CN107126189B - Optical module and retina image-forming equipment for retina image-forming - Google Patents
Optical module and retina image-forming equipment for retina image-forming Download PDFInfo
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- CN107126189B CN107126189B CN201611182890.8A CN201611182890A CN107126189B CN 107126189 B CN107126189 B CN 107126189B CN 201611182890 A CN201611182890 A CN 201611182890A CN 107126189 B CN107126189 B CN 107126189B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/1025—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for confocal scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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Abstract
The present invention provides a kind of optical module for retina image-forming, including light source module, total spectroscope, image-forming module, scan module and flat-field objective, total spectroscope is arranged between light source module and scan module, flat-field objective setting is in scan module and by between inspection position, light source module is used to issue the detection light for illuminating eyeground to total spectroscope, detection light is guided through total spectroscope to scan module, and via scan module and flat-field objective directive by inspection position, reflection light can pass through scan module and reach total spectroscope, scan module includes scanning objective, scanning objective can be moved back and forth along the central axis of the scanning objective, flat-field objective can be moved back and forth along the central axis of the flat-field objective.The present invention also provides a kind of retina image-forming equipment.Retina image-forming equipment adjusts the compensation defocusing amount of flat-field objective according to the ametropia degree of human eye, and can change the defocusing amount of scanning objective, to obtain the clear image of different layers on retina.
Description
Technical field
The present invention relates to medical instruments fields, and in particular, to a kind of optical module and one kind for retina image-forming
Retina image-forming equipment including the optical module.
Background technique
The retinal map of human eye seems important information indispensable in ophthalmic diagnosis and treatment, real-time tracking eyeground view
The pattern variation of film will be helpful to the early diagnosis and prevention of body illness.Cofocus scanning technology is applied to living body by R.H.Webb
The confocal vacuum pinhole of human eye retina's imaging, end of probe is used to shield the stray light of the non-focal plane of sample, to obtain sample coke
The full resolution pricture in face.However, causing resolution ratio not high, same time point using scanning electricity distribution disperse in above-mentioned confocal technology
Energy is small, and using dim light point detector, the picture contrast of acquisition is low, and image taking speed is slow.
To solve the above-mentioned problems, there is the confocal imaging device scanned based on line.But current confocal imaging device
It is only capable of obtaining the plan view of retina, cannot achieve the solid detection to retina.
Therefore, how to realize becomes this field technical problem urgently to be resolved to the three-dimensional detection of retina.
Summary of the invention
It include the optical module the purpose of the present invention is to provide a kind of optical module for retina image-forming and one kind
Retina image-forming equipment, the stereo-picture of retina can be obtained using the retina image-forming equipment.
To achieve the goals above, as one aspect of the present invention, a kind of optics group for retina image-forming is provided
Part, the optical module include light source module, total spectroscope, image-forming module, scan module and flat-field objective, total spectroscope
It is arranged between the light source module and the scan module, the flat-field objective setting is in the scan module and by inspection position
Between, the light source module is used to issue the detection light for illuminating eyeground to total spectroscope, described in the detection light passes through
Total spectroscope is guided to the scan module, and is come via the scan module and the flat-field objective directive by inspection position
The scan module can be passed through from the reflection light by inspection position and reaches total spectroscope, and is guided by total spectroscope
To the image-forming module, wherein the scan module includes scanning objective, and the scanning objective can be along the scanning objective
Mandrel line moves back and forth, and the flat-field objective can be moved back and forth along the central axis of the flat-field objective.
Preferably, the scan module includes the first guide rail, the extending direction and the scanning objective of first guide rail
Central axial direction it is consistent, the scanning objective is slidably disposed on first guide rail.
Preferably, the optical module includes the second guide rail, the extending direction and the flat-field objective of second guide rail
Central axial direction it is consistent, the flat-field objective is slidably disposed on second guide rail.
Preferably, the optical module further includes the first cylindrical lens, and first cylindrical lens is arranged in the total score
Between light microscopic and the scan module, first cylindrical lens becomes line for will transmit through total spectroscopical optical beam transformation
Go out after light beam and injects the scan module.
Preferably, the light source module includes the broadband point light source, collimation lens and the first filter set being arranged successively, institute
Broadband point light source is stated for issuing the broad band laser of multi-wavelength, first filter set includes multiple first optical filters, institute
The quantity for stating the first optical filter is identical as the species number of wavelength of laser that the broadband point light source issues, first optical filter
The laser filter that the broadband point light source can be issued is at the laser with predetermined wavelength, each first optical filter
It is separately provided in the optical path of the optical module；
The image-forming module includes the first image-forming objective lens and the second filter set, and second filter set is arranged described
Between total spectroscope and first image-forming objective lens, the light of total spectroscope reflection is entered by second filter set
First image-forming objective lens, second filter set include multiple second optical filters, and multiple second optical filters distinguish energy
Enough penetrate the fluorescence of different wave length.
Preferably, the light source module includes the first turntable, is provided on first turntable and multiple first filters
The one-to-one multiple first optical filtering through-holes of mating plate, first optical filter are arranged in corresponding first optical filtering through-hole.
Preferably, the image-forming module includes the second turntable, is provided on second turntable and multiple second filters
The one-to-one multiple second optical filtering through-holes of mating plate, second optical filter are arranged in corresponding second optical filtering through-hole.
Preferably, the broadband point light source includes argon laser transmitter and semiconductor laser transmitter, the argon laser hair
Emitter can emission center wavelength be 488nm broad band laser and central wavelength be 514nm broad band laser, the semiconductor swash
Optical transmitting set can emission center wavelength be 795nm broad band laser and central wavelength be 830nm broad band laser；
First filter set include can filter out wavelength be 488nm laser the first optical filter, wavelength can be filtered out
For the laser of 514nm the first optical filter, the first optical filter of the laser that wavelength is 795nm can be filtered out and wavelength can be filtered out
For the first optical filter of the laser of 830nm；
Second filter set includes that can filter out the second optical filter and can filter out wavelength that wavelength is 500nm fluorescence
For the second optical filter of 810nm fluorescence.
Preferably, the scan module further includes scanning galvanometer and the first dichroic beamsplitter, first dichroic point
Light microscopic, the scanning objective are sequentially arranged between the scanning galvanometer and the flat-field objective；
The optical module further includes sighting target module, and the sighting target module includes light emitting array and third image-forming objective lens, institute
Stating light emitting array includes multiple light-emitting components for capableing of independent control, and the light that any one of light-emitting component issues can be injected
The third image-forming objective lens, and the first dichroic beamsplitter as described in directive after third image-forming objective lens focusing, and by described
First dichroic beamsplitter reflexes to the flat-field objective.
Preferably, the optical module further includes pupil detection module, and the pupil detection module includes the second dichroic
Spectroscope, annular light source and the second image-forming objective lens, the annular light source have the hollow portion for capableing of light transmission,
Second dichroic beamsplitter is arranged between first dichroic beamsplitter and the third image-forming objective lens,
Light across the third image-forming objective lens can pass through second dichroic beamsplitter, and the annular light source is arranged described
Flat-field objective and it is described by inspection position between, the annular light source can towards by inspection position shine, and the light source module send out
Luminous energy out passes through the hollow portion of the annular light source, can pass through the annular light source from the reflected light by inspection position
Hollow portion irradiate to first dichroic beamsplitter, and from first dichroic beamsplitter reflex to the described 2nd 2 to
The light that first dichroic beamsplitter reflects can be reflexed to described second by color spectroscope, second dichroic beamsplitter
Image-forming objective lens.
