CN106176299A - A kind of oral-care toothpaste containing polyglutamic acid and preparation method thereof - Google Patents
A kind of oral-care toothpaste containing polyglutamic acid and preparation method thereof Download PDFInfo
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- CN106176299A CN106176299A CN201610828648.7A CN201610828648A CN106176299A CN 106176299 A CN106176299 A CN 106176299A CN 201610828648 A CN201610828648 A CN 201610828648A CN 106176299 A CN106176299 A CN 106176299A
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- Prior art keywords
- polyglutamic acid
- oral
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- parts
- sodium
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 43
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 43
- 108010020346 Polyglutamic Acid Proteins 0.000 title claims abstract description 37
- 229920002643 polyglutamic acid Polymers 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 12
- 150000004676 glycans Chemical class 0.000 claims abstract description 11
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 11
- 239000005017 polysaccharide Substances 0.000 claims abstract description 11
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 8
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 claims abstract description 8
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 8
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims abstract description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 8
- 229940048086 sodium pyrophosphate Drugs 0.000 claims abstract description 8
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims abstract description 8
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims abstract description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 7
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 7
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 6
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000600 sorbitol Substances 0.000 claims abstract description 6
- 235000010356 sorbitol Nutrition 0.000 claims abstract description 6
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 6
- 239000011718 vitamin C Substances 0.000 claims abstract description 6
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 6
- 229940046009 vitamin E Drugs 0.000 claims abstract description 6
- 239000011709 vitamin E Substances 0.000 claims abstract description 6
- 238000000855 fermentation Methods 0.000 claims description 23
- 230000004151 fermentation Effects 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 9
- 239000002609 medium Substances 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000001963 growth medium Substances 0.000 claims description 6
- 241000194108 Bacillus licheniformis Species 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 5
- 238000009423 ventilation Methods 0.000 claims description 5
- 230000004913 activation Effects 0.000 claims description 4
- 235000001014 amino acid Nutrition 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 238000011218 seed culture Methods 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 4
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 claims description 3
- 239000004475 Arginine Substances 0.000 claims description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004473 Threonine Substances 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 229940041514 candida albicans extract Drugs 0.000 claims description 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 3
- 229960001231 choline Drugs 0.000 claims description 3
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 3
- 239000002054 inoculum Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000012533 medium component Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 3
- 235000008160 pyridoxine Nutrition 0.000 claims description 3
- 239000011677 pyridoxine Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000012137 tryptone Substances 0.000 claims description 3
- 239000012138 yeast extract Substances 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims description 2
- 238000007872 degassing Methods 0.000 claims description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000035800 maturation Effects 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 229960003885 sodium benzoate Drugs 0.000 claims description 2
- 238000012859 sterile filling Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- IZPNTDOWOBGHEG-UHFFFAOYSA-M sodium benzene formate Chemical compound [Na+].[O-]C=O.C1=CC=CC=C1 IZPNTDOWOBGHEG-UHFFFAOYSA-M 0.000 claims 1
- 238000010025 steaming Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 210000000214 mouth Anatomy 0.000 abstract description 11
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract description 5
- 235000013922 glutamic acid Nutrition 0.000 abstract description 5
- 239000004220 glutamic acid Substances 0.000 abstract description 5
- 235000016709 nutrition Nutrition 0.000 abstract description 5
- 230000035764 nutrition Effects 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 3
- 230000000975 bioactive effect Effects 0.000 abstract description 3
- 210000004195 gingiva Anatomy 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 239000003223 protective agent Substances 0.000 abstract description 2
- 235000008935 nutritious Nutrition 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 206010013781 dry mouth Diseases 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920002627 poly(phosphazenes) Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 244000173166 Pyrus ussuriensis Species 0.000 description 2
- 235000011572 Pyrus ussuriensis Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- QWWVBNODQCWBAZ-WHFBIAKZSA-N (2r)-2-amino-3-[(2r)-2-carboxy-2-(methylamino)ethyl]sulfanylpropanoic acid Chemical compound CN[C@H](C(O)=O)CSC[C@H](N)C(O)=O QWWVBNODQCWBAZ-WHFBIAKZSA-N 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910052564 epsomite Inorganic materials 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 229910052603 melanterite Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 235000013557 nattō Nutrition 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- -1 odonthemodia Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of oral-care toothpaste containing polyglutamic acid, including the raw material of following parts by weight: γ polyglutamic acid 0.2 0.8 parts, pulullan polysaccharide 13 parts, Sorbitol 10 parts, glycerol 9 parts, sodium lauryl sulfate 3 parts, 1 part of essence, cellulose gum 1 part, sodium pyrophosphate 0.2 part, saccharin sodium 0.2 part, sodium benzoate 0.02 part, vitamin C 0.2 part, vitamin E 0.5 part, SOD 0.05 part, CPP 0.02 part.The present invention uses polyglutamic acid as efficacy factor, and not only nutrition oral cavity, tooth-whitening, balance flora, prevention oral problem, the glutamic acid after polyglutamic acid degraded simultaneously is nontoxic, effect nutritious to tooth and gingiva.Polyglutamic acid, as the protective agent of bioactive substance, can farthest be protected its activity in toothpaste body, extend its action time, plays its effect, without any side effects to human body, more natural, more healthy.
