CN1051466C - External medicine for treating seborrheic alopecia - Google Patents
External medicine for treating seborrheic alopecia Download PDFInfo
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- CN1051466C CN1051466C CN95103743A CN95103743A CN1051466C CN 1051466 C CN1051466 C CN 1051466C CN 95103743 A CN95103743 A CN 95103743A CN 95103743 A CN95103743 A CN 95103743A CN 1051466 C CN1051466 C CN 1051466C
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- seborrheic alopecia
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- 239000003814 drug Substances 0.000 title claims abstract description 44
- 201000004384 Alopecia Diseases 0.000 title claims abstract description 34
- 231100000360 alopecia Toxicity 0.000 title claims abstract description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims abstract description 10
- 229930002330 retinoic acid Natural products 0.000 claims abstract description 10
- 241000222336 Ganoderma Species 0.000 claims abstract description 9
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 9
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 9
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 241000628997 Flos Species 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000469 ethanolic extract Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 2
- 239000003860 topical agent Substances 0.000 claims 1
- 240000008574 Capsicum frutescens Species 0.000 abstract 1
- 235000002568 Capsicum frutescens Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 241001289529 Fallopia multiflora Species 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 abstract 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 12
- 230000028327 secretion Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 210000002374 sebum Anatomy 0.000 description 6
- 231100000331 toxic Toxicity 0.000 description 6
- 230000002588 toxic effect Effects 0.000 description 6
- 210000003780 hair follicle Anatomy 0.000 description 5
- 210000004209 hair Anatomy 0.000 description 4
- 150000004492 retinoid derivatives Chemical class 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 239000003098 androgen Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- VRSMJNVXOITYPE-FSDIUQKZSA-N ethyl 4-[[(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1NC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VRSMJNVXOITYPE-FSDIUQKZSA-N 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000007287 cheilitis Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000005211 surface analysis Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses an external medicine for treating seborrheic alopecia, which is an external medicine prepared from polygonum multiflorum, drynaria rhizome, lucid ganoderma, salvia miltiorrhiza, ligusticum wallichii, hot pepper, safflower, tert-butyl p-hydroxyanisole, 2, 6-di-tert-butyl p-cresol, citric acid, tween 80, all-trans retinoic acid and 75% ethanol.
Description
The present invention relates to a kind of medicine for the treatment of seborrheic alopecia.Specifically a kind of medicine for external use made from Chinese herbal medicine and vitamin medicaments cooperation.
Alopecia is a kind of dermatosis of common pilosity, mainly is divided into two types, promptly non-seborrheic alopecia (bald as class) and seborrheic alopecia.The treatment of non-seborrheic alopecia is easier, existing many effective patent medicine.Non-seborrheic alopecia just has curative effect preferably to class is bald etc. as the medicine made by Chinese medicines such as Radix Polygoni Multiflori, Fructus Lycii.Yet for seborrheic alopecia, these medicines almost can be described as invalid or curative effect very little.The treatment of seborrheic alopecia can be described as a difficult problem of current dermatology circle, though people have done many effort, does not still have real effectively medicine and Therapeutic Method so far and comes out.
The essential cause of disease of seborrheic alopecia is still not really clear at present, but it is generally acknowledged may with androgen secretion cross prosperous relevant because few people suffer from seborrheic alopecia among the women.As if yet it is not the immediate cause of seborrheic alopecia again that androgen secretion is crossed prosperous.It is reported that the medicine that has the people to take the antiandrogen medicine once for the seborrheic alopecia patient is treated seborrheic alopecia with the concentration that reduces androgen in the blood of human body, but does not have what effect.The immediate cause that it is considered herein that seborrheic alopecia is because the human endocrine imbalance causes that sebum secretion is prosperous excessively, and contained some material such as oleic acid, linoleic acid, Squalene etc. cause hair to poison, wither, come off to the toxic effect of hair follicle in the too much sebum.It may be the immediate cause of seborrheic alopecia that thereby the proof sebum secretion is crossed prosperous.
From last surface analysis as can be known, at first should want effectively to suppress or to reduce the excessive secretion of scalp fat to the real effectively medicine of seborrheic alopecia.
