410C - Medicated tooth-cleaning chewing gum - Google Patents
Medicated tooth-cleaning chewing gum Download PDFInfo
- Publication number
- CN1073410C CN1073410C CN96116043A CN96116043A CN1073410C CN 1073410 C CN1073410 C CN 1073410C CN 96116043 A CN96116043 A CN 96116043A CN 96116043 A CN96116043 A CN 96116043A CN 1073410 C CN1073410 C CN 1073410C
- Authority
- CN
- China
- Prior art keywords
- tooth
- medicated
- chewing gum
- cleaning
- flos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 13
- 229940112822 chewing gum Drugs 0.000 title claims abstract description 10
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 13
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 8
- 150000007524 organic acids Chemical class 0.000 claims abstract description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 3
- 239000004088 foaming agent Substances 0.000 claims abstract description 3
- 239000004094 surface-active agent Substances 0.000 claims abstract description 3
- 241000628997 Flos Species 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 5
- 239000000551 dentifrice Substances 0.000 claims description 5
- 239000002002 slurry Substances 0.000 claims description 5
- 238000005516 engineering process Methods 0.000 claims description 4
- 238000012869 ethanol precipitation Methods 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000006286 aqueous extract Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 229940068682 chewable tablet Drugs 0.000 claims 2
- 239000007910 chewable tablet Substances 0.000 claims 2
- 238000002791 soaking Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 230000001680 brushing effect Effects 0.000 abstract description 4
- 210000000214 mouth Anatomy 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 208000002925 dental caries Diseases 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000288784 Barleria cristata Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 244000223014 Syzygium aromaticum Species 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000000606 toothpaste Substances 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 239000000955 prescription drug Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The present invention uses officinal magnolia barks of traditional Chinese medicine, philippine violet herb, safflowers, honeysuckle flowers and cloves as compounding prescriptions. The previous components are and extracted and purified, organic acid and carbonate or bicarbonate are used as effervescent agents, and surface active agents are used as foaming agents to prepare medicated tooth-cleaning chewing gum provided by the present invention. The medicated tooth-cleaning chewing gum can be of various application forms, and can be directly chewed or dissolved in the mouth. Indicated by tests, the medicated tooth-cleaning chewing gum has the obvious functions of teeth cleaning, caries prevention and sterilization. The present invention is suitable for children to replace tooth brushing and adults at inconvenient tooth brushing occasions for oral cavity cleaning, treatment and health care, and has no toxic and side effect.
Description
The present invention relates to the clean and preparation technology of a kind of dental care product ability to speak.
Brushing teeth with toothpaste, toothbrush, to clean the teeth be a kind of mode of traditional maintenance oral hygiene.In order when cleaning the teeth, to reach the effect of tooth protection, some medicated toothpaste have been invented in succession, such as the toothpaste of the trades mark such as Herba Pileae Scriptae, Radix Zanthoxyli, stomach health.In order to overcome the shortcoming of toothpaste, there are some solid dentifrice etc. to use again as dental care product.No matter be toothpaste or dentifrice, all reach and clean the teeth, tooth protection, remove the purpose of smelling with the mechanism of its dirt of dispelling, bactericidal action and toothbrush.But this kind mode causes the infringement to tooth, gum easily to child and gingiva bleeder; When the patient of handicapped old man, bed, Out Traveler etc. are brushed teeth inconvenience, how effectively the tooth-cleaning action of toothpaste, the mechanical function of toothbrush and the health care and the therapeutical effect of medicine to be incorporated into one, convenient, fast, cleaning teeth just seems important unusually effectively.
It is clean that the object of the invention is to formulate a kind of New-type oral cavity articles for use ability to speak easy to use, satisfactory for result, can interrogate speed after product uses comes into force, have preventing decayed tooth, sterilization, antiinflammatory, remove the effect of smelling, this product produces foamy mechanism and also has the oral foreign body of removing, the dirt of the dispelling effect of keeping a public place clean when chewing simultaneously.
The present invention is to be major ingredient with special Chinese medicine extract, with organic acid and carbonate or bicarbonate salts is effervescent, with the surfactant is foaming agent, after adding an amount of adjuvants such as correctives, can be made into powder, or be pressed into tablet, also can add in the substrate of dentifrice or chewing gum, make other forms of product, the ability to speak that is the present invention is clean.
