CN106615689A - Intestine health-caring agent used for improving production performances of weak stiff pigs, as well as preparation method and usage method thereof - Google Patents
Intestine health-caring agent used for improving production performances of weak stiff pigs, as well as preparation method and usage method thereof Download PDFInfo
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Abstract
The invention belongs to the field of feed additives, and especially discloses an intestine health-caring agent used for improving production performances of weak stiff pigs, as well as a preparation method and a usage method thereof. The intestine health-caring agent used for improving the production performances of the weak stiff pigs comprises the following ingredients in parts by weight: 1-3 parts of chito-oligosaccharides, 4-6 parts of vitamin C, 5-10 parts of whey protein, 5-8 parts of lactic acid powder, 4-6 parts of lysine, 10-20 parts of tryptophan, 1-3 parts of inosine, 0.3-0.5 part of vitamin B1, 3-8 parts of citric acid, 2-5 parts of sodium chloride, and the balance anhydrous glucose so as to make the total parts by weight to 100 parts. On basis of the symptoms and the characteristics of the weak stiff pigs, the intestine health-caring agent activates body functions of the weak stiff pigs from various aspects, so that the intestine health-caring agent is capable of improving body immunity and enhancing disease resistance of the weak stiff pigs. The intestine health-caring agent used for improving the production performances of the weak stiff pigs is safe, effective, free of residues, and free of disease resistance.
Description
Technical field
The invention belongs to feed additive field, and in particular to a kind of enteron aisle health-care agent of the weak cad pig production performance of raising and
Its preparation method and using method.
Background technology
Weak cad pig is the swinery classification that a pig farm cannot prevent, and this part pig feed intake is low, is grown extremely slow,
The ratio normal pig even having is delivered for sale for late 2-3 month, and raising the weak cad pig in this part only can cause in pig farm human and material resources, financial resources
Waste, so this part pig very reluctantly have to be carried out harmless treatment by some pig farms, so directly affect pig benefit.
Forming the main cause of weak cad pig has：1st, most direct the reason for is to recover bad after morbidity, particularly intestines and stomach class
Disease, such as virus diarrhea, meeting major injury intestinal villus, destroy intestinal microecology flora, cause serious flora imbalance, digestion
Malabsorption, so as to cause nutriment can not by good digestion, absorption, utilize and form weak cad pig.2nd, it is chronic debilitating
Disease：Such as chronic hyperplastic enteritis, PCV-II, streptococcus, consume for a long time nutrition, or because sick and weak feed intake declines, all can
Form weak cad pig.3rd, nutrition supply is uneven：Lack protein, mineral matter, trace element and vitamin in sow diets, cause
Fetus congenital development is not enough, and nutrition supply is uneven, affects sow milk water quality, causes piglet production bad.4th, indivedual pig farms
Do not note the genetic connection of pig, inbreeding can cause offspring's kind to degenerate, affect later period growth and development.5th, size is inhomogenous
Pig is closed when same column home is raised, and weak pig is robbed less than feed, and feed intake is not enough, it is impossible to meet the growth needs of pig.6th, inside and outside
Parasitic disease：Such as roundworm, lung filaria, whipworm, fasciolopsis, acarid, kidney worm (Eustrongylus gigas), the infection of pig louse, so as to hinder the normal of pig
Grow.
Weak cad pig is poor due to itself physique, and vitality is fragile, and while management difficulty is increased, its incubation rate is low, causes
Sow and the waste of feed, increase feeding and management cost, reduce sow plant productivity, and weak cad pig is used as epidemic disease Risk factor
In susceptible animal, the pathogenic microorganism originally with swinery in stable state is made, after infecting weak cad pig so as to present and cause a disease
Property, increase transmission of disease probability.So how could solve the problems, such as weak cad pigIf the weak cad pig in this part can be made short
Deadlock is taken off in time, raising output capacity can be played, increase the purpose of pig effect.
The content of the invention
To overcome existing weak cad pig to take off weak/stiff difficult problem, the purpose of the present invention aims to provide a kind of weak cad pig productivity of raising
Enteron aisle health-care agent of energy and preparation method thereof and using method.