Description
Technical field
The present invention relates to cosmetics of everyday use field, a kind of oral-care toothpaste containing polyglutamic acid and preparation side thereof
Method.
Background technology
Along with gradually stepping up of human living standard, care concepts and the custom in oral cavity be there occurs by increasing people
Large change.Meanwhile, the fast pace of the modern life, high pressure allow Chinese oral conditions day by day complicate, variation, to contain
Fluorine toothpaste, Chinese herbal toothpaste, desensitizing toothpaste are that traditional effect type toothpaste of representative is gradually subdivided.From the beginning of 2005, at cloud
Under the drive of south BAIYAO toothpaste, a considerable amount of well-known toothpaste brands are proposed high-end effect toothpaste, effect of toothpaste, product successively
Matter, it is packaged to be further lifting.The function of effect type toothpaste is broadly divided into two big classes at present: one is prevention and auxiliary treatment
Some oral disease, such as decayed tooth, odonthemodia, gingivitis, periodontitis, oral ulcer, tooth defect etc..Two are to aid in adjusting and changing
Kind oral conditions, such as whitening teeth, removes halitosis, removes dental calculus, removes tooth stain and dental plaque etc..It is following along with consumer is to oral cavity
The oral conditions more degree of depth is understood by concern change and the medical facility of problem, also has some new functional requirements.Such as anti-mouth
Dry toothpaste, toothpaste with dental-filling function are mined out.Patent CN105267234A proposes a kind of compositions alleviating dry mouth symptom and
Its preparation method, where it is proposed use hyaluronic acid, pulullan polysaccharide, polyglutamic acid one or more.Can alleviate by
In disease, use medicine, chemicotherapy and the aging chronic and temporary xerostomia caused, it is possible to lubrication oral cavity, and keep mouth
Chamber moistens.
And polyglutamic acid, also known as natto gum, it is a kind of water solublity, biodegradation, without toxicity, use microbe fermentation method
The biopolymer prepared.Its moisturizing lock water effect is 500 times of hyaluronic acid, due to the molecular structure that it is special so that it is tool
Have extremely strong moisture-retaining capacity, can effectively increase the moisture-retaining capacity of skin, promote skin health, its effect due to hyaluronic acid with
And collagen protein.As brightening agent, there is long-acting lasting antiallergic performance.The toothpaste that with the addition of polyglutamic acid is a kind of natural port
Chamber care product, both can realize nutrition oral cavity, balances flora, the effect of prevention oral problem, turn avoid chemicals
Drug resistance and Chinese herbal medicine effective ingredients shortcoming on the low side.And without any side effects to human body, more natural, more healthy.
Summary of the invention
It is an object of the invention to provide a kind of nutrition oral cavity, tooth-whitening, balance flora, the oral cavity of prevention oral problem is protected
Reason toothpaste and preparation method thereof, this toothpaste is using polyglutamic acid macromolecule natural, nuisanceless, that have no side effect as effective ingredient
Add in mastic, compounding with vitamin, aminoacid and the bioactive substance such as lysozyme, SOD, CPP.