Preferably, the pupil detection module further includes face battle array optical detector, and the face battle array optical detector is for receiving institute
State the light of the second image-forming objective lens sending.
Preferably, the transmissivity of second dichroic beamsplitter is less than the reflectivity of second dichroic beamsplitter.
Preferably, the image-forming module further includes the second cylinder for successively arranging of light emission side in first image-forming objective lens
Lens, slit diaphragm and photodiode array, wherein the slit diaphragm, the light source and described be in by inspection position are total to
Yoke position.
Preferably, the slit width of the slit diaphragm is equal to the Airy spot diameter of first image-forming objective lens.
Preferably, total spectroscope includes light-reflecting portion and the transmittance section that is formed in the light-reflecting portion, the light-reflecting portion
Reflective surface is arranged towards the scan module, the light source module, total spectroscope, the scan module and the flat-field objective
It is listed in first straight line, the image-forming module is arranged in the second straight line vertical with the first straight line, so that the light
The detection light that source module issues can pass through the transmittance section, and the reflected light that the position You Shoujian returns can be anti-by the light-reflecting portion
It is incident upon the image-forming module.
Preferably, total spectroscope includes transparent bodies and the spectro-film that is arranged in the transparent bodies, the light
One of source module and the image-forming module, total spectroscope, the scan module and the flat-field objective are arranged same
In one first straight line, vertical with the first straight line is arranged in the other of the light source module and the image-forming module
On two straight lines.
As another aspect of the present invention, a kind of retina image-forming equipment is provided, the retina image-forming equipment includes
Optical module and processor, the optical module are above-mentioned optical module provided by the present invention, and the processor includes image
Generation module, described image generation module are used to generate corresponding image according to the light being emitted from the image-forming module.
Preferably, the optical module includes the second image-forming objective lens, and described image generation module is also used to according to described the
The light that two image-forming objective lens issue generates corresponding image.
Since the human eye of most people is ametropia, and the flat-field objective in the optical module of the application is along the flat-field objective
Central axis reciprocating movement can produce different refraction compensation amounts, therefore, the ametropia defocusing amount of different human eyes
To be compensated, the available clearly human eye retina's image of optical module provided by the present invention is utilized.
Retina is about 300 microns of a thickness of the film positioned at human eye eyeground, including nerve fibre layer, neuronal cell layers,
The multilayers such as vascular lamina, visual cell's layer and melanin epithelium layer.Different diseases and physiology course also can retina not
It is showed in same layer.Scanning objective can be moved back and forth along center axis thereof, so that different defocusing amounts is generated, different
Under defocusing amount, it can be observed that the image of retina different depth layer, that is to say, that scanning objective can be different deep by retina
The light of degree layer transmitting is transferred to image-forming module, and the image of retina different layers is obtained by image-forming module.
Longitudinal chromatography can be carried out to retina using optical module provided by the present invention, can obtain the three of retina
Image is tieed up, and observes the image of retina different layers, improves the accuracy of clinical examination and comprehensive.
Detailed description of the invention
The drawings are intended to provide a further understanding of the invention, and constitutes part of specification, with following tool
Body embodiment is used to explain the present invention together, but is not construed as limiting the invention.In the accompanying drawings:
Fig. 1 is the structural schematic diagram of retina image-forming equipment provided by the present invention；
Fig. 2 a is a kind of total spectroscopical schematic diagram of embodiment；
Fig. 2 b is the schematic diagram of total spectroscopical another embodiment；
Fig. 3 is a kind of schematic diagram of embodiment of the first turntable；
Fig. 4 (a) is the timing diagram of scanning drive signal；
Fig. 4 (b) is the timing diagram for scanning synchronization signal；
Fig. 4 (c) is the timing diagram of frame synchronizing signal；
Fig. 4 (d) is the timing diagram of the linear array photodetector signal through frame synchronization modulation；
Fig. 5 is the flow chart using the method for retina image-forming equipment provided by the present invention detection retina.
Description of symbols
100: light source module 110: broadband point light source
120: 130: the first filter set of collimation lens
200: 300: the first cylindrical lens of total spectroscope
400: scan module 410: scanning galvanometer
420: the first dichroic beamsplitters 430: scanning objective
500: sighting target module 510: light emitting array
520: third image-forming objective lens 600: flat-field objective
700: 710: the second dichroic beamsplitter of pupil detection module
720: 730: the second image-forming objective lens of annular light source
740: face battle array photodetector 800: image-forming module
810: the second filter set, 820: the first image-forming objective lens
830: the second cylindrical lenses 840: slit diaphragm
850: photodiode array 900: main control computer
11: human eye 410a: function card
850a: 131: the first turntable of image pick-up card
131a: the first the 131b: the first clear opening of optical filtering through-hole
Specific embodiment
Below in conjunction with attached drawing, detailed description of the preferred embodiments.It should be understood that this place is retouched
The specific embodiment stated is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
As shown in Figure 1, a kind of optical module for retina image-forming is provided as one aspect of the present invention, it is described
Optical module includes light source module 100, total spectroscope 200, image-forming module 800, scan module 400 and flat-field objective 600.Total score
Light microscopic 200 is arranged between light source module 100 and scan module 400, and flat-field objective 600 is arranged in scan module 400 and is examined
Between position.It should be pointed out that human eye 11 is located at by inspection position.
Light source module 100 is used to issue the detection light (the detection light is light pencil) illuminated by inspection position, the detection light
Through total spectroscope 200 guidance to scan module 400, and via 400 directive of scan module by inspection position, with illuminate be located at by
It examines at position, i.e. 11 eyeground of human eye.Reflection light from 11 eyeground of human eye can pass through scan module 400 and reach total spectroscope
200, and by total guidance of spectroscope 200 to image-forming module 800.Wherein, scan module 400 includes scanning objective 430, the scanning
Object lens 430 can be moved back and forth along the central axis of the scanning objective 430, and flat-field objective 600 can be along the flat-field objective 600
Central axis moves back and forth.
It is to be understood that " total spectroscope guidance " herein includes two kinds of situations, a kind of situation be through total spectroscope,
Another situation is that being reflected by total spectroscope.Both of these case will be hereinafter described in detail, not repeated first here.
When being imaged using retina of the optical module to tester, the eyes to be detected of tester are located at
It is described by inspection position, and human eye to be detected 11, scanning objective 430, total spectroscope 200, light source module 100 are respectively positioned on always
On line.When testing tester, light source module 100 is opened, to generate detection light.The detection light passes through total spectroscope
200, after the scanning objective 430 of scan module 400, human eye 11 is reached.The light of the retinal reflex on human eye eyeground can pass through
Reach total spectroscope 200 after scanning objective 430, and by total spectroscope 200 guidance to image-forming module 800, by acquisition by
As the light of module 800 can obtain the image of retina.