For achieving the above object, the technical scheme that the present invention takes is as follows：
A kind of enteron aisle health-care agent for improving weak cad pig production performance, in terms of parts by weight, is made up of following components：Chitosan oligosaccharide 1-3
Part, vitamin C 4-6 parts, lactalbumin 5-10 parts, lactic acid powder 5-8 parts, lysine 4-6 parts, tryptophan 10-20 parts, inosine 1-3
Part, Cobastab10.3-0.5 parts, citric acid 3-8 parts, sodium chloride 2-5 parts, DEXTROSE ANHYDROUS adds to 100 parts.
The present invention activates from every side the physical function of weak cad pig according to the symptom and feature of weak cad pig, improves body and exempts from
Epidemic disease power, strengthens resistance against diseases, safely and effectively, and noresidue, have no drug resistance.Wherein, prescription compatibility of medicines mechanism is：
Chitosan oligosaccharide, is that a kind of degree of polymerization for obtaining the special biological enzyme technology degradeds of shitosan Jing oligosaccharides between 2 ~ 20 is produced
Product, molecular weight≤3200Da is the water-soluble preferable, low molecular weight product that function is big, biologically active is high.Chitosan oligosaccharide tool is anti-
Oxidation, antibacterial activity, anti-inflammatory promote the multiple pharmacological effects such as wound healing, immunological regulation, strengthen immunity.Life is improved to pig
Long performance, the absorption for reducing the death rate, promoting nutriment, the effect of raising immunity of organisms.
Vitamin C, is that antibody and collagen are formed, tissue repairing（Including some redoxes）, phenylalanine, junket ammonia
Acid, the metabolism of folic acid, iron, the utilization of carbohydrate, fat, the synthesis of protein maintain immunologic function, hydroxylation and hydroxyl color
Amine, keeps the complete of blood vessel, promotes the institute such as nonheme iron absorption required.Gut barrier function destruction caused by induced by endotoxin
There is obvious therapeutic action, can substantially reduce bacterial translocation incidence and the bacterium amount of migrating, data display vitamin C is viscous to intestines
The curative effect of envelope barrier destruction is substantially better than the intestinal mucosal barrier destruction caused by endotoxin, and oral and two kinds of medications of intravenously administrable
Approach is compared, and oral route is better than intravenous route.
Lactalbumin（whey protein）It is referred to as the king of albumen, is a kind of protein extracted from milk, has
Be of high nutritive value, absorption easy to digest, containing various active composition the features such as, be generally acknowledged human body good protein replenishers it
One.First, in various protein, the nutritive value of lactalbumin is highest.Second, lactalbumin is easier to digested suction
Receive, lactalbumin contains 60% in breast milk, and casein contains 40%.3rd, in lactalbumin fat, lactose content it is low, but it contain β-
Lactoglobulin, ALA, immunoglobulin (Ig), also other various active compositions.
Lactic acid powder, not only can reduce the pH value of gastric content and feed, and with special fragrance, can improve son
The feed intake of pig.Lactic acid can suppress colibacillary breeding in enteron aisle, and Escherichia coli are endotoxic main sources, stress bar
Under part, intestinal mucosal permeability increases, and endotoxin causes inflammatory reaction into blood, the use of acidulant is to suppress pathogenic microorganism
One of approach, pathogenic microorganism is difficult breeding under low ph value.And the beneficial bacterium such as lactic acid bacteria is adapted to grow at low ph values, addition breast
After acid, the Bacillus acidi lactici quantity of intestinal mucosa adhesion increases, and the Bacillus acidi lactici on intestinal mucosa is effectively supported by occupy-place and repulsive interaction
The invasion of imperial pathogenic microorganism, ensures the safety of stiff piglet.
Lysine, enhancing development strengthens immunologic function, improves a poor appetite.It is the requisite composition portion of protein
Point, the growth and development appropriate for body serves important function.Body is unable to rely after synthetic lysine, and deaminizating in itself
Propylhomoserin can not update recovery, can not be replaced by any similar amino acid, so, lysine is most easy in pig feed
One of amino acid of shortage.