The present invention solves above-mentioned technical problem and be the technical scheme is that a kind of oral-care toothpaste containing polyglutamic acid
Preparation method, it is characterised in that comprise the following steps:
(1) gamma-polyglutamic acid-and pulullan polysaccharide are first dissolved in distilled water, and stir so that it is become thickness
The liquid of shape；
(2) at ambient temperature, in the viscous liquid obtained in step (1) add vitamin, aminoacid, SOD,
CPP, mix homogeneously；
(3) being mixed with toothpaste matrix by the liquid that step (2) obtains, send into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred is ground
Grind degassing in 30 minutes；Add the mixing in 15 minutes of essence agitation grinding, it is thus achieved that lotion of toothpaste, by packing after sterile filling；
Described toothpaste matrix includes Sorbitol, glycerol, sodium lauryl sulfate, cellulose gum, sodium pyrophosphate, saccharin
Sodium, sodium benzoate.
Further, in described toothpaste, the parts by weight of material are as follows: gamma-polyglutamic acid-0.2-0.8 part, pulullan polysaccharide 1-
3 parts, Sorbitol 10 parts, glycerol 9 parts, sodium lauryl sulfate 3 parts, 1 part of essence, cellulose gum 1 part, sodium pyrophosphate 0.2 part,
Saccharin sodium 0.2 part, sodium benzoate 0.02 part, vitamin C 0.2 part, vitamin E 0.5 part, SOD 0.05 part, CPP 0.02 part.
Further, the preparation method of described gamma-polyglutamic acid-comprises the following steps:
(1) actication of culture: be seeded on slant medium by Bacillus licheniformis, cultivates 16 hours, repeatedly activates for 37 DEG C
2-3 time, obtain the inclined-plane seed of maturation；
(2) preparation of seed liquor: the inclined-plane seed after activation in step (1) is inoculated in and cultivates equipped with 50ml liquid seeds
In the 500ml triangular flask of base, 37 DEG C, 220rpm cultivation obtains seed liquor to exponential phase in 16 hours；
(3) ferment tank: the seed liquor in step (2) is inoculated in the inoculum concentration of medium body fraction 5% and sends out
In ferment tank, 30L ferment tank culture medium liquid amount is 15L, Preliminary fermentation temperature 38-40 DEG C, tank pressure 0.01-0.05Mpa, logical
Air quantity 0.5-1.0vvm, rotating speed 400-600rpm；When fermentation liquid OD660 is at 0.550-0.600, and control fermentation temperature 30-
35 DEG C, regulation rotating speed to 200-350rpm, ventilation 1.5-2.0vvm, pH is at 7.2-7.5 in control, ferments 2-6 hour, is contained
The fermentation liquid of gamma-polyglutamic acid-；
(4) extraction of polyglutamic acid: remove thalline by centrifugal for the fermentation liquid obtained in step (3), by supernatant addition 5 times
The ethanol of supernatant volume, separates out polyglutamic acid, obtains gamma-polyglutamic acid-, then redissolving in supernatant equal-volume after filtration
Distilled water in, utilize spray drying process to prepare dry powder gamma-polyglutamic acid-.Simultaneously by supernatant flowing phase dilution several times
To the content of gamma-polyglutamic acid-at 1-3g/L, being detected relative to its molecular weight by high-efficient liquid, molecular weight is 20 ten thousand to 200
Ten thousand dalton.
Further, in described step (2), seed culture medium consists of: glucose 30g/L, yeast extract 7g/L, tryptone
10g/L, K2HPO40.5g/L, MgSO4·7H2O 0.5g/L, pH7.2, surplus pure water.
Further, in described step (3), fermentation medium component is: glucose 80g/L, sodium chloride 10g/L, MgSO4·
7H2O 1g/L, anhydrous calcium chloride 1g/L, FeSO4·7H2O 0.02g/L, KCl 0.5g/L, arginine 0.8g/L, histidine
0.5g/L, threonine 0.5g/L, methionine 0.4g/L, glutamine 0.5g/L, choline 0.31g/L, pyridoxol 0.001g/L.
A kind of oral-care toothpaste containing polyglutamic acid, it is characterised in that: obtained by the preparation method of above-mentioned any one.
The present invention produces the bacterial strain of high molecular gamma-polyglutamic acid-and is specially Bacillus licheniformis (Bacillus
licheniformis)CGMCC NO.3336.This bacterial strain is preserved in Chinese microorganism strain preservation on October 14th, 2009
Administration committee's common micro-organisms center, preserving number is CGMCC NO.3336.
It is an advantage of the current invention that: polyglutamic acid used in the present invention as efficacy factor, not only nutrition oral cavity, whitening
Tooth, balances flora, prevents oral problem, and the glutamic acid after polyglutamic acid degraded simultaneously is nontoxic, has tooth and gingiva
Nutrition.Polyglutamic acid, as the protective agent of bioactive substance, can farthest protect its work in toothpaste body
Property, extend its action time, play its effect.And without any side effects to human body, more natural, more healthy.
