CN107050136A - Treat the nanometer emulsifiable paste of neurodermatitis - Google Patents

Abstract

The invention discloses a Shenpiling nano-cream, which belongs to the technical field of fine chemical small product cream configuration production. Control neurodermatitis class nano-emulsion by described scorpion snake oil and Fructus Cnidii white tinea skin, black snake viper gallbladder, Fructus Kochia Cnidii controls neurodermatitis, eczema, genital itching, external liniment for psoriasis, capsule Composition of nano cream and Huang Dan Phellodendron cortex for treating neurodermatitis stubborn ringworm. Neurodermatitis is a common pruritic skin disease clinically characterized by lichenification and severe itching. It is difficult to be cured by general treatment. The present invention basically uses ultra-fine and nano-sized crushing technology based on traditional clinical experience to increase the penetration of traditional Chinese medicine. The large area of action has stronger and wider efficacy, and the bioavailability and clinical efficacy have brought breakthroughs in the clinical practice of traditional Chinese medicine and achieved unexpected results in the treatment of neurodermatitis.

Description

Nano cream for neurodermatitis

Technical field:

The invention discloses a Shenpiling nano-emulsion, which belongs to the technical field of preparation and production of nano-emulsion, a small fine chemical product.

Background technique:

Shenpiling nano-emulsion is a nano-emulsion made by modern high-tech nano-powder pulverization, colloidal grinding, homogeneous emulsification, which is specially used for the treatment of neurodermatitis.

Neurodermatitis, also known as chronic lichen simplex, is a common chronic pruritic skin disease characterized by skin lichenification and severe itching. The etiology is not very clear, but it is mostly related to neuropsychiatric factors, such as excessive excitement or anxiety, excessive sadness, etc. The main clinical manifestations are severe pruritus, and after scratching, skin hypertrophy and mossy changes may follow after skin grooves deepen. Clinically, there are limitations and generalizations, and limitations are more common.

Western medicine mainly adopts systemic treatment, local treatment and physical therapy. Traditional Chinese medicine calls it "sheling sore" or "psoriasis". It is mostly caused by wind-damp accumulation, stagnation of the liver into fire, and coquettish blood deficiency.

Invention content:

The object of the present invention is to provide a kind of Shenpiling nano-emulsion.

The technical solution of the present invention is.

1, a kind of Shenpiling nano emulsifiable cream, it is characterized in that: described scorpion snake oil controls neurodermatitis, forms % by following mass proportioning

Preparation:

The above materials except vaseline and musk are pulverized into 60-mesh coarse powder and 8 times of water to make a suspension, and then uniformly refined with a homogeneous emulsifier, and processed with a nano-sized particle size ultra-fine micronization device to make a particle size Small molecules with nanoparticle size of 0.1-2μm can quickly enter the blood through the skin, pores, and sweat gland pores, improving and enhancing the bioavailability and clinical efficacy of the drug, and bringing breakthrough and unexpected effects to the clinical practice of traditional Chinese medicine. Add Vaseline to Vaseline and heat to 60°C, stir evenly, add musk powder, and finally add musk powder and continue stirring until cold to prepare a nano-cream for treating neurodermatitis.

How to use: Apply a little ointment on the gauze, apply it on the affected area and bandage it properly, once a day, or change it every 2-3 days. If you take too much medicine, it is easy to form herpes reaction in the local area. During the treatment, you should not eat spicy and irritating food.

Indications: neurodermatitis.

Clinical curative effect: A total of 32 cases were treated and all were cured.

Experience: Sulfur iodine detoxifies and kills insects, relieves itching and dries dampness, cooperates with arsenic and stone corrosion to attack poison, expresses the expression of medicine, scorpion, burdock, cicada slough, dispels wind and disperses stagnation, dredges collaterals and quenches wind, adjuvant with Panax notoginseng and musk to promote blood circulation Dispersing blood stasis, priming medicine infiltration, stagnation in blood circulation. This product has the functions of drying dampness and dispelling cold, promoting blood circulation and detoxification. Although it is toxic, no adverse reactions have been found in clinical application.

2, a kind of Shenpiling nano emulsifiable cream, it is characterized in that: described cnidium fructus alba skin controls neurodermatitis, forms % by following mass proportioning

Preparation:

Except for the yellow wax and rosin snake oil, the above materials are all made into nano powder with a particle size of 0.1-2 μm by nano-grinding technology. Boil the viper oil and remove from the fire, then add yellow wax and rosin, and add the prepared powder when the medicine is cooled to 50°C. A good nano-mixed powder needs to be stirred quickly to make the nano-powder evenly distributed, and then cooled, bottled and packaged for storage.