Tryptophan, this product is important nutritional agents, may participate in the renewal of plasma proteins in animal body, and can promote core yellow
Element plays a role, and additionally aids the synthesis of nicotinic acid and ferroheme, pregnant animal fetus internal antibody can be dramatically increased, to lactation period
Cow and sow have promotion galactogogue action.When livestock and poultry lack tryptophan, growth retardation, Body weight loss, Fat Accumulation is reduced,
Sire orchiatrophy.
Inosine, participates in nucleic acid in vivo metabolism, and energetic supersession and protein synthesize, and activate pyruvate oxidation enzyme system, improve auxiliary
The activity of enzyme A, can make the histocyte under low energy anaerobic condition proceed metabolism.Inosine contributes to wounded hepatocytes work(
The recovery of energy, can also stimulate produce in vivo antibody, and improve absorption of the enteron aisle to iron.
Cobastab1, the normal function of maintenance nerve fiber, heart and digestive system is played an important role.During shortage,
Pyruvic acid, lactic acid increase in blood, and affect human body energy to supply, and polyneuritis, myocardial dysfunction, digestion occur not
Good, growth retardation etc..
Citric acid, is the most important constituent of tricarboxylic acid cycle in animal body, has in pig and adjusts gastric emptying speed
Degree, promotion nutrient digestion absorb and reduce the effect such as injury of gastrointestinal tract by reducing gut pH, can adjust as pig feed
Section agent.Citric acid has the effect that：1st, the acidity in animal stomach is improved, pepsin activity is improved, so as to increase body pair
The digestion of protein.2nd, promote the breeding of lactic acid bacteria beneficial bacterium, suppress to be harmful to micro- life in the alimentary canals such as Escherichia coli, staphylococcus
The breeding of thing, so as to reduce the generation of grice diarrhoea.3rd, play block effect to the metal ion in feed, become feed anti-oxidant
Agent, also can in vivo promote conversion of the oxidized form glutathione to Reductive glutathione as animal body antioxidase.4、
ATP can promptly be synthesized under stress situation, so as to improve the anti-stress ability of animal.
Sodium chloride, electrolyte complementary medical, for adjusting internal fluid and electrolyte balance.In animal body, sodium is extracellular
Particularly important cation in liquid, is to maintain the important component of extracellular fluid osmotic pressure and capacity.Sodium ion is in extracellular fluid
Normal concentration, be maintain cell excitability, the necessary condition of nervomuscular irritability.In vivo a large amount of sodium of losing can cause low
Sodium syndrome, shows as asthenia universalis, muscle clonic spasm, dyshaemia etc., heavy then dead.
The preparation method of enteron aisle health-care agent of the present invention, step is as follows：
（1）, by lactalbumin, lactic acid powder, lysine, tryptophan, citric acid according to adding proportion premix be combined into premix A；
（2）, by Cobastab1, vitamin C according to adding proportion premix be combined into premix B；
（3）, by chitosan oligosaccharide, inosine according to adding proportion premix be combined into premix C；
（4）, premix A, premix B, premix C, sodium chloride, DEXTROSE ANHYDROUS be well mixed, obtain final product enteron aisle guarantor
Strong agent.
The using method of enteron aisle health-care agent of the present invention：
1st, mix fodder using method：Enteron aisle health-care agent 700-800g of the present invention is watered 20-40kg, pours and mixes piglet feed 60-80kg,
Feed weak cad pig, free choice feeding, it then follows from less to more, gradually the principle of dosage, is defined in hopper without residue, 4- is fed daily
6 times, feeding time is 15-25 days；
2nd, drinking-water using method：Enteron aisle health-care agent 700-800g of the present invention is watered 70-80kg, pours into pig house specialized water tank and passes through
Drinking-water line allows weak cad pig free water, and the drinking-water time is 15-25 days.
The present invention has the advantage that and beneficial effect：（1）The present invention can improve body intestinal environment, strengthen resistance against diseases；
（2）Various nutrition needed for the weak cad pig of present invention supplement, improve immunity of organisms；（3）Inventive mixture is rich with raw material sources
Richness, and production technology is easy；（4）Inventive mixture is readily absorbed by into after body, and clinical feeding is convenient, is adapted to colony
Use, use manpower and material resources sparingly；（5）Active constituent content of the present invention is clearly, accurate to amount, quality controllable.