The wherein effect of pulullan polysaccharide, it is possible to quickly form water-retaining film, and polyglutamic acid is with the use of can more moisturizing
Whitening, increases oral cavity lubrication sense, extends efficacy factor action time.
It is simple that the method prepares polyglutamic acid technological process, especially succinct effective downstream extraction technique, this extraction
Technique can be greatly reduced production cost, also can reduce the loss rate of polyglutamic acid simultaneously so that polyglutamic acid last
Productivity improves；It addition, the method is obtained in that the polyglutamic acid of high molecular, is conducive to making and nourishes the shampoo repaired.Specially
Profit CN105267234A compositions alleviating dry mouth symptom and preparation method thereof is mainly used in alleviating dry mouth symptom.This
Polyglutamic acid in bright, in addition to having compounded pulullan polysaccharide, also added the biological active matters such as vitamin, aminoacid, SOD, CPP
Matter, is better able to meet the multiple requirement of mouth care.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below
Clear, complete description, described embodiment is a part of embodiment of the present invention rather than whole embodiments.Based on this
Embodiment in invention, the every other reality that those of ordinary skill in the art are obtained under not making creative work premise
Execute example, broadly fall into the scope of protection of the invention.
Embodiment 1
One, polyphosphazene polymer glutamic acid is prepared
(1) actication of culture: Bacillus licheniformis CGMCC NO.3336 original strain is seeded on slant medium, in
Cultivate 16 hours for 37 DEG C, so activation 2-3 time, the inclined-plane seed that preparation is ripe；
(2) preparation of seed liquor: the inclined-plane seed after a ring activation is inoculated in the 500ml equipped with 50ml fluid medium
In triangular flask, 37 DEG C, 220rpm cultivates 16 hours to exponential phase；
Described seed culture medium consists of: glucose 30g/L, yeast extract 7g/L, tryptone 10g/L, K2HPO4
0.5g/L, MgSO4 7H2O 0.5g/L, pH7.2, insufficient section pure water is supplied；
(3) ferment tank: the seed liquor in step (2) is inoculated in fermentation tank, 30L fermentation tank with the inoculum concentration of 10%
Fermentation medium liquid amount is 15L, Preliminary fermentation temperature 38-40 DEG C, tank pressure 0.01-0.05Mpa ventilation 0.5-1.0vvm, turns
Speed 400-600rpm；When fermentation liquid OD660 is at 0.550-0.600, and controlling fermentation temperature 30-35 DEG C, regulation rotating speed is extremely
200-350rpm, ventilation 1.5-2.0vvm, control pH before 7.2-7.5 to fermentation ends 2-6 hour.
Described fermentation medium component is: glucose 80, sodium chloride 10g/L, MgSO4 7H2O 1g/L, anhydrous calcium chloride
1g/L, FeSO4 7H2O 0.02g/L, KCl 0.5g/L, arginine 0.8g/L, histidine 0.5g/L, threonine 0.5g/L, first
Methyllanthionine 0.4g/L, glutamine 0.5g/L, choline 0.31g/L, pyridoxol 0.001g/L,
(4) extraction of polyglutamic acid: be centrifuged after fermentation ends and remove thalline, then with the ethanol of 5 times of supernatant volume, precipitate with ethanol
Separate out polyglutamic acid, then redissolving in the distilled water of supernatant volume, utilizing spray drying process to prepare dry powder polyglutamic
Acid.Supernatant is used flowing phase dilution several times to the content of gamma-polyglutamic acid-at 1-3g/L simultaneously, by high-efficient liquid relative to its point
Son amount detects, and molecular weight is 20 ten thousand to 200 ten thousand dalton.