Instructions:

When using it, first apply a circle of Vaseline around the lesion, the purpose is to protect the surrounding normal skin, then apply a layer of 1-1.5mm thick Shenpiling nano-cream on the lesion, and then wrap it with gauze once a day for 6 consecutive days , withdrawal for 1 day, 14 days as a course of treatment.

This prescription can dry dampness, relieve itching and kill insects, and has a good curative effect on localized neurodermatitis and itching that severely affect sleep and workers.

3. A nano-emulsion of Shenpiling, characterized in that: the skin of the black snake Viper for neurodermatitis is composed of the following proportions by mass: %

Wherein (1) nanocapsule powder, is made up of following mass parts proportioning

Preparation:

The above substances are extracted with conventional carbon dioxide or with 60% alcohol, extracted by the extraction method, evaporated by thin film, recovered alcohol, and concentrated into a 1:1 stream containing 1g of the original crude drug per milliliter and a relative density of 1.03-1.05 For extract. When in use, the liquid extract is vacuum-dried and ground into fine powder and mixed with other materials, and the mixed material is crushed, emulsified, homogenized, and dispersed with a nano-sized ultra-fine general-purpose device to granulate it into nano-sized particles. Small molecules with a diameter of 2000-2600 mesh, the central particle size is 0.1-2μm, because the absorption of drugs is often dominated by the dissolution rate of the drug absorption site, and reducing the particle size can increase the surface ratio exposed to the medium Area, and promote dissolution, thereby improving the absorption and utilization of drugs, increasing the efficacy and therapeutic effect. The prepared nanopowder is packed into capsules.

Usage: 0.5g per capsule, 1-2 times per person per day, two capsules each time, two weeks as a course of treatment, generally one course of treatment at the same time externally apply nano-cream and externally apply Shenpiling nano-cream 2-3 times a day , has a better effect.

(2) The preparation method of Shenpiling nano-emulsion is to form according to the following mass parts proportioning

Preparation:

Mix the above-mentioned materials that have been ground into nano-powder with vaseline to make Shenpiling nano-cream, apply it to the skin lesions 2-3 times a day, use it for one week, stop the drug for 3-5 days, and use it for another week, usually 3-3 times a day. 5 weeks to heal.

Brief analysis of prescriptions: in the prescription, Dilong is salty and cold, clearing away heat and dredging collaterals; black snake is sweet and flat in nature and non-toxic, dispelling wind, dredging collaterals and relieving itching. Snake skin can cure stubborn skin diseases.

Tribulus terrestris dispels wind and relieves itching, and is often used in the treatment of scaly or itchy skin diseases; Donglingcao clears away heat and reduces inflammation; Wind; Atractylodes expelling wind and dampness; baicalein in Scutellaria baicalensis and total alkaloids in Sophora flavescens have strong anti-allergic effects; Shouwu nourishes kidney and nourishes yin, strengthens the body and strengthens the body; Jiaohawthorn eliminates food and stomach. Combination of various medicines can treat both symptoms and root causes, that is, to remove wind-heat on the outside, and clear blood heat inside, strengthen the body and nourish yin. It needs to be applied flexibly according to the condition in clinical practice.

Medical record example: Chai, female, 30 years old, went to see a doctor on April 5, 2015. Whole body skin pruritus 5 years, increases the weight of every winter and spring, food is not delicious, also can't sleep, miserable. He was treated in hospitals in Beijing, Shanghai and other places. He used chlorpheniramine, astemizole, diphenhydramine, dexamethasone, calcium gluconate, oxypicuramin and traditional Chinese medicine successively. lasting. In recent months, severe itching, skin thickening in the neck, elbow fossa, and popliteal fossa, irritability, dry mouth, poor appetite, insomnia all night, general weakness, red tip of the tongue, less coating, rapid pulse. It becomes blood-heat, which is abundant inside, and is attacked by wind evil outside, and the wind-heat stagnates on the skin surface. Control when removing heat from blood and detoxifying, expelling wind and relieving itching. Yulongshe Xiaoitching Soup Flower Contains: Earthworm, Blackhead Snake, Angelica, Sophora flavescens each 15g, Radix Orbis terrestris, Tribulus terrestris, Shengdi, Licorice each 10g, Lithopsia cassia mother-of-pearl each 40g, (decoction first) daily 1 dose, decoct in water, apply Shenxiaoling nano cream for external use, 3 times a day. Follow-up consultation after 3 days: the itching is greatly reduced, and the patient can rest for several hours at night. The effect was not improved, and another 3 doses were administered, and the daytime itching was mostly confined to the neck, limbs, and tail sacrum. Another 5 doses were given, scratches and blood stains were found on most of the calves, but the skin on the neck, elbow fossa, popliteal fossa, and coccyx was dry and desquamated. After another 3 doses, she used Shenpiling nano cream for external rubbing, and she was told that the disease had recovered after 10 days, and no recurrence was found in the follow-up after half a year.

