CN1048881C - Medicine for curing tumour and preparation method thereof - Google Patents
Medicine for curing tumour and preparation method thereof Download PDFInfo
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- CN1048881C CN1048881C CN93120005A CN93120005A CN1048881C CN 1048881 C CN1048881 C CN 1048881C CN 93120005 A CN93120005 A CN 93120005A CN 93120005 A CN93120005 A CN 93120005A CN 1048881 C CN1048881 C CN 1048881C
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Abstract
The present invention relates to a medicine for treating tumors and a preparation method thereof. The medicine has the formula comprising 1 to 10kg of radix semiaquilegiae, 1 to 10kg of yangtao actinidia root, 1 to 10kg of angelica, 1 to 5kg of astragalus root, 10 to 25kg of walnut husk, 5 to 20kg of walnut twig, 1 to 5kg of barbary wolfberry fruit and 1 to 15kg of white sugar. The medicine can be prepared into oral liquid, or granules, or capsules. The medicine is mainly used for treating various tumors, such as esophagus cancer, stomach cancer, colon cancer, etc., and is used for the auxiliary therapy of radiotherapy and chemotherapy of intermediate cancers and late cancers.
Description
The present invention relates to a kind of medicine and the compound method thereof for the treatment of tumor, the particularly medicine of Chinese medicine tumor and compound method thereof.
Tumor, particularly esophageal carcinoma, gastric cancer, colon cancer are common malignancy.At present, aspect treatment esophageal carcinoma, gastric cancer, colon cancer, adopt operative treatment both at home and abroad more, or radiotherapy, or chemotherapy, or immunization method, or optical treatment.Effect is not very good yet, and bigger to the human body wound, and untoward reaction is many, and patient is reluctant to accept.Domesticly adopt dialectical executing to control aspect the above-mentioned disease of traditional Chinese medical herbal treatment, it is also undesirable to produce effects more.Chinese patent medicine cancer therapy drugs such as " TIANXIAN WAN " is too low because of effective percentage, and the patient also is reluctant to accept.Therefore, a kind of medicine for the treatment of tumor of research is very important.
The objective of the invention is to overcome the prior art characteristics, provide a kind of treatment tumor, especially esophageal carcinoma, gastric cancer, colon cancer curative effect preferable, medicine that untoward reaction is minimum and compound method thereof.
Medicine of the present invention be according to the traditional Chinese medical science to carcinoma, should take stopgap measures, more to effect a permanent cure, giving consideration to both the incidental and fundamental, reinforcement and elimination in combination, eliminating pathogenic factor for supporting vital QI, regulating YIN and YANG, QI and blood, internal organs, meridian function balance are transferred body resistance against diseases, adjust immunologic function.Radix Semiaquilegiae, Radix Actinidiae Chinensis heat-clearing and toxic substances removing in the prescription, blood stasis-eliminating and stagnation-dissipating, promoting blood circulation and detumescence, " Shaanxi Chinese herbal medicine " carries Radix Actinidiae Chinensis can treat the gastronintestinal system tumor, the prescription,local that " traditional Chinese medical science oncology " introduces is also put down in writing with Radix Actinidiae Chinensis curing oncoma and lacteal tumor, and " Zhejiang traditional herbal medicine " carries Radix Semiaquilegiae can control breast carcinoma; The nourshing blood and promoting blood circulation of Radix Angelicae Sinensis energy, hard masses softening and resolving, soothing liver-QI for relieving depression rushes down the internal organs pyretic toxicity, has nourishing yin effect concurrently, controls whole body swelling, the blood vessels discord; Radix Astragali benefiting QI for activating blood circulation, the spleen reinforcing of heart tonifying YIN nourishing, promoting tissue regeneration by removing blood stasis is controlled the card of all weakness of QI blood deficiency; Fructus Lycii nourishing kidney, lung moistening, tonifying liver, make eye bright raise immunity, treating the liver deficiency of the kidney yin; Exocarpium Juglandis Immaturus energy removing toxic substances and promoting subsidence of swelling is controlled the swollen sore of pain, and gastronintestinal system is had obvious analgesic effect; Ramulus Juglandis can detoxify by parasite killing, and analgesia is enriched blood, and appetite stimulator improves the tumor symptom, and clinical have report to can be used for various treatment for cancer, and particularly to cervical cancer and pulmonary carcinoma, effect is more remarkable.This formulary has suffered heat and toxic materials clearing away medicine, the hard masses softening and resolving medicine, and the phlegm-eliminiating and qi-regulating medicine, promoting blood flow and remove blood stasis drug, the reducing swelling and alleviating pain medicine, the tonify deficiency drug supporting healthy energy, reinforcement and elimination in combination, synergism has reached the antitumor purpose.