Two, toothpaste is prepared
Toothpaste of the present invention, including the component of following parts by weight: gamma-polyglutamic acid-0.2 part, pulullan polysaccharide 1
Part, Sorbitol 10 parts, glycerol 9 parts, sodium lauryl sulfate 3 parts, 1 part of essence, cellulose gum 1 part, sodium pyrophosphate 0.2 part,
Saccharin sodium 0.2 part, sodium benzoate 0.02 part, vitamin C 0.2 part, vitamin E 0.5 part, SOD 0.05 part, CPP 0.02 part
Embodiment 2
The preparation method of polyphosphazene polymer glutamic acid and the preparation method of toothpaste are substantially with embodiment 1；
Described toothpaste, including the component of following parts by weight: gamma-polyglutamic acid-0.5 part, pulullan polysaccharide 3 parts, Pyrusussuriensis
Sugar alcohol 10 parts, glycerol 9 parts, sodium lauryl sulfate 3 parts, 1 part of essence, cellulose gum 1 part, sodium pyrophosphate 0.2 part, saccharin sodium
0.2 part, sodium benzoate 0.02 part, vitamin C 0.2 part, vitamin E 0.5 part, SOD 0.05 part, CPP 0.02 part
Embodiment 3
The preparation method of polyphosphazene polymer glutamic acid and the preparation method of toothpaste are substantially with embodiment 1；
Described toothpaste, including the component of following parts by weight: gamma-polyglutamic acid-0.8 part, pulullan polysaccharide 2 parts, Pyrusussuriensis
Sugar alcohol 10 parts, glycerol 9 parts, sodium lauryl sulfate 3 parts, 1 part of essence, cellulose gum 1 part, sodium pyrophosphate 0.2 part, saccharin sodium
0.2 part, sodium benzoate 0.02 part, vitamin C 0.2 part, vitamin E 0.5 part, SOD 0.05 part, CPP 0.02 part.
The different age people statistical result to toothpaste using effect
Various embodiments above only in order to technical scheme to be described, is not intended to limit；Although with reference to aforementioned each reality
Execute example the present invention has been described in detail, it will be understood by those within the art that: its still can to aforementioned respectively
Technical scheme described in embodiment is modified, or the most some or all of technical characteristic is carried out equivalent；And
These amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
Claims (6)
1. the preparation method of the oral-care toothpaste containing polyglutamic acid, it is characterised in that comprise the following steps:
(1) gamma-polyglutamic acid-and pulullan polysaccharide are first dissolved in distilled water, and stir so that it is become thick
Liquid；
(2) at ambient temperature, the viscous liquid obtained in step (1) adds vitamin, aminoacid, SOD, CPP, mixes
Close uniformly；
(3) being mixed with toothpaste matrix by the liquid that step (2) obtains, send into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred grinds 30
Minute degassing；Add the mixing in 15 minutes of essence agitation grinding, it is thus achieved that lotion of toothpaste, by packing after sterile filling；
Described toothpaste matrix include Sorbitol, glycerol, sodium lauryl sulfate, cellulose gum, sodium pyrophosphate, saccharin sodium,
Sodium benzoate.
The preparation method of a kind of oral-care toothpaste containing polyglutamic acid the most according to claim 1, it is characterised in that institute
State the parts by weight of each material in toothpaste as follows: gamma-polyglutamic acid-0.2-0.8 part, pulullan polysaccharide 1-3 part, Sorbitol 10
Part, glycerol 9 parts, sodium lauryl sulfate 3 parts, 1 part of essence, cellulose gum 1 part, sodium pyrophosphate 0.2 part, saccharin sodium 0.2 part, benzene
Sodium formate 0.02 part, vitamin C 0.2 part, vitamin E 0.5 part, SOD 0.05 part, CPP 0.02 part.
The preparation method of a kind of oral-care toothpaste containing polyglutamic acid the most according to claim 1, it is characterised in that institute
The preparation method stating gamma-polyglutamic acid-comprises the following steps:
(1) actication of culture: be seeded on slant medium by Bacillus licheniformis, cultivates 16 hours, repeatedly activates 2-3 for 37 DEG C
Secondary, obtain the inclined-plane seed of maturation；
(2) preparation of seed liquor: the inclined-plane seed after activation in step (1) is inoculated in equipped with 50ml liquid seed culture medium
In 500ml triangular flask, 37 DEG C, 220rpm cultivation obtains seed liquor to exponential phase in 16 hours；
(3) ferment tank: the seed liquor in step (2) is inoculated in fermentation tank with the inoculum concentration of medium body fraction 5%
In, 30L ferment tank culture medium liquid amount is 15L, Preliminary fermentation temperature 38-40 DEG C, tank pressure 0.01-0.05Mpa, ventilation
0.5-1.0vvm, rotating speed 400-600rpm；When fermentation liquid OD660 is at 0.550-0.600, and control fermentation temperature 30-35 DEG C,
Regulation rotating speed to 200-350rpm, ventilation 1.5-2.0vvm, control pH at 7.2-7.5, ferment 2-6 hour, obtain containing γ-
The fermentation liquid of polyglutamic acid；
(4) extraction of polyglutamic acid: remove thalline by centrifugal for the fermentation liquid obtained in step (3), supernatant is added 5 times of supernatant
The ethanol of volume, separates out polyglutamic acid, obtains gamma-polyglutamic acid-, then redissolving in the isopyknic steaming of supernatant after filtration
In distilled water, spray drying process is utilized to prepare dry powder gamma-polyglutamic acid-.