[Addition and subtraction] If the blood heat is obvious, remove Cangzhu, Chuanqiong, and add paeonol, comfrey; for severe itching accompanied by upset and insomnia, add gardenia, twig, mother of pearl, and cassia; for hypertrophic skin lesions, add Centipede, Danshen, and whole insects; for those with long course of disease and weak body, add skullcap, heterophylla, and sealwort; add Pueraria root for skin lesions on the neck; Indications: neurodermatitis.

4, a kind of Shenpiling nano-emulsion, it is characterized in that: described Kochia Cnidium controls neurodermatitis eczema vulva pruritus psoriasis, forms % according to the following mass distribution ratio

Wherein (1) outer coating nano-milk tincture is made up of following mass parts

Preparation:

The above-mentioned traditional Chinese medicine is made into nanometer powder, added into alcohol and then added with Baijiangdan musk.

This product has the functions of expelling wind and clearing heat, detoxifying and relieving itching, promoting blood circulation and dispelling blood stasis, antibacterial and anti-inflammatory.

Indications: localized neurodermatitis. It is also effective for chronic eczema, genital pruritus, and prurigo nodularis.

Usage: Use a cotton ball dipped in this product to rub the affected area several times a day. It can also be used to add appropriate amount of water to the nano-powder. After decocting, soak or fumigate the affected area while it is hot. One dose per day, each dose can be used 2-3 times, 30 minutes each time.

Brief analysis of prescriptions: in the prescription, Sophora flavescens clears heat, detoxifies and dehumidifies, Kochia scoparia disperses wind and relieves itching, Cnidium chinensis and alum dry dampness and kill insects, pepper warms yang and dredges collaterals. Decoction and hot washing of various medicines can dredge the veins, flow Qi and blood, and have the effect of softening skin lesions, removing evil and relieving itching.

Addition and subtraction: add Speranthum 60g for stubborn skin lesions; add Smilax smilax 30g for lesions in the genitals; add 20g for those with anal lesions.

Medical record example: Tan, female, 24 years old, worker. First visit on June 5, 2014. Chief complaint: "ringworm" in the cervical spine for 2 years. Examination: There is a mossy area of about 4cm*3cm in the back of the cervical spine. The skin of the affected area is rough and thick, with scratches and blood scabs on the surface.

(2) Qufengjiedu Shenpiling nano cream, composed of the following proportions by mass

Preparation:

The above-mentioned materials are made into nano-powder capsules with a particle size of 0.1-2 μm, each 0.5 g, and taken with warm boiled water. Avoid spicy, pungent, alcoholic and greasy products during the medication period.

Get above-mentioned traditional Chinese medicine nano-powder 20g and add with white vaseline or Viper oil 80g and be mixed with 20% nano-emulsion, heat and stir to make Shenpiling snake oil nano-emulsion and apply 2-3 times a day until fully recovered.

Indications: Psoriasis

Brief analysis of prescriptions: This prescription uses Siwu decoction to nourish blood and nutrition, uses ephedra, almond, windproof, and Kochia to dispel wind, disperse the lungs and support the body, and uses flavescens, Qingdai, tinea skin, Phellodendron, centipede, and licorice to clear away heat and detoxify . Pit Viper meat dispels wind, relieves itching and moisturizes dryness.

Addition and subtraction: add yellow for stomach fire and constipation; add pinellia and melon wilt for cough and excessive phlegm; add gall grass and gardenia for hyperactivity of heart fire;

5. A Shenpiling nano-emulsion, characterized in that: the Huangdan Phellodendron treats neurodermatitis and tinea, and is composed of the following proportions by mass: %

Preparation:

The ultra-fine powder of the above-mentioned traditional Chinese medicine is made into a nano-powder with a particle size of less than 0.1-2 μm by using a homogeneous emulsifier ultra-fine nano-pulverization device, adding snake oil and petroleum jelly, heating to 85°C and stirring evenly, and preparing a nano-cream for external use.

This product has the functions of killing parasites and relieving itching, drying dampness and detoxification, and is used for treating stubborn tinea neurodermatitis.