Pharmaceutical formulation of the present invention is made up of following medicine: Radix Semiaquilegiae 1-10 kilogram, Radix Actinidiae Chinensis 1-10 kilogram, Radix Angelicae Sinensis 1-10 kilogram, Radix Astragali 1-5 kilogram, juglans 10-25 kilogram, Ramulus Juglandis 5-20 kilogram, Fructus Lycii 1-5 kilogram, white sugar 1-15 kilogram.
Manufacturing process of the present invention is: 1, produce the Radix Angelicae Sinensis volatile oil extracting solution: get and be placed on above the porous plate of boiler lower device after Radix Angelicae Sinensis is cleaned, feed steam, collect the mixed liquor of Radix Angelicae Sinensis volatile oil and water, low tempertaure storage is standby, and the Radix Angelicae Sinensis slag is continued to employ next procedure.
2. the extraction of juglone crude mixture: get juglans and Ramulus Juglandis, the person of frying in shallow oil twice after cleaning adds water for the first time and decocted 3 hours for 30,000 milliliters, add for the second time 20,000 milliliters in water, decoct 2 hours collecting decoctions and filter, filtrate decompression is concentrated into 1.5 ten thousand milliliters, transfers PH1.5 with 6mol/L hydrochloric acid, precipitation is separated out, put cold room and placed 24 hours, filter, discard filtrate, solid refluxes with 2000 milliliters of petroleum ether and dissolves, filter, reclaim petroleum ether, get thick paste, adding the stirring of 3000 ml distilled waters is 8 with 6mol/L sodium hydroxide accent PH down, solution is clarified substantially, filtered, filtrate contains juglone, effective ingredient such as Semen Juglandis hydroquinone and juglanin, low temperature is placed standby.
3. get Radix Semiaquilegiae, Radix Actinidiae Chinensis, the Radix Astragali, Fructus Lycii and Radix Angelicae Sinensis slag, decoct secondary, add 30,000 milliliters in water for the first time; Decocted 4 hours, add for the second time 20,000 milliliters in water, decocted 2 hours, collecting decoction is evaporated to the thick paste shape with three layers of filtered through gauze, it is 60% to containing the alcohol amount that the cooling back adds ethanol, sealing was placed 7 days, made precipitation fully, filtered, reclaim ethanol, it is an amount of to add water, places 24 hours water precipitating, is filtered to clear and bright, with Radix Angelicae Sinensis volatile oil extracting solution and juglone mixture extracting solution, sucrose, add medicinal liquid, stir, adjust ten thousand milliliters of total amounts to 10 with distilled water, stir evenly, filtration, fill, 100 ℃ of sterilizations 30 minutes.
This be have have heat-clearing and toxic substances removing, the effect of eliminating pathogenic factor for supporting vital QI.Be applicable to the auxiliary treatment of kinds of tumors such as esophageal carcinoma, gastric cancer, colon cancer and radiotherapy of middle and advanced stage cancerous protuberance and chemotherapy.
Oral, every day two to three times, each 10 to 20 milliliters, the time spent shakes up.
Avoiding sour, peppery, greasy food, cigarette, taboo spills.
10 milliliters every bottle of this product contain crude drug (g/ml) 100%.Answer lucifuge, seal, be stored in shady and cool place.