Since the human eye of most people is ametropia, and the flat-field objective 600 in the optical module of the application is along the flat field
The central axis reciprocating movement of object lens 600 can produce different refraction compensation amounts, therefore, the ametropia defocus of different human eyes
Available compensation is measured, the available clearly human eye retina's image of optical module provided by the present invention is utilized.
Retina is about 300 microns of a thickness of the film positioned at human eye eyeground, including nerve fibre layer, neuronal cell layers,
The multilayers such as vascular lamina, visual cell's layer and melanin epithelium layer.Different diseases and physiology course also can retina not
It is showed in same layer.Scanning objective 430 can be moved back and forth along center axis thereof, can be with to generate different defocusing amounts
Observe the image of retina different depth layer, that is to say, that scanning objective 430 can emit retina different depth layer
Light is transferred to image-forming module 800, and the image of retina different layers is obtained by image-forming module.
Specifically, by adjust scanning objective 430 defocusing amount, can obtain respectively nerve fibre layer, neuronal cell layers,
The image of vascular lamina, visual cell layer and melanin epithelium layer.It can be to view using optical module provided by the present invention
Film carries out longitudinal chromatography, can obtain the 3-D image of retina, and observe the image of retina different layers, improve clinical inspection
The accuracy looked into and comprehensive.
For example, when the defocusing amount of scanning objective 430 is 0, blood vessel can be obtained when in optical module provided by the present invention
The figure of layer；When the defocusing amount of scanning objective 430 is -100 microns, the image of nerve fibre layer by layer can be obtained；Work as scanning
When the defocusing amount of object lens 430 is 100 microns, the image of cellular layer can be obtained.
In the present invention, specific restriction is not done to the specific structure of total spectroscope 200.Below with reference to two kinds of total light splitting
The above " total spectroscope guidance " is described in detail in the specific embodiment of mirror 200.
In the first situation, that is, situation shown in Fig. 1, total spectroscope 200 may include transparent bodies and be arranged in institute
State the spectro-film in transparent bodies.That is, total spectroscope 200 can be light splitting plain film or Amici prism.
One of light source module 100 and image-forming module 800, total spectroscope 200, scan module 400 and flat-field objective 600
It is arranged on same first straight line L1, the angle between spectro-film and first straight line L1 is 45 °, light source module 100 and imaging mould
The other of block 800 is arranged on the second straight line L2 vertical with the first straight line L1.
Which one in specific light source module 100 and image-forming module 800 is arranged on first straight line L1, which one setting exists
It is then determined by the transflection ratio of spectro-film on second straight line L2.
For example, in embodiment shown in Fig. 1, in order to realize the imaging of retina, the transmissivity of total spectroscope 200
Less than the reflectivity of total spectroscope 200, it is preferable that total spectroscopical transflection ratio can be set to 1:9.In this case,
" the detection light is guided through total spectroscope 200 to scan module 400 " refers to that detection light reaches scanning mould through total spectroscope 200
Block 400 " can pass through scan module 400 from the reflected light by inspection position and reach total spectroscope 200, and by total spectroscope 200
It guides to image-forming module 800 " and refers to that can pass through scan module 400 from the reflected light by inspection position reaches total spectroscope 200,
And image-forming module 800 is reflexed to by total spectroscope 200.
When the transmissivity of total spectroscope 200 is greater than the reflectivity of total spectroscope 200, image-forming module 800 can be set
It sets on first straight line L1, light source module 100 is arranged on second straight line L2.In this embodiment it is preferred to can be with
9:1 is set by the transflection ratio of total spectroscope 200.In this case, " the detection light is guided through total spectroscope 200 to sweeping
It retouches module 400 " and refers to that detection light by total spectroscope 200 reflexes to scan module 400, " from can by the reflected light of inspection position
Total spectroscope 200 is reached across scan module 400, and refers to come from by total spectroscope 200 guidance to image-forming module 800 " and be examined
The reflected light of position can pass through scan module 400 and reach total spectroscope 200, and reach image-forming module through total spectroscope 200
800。
In second situation, as shown in Figure 2 a and 2 b, total spectroscope 200 can also be hollow reflecting mirror.Such as Fig. 2 institute
Show, total spectroscope 200 includes light-reflecting portion 220 and the transmittance section 210 being formed in the light-reflecting portion 220, the reflective surface of light-reflecting portion 220
Image-forming module 800 is reflexed to towards scan module 400, and by the light of fundus reflex.In this embodiment, light-reflecting portion
220 reflective surface is towards scan module 400, and the angle between scan module 400 is 45 °, light source module 100, total light splitting
Mirror 200, scan module 400 and flat-field objective 600 are arranged on first straight line L1, image-forming module 800 setting with first straight line
L2 in L1 vertical second straight line.The detection light that light source module 100 issues can pass through transmittance section 210, and the position You Shoujian returns
Reflected light image-forming module 800 can be reflexed to by light-reflecting portion 220.
Total spectroscope 200 shown in Fig. 2 a and Fig. 2 b can eliminate stray light, so that the eye fundus image finally obtained is more
It is clear to add.
As shown in Figure 2 a, transmittance section 210 can be round tube hole.The diameter of transmittance section 210 is preferably 3mm, at this point, transmittance section
Stray light can be filtered out.Detection light emission after having filtered out stray light enters scan module 400.
Certainly, transmittance section 210 can also be the hole of other shapes, for example, transmittance section 210 can be width shown in Fig. 2 b
Degree is the slit of 3mm.
In the present invention, to how motion scan object lens 430 are not particularly limited.As an implementation, it sweeps
Retouching module 400 may include the first guide rail (not shown), the extending direction of first guide rail and the central axis of scanning objective 430
Direction is consistent, and scanning objective 430 is slidably disposed on first guide rail.To how to drive scanning objective 430 first
Sliding is not particularly limited on guide rail, for example, can drive scanning objective 430 sliding along the first guide rail by stepper motor
It is dynamic.The advantages of stepper motor is arranged is, the position of scanning objective 430 can be accurately controlled, so as to accurately control
The defocusing amount of scanning objective 430, so that detection image is more accurate.
In the present invention, also not special requirement how is moved to flat-field objective 600, for example, the optical module
It may include the second guide rail (not shown), the extending direction of second guide rail is consistent with the central axial direction of flat-field objective 600,
Flat-field objective 600 is slidably disposed on second guide rail.It is similar with driving scanning objective 430, stepping electricity can be passed through
Machine drives flat-field objective 600 to slide along the second guide rail.
It preferably, is Line beam into the detection light of scan module 400, correspondingly, the optical module can also include
First cylindrical lens 300, first cylindrical lens are arranged between total spectroscope 200 and scan module 400.First cylindrical lens
300 light pencils that can will transmit through total spectroscope 200 are converted to line-structured light, and line-structured light enters after passing through scan module 400
Human eye, and on the retina of human eye formed a linear structure light, into eyeground line-structured light by after retinal reflex, take
Strength information with the line-structured light on retina reflexes to image-forming module 800 by total spectroscope 200 along backtracking.