Specific embodiment
Explanation, but the protection model of the present invention are further explained to technical scheme with reference to specific embodiment
Enclose and be not limited thereto.
Embodiment 1
Formula（Weight portion）：1 part of chitosan oligosaccharide, 4 parts of vitamin C, 10 parts of lactalbumin, 8 parts of lactic acid powder, 4 parts of lysine, tryptophan
10 parts, 2 parts of inosine, Cobastab10.3 part, 8 parts of citric acid, 4 parts of sodium chloride, DEXTROSE ANHYDROUS add to 100 parts.
Preparation method：
（1）, by the metastable lactalbumin of physicochemical property, lactic acid powder, lysine, tryptophan, citric acid according to adding proportion
Premix is combined into premix A；
（2）, by active component Cobastab1, vitamin C according to adding proportion premix be combined into premix B, to ensure vitamin
Activity；
（3）, by micro constitutent chitosan oligosaccharide, inosine according to adding proportion premix be combined into premix C, to ensure mixture homogeneity；
（4）, by premix A, premix B, premix C, sodium chloride, DEXTROSE ANHYDROUS be placed in stainless steel mixer mix
Close uniform, obtain final product enteron aisle health-care agent.
Embodiment 2
Formula（Weight portion）：2 parts of chitosan oligosaccharide, 6 parts of vitamin C, 5 parts of lactalbumin, 6 parts of lactic acid powder, 5 parts of lysine, tryptophan
15 parts, 3 parts of inosine, Cobastab10.5 part, 5 parts of citric acid, 3 parts of sodium chloride, DEXTROSE ANHYDROUS add to 100 parts.
Preparation method is with embodiment 1.
Embodiment 3
Formula（Weight portion）：3 parts of chitosan oligosaccharide, 5 parts of vitamin C, 6 parts of lactalbumin, 7 parts of lactic acid powder, 6 parts of lysine, tryptophan
20 parts, 1 part of inosine, Cobastab10.4 part, 6 parts of citric acid, 5 parts of sodium chloride, DEXTROSE ANHYDROUS add to 100 parts.
Preparation method is with embodiment 1.
Impact to the growth of weak cad pig
Carry out as follows：
（One）Test method
（1）Experimental design：Test is designed using single-factor randomized block experiment, is selected and wean on the same day and proceed on the same day child care
The weanling pig of house（28 ages in days wean）, it is Normal group therefrom to select 48 healthy weanling pigs（6 repetitions, each weight
It is multiple 8）, select 144 weak cad pigs of same batch and be randomly divided into three groups（Per group of 6 repetitions, each repeats 8）, one group is weak deadlock
Pig control group, one group is weak cad pig spice feeding experiment group, and one group is weak cad pig drinking-water feeding experiment group.It is Normal group, weak
The all pigs of cad pig control group, weak cad pig spice feeding experiment group and weak cad pig drinking-water feeding experiment group feed same basic day
Grain -- the sucking pig complete feed of the honest Co., Ltd's production in Nanyang, and weak cad pig spice feeding experiment group and the drinking-water feeding of weak cad pig
Two groups of test group feeds in addition the enteron aisle health-care agent of the embodiment of the present invention 2.Whole experimental period is 20 days.
Enteron aisle health-care agent using method in weak cad pig spice feeding experiment group：
Enteron aisle health-care agent 750g of the present invention is watered 30kg, pours and mixes sucking pig complete feed 70kg, free choice feeding, it then follows from less to more,
Gradually the principle of dosage, is defined in hopper without residue, daily feeding 6 times, and feeding time is 20 days.
Enteron aisle health-care agent using method in weak cad pig drinking-water feeding experiment group：
Enteron aisle health-care agent 750g of the present invention is watered 75kg, pours into pig house specialized water tank and allows weak cad pig freely to drink by line of drinking water
Water, the drinking-water time is 20 days.