The present invention is in applying clinical in 1970, through more than 20 years using and studying, proves that this product has dispersing swelling and dissipating binds, supplementing QI for promoting the production of body fluid, and the effect of reinforcing body resistance has the symptom of improvement to kinds of tumors, appetite stimulator and increase the effect of body resistance against diseases.In order to make the present invention become commodity, be the extensive patients service better, since 1989, the present invention has been carried out systematic study according to the pertinent regulations of " provisions for new drugs approval ".Through PLA General Hospital, air force general hospital, Navy General Hospital, Dongxing, Tianjin hospital application Drug therapy esophageal carcinoma 125 examples of the present invention, effective percentage is 79.23%, treatment gastric cancer 123 examples, effective percentage 75.34%.Animal experiment proves that this product can obviously suppress the growth of S130 sarcoma, significantly promotes the effect of the inductive immunosuppressed mice lymphopoiesis of PHA, and the delayed hypersensitivity of normal and immunosuppressant Mus is obviously strengthened.Acute toxicity test and long term toxicity test proof this product are nontoxic.
Embodiment:
Get Ramulus Juglandis 12kg, juglans 18kg cleans and decocts twice, decocts 3 hours for the first time, add 30,000 milliliters in water, decocted 2 hours for the second time, add 20,000 milliliters in water, collecting decoction, filter, be evaporated to 1.5 ten thousand milliliters, transfer PH1.5 with 6N HCL, precipitation is separated out put cold room placement 24 hours, filter, discard filtrate, solid refluxes with 2000 milliliters of petroleum ether and dissolves, and filters, and reclaims petroleum ether, get thick paste, add 3000 ml distilled waters and stir, use 6N N
aIt is 8 that OH transfers PH, filters filtrate for later use.Radix Angelicae Sinensis 2kg, the water flowing steam distillation extracts volatile oil, and device is preserved in addition.Radix Angelicae Sinensis slag and Radix Semiaquilegiae 4kg, Radix Actinidiae Chinensis 4kg, Huang Shi 2kg, Fructus Lycii 2kg decoct secondary, the 1st time 4 hours, add 30,000 milliliters in water, the 2nd time 2 hours, add 20,000 milliliters in water, collecting decoction filters, and is evaporated to the thick paste shape, adding ethanol after the cooling is 60% to containing the alcohol amount, seal 7 days, make complete, the filtration of precipitation, reclaim ethanol, it is an amount of to add water, place 24 hours water precipitating, be filtered to clear and brightly, add Radix Angelicae Sinensis volatile oil and Ramulus Juglandis, juglans extracting solution, sucrose 2kg stirs, be adjusted to 100,000 milliliters with distilled water, stir well, filtration, fill, 100 ℃ of sterilizations 30 minutes.
This product is dark-brown clear liquid (storage for a long time is slightly slightly muddy); Sweet, little perfume (or spice) of distinguishing the flavor of.
The discriminating of this product: (1), get 10 milliliters of this product with 10 milliliters of extracted with diethyl ether, discards water layer, the ether layer adds 2 milliliters of washings, discard water layer, ether liquid evaporate to dryness to the water-bath adds 2 milliliters of dissolvings of benzene; get 1 of benzole soln; put in the test tube, add 25% sodium carbonate liquor, and each 1 of the benzole soln of 4% formaldehyde and 5% o-dinitrobenzene; behind the mixing is put 1-4 minute apparent purple of heating in the water-bath.
(2), get 10 milliliters of this product, with (1) method, get ether liquid and to water-bath, be concentrated into 2 milliliters, get 1 of concentrated solution, to filter paper, aqueous sodium carbonate is sprayed in dry back, color becomes orange-yellowly from faint yellow, puts under the ultraviolet (365NM) and to observe, and color becomes the glimmering color of sky blue from glassy yellow fluorescence.
(3), get 2 milliliters of the ether liquid that (2) make, evaporate to dryness, residue add 2 milliliters of hydrochloric acid solutions (1 → 100) dissolving, filter, and add 3 of potassium mercuric iodides, generate pale precipitation.