The content of various compositions among the present invention: Chinese medicine extract: organic acid: the weight ratio of carbonate or bicarbonate salts is 0.1～5: 10～30: 10～30.
Special Chinese medicine extract is according to motherland's traditional medical theory among the present invention, means such as utilization modern pharmacology, pharmaceutics are made, form by Cortex Magnoliae Officinalis, Herba Violae, Flos Carthami, Flos Lonicerae and Flos Caryophylli in the prescription, have the dental caries of control, bactericidal antiphlogistic, keep a public place clean remove smell, refrigerant synergism such as promote the production of body fluid.This prescription content is with in the weight ratio Cortex Magnoliae Officinalis of medical material: Herba Violae: Flos Carthami: Flos Lonicerae: Flos Caryophylli is 3～5: 1～3: 1～3: 1～3: 1～3, and through extracting refining forming.
Effervescent combines with carbonate or bicarbonate salts with organic acid such as citric acid, malic acid, fumaric acid etc. among the present invention.
Correctives is made up of thin brain sweeting agent etc.
Preparation technology of the present invention is as follows:
The first step: after earlier medicine Cortex Magnoliae Officinalis (3～5 parts), Herba Violae (1～3 part), Flos Carthami (1～3 part), Flos Lonicerae (1～3 part), Flos Caryophylli (1～3 part) being soaked, decoct, aqueous extract adds ethanol precipitation impurity, filters.Filtrate evaporation, the dry dry extract that gets are pulverized the back and are become medicated powder.
Second step: get carbonate or bicarbonate, medicated powder, pulverize the mixing back and will starch granulation with starch.Organic acid, medicated powder are pulverized the mixing back and are granulated with starch slurry.Two kinds of granules are dried respectively after do not have moisture, granulate.With effervescent, correctives and other right amount of auxiliary materials, pulverize back and two kinds of granule mix homogeneously.
The 3rd step: but press forming is good with special-shaped sheet.Also can add to and make other types of service, plastic sealing pack in dentifrice or the chewing gum base.
The ability to speak that the present invention makes is clean, directly chew during use with or containing spue after 30 seconds～1 minute and get final product.Disintegrate rapidly, be uniformly dispersed, in the oral cavity, produce a large amount of fine foams.The present invention is except that cleaning the teeth of having of medicine, preventing decayed tooth, bactericidal action, and foamy mechanism also has in the dental surface of removing tartar, the teeth space functions such as food debris.This product is easy to carry, convenient, effect is lasting rapidly, mouthfeel is good, the time occasion that inconvenience is brushed teeth such as is particularly useful for after out of town trip and the working lunch.To child and gingiva bleeder, the infringement of having avoided brushing teeth to its tooth, gum.In addition, this product also can cooperate toothbrush to use.Application prospect is good, is the novel dental care product of a class.
Embodiment 1:
Prescription drug Cortex Magnoliae Officinalis 5g, Herba Violae lg, Flos Carthami 1g, Flos Lonicerae 1g, Flos Caryophylli 1g, water 50ml soak, decoct after 2 hours concentrated.Concentrated solution adds ethanol precipitation impurity, filters.Filtrate evaporation, the dry dry extract that gets are pulverized the back and are become medicated powder, extract yield 10%～15%.
In 100 consumptions, sodium bicarbonate 19.06g, medicated powder 0.3g pulverize the mixing back and granulate with starch slurry.Citric acid 15.6g, medicated powder 0.2g pulverize the mixing back and granulate with starch slurry.Two kinds of granules are being dried to not having moisture, granulate below 70 ℃ respectively.Get sodium laurylsulfate 1.5g, Mentholum 0.4g, Pulvis Talci 0.5g, glucide 0.3g, magnesium stearate 0.1g, pulverize back and two kinds of granule mix homogeneously, be pressed into the tablet of heavy 0.3g, plastic sealing pack.
Embodiment 2:
Prescription drug Cortex Magnoliae Officinalis 5g, Herba Violae 1g, Flos Carthami 1g, Flos Lonicerae 1g, Flos Caryophylli 1g, water 50ml soak, decoct after 2 hours concentrated.Concentrated solution adds ethanol precipitation impurity, filters.Filtrate evaporation, the dry dry extract that gets are pulverized the back and are become medicated powder, extract yield 10%～15%.