The present invention makes full use of natural animal and plant medicines in the natural world, on the basis of inheriting traditional Chinese medicines to treat neurodermatitis, and makes full use of the Shenpiling nano-cream made by modern nano-pharmaceutical technology, which is applied in clinic to obtain better results.

We know that nanotechnology has been widely used in many fields since its inception, and breakthroughs have been made. Its penetration and influence on the field of pharmacy is obvious. Studies have shown that the application of nano-biotechnology can improve the absorption of drugs, change the transport process of drugs in the human body, and enhance the efficacy of drugs. Nanoparticles can be used as delivery carriers for various drugs such as DNA, antineoplastic drugs, proteins and peptides. In the 21st century with the theme of life science, nanotechnology will be further closely integrated with pharmaceutical science to promote the rapid development of pharmaceutical research.

Natural botanical medicines are used in the treatment of neurodermatitis. It is a kind of external rubbing, coating, applying, washing, and showering that modern Chinese medicine creams go towards to avoid the toxic and side effects and adverse reactions of chemical medicines. The development trend of modern Chinese medicine cosmetics that vascular permeation and absorption achieves moisturizing and beautifying skin. It is known that the absorption of drugs is often dominated by the dissolution rate of the drug at the absorption site, and reducing the particle size can increase the surface area exposed to the medium to promote dissolution, thereby improving the absorption of the drug; the macromolecules of the drug are granulated into nano Small molecules at the particle size level can enter or penetrate the interstitial space through the sweat glands of the skin pores, and can also enter the body through the smallest capillaries of the human body and distribute widely, thus greatly improving the bioavailability of the drug. Due to the smaller particle size and larger surface area of nanomedicine, the adhesion to biofilm is improved, so it is beneficial to increase the contact area between the drug and the skin and prolong the contact time, which is conducive to absorption and improves the bioavailability of externally applied drugs. Therefore, the use of natural herbal medicines in the treatment of various intractable skin diseases must follow the development path of modern nanotechnology.

Below in conjunction with implementation example the present invention is further clarified:

Specific implementation method:

Embodiment 1: a kind of Shenpiling nano-emulsion is characterized in that: described scorpion snake oil controls neurodermatitis, forms % by following mass proportioning

Embodiment 2: a kind of Shenpiling nano emulsifiable cream is characterized in that: described Cnidiac Fructus Fructus Rhizoma Cnidii Cortex is controlled neurodermatitis, forms % by following mass parts proportioning

Embodiment 3: a kind of Shenpiling nano emulsifiable cream is characterized in that: the described black snake halys halys skin controls neurodermatitis, forms % according to the following mass parts proportioning

Wherein (1) nanocapsule powder, is made up of following mass parts proportioning

(2) The preparation method of Shenpiling nano-emulsion is to form according to the following mass parts proportioning

Embodiment 4: a kind of Shenpiling nano emulsifiable cream is characterized in that: said Fructus Kochia Cnidii controls neurodermatitis eczema vulva pruritus psoriasis, forms % by following mass distribution ratio

Wherein (1) outer coating nano-milk tincture is made up of following mass parts

(2) Qufengjiedu Shenpiling nano cream, composed of the following proportions by mass

Embodiment 5: a kind of Shenpiling nano-emulsion is characterized in that: described Huang Dan Phellodendron Phellodendron treats neurodermatitis stubborn ringworm, forms % by following mass proportioning

Claims (5)

1. a kind of Shenpiling nano emulsifiable cream is characterized in that: described scorpion snake oil controls neurodermatitis, forms % by following mass proportioning 2. a kind of Shenpiling nano emulsifiable cream is characterized in that: described Cnidium Fructus Cnidii alba skin controls neurodermatitis, forms % by following mass parts proportioning 3. A kind of Shenpiling nano emulsifiable cream, it is characterized in that: described black snake Agkistrodon halys skin controls neurodermatitis, forms % by following mass proportioning Wherein (1) nanocapsule powder, is made up of following mass parts proportioning (2) The preparation method of Shenpiling nano-emulsion is to form according to the following mass parts proportioning 4. a kind of Shenpiling nano emulsifiable cream is characterized in that: described Kochia Cnidii controls neurodermatitis eczema vulva pruritus psoriasis, forms % by following mass distribution ratio Wherein (1) outer coating nano-milk tincture is made up of following mass parts (2) Qufengjiedu Shenpiling nano cream, composed of the following proportions by mass 5. A kind of Shenpiling nano emulsifiable cream, it is characterized in that: described Huang Dan Phellodendron treats neurodermatitis stubborn ringworm, forms % by following mass proportioning