In the present invention, the first cylindrical lens 300 can be can eliminate color difference in 400nm-900nm wavelength band
Achromatism gluing cylindrical lens.For example, the ACY254-050-A of thorlabs formula can be selected as the first cylindrical lens
300。
In the present invention, the specific structure to light source module 100 and without limitation.In the embodiment shown in figure 1, light
Source module 100 includes broadband point light source 110, the collimation lens 120 being arranged successively.Herein, broadband point light source 110 can be magnetic tape trailer
Fine point light source.The light that broadband point light source 110 issues becomes collimated light beam after collimation lens 120.
Each layer is different to the susceptibility of spectrum in retina, can according to specific requirements to the different layers of different retinas into
Row imaging or contrast imaging.For example, if you need to observe visual cell's layer, it is proper near infrared light；It is thin such as to observe intravascular blood
Born of the same parents' flowing is then proper with green light；If you need to observe melanin epithelial layer, then need to excite using the 568nm of lipofuscin
Autofluorescence effect.In order to realize the above functions, light source module 100 should can issue above-mentioned various light.
In the present invention, light source module 100 may include multiple point light sources 110, and multiple point light sources 110 issue difference respectively
The laser of wavelength, to cooperate scan module and image-forming module to provide light source as different layers.
In order to simplify the structure of light source module 100, it is preferable that light source module 100 includes the broadband point light source being arranged successively
110, collimation lens 120 and the first filter set 130.The broadband point light source 110 is used to issue the broad band laser of multi-wavelength.
First filter set 130 includes multiple first optical filters, what the quantity of first optical filter and the broadband point light source issued
The species number of the wavelength of laser is identical, and the laser filter that first optical filter can issue the point light source is predetermined at having
The laser of wavelength, each first optical filter are detachably provided in the optical path of the optical module.Correspondingly, it is imaged
Module 800 includes the second filter set, and second filter set 810 is arranged in total spectroscope 200 and the first image-forming objective lens 820
Between, the second filter set 810 includes multiple second optical filters, and multiple second optical filters are able to through the glimmering of different wave length
Light.
Herein, " separably it is arranged " and refers to, it can be by the first optical filter in first filter set from optical path
It takes out, the first optical filter can also be arranged in the optical path.
What it is due to the sending of point light source 110 is broad band laser, can be obtained after the optical filtering of the first optical filter with respective wavelength
Laser of narrowband.The cost of optical filter can be held lower than the cost of point light source moreover, optical filter is small in size, does not need to be powered on very much
It changes places and is mounted in the optical module or is removed from the optical module.
In the present invention, when needing to obtain the image of retina, the light that light source 110 issues is point light source, by collimation
Collimated light beam is collimated into after lens 120, and by total spectroscope 200 after the spectral line required for required the first optical filter selection
Light splitting, is transformed to one-dimensional Line beam through the first cylindrical lens of part 300 of total spectroscope 200, and reach scan module
400, by being propagated in human eye after scan module 400.
In the present invention, to the first optical filter how replaced in the first filter set there is no special requirement, as
A kind of preferred embodiment, as shown in figure 3, the light source module includes the first turntable 131,131 are provided on first turntable
With the one-to-one multiple first optical filtering through-hole 131a of multiple first optical filters, first optical filter is arranged corresponding first
In optical filtering through-hole 131a.By rotating the first turntable, required first optical filter can be arranged in the optical path.
Preferably, as shown in figure 3, being also provided with the first clear opening 131b on the first turntable 131, first clear opening
Any optical filter is not provided in 131b, light can directly pass through.In this embodiment, it can be realized by rotary turnplate
It is arranged in the optical path or removes the first optical filter without removing rotary turnplate, is operated on it convenient for operator.
Similarly, in the present invention, also not special to the second optical filter how replaced in the second filter set to want
It asks.First imaging includes the second turntable as a preferred implementation manner, is provided with and multiple institutes on second turntable
The one-to-one multiple second optical filtering through-holes of the second optical filter are stated, the second optical filter setting filters logical corresponding second
Kong Zhong.By rotating the second turntable, required second optical filter can be arranged in light path.
It is operated for ease of operation, it is preferable that it is similar with the first turntable, second can be arranged in the second turntable
Clear opening is not provided with any optical filter in second clear opening, and light can directly pass through.
The point light source includes argon laser transmitter and semiconductor laser transmitter, institute as a preferred implementation manner,
State argon laser transmitter can emission center wavelength be 488nm broad band laser and central wavelength be 514nm broad band laser, institute
State semiconductor laser transmitter can emission center wavelength be 795nm broad band laser and central wavelength be 830nm broadband swash
Light.
First filter set include can filter out wavelength be 488nm laser the first optical filter, wavelength can be filtered out
For the laser of 514nm the first optical filter, the first optical filter of the laser that wavelength is 795nm can be filtered out and wavelength can be filtered out
For the first optical filter of the laser of 830nm.
Second filter set includes that can filter out the second optical filter and can filter out wavelength that wavelength is 500nm fluorescence
For the second optical filter of 810nm fluorescence.
In specific application, it controls to the property of can choose argon laser transmitter and semiconductor laser transmitter shines.
When needing to carry out fluorescein sodium radiography to eyeground, the first optical filter that wavelength is 488nm laser will be filtered out
With can filter out wavelength be 500nm fluorescence the second optical filter setting in the optical path, so as to realize fluorescein sodium radiography at
Picture.
When be imaged without red light to retina, the first optical filter that wavelength is 514nm laser can will be filtered out
Setting in the optical path, and the second all optical filters is taken out from optical path, so as to realize to retina without red light
Imaging.
When needing to carry out indocyanine-green dyestuff contrast imaging to eyeground, the laser that wavelength is 795nm will be filtered out
First optical filter and the second optical filter setting for filtering out the fluorescence that wavelength is 810nm in the optical path, are realized to indocyanine-green radiography
Imaging.
When needing to carry out infrared imaging to retina, will filter out the laser that wavelength is 830nm first is filtered
Piece is arranged in the optical path, while the second optical filter being taken out from optical path, realizes the infrared imaging to retina.
As a preferred implementation manner, as shown in Figure 1, scan module 400 can also include scanning galvanometer 410 and first
Dichroic beamsplitter 420, the first dichroic beamsplitter 420, scanning objective 430 are sequentially arranged in scanning galvanometer 410 and flat field object
Between mirror 600.
As shown in the figure, the angle between the spectro-film and first straight line L1 of the first dichroic beamsplitter 420 can be
45°。
Retina different zones are imaged in order to realize, it is preferable that the optical module can also include sighting target mould
Block 500.As shown in fig. 1, sighting target module 500 includes light emitting array 510 and third image-forming objective lens 520.Light emitting array includes more
A light-emitting component (light-emitting component can be LED) for capableing of independent control, the equal energy of light that any one light-emitting component issues
Third image-forming objective lens 520 are enough injected, which is focused incident ray, the light directive after focusing the
One dichroic beamsplitter 420, and flat-field objective 600, and final directive human eye 11 are reflexed to by first dichroic beamsplitter 420
The corresponding region on eyeground.