From the forties, just have the human vitamin A to treat a skin ulcer, acne also is owing to sebum secretion is crossed the prosperous dermatosis that causes, but the ability of vitamin A inhibition sebum secretion is very not strong, and bigger toxic and side effects is arranged, comprise xerosis cutis, headache, osteodynia, alopecia etc.In recent decades, on the basis of vitamin A, successively synthesize hundreds of kind retinoid material and come safer and more effective treatment acne.These materials all have the effect of obvious suppression sebum secretion.Yet it also is incomplete only treating seborrheic alopecia with the retinoid material.The most of scalp hair follicles of seborrheic alopecia patient are impaired serious, and the atrophy of scalp blood capillary causes hair malnutrition.Though only can reduce the toxic action that is subjected to the elimination hair follicle, but still can not stop the impaired alopecia of hair follicle with the treatment of retinoid material.The observed clinically fact of the inventor is, even use the retinoid material to treat undesired the coming off that many patient's hairs still can continue.
The inventor had once applied for a kind of endo-medicine (application number 92113387.1) for the treatment of seborrheic alopecia in 92 years, this application is to cooperate Chinese medicine Radix Polygoni Multiflori, Semen Cuscutae, Fructus Mori, Fructus Ligustri Lucidi, Herba Ecliptae to make capsule with Viaminate.But this effect of drugs is still not ideal, and if the Viaminate use amount excessive, have the side effect that causes alopecia on the contrary, symptoms such as cheilitis also can appear in the patient who has, and are not suitable for clinical practice.Through clinical practice in a few years, formulated the inventor and a kind ofly can effectively treat seborrheic alopecia and on the less endo-medicine basis of side effect, developed a kind of medicine for external use for the treatment of seborrheic alopecia again.
Therefore, the object of the invention provides a kind of external used medicine for the treatment of seborrheic alopecia, and this medicine has reduced the toxic and side effects of medicine in the past, and is used with oral medicine, and therapeutic effect is good.
The prescription of medicine of the present invention is formed:
Radix Polygoni Multiflori 45-55 gram Rhizoma Drynariae 25-35 gram
Ganoderma 15-25 gram Radix Salviae Miltiorrhizae 10-20 gram
Rhizoma Chuanxiong 10-20 gram Flos Carthami 8-15 gram
Fructus Capsici 8-15 gram
Butylated hydroxyarisol 0.2-0.5 gram
2,6 ditertiary butyl p cresol 0.2-0.5 gram
Citric acid 0.1-0.5 gram
Tween 80 0.05-0.2 gram
All-trans-retinoic acid 0.05-5 gram
75% ethanol 1200-16000 gram.
The preparation method of medicine of the present invention is:
By above-mentioned prescription Chinese medicine Radix Polygoni Multiflori, bone marrow benefit, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Fructus Capsici being added 75% soak with ethanol spends the night, extracting liquid filtering, get the ethanol extract of Chinese medicine, then, in said extracted liquid, add the butylated hydroxyarisol of formula ratio, 2, the 6-ditertbutylparacresol, citric acid, all-trans-retinoic acid and Tween 80, mix homogeneously makes medicine for external use 1000 grams of the present invention.
The optimization formula of preparation medicine of the present invention is:
Radix Polygoni Multiflori 50 gram Rhizoma Drynariae 30 grams
Ganoderma 20 gram Radix Salviae Miltiorrhizaes 15 grams
Rhizoma Chuanxiong 15 gram Flos Carthamis 10 grams
Fructus Capsici 10 grams
Butylated hydroxyarisol 0.04%
2,6 ditertiary butyl p cresol 0.04%
Citric acid 0.02%
Tween 80 0.01%
All-trans-retinoic acid 0.03%
75% ethanol, 1500 grams.
Adopt above-mentioned same procedure, make medicine for external use 1000 grams of the present invention.
Clinical data shows, use another oral medicine of medicine of the present invention and inventor development to be used, can obtain very ideal therapeutic effect, because all-trans-retinoic acid can be eliminated the deleterious factor of hair follicle, hair growth nutrient mass-energy is played a role, improved the nutritional status of hair, thereby can prevent undesired alopecia completely, improved old state widely, and promote New Development to regenerate, the adding of Chinese medicine ingredients, strengthened nourishing blood, invigorate blood circulation, the effect of hair growth promoting, be prepared into exterior-applied formulation, make medicine directly act on focus in use, the succeeding in developing of medicine of the present invention, overcome the difficult problem of seborrheic alopecia treatment clinically, reduced the toxic and side effects of clinical application, provide a kind of new less medicine of effective toxic and side effects again, increased the chance of selecting medication for the alopecia patient for treating seborrheic alopecia clinically.
Provide some embodiment below, further describe the present invention in further detail.