In 100 consumptions, sodium bicarbonate 19.06g pulverizes the back and crosses 60 mesh sieves; Citric acid 15.6g pulverizes the back and crosses 60 mesh sieves; Medicated powder 0.5g crosses 60 mesh sieves.Other gets sodium laurylsulfate 1.5g, Mentholum 0.4g, Pulvis Talci 0.5g, glucide 0.3g, magnesium stearate 0.1g, pulverizes back and last three kinds of composition mix homogeneously, is pressed into the tablet of heavy 0.3g, plastic sealing pack.
Embodiment 3:
Use the clean antibacterial controlled trial of ability to speak.
Albumen, agar culture medium are made solid plate, sterilization.With using the inoculation of the clean collutory of ability to speak, be contrast with the collutory of not medication, constant temperature is 24 hours in 37 ℃ of incubators.The contrast flat board is covered with bacterium colony, and only sporadically appear 2～3 of bacterium colonies of the flat board of medication, and a little less than the growth extremely, significant difference being arranged, drug effect is obvious.
Claims (2)
1, a kind of medicated tooth-cleaning chewing gum and preparation technology thereof, it is characterized in that this chewable tablet is is major ingredient with special Chinese medicine extract, with organic acid and carbonate or bicarbonate salts is effervescent, is foaming agent with the surfactant, adds an amount of adjuvants such as correctives and makes; Each composition weight ratio wherein: Chinese medicine extract: organic acid: carbonate or bicarbonate salts are 0.1～5: 10～30: 10～30; Chinese medicine extract is formulated by Cortex Magnoliae Officinalis, Herba Violae, Flos Carthami, Flos Lonicerae, Flos Caryophylli, and its weight ratio Cortex Magnoliae Officinalis: Herba Violae: Flos Carthami: Flos Lonicerae: Flos Caryophylli is 3～5: 1～3: 1～3: 1～3: 1～3.
2, the medicated tooth-cleaning chewing gum according to claim 1, it is characterized in that this chewable tablet preparation technology is: 1. earlier Chinese medicine Cortex Magnoliae Officinalis, Herba Violae, Flos Carthami, Flos Lonicerae, Flos Caryophylli are prepared in proportion, after soaking, decocting, aqueous extract adds ethanol precipitation impurity, filter, treat filtrate evaporation, the dry dry extract that gets, pulverize the back and become medicated powder; 2. get carbonate or bicarbonate, medicated powder, pulverize the mixing back and granulate with starch slurry; Organic acid, medicated powder are pulverized the mixing back and are granulated with starch slurry; Two kinds of granules are dried respectively after do not have moisture, granulate; With effervescent, correctives and other right amount of auxiliary materials, pulverize back and two kinds of granule mix homogeneously; 3. but press forming also can be made into powder, or adds in the dentifrice, makes the product of other form, plastic sealing pack in the substrate of chewing gum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116043A CN1073410C (en) | 1996-11-08 | 1996-11-08 | Medicated tooth-cleaning chewing gum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116043A CN1073410C (en) | 1996-11-08 | 1996-11-08 | Medicated tooth-cleaning chewing gum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1181927A CN1181927A (en) | 1998-05-20 |
| CN1073410C true CN1073410C (en) | 2001-10-24 |
Family
ID=5123234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96116043A Expired - Fee Related CN1073410C (en) | 1996-11-08 | 1996-11-08 | Medicated tooth-cleaning chewing gum |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1073410C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7470442B2 (en) | 2005-12-02 | 2008-12-30 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100387091B1 (en) * | 2000-02-16 | 2003-06-11 | 주식회사 엘지생활건강 | Composition for enhancing oral hygiene containing extract of safflower seed |
-
1996
- 1996-11-08 CN CN96116043A patent/CN1073410C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《辽宁中医杂志》1993,20(1) 1993.1.1 王明辉"口喉宁"治疗口咽病82例;《陕西中医》1985,6(3) 1985.1.1 王聚春，中医药治疗多发性龈脓肿31例初步小结 * |
| 《辽宁中医杂志》1993,20(1) 1993.1.1 王明辉"口喉宁"治疗口咽病82例 * |
| 《陕西中医》1985,6(3) 1985.1.1 王聚春，中医药治疗多发性龈脓肿31例初步小结 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US7470442B2 (en) | 2005-12-02 | 2008-12-30 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1181927A (en) | 1998-05-20 |
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