In this embodiment, it is shone by controlling the light-emitting component of 510 different location of light emitting array, personnel can be made
Different regions is illuminated on 11 retina, so as to realize the imaging to retina different zones.
In the present invention, to how to drive, each light-emitting component of light emitting array 510 is luminous not to do special restriction.Example
Such as, can by USB interface, bluetooth, cable interface, any one data connection port in serial ports parallel port be by light emitting array
510 are connected with main control computer 900, control light-emitting component different on light emitting array 510 by main control computer 900 and shine.
The central axis of the third image-forming objective lens 520 of sighting target module 500 is in first straight line L1.
In order to realize pupil of human is measured in real time, convenient for system debug, facilitate subject carry out imaging inspection, it is excellent
Selection of land, the optical module further include pupil detection module 700, which includes the second dichroic beamsplitter
710, annular light source 720 and the second image-forming objective lens 730.
In flat-field objective 600 and by between inspection position, the phase can shine the setting of annular light source 720 towards by inspection position.
The first dichroic beamsplitter 420 and third object lens of scan module 400 is arranged in second dichroic beamsplitter 710
Between 520, and the angle between the spectro-film of the second dichroic beamsplitter 710 and the central axis of third object lens 520 is 45 °.
The hollow portion that annular light source 720 can be through from the reflected light by inspection position is irradiated to the first dichroic beamsplitter
420, and the second dichroic beamsplitter 710 is reflexed to by first dichroic beamsplitter 420, second dichroic beamsplitter 720
The light that first dichroic beamsplitter 420 reflects can be reflexed to the second image-forming objective lens 730.It can by the second image-forming objective lens 730
To obtain the image of pupil of human.The central axis of second image-forming objective lens 730 and the central axis of third image-forming objective lens 520 hang down
Directly.
Annular light source 720 can be the LED lamp tube of annular arrangement, and centre is circular through hole.Annular light source issues after lighting
Optical illumination eye cornea, directly through the centre of annular light source 720 after the annular beam reflection that cornea emits annular light source
Then light hole reflexes to the second dichroic beamsplitter 710 through the first dichroic beamsplitter 420, and is divided through the second dichroic
Mirror 710 by the second image-forming objective lens 730 focuses entering surface battle array photodetector 740 after reflecting, and face battle array photodetector 740 is by light intensity
Degree signal is converted into electric signal, is directly output to main control computer 900, to obtain pupil of human image by computer 900, realizes
To the real-time monitoring of pupil, the functions such as alignment and positioning for system optics imaging, and figure can be carried out by main control computer 900
As storage, image procossing and analysis, file process etc..
In the present invention, the specific structure of annular light source is not particularly limited, for example, annular light source can be it is more
The annular light source that a LED is arranged in.It should be pointed out that be among annular light source it is hollow, can permit detection light and anti-
Penetrate passing through for light.
Preferably, pupil detection module 700 can also include face battle array optical detector 740, and face battle array optical detector 740 can be with
The light from the second image-forming objective lens 730 is detected, and is imaged.
Preferably, image-forming module 800 further include the first image-forming objective lens 820 the second cylinder for being arranged successively of light emission side it is saturating
Mirror 830, slit diaphragm 840 and photodiode array 850.
The light that total spectroscope 200 reflects matches magnifying power by the first image-forming objective lens 820, by the second cylindrical lens
830 are focused into Line beam, reach photodiode array 850 across slit diaphragm 840 and obtain retina Line beam lighting position
Continuous intensity signal.
The utilization rate of light can be improved in second cylindrical lens 830, reduces energy loss.Slit diaphragm 840 can filter out
Veiling glare, so that the image finally obtained is more clear.
Preferably, the slit width of the slit diaphragm is equal to the Airy spot diameter of the image-forming objective lens, so as to complete
The stray light of the non-position of focal plane of human eye retina is filtered out entirely, guarantees confocal imaging resolution ratio with higher.
410 pairs of scanning galvanometer incident line-structured lights carry out one-dimensional scanning, and are scanned after object lens 430 match through flat field
Object lens 600 spread into human eye after converting, and line-structured light is focused on the one-dimensional knot of retina by the optical system of human eye
There is scattering process on structure light beam, human eye eyeground to incident light, and scattering light carries the imaging beam of the intensity signal of human eye retina,
The imaging beam is emitted after reflecting from human eye retina.The imaging beam of subsequent human eye reflection is transformed into flat through flat-field objective 600
Field light beam continues along backtracking to total spectroscope 200, which reflexes to image-forming module 800 for imaging beam.
Since retina is the curved-surface structure with greater curvature, the imaging beam that retinal reflex goes out is with biggish abnormal
Transshaping is poor, and therefore, imaging beam is also curve form, and the optical system parameter and view of human eye are combined using flat-field objective 600
Membrane structure can satisfy the imaging beam of retina camber reflection becoming flat field light beam, eliminate distortion effects.
In specific embodiment shown in Fig. 1, image-forming module 800 include be arranged successively the second filter set 810,
First image-forming objective lens 820, the second cylindrical lens 830, slit diaphragm 840 and photodiode array 850.Imaging beam is through second
After spectral line required for the second optical filter in filter set 810 is selected after the focusing of the first image-forming objective lens 820, by the second cylinder
Lens 830 are reduced into Line beam, and photodiode array 850 is entered after slit diaphragm 840 filters out stray light.
In optical module provided by the present invention, using the image quality in retina difference visual field as evaluation index, so that
Cable architecture light beam reaches diffraction limit to the illuminating effect of human eye retina.
As another aspect of the present invention, a kind of retina image-forming equipment is provided, the retina image-forming equipment includes
Optical module and processor, wherein the optical module is above-mentioned optical module provided by the present invention, and the processor includes
Image generation module, the image generation module are used to generate corresponding image according to the light being emitted from the image-forming module.
As mentioned above it is possible, since scanning objective 430 can produce different defocusing amounts, it can be on retina
Different layers are imaged, and may be implemented to check retina more fully hereinafter.Also, flat-field objective 600 can produce different
Defocusing amount compensates so as to the ametropia phenomenon to human eye, so that can obtain clearly for different patients
Eye fundus image.
In the present invention, processor may include main control computer 900.
When the optical module includes photodiode array 850 and scanning galvanometer 410, image generation module be can wrap
It includes image pick-up card 850a and card 410a occurs for function.The input terminal of image pick-up card 850a and photodiode array 850
Output end end is connected, and the electric signal for being generated according to photodiode array 850 generates corresponding image.Function card
410a is connected with scanning galvanometer 410 and main control computer 900 respectively, for driving scanning galvanometer 410.
In the present invention, main control computer 900 is mainly used for exporting various control commands, to realize to the reconstruct of image, aobvious
Show, store, handle and analyze and the functions such as file process.
Certainly, when photodiode array 850 is cable interface, image generation module can not include that described image is adopted
Truck, the electric signal that photodiode array 850 exports generate corresponding image.
When the optical module includes pupil detection module 700, image generation module is also used to generate pupil detection mould
The image that block 700 obtains.In embodiment shown in Fig. 1, the output end of main control computer 900 and face battle array optical detector 740
It is connected.
It is described below with reference to working principle of the Fig. 1 and Fig. 4 to retina image-forming equipment provided by the present invention.