Embodiment 1: Radix Polygoni Multiflori 50 gram Rhizoma Drynariae 30 grams
Ganoderma 20 gram Radix Salviae Miltiorrhizaes 15 grams
Rhizoma Chuanxiong 15 gram Flos Carthamis 10 grams
Fructus Capsici 10 grams
Butylated hydroxyarisol 0.04%
2,6 ditertiary butyl p cresol 0.04%
Citric acid 0.02%
Tween 80 0.01%
All-trans-retinoic acid 0.03%
75% ethanol, 1500 grams.
By above-mentioned formula ratio Chinese medicine Radix Polygoni Multiflori, bone marrow benefit, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Fructus Capsici being added 75% soak with ethanol spends the night, extracting liquid filtering, get the ethanol extract of Chinese medicine, then, in said extracted liquid, add the butylated hydroxyarisol of formula ratio, 2, the 6-ditertbutylparacresol, citric acid, all-trans-retinoic acid and Tween 80, mix homogeneously makes medicine for external use 1000 grams of the present invention.
Claims (2)
1. external used medicine for the treatment of seborrheic alopecia is characterized in that it is the topical agent of being made by the raw material of following dosage:
Radix Polygoni Multiflori 45-55 gram Rhizoma Drynariae 25-35 gram
Ganoderma 15-25 gram Radix Salviae Miltiorrhizae 10-20 gram
Rhizoma Chuanxiong 10-20 gram Flos Carthami 8-15 gram
Fructus Capsici 8-15 gram
Butylated hydroxyarisol 0.2-0.5 gram
2,6 ditertiary butyl p cresol 0.2-0.5 gram
Citric acid 0.1-0.5 gram
Tween 80 0.05-0.2 gram
All-trans-retinoic acid 0.05-5 gram
75% ethanol 1200-16000 gram.
2. preparation method for the treatment of the seborrheic alopecia medicine is characterized in that raw material is:
Radix Polygoni Multiflori 45-55 gram Rhizoma Drynariae 25-35 gram
Ganoderma 15-25 gram Radix Salviae Miltiorrhizae 10-20 gram
Rhizoma Chuanxiong 10-20 gram Flos Carthami 8-15 gram
Fructus Capsici 8-15 gram
Butylated hydroxyarisol 0.2-0.5 gram
2,6 ditertiary butyl p cresol 0.2-0.5 gram
Citric acid 0.1-0.5 gram
Tween 80 0.05-0.2 gram
All-trans-retinoic acid 0.05-5 gram
75% ethanol 1200-16000 gram
Processing technique is as follows:
Chinese medicine Radix Polygoni Multiflori, Rhizoma Drynariae, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Fructus Capsici being added 75% soak with ethanol spends the night, extracting liquid filtering, get the ethanol extract of Chinese medicine, then, in said extracted liquid, add butylated hydroxyarisol, 2, the 6-ditertbutylparacresol, citric acid, all-trans-retinoic acid and Tween 80, fully mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95103743A CN1051466C (en) | 1995-04-18 | 1995-04-18 | External medicine for treating seborrheic alopecia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95103743A CN1051466C (en) | 1995-04-18 | 1995-04-18 | External medicine for treating seborrheic alopecia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1133716A CN1133716A (en) | 1996-10-23 |
| CN1051466C true CN1051466C (en) | 2000-04-19 |
Family
ID=5074843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95103743A Expired - Fee Related CN1051466C (en) | 1995-04-18 | 1995-04-18 | External medicine for treating seborrheic alopecia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1051466C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1065435C (en) * | 1996-08-09 | 2001-05-09 | 梅晓春 | Efficient low-side effect external use medicine for curing seborrheic baldness |
| CN1107519C (en) * | 2000-07-17 | 2003-05-07 | 复旦大学附属华山医院 | Medicinal composition for treating alopesia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087267A (en) * | 1992-11-23 | 1994-06-01 | 梅晓春 | A kind of prescription for the treatment of seborrheic alopecia |
-
1995
- 1995-04-18 CN CN95103743A patent/CN1051466C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087267A (en) * | 1992-11-23 | 1994-06-01 | 梅晓春 | A kind of prescription for the treatment of seborrheic alopecia |
Non-Patent Citations (1)
| Title |
|---|
| 湖北中医杂志1991,13(6) 1991. 6.30 张忠兴,速效克秃灵生发精治疗斑秃882例临床观察 * |
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| Publication number | Publication date |
|---|---|
| CN1133716A (en) | 1996-10-23 |
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