（2）Observation and performance test project
Pig body weight：Before the 1st day morning of on-test raises, pig is carried out to weigh on an empty stomach, be recorded as just starting weight；Off-test
Pig is carried out afterwards weighing on an empty stomach, be recorded as end weight；The daily gain in experimental period is calculated afterwards.
Feed feed intake：1 total feed intake per hurdle pig is counted weekly, and the full period feeding of pig is calculated after off-test
Amount：Calculate the daily feed intake and full period daily ingestion amount of every pig (weekly) stage by stage.
Feedstuff-meat ratio：Calculate the average full period daily gains of the feedstuff-meat ratio of full period=average full period daily ingestion amount ÷.
The colour of skin and hair condition：During wean, wean after weekly, test before（It is calculated as the initial colour of skin and hair condition）, off-test, respectively
The colour of skin and hair condition to every pig is evaluated, and standards of grading are shown in Table 1.
Health status：Daily per the diarrhoea status of hurdle pig, daily each statistics 1 time sooner or later, calculates every with full period weekly statistics
Diarrhea rate (the total head time ÷ (pig's head number × test number of days) of diarrhea rate=diarrhoea of group.
On-test, at the end of, underproof weak cad pig is taken pictures respectively, to carry out visual analysis contrast.
（Two）As a result with analysis：The results are shown in Table 2.
From table 2, two groups of weak cad pig test group feedstuff-meat ratios are respectively 1.45 and 1.43, than Normal group feedstuff-meat ratio
1.36 is slightly higher, significantly reduces than weak cad pig control group feedstuff-meat ratio 3.14, and two groups of weak cad pig test group colours of skin and hair condition are relative
Obvious improvement is obtained in weak cad pig control group, the diarrhea rate of weak cad pig test group is also significantly lower than weak cad pig control group.
It is indicated above that the enteron aisle health-care agent of patent of the present invention significantly improves the daily gain and the price of deed of weak cad pig, improve
The colour of skin and hair condition, reduce weak cad pig diarrhea rate.
Claims (3)
1. a kind of enteron aisle health-care agent for improving weak cad pig production performance, it is characterised in that in terms of parts by weight, by following component groups
Into：Chitosan oligosaccharide 1-3 parts, vitamin C 4-6 parts, lactalbumin 5-10 parts, lactic acid powder 5-8 parts, lysine 4-6 parts, tryptophan 10-
20 parts, inosine 1-3 parts, Cobastab10.3-0.5 parts, citric acid 3-8 parts, sodium chloride 2-5 parts, DEXTROSE ANHYDROUS adds to 100
Part.
2. a kind of method for preparing enteron aisle health-care agent as claimed in claim 1, it is characterised in that step is as follows：
（1）, by lactalbumin, lactic acid powder, lysine, tryptophan, citric acid according to adding proportion premix be combined into premix A；
（2）, by Cobastab1, vitamin C according to adding proportion premix be combined into premix B；
（3）, by chitosan oligosaccharide, inosine according to adding proportion premix be combined into premix C；
（4）, premix A, premix B, premix C, sodium chloride, DEXTROSE ANHYDROUS be well mixed, obtain final product enteron aisle guarantor
Strong agent.
3. a kind of using method of enteron aisle health-care agent as claimed in claim 1, it is characterised in that take following mix fodders to make
With method or drinking-water using method；Wherein, mix fodder using method is：Enteron aisle health-care agent 700-800g is watered 20-40kg, pours and mixes
Piglet feed 60-80kg, free choice feeding, feeding time is 15-25 days；Drinking-water using method be：Enteron aisle health-care agent 700-800g
70-80kg, free water are watered, the drinking-water time is 15-25 days.
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| CN107897512A (en) * | 2017-11-30 | 2018-04-13 | 河南普尼尔生物制药有限公司 | It is a kind of to be used to improve enteron aisle health-care agent of chicken intestinal health and preparation method thereof |
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| CN108740443A (en) * | 2018-06-28 | 2018-11-06 | 河南普尼尔生物制药有限公司 | It is a kind of conditioning sow gastrointestinal tract function detoxification take off mould dose and preparation method thereof |
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Application publication date: 20170510 |