In the embodiment shown in figure 1, optical module includes that light source module 100, total spectroscope 200, the first cylinder are saturating
Mirror 300, scan module 400, sighting target module 500, flat-field objective 600, pupil detection module 700 and image-forming module 800.
Light source module 100 includes point light source 110, collimation lens 120 and the first filter set.Point light source 110 swashs including argon
Optical transmitting set and semiconductor laser transmitter, argon laser transmitter can emission center wavelength be 488nm laser and middle cardiac wave
The laser of a length of 514nm, semiconductor laser transmitter can emission center wavelength be 795nm laser and central wavelength be
The laser of 830nm.
First filter set includes four narrow band filters, and can respectively filter out the light of 488nm wavelength first is filtered
Piece, can filter out 514nm wavelength light the first optical filter, can filter out 795nm wavelength light the first optical filter and can filter out
First optical filter of the light of 830nm wavelength.
Collimation lens 120 is achromatic doublet, which can eliminate in 400nm-900nm wavelength band
Light color difference, the focal length of collimation lens 120 is 30mm.
Total spectroscope 200 uses total spectroscope shown in Fig. 2 including transmittance section and reflecting part, and the diameter of transmittance section is
3mm。
First cylindrical lens 300 uses achromatism gluing cylindrical lens, can eliminate in 400nm-900nm wavelength band
The color difference of light, the present invention in use thorlabs company ACY254-050-A.
Scan module 400 includes scanning galvanometer 410, the first dichroic beamsplitter 420 and the scanning objective being arranged successively
430.Wherein, scanning galvanometer 410 is reflective scanning mode galvanometer, uses Cambridge Technology company in the present invention
Model 6210H type product, effective optics bore are 3mm.First dichroic beamsplitter 420 is spectrum mirror.Scanning objective
430 be achromatism balsaming lens, uses 400nm to 900nm achromatic lens, focal length 50mm in the present invention.
Flat-field objective 600 eliminates the non-flat field distortion of retina curved surface, and the flat-field objective of Volk company is used in the present invention,
Model VOLK slit-lamp preset lens 66D.
Pupil detection module 700 includes the second dichroic beamsplitter 710, annular light source 720,730 and of the second image-forming objective lens
Face battle array optical detector 740.
Second dichroic beamsplitter 710 is light splitting plain film, the spectrum line and annular light source being emitted according to sighting target module 500
The light beam spectral line of 720 outgoing designs the light splitting membrane system of the second dichroic beamsplitter 710.
The diameter of the intermediate circular through hole of annular light source 720 is 10mm.
Second image-forming objective lens 730 are achromatic doublet, use 400nm-900nm achromatism, focal length in the present invention
For 80mm.
Face battle array photodetector 740 can be surface array charge-coupled device or face battle array complementary metal oxide semiconductor battle array
Column or face battle array photodiode array, the surface array charge-coupled camera of Basler company, Germany, model are used in the present embodiment
DaA1920-30um, pixel are 1920 × 1080, black and white imaging, and frame frequency is per second up to 30 frames.
Sighting target module 500 includes light emitting array 510 and third image-forming objective lens 520.The LED battle array that light emitting array 510 is 8 × 8
Column, the center spacing of two adjacent LEDs are 2mm.Third image-forming objective lens 520 are double glued achromatic lens, focal length 100mm.
Image-forming module 800 includes the second filter set 810, the first image-forming objective lens 820, the second cylindrical lens 830, slit light
Door screen 840 and photodiode array 850.Second filter group includes that can filter out the second optical filter of 500nm wavelength and filter out
Second filter plate of 810nm wavelength.
First image-forming objective lens 820 are achromatic doublet, use 400nm-900nm achromatism, focal length in the present invention
For 100mm.
Second cylindrical lens 830 uses achromatism gluing cylindrical lens, to achromatism in 400nm-900nm wavelength band,
The ACY254-050-A cylindrical lens of thorlabs company is used in the present embodiment.
Slit diaphragm 840 is adjustable slit diaphragm, is stood upright the APAS80-1A of Chinese light in the present embodiment using Beijing, position
It sets and eye ground planar conjugate.
Photodiode array 850 be linear charge-coupled array or linear array complementary metal oxide semiconductor array or
Person's linear array photodiode array uses the line array CCD of BASLER company, model spL2048-140km, line in the present embodiment
Pixel is 2*2048, and pixel dimension is 10 μm of 10 μ m.Continuous light intensity signal is converted to simulation electricity by photodiode array 850
Signal generates synchronizing voltage with scanning galvanometer 410, is delivered to is made of function generation card 410a and image pick-up card 850a together
Control processor, image pick-up card 850a are first modulated scanning synchronizing voltage, frame synchronizing signal are obtained, further according to the frame
The analog electrical signal that synchronization signal exports photodiode array 850 samples, and determines the strength information pair at a certain moment
Which bar line on retina is answered, and finally restores the real-time strong of a certain rectangular area on retina on main control computer 900
Spend information.It is specific as follows:
As shown in Fig. 4 (a), the scanning drive signal of scanning galvanometer 410 is sawtooth signal, needs to be converted framing same
Walk signal.It sees in the present embodiment, the feedback driving signal of zig-zag can be converted by frame synchronizing signal using comparator.
Due to the amplitude of scanning drive signal be it is adjustable according to the requirement of scanning area, so if directly by scanning drive signal
It compares to obtain frame synchronizing signal with a fixed level value, the frame synchronizing signal obtained in this way is that amplitude is relevant, is scanned every time
After the range-adjusting of driving signal, require to provide comparative level again, such operability is too poor.Therefore in the design,
Position signal is compared (shown in such as Fig. 4 (b)) with zero level, obtains scanning synchronization signal (shown in such as Fig. 4 (c)), this
Process is unrelated with the amplitude of scanning drive signal.Scanning synchronization signal is translated further according to actual needs, delay
To obtain a stable frame synchronizing signal (shown in such as Fig. 4 (c)).
In Fig. 4 (c), what D1 was indicated is delay, the pulsewidth for the frame synchronizing signal that D2 is indicated.In Fig. 4 (d), what S was indicated
It is the signal that photodiode array detects, it is herein zero level that V was indicated, which is level reference,.
As shown in Figure 1, from the scanning drive signal that scanning galvanometer 410 exports needing that card 410a occurs by function to modulate
To frame synchronizing signal, the signal that photodiode array 850 exports needs to be modulated using the frame synchronizing signal, then
Input picture capture card 850a is sampled, and picture signal is reconstructed, and output carries out image acquisition to main control computer 900 and shows
Show, image storage, image procossing and analysis, file process etc..
The function card that card 410a uses National Instruments, model NI PCI-6221 occur for function.
Image pick-up card 850a uses the image card of National Instruments, model NI PCI-5122.
It is shown in Fig. 5 and utilizes the side that the retina of subject is imaged in retina image-forming equipment shown in Fig. 1
Method.