The preparation method of a kind of oral-care toothpaste containing polyglutamic acid the most according to claim 3, it is characterised in that institute
State seed culture medium in step (2) to consist of: glucose 30 g/L, yeast extract 7 g/L, tryptone 10 g/L, K2HPO4 0.5
G/L, MgSO4•7H2O 0.5 g/L, pH7.2, surplus pure water.
The preparation method of a kind of oral-care toothpaste containing polyglutamic acid the most according to claim 3, it is characterised in that institute
Stating fermentation medium component in step (3) is: glucose 80 g/L, sodium chloride 10g/L, MgSO47H2O 1g/L, anhydrous chlorination
Calcium 1g/L, FeSO4•7H2O 0.02g/L, KCl 0.5g/L, arginine 0.8g/L, histidine 0.5g/L, threonine 0.5g/L,
Methionine 0.4g/L, glutamine 0.5g/L, choline 0.31g/L, pyridoxol 0.001g/L.
6. the oral-care toothpaste containing polyglutamic acid, it is characterised in that: by the preparation method of claim 1-5 any one
Obtain.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210376A (en) * | 2018-04-04 | 2018-06-29 | 杭州纳美智康科技有限公司 | A kind of tooth-caring toothpaste and preparation method thereof |
| WO2020000771A1 (en) * | 2018-06-29 | 2020-01-02 | 三椒口腔健康股份有限公司 | Bamboo vinegar toothpaste and preparation method therefor |
| CN111603407A (en) * | 2020-06-22 | 2020-09-01 | 江西草珊瑚口腔护理用品有限公司 | A whitening toothpaste containing multiple amino acids |
| CN111936114A (en) * | 2018-03-29 | 2020-11-13 | 宝洁公司 | Oral care composition for promoting gum health |
| CN112089643A (en) * | 2020-09-25 | 2020-12-18 | 华熙生物科技股份有限公司 | Oral care composition containing hyaluronic acid or salt thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267234A (en) * | 2015-10-29 | 2016-01-27 | 山东省药学科学院 | Composition for relieving xerostomia and preparation method thereof |
| CN105603013A (en) * | 2015-12-11 | 2016-05-25 | 天津北洋百川生物技术有限公司 | Preparation method for gamma-polyglutamic acid, and hand cream and preparation method thereof |
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2016
- 2016-09-18 CN CN201610828648.7A patent/CN106176299A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267234A (en) * | 2015-10-29 | 2016-01-27 | 山东省药学科学院 | Composition for relieving xerostomia and preparation method thereof |
| CN105603013A (en) * | 2015-12-11 | 2016-05-25 | 天津北洋百川生物技术有限公司 | Preparation method for gamma-polyglutamic acid, and hand cream and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111936114A (en) * | 2018-03-29 | 2020-11-13 | 宝洁公司 | Oral care composition for promoting gum health |
| CN111936114B (en) * | 2018-03-29 | 2023-11-17 | 宝洁公司 | Oral care compositions for promoting gum health |
| CN108210376A (en) * | 2018-04-04 | 2018-06-29 | 杭州纳美智康科技有限公司 | A kind of tooth-caring toothpaste and preparation method thereof |
| WO2020000771A1 (en) * | 2018-06-29 | 2020-01-02 | 三椒口腔健康股份有限公司 | Bamboo vinegar toothpaste and preparation method therefor |
| CN111603407A (en) * | 2020-06-22 | 2020-09-01 | 江西草珊瑚口腔护理用品有限公司 | A whitening toothpaste containing multiple amino acids |
| CN112089643A (en) * | 2020-09-25 | 2020-12-18 | 华熙生物科技股份有限公司 | Oral care composition containing hyaluronic acid or salt thereof |
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Application publication date: 20161207 |