As shown in Figure 1, by observe be imaging human eye 11, firstly, system be able to achieve to the retina of human eye 11 into
Line scan imaging function includes at least four functional imagings, specific as follows:
After manually injecting fluorescent sodium dye to subject, argon laser transmitter is opened, passes through the first turntable setting the
One filter set therefrom chooses the first optical filter that can filter out the laser that wavelength is 488nm, and the light beam is through the optical module
Illumination retina is propagated, thus exciting eye bottom uranin dyestuff, while the second filter set is arranged by the second turntable, therefrom
The second optical filter that can filter out that wavelength is 500nm fluorescence is chosen, is realized to retina fluorescein sodium contrast imaging.
Argon laser transmitter is opened, the first filter set is arranged by the first turntable, therefrom choosing wavelength is swashing for 514nm
First optical filter of light, which propagates illumination eyeground through the optical module, while being filtered by the second turntable setting second
Second optical filter is taken out from optical path, imaging beam is allowed directly to pass through by piece group, realizes being imaged without red light to retina.
After manually injecting indocyanine-green dyestuff to subject, semiconductor laser transmitter is opened, the first turntable is passed through
First filter set is set, therefrom chooses the first optical filter that can filter out the laser that wavelength is 795nm, the light beam is through the light
It learns component and propagates illumination retina, thus exciting eye bottom indocyanine-green dyestuff, while the second optical filter is arranged by the second turntable
Group is therefrom chosen the second optical filter that can filter out that wavelength is 810nm fluorescence, is realized to indocyanine-green contrast imaging.
Semiconductor laser transmitter is opened, the first filter set is arranged by the first turntable, wave can be filtered out by therefrom choosing
First optical filter of the laser of a length of 830nm, which propagates illumination eyeground through the optical module, while passing through the second turntable
Second filter set is set, the second optical filter is taken out from optical path, imaging beam is allowed directly to pass through, is realized to the red of retina
Outer light imaging.
The specific operating process of the present invention, as shown in Figure 5:
Booting checks system hardware, and subject is prepared accordingly, if fluorescence imaging need to be carried out, needs manual injection glimmering
Photoinitiator dye.
S1, subject's number of people is placed in Head supporting rack, lights the position for adjusting Head supporting rack according to annular light source 720, so that annular
The cornea for the bright human eye 11 of illumination that light source 720 issues.
The light that S2,11 corneal reflection of human eye are returned focuses entering surface battle array photodetector 740 along paths, realizes to human eye
The real-time monitoring of 11 pupils illustrates that human eye has adjusted the center of optical path when pupil is located among imaging viewing field；
S3, point light source 110 is opened, opens scanning galvanometer 410, opened and card 410a, image pick-up card 850a are occurred by function
The control processor formed with main control computer 900 makes flat-field objective 600 with second for the ametropia defocusing amount of human eye 11
Guide rail generates defocusing compensation amount, compensates the defocusing amount of human eye；
S4, the combination that the first optical filter and the second optical filter that set are chosen according to imaging function, allow subject to keep eye
Eyeball is stablized, and turn-on data capture program acquires video；
S5, the retinal area being imaged as needed light corresponding one on light emitting array 510 by control processor
LED, guidance retina region are illuminated；
S6, so that scanning objective 430 is generated defocus with the first guide rail, illuminate retina different depth layer, obtain retina not
With the 3-D image of depth layer.
It is understood that the principle that embodiment of above is intended to be merely illustrative of the present and the exemplary implementation that uses
Mode, however the present invention is not limited thereto.For those skilled in the art, essence of the invention is not being departed from
In the case where mind and essence, various changes and modifications can be made therein, these variations and modifications are also considered as protection scope of the present invention.
Claims (14)
1. a kind of optical module for retina image-forming, the optical module includes light source module, total spectroscope, imaging mould
Block, scan module and flat-field objective, total spectroscope are arranged between the light source module and the scan module, described flat
In the scan module and by between inspection position, the light source module is used to be used for total spectroscope sending for field object lens setting
The detection light on eyeground is illuminated, the detection light is guided through total spectroscope to the scan module, and via the scanning mould
Block and the flat-field objective directive can be passed through the scan module from the reflection light by inspection position and reached by inspection position
Total spectroscope, and guided by total spectroscope to the image-forming module, the scan module includes scanning objective, described
Scanning objective can be moved back and forth along the central axis of the scanning objective, and the flat-field objective can be along the center of the flat-field objective
Axis moves back and forth, which is characterized in that
Total spectroscope includes light-reflecting portion and the transmittance section that is formed in the light-reflecting portion, and the reflective surface of the light-reflecting portion is towards institute
Scan module is stated, the light source module, total spectroscope, the scan module and the flat-field objective are arranged in first straight line
On, the image-forming module is arranged in the second straight line vertical with the first straight line, so that the light source module issued
The transmittance section can be passed through by detecting light, and the reflected light that the position You Shoujian returns can reflex to the imaging by the light-reflecting portion
Module,
The scan module further includes scanning galvanometer and the first dichroic beamsplitter, and first dichroic beamsplitter described is swept
Object lens are retouched to be sequentially arranged between the scanning galvanometer and the flat-field objective；
The optical module further includes sighting target module, and the sighting target module includes light emitting array and third image-forming objective lens, the hair
Optical arrays include multiple light-emitting components for capableing of independent control, and the light that any one of light-emitting component issues can be injected described
Third image-forming objective lens, and the first dichroic beamsplitter as described in directive after third image-forming objective lens focusing, and by described first
Dichroic beamsplitter reflexes to the flat-field objective,
The optical module further includes pupil detection module, and the pupil detection module includes the second dichroic beamsplitter, annular
Light source and the second image-forming objective lens, the annular light source have the hollow portion for capableing of light transmission,
Second dichroic beamsplitter is arranged between first dichroic beamsplitter and the third image-forming objective lens, passes through
The light of the third image-forming objective lens can pass through second dichroic beamsplitter, and the annular light source is arranged in the flat field
Object lens and it is described by inspection position between, the annular light source can towards by inspection position shine, and the light source module issue
Luminous energy passes through the hollow portion of the annular light source, can pass through in the annular light source from the reflected light by inspection position
Empty portion is irradiated to first dichroic beamsplitter, and reflexes to second dichroic point by first dichroic beamsplitter
The light that first dichroic beamsplitter reflects can be reflexed to second imaging by light microscopic, second dichroic beamsplitter
Object lens.
2. optical module according to claim 1, which is characterized in that the scan module includes the first guide rail, and described the
The extending direction of one guide rail is consistent with the central axial direction of the scanning objective, and the scanning objective is slidably disposed on institute
It states on the first guide rail.
3. optical module according to claim 1, which is characterized in that the optical module includes the second guide rail, and described the
The extending direction of two guide rails is consistent with the central axial direction of the flat-field objective, and the flat-field objective is slidably disposed on institute
It states on the second guide rail.
4. optical module according to claim 1, which is characterized in that the optical module further includes the first cylindrical lens,
First cylindrical lens is arranged between total spectroscope and the scan module, and first cylindrical lens is used for will be saturating
Go out to inject the scan module after crossing total spectroscopical optical beam transformation and becoming Line beam.
5. optical module according to claim 1, which is characterized in that the light source module includes the broadband point being arranged successively
Light source, collimation lens and the first filter set, the broadband point light source are used to issue the broad band laser of multi-wavelength, and described first
Filter set includes multiple first optical filters, the wave for the laser that the quantity of first optical filter and the broadband point light source issue
Long species number is identical, and the laser filter that first optical filter can issue the broadband point light source is at predetermined wavelength
Laser, each first optical filter is detachably provided in the optical path of the optical module；
The image-forming module includes the first image-forming objective lens and the second filter set, and second filter set is arranged in the total score
Between light microscopic and first image-forming objective lens, the light of total spectroscope reflection passes through described in second filter set entrance
First image-forming objective lens, second filter set include multiple second optical filters, and multiple second optical filters are able to
Cross the fluorescence of different wave length.
6. optical module according to claim 5, which is characterized in that the light source module includes the first turntable, and described the
It is provided on one turntable and is set with the one-to-one multiple first optical filtering through-holes of multiple first optical filters, first optical filter
It sets in corresponding first optical filtering through-hole.
7. optical module according to claim 5, which is characterized in that the image-forming module includes the second turntable, and described the
It is provided on two turntables and is set with the one-to-one multiple second optical filtering through-holes of multiple second optical filters, second optical filter
It sets in corresponding second optical filtering through-hole.
8. optical module according to claim 5, which is characterized in that the broadband point light source include argon laser transmitter and
Semiconductor laser transmitter, the argon laser transmitter can emission center wavelength be 488nm broad band laser and central wavelength
For the broad band laser of 514nm, the semiconductor laser transmitter being capable of broad band laser and center of the emission center wavelength for 795nm
Wavelength is the broad band laser of 830nm；
First filter set includes that can filter out the first optical filter that wavelength is 488nm laser, can filter out wavelength to be
First optical filter of the laser of 514nm, the first optical filter that the laser that wavelength is 795nm can be filtered out and wavelength can be filtered out it is
First optical filter of the laser of 830nm；
Second filter set includes that can filter out the second optical filter that wavelength is 500nm fluorescence and can filter out wavelength to be
Second optical filter of 810nm fluorescence.
9. optical module as claimed in any of claims 1 to 8, which is characterized in that the pupil detection module is also
Including face battle array optical detector, the face battle array optical detector is used to receive the light that second image-forming objective lens issue.
10. optical module according to claim 9, which is characterized in that the transmissivity of second dichroic beamsplitter is small
In the reflectivity of second dichroic beamsplitter.
11. the optical module according to any one of claim 5 to 8, which is characterized in that the image-forming module further includes
In the second cylindrical lens, slit diaphragm and the photodiode array that the light emission side of first image-forming objective lens is successively arranged,
In, the slit diaphragm, the broadband point light source and it is described by inspection position be in conjugate position.
12. optical module according to claim 11, which is characterized in that the slit width of the slit diaphragm is equal to described
The Airy spot diameter of first image-forming objective lens.
13. a kind of retina image-forming equipment, which is characterized in that the retina image-forming equipment includes optical module and processor,
The optical module is optical module described in any one of claim 1 to 12, and the processor includes that image generates mould
Block, described image generation module are used to generate corresponding image according to the light being emitted from the image-forming module.
14. retina image-forming equipment according to claim 13, which is characterized in that described image generation module is also used to root
Corresponding image is generated according to the light that second image-forming objective lens issue.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019534783A JP7421175B2 (en) | 2016-05-31 | 2017-12-14 | Optical unit and retinal imaging device used for retinal imaging |
| US16/471,846 US11583180B2 (en) | 2016-05-31 | 2017-12-14 | Optical component for retinal imaging and retina imaging device |
| PCT/CN2017/116197 WO2018113585A1 (en) | 2016-05-31 | 2017-12-14 | Optical component for retinal imaging and retina imaging device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016103793752 | 2016-05-31 | ||
| CN201610379375 | 2016-05-31 |
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| CN107126189A CN107126189A (en) | 2017-09-05 |
| CN107126189B true CN107126189B (en) | 2019-11-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611182890.8A Active CN107126189B (en) | 2016-05-31 | 2016-12-20 | Optical module and retina image-forming equipment for retina image-forming |
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| Country | Link |
|---|---|
| US (1) | US11583180B2 (en) |
| JP (1) | JP7421175B2 (en) |
| CN (1) | CN107126189B (en) |
| WO (1) | WO2018113585A1 (en) |
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| CN107126189B (en) | 2016-05-31 | 2019-11-22 | 瑞尔明康（杭州）医疗科技有限公司 | Optical module and retina image-forming equipment for retina image-forming |
| CN108371540A (en) * | 2018-01-22 | 2018-08-07 | 深圳盛达同泽科技有限公司 | Retina digital imaging system and retina digital imaging instrument |
| CN108324240A (en) | 2018-01-22 | 2018-07-27 | 深圳盛达同泽科技有限公司 | Fundus camera |
| CN108378825A (en) * | 2018-03-23 | 2018-08-10 | 张栋 | A kind of medical four colors multispectral imaging method and apparatus that black and white one camera is realized |
| CN110893094A (en) * | 2018-09-12 | 2020-03-20 | 瑞尔明康（杭州）医疗科技有限公司 | Optical assembly and retinal imaging device |
| CN109222886B (en) * | 2018-11-16 | 2024-04-12 | 苏州巨目光学科技有限公司 | Diopter adjustable regulating eye |
| CN109381159A (en) * | 2018-11-20 | 2019-02-26 | 温州医科大学附属眼视光医院 | Funduscopy system |
| CN110115559B (en) * | 2019-03-07 | 2024-01-23 | 中国科学院苏州生物医学工程技术研究所 | Fundus multimode synchronous imaging system |
| CN110584592B (en) * | 2019-09-09 | 2021-06-18 | 中国科学院苏州生物医学工程技术研究所 | Large-field-of-view adaptive optical retina imaging system and method for common-path beam scanning |
| JP7638067B2 (en) * | 2020-03-13 | 2025-03-03 | 株式会社トプコン | Ophthalmic device, control method thereof, and program |
| EP4294252B1 (en) * | 2021-03-22 | 2026-03-11 | The Medical College of Wisconsin, Inc. | Laser-speckle contrast imaging system and method |
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| CN114587268A (en) * | 2022-04-06 | 2022-06-07 | 上海观爱医疗科技有限公司 | Full-automatic optometry topographic map instrument and optometry method |
| CN116616695B (en) * | 2023-04-07 | 2024-05-14 | 瑞尔明康(浙江)医疗科技有限公司 | Method for acquiring human eye optical characteristics, large field of view optometry device and optometry system |
| CN118717029B (en) * | 2024-09-02 | 2024-11-12 | 中国科学院长春光学精密机械与物理研究所 | Retinal defocus detection device and method based on human eye wavefront and retinal imaging |
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Also Published As
| Publication number | Publication date |
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| JP2020503117A (en) | 2020-01-30 |
| US20200214558A1 (en) | 2020-07-09 |
| WO2018113585A1 (en) | 2018-06-28 |
| JP7421175B2 (en) | 2024-01-24 |
| CN107126189A (en) | 2017-09-05 |
| US11583180B2 (en) | 2023-02-21 |
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