The inspection relative density of this product is not less than 1.10, (34 pages of 90 editions second appendix of Chinese Pharmacopoeia).
(4), get 15 milliliters of this product to separatory funnel, with extracted with diethyl ether 2 times, each 10 milliliters, combined ether liquid, add 5 ml distilled waters and wash once, discard water layer, the ether layer is concentrated into 0.5 milliliter, get the 2UI point sample to HF254 silica gel fluorescent screen, use benzene: acetone: methanol (80: 18: 2) launches, and exhibition volatilizes apart from 8CM, put under the ultraviolet light (λ 254NM) and observe, RF0.60 glassy yellow fluorescence speckle is the feature speckle of Exocarpium Juglandis Immaturus; RF0.52 sky blue fluorescence speckle is the feature speckle of Radix Actinidiae Chinensis; RF0.49 pale blue fluorescence speckle is the feature speckle of Radix Semiaquilegiae.
(5), pH value should be at 3.5-4.5, (40 pages of 90 editions the 1st appendix of Chinese Pharmacopoeia).
(6), device difference: get 5 bottles of test samples, content is poured into respectively in the dry graduated cylinder after calibrated, at room temperature inspect, every bottle amount should be no less than labelled amount, when being less than labelled amount if any 1 bottle, must not surpass 5.0% of labelled amount.
(7), other: should meet every regulation relevant under the mixture item (15 pages of 90 editions the 1st appendix of Chinese Pharmacopoeia)
Claims (2)
1. medicine for the treatment of tumor is characterized in that it is made by following raw materials according: Radix Semiaquilegiae 1-10 kilogram, Radix Actinidiae Chinensis 1-10 kilogram, Radix Angelicae Sinensis 1-10 kilogram, Radix Astragali 1-5 kilogram, juglans 10-25 kilogram, Ramulus Juglandis 5-20 kilogram, Fructus Lycii 1-5 kilogram, white sugar 1-15 kilogram.
2. the medicine of treatment tumor according to claim 1 is characterized in that it is by following technology manufacturing:
(1) preparation Radix Angelicae Sinensis volatile oil extracting solution: get and be placed on above the porous plate of boiler lower device after Radix Angelicae Sinensis is cleaned, feed steam, collect the mixed liquor of Radix Angelicae Sinensis volatile oil and water, low tempertaure storage is standby, and the Radix Angelicae Sinensis slag is continued to employ next process;
(2) extraction of juglone crude mixture: get juglans and Ramulus Juglandis, clean the back and decoct twice, add water 30,000 ml for the first time, decocted 3 hours, adding for the second time water ten thousand 2ml decocted 2 hours, collecting decoction filters, and filtrate decompression is concentrated into 1.5 ten thousand ml, transfers PH1.5 with 6mol/L hydrochloric acid, precipitation is separated out, put cold room and placed 24 hours, filter, discard filtrate, solid refluxes with the 2000ml petroleum ether and dissolves, filter, reclaim petroleum ether, get thick paste, adding the stirring of 3000ml distilled water is 8 with 6mol/L sodium hydroxide accent PH down, solution is clarified substantially, filtered, filtrate low temperature is placed standby;
(3) get Radix Semiaquilegiae, Radix Actinidiae Chinensis, the Radix Astragali, Fructus Lycii and Radix Angelicae Sinensis slag decoct secondary, add water 30,000 ml for the first time, decocted 4 hours, and added water 20,000 ml for the second time, decocted 2 hours, collecting decoction, be evaporated to the thick paste shape with three layers of filtered through gauze, it is 60% to containing the alcohol amount that the cooling back adds ethanol, and sealing was placed 7 days, precipitation is filtered fully, reclaim ethanol, it is an amount of to add water, places 24 hours water precipitating, be filtered to clear and bright, with Radix Angelicae Sinensis volatile oil extracting solution and juglans, the extracting solution of Ramulus Juglandis, sucrose adds medicinal liquid, stirs, adjust total amount to 10 ten thousand ml with distilled water, stir evenly, filter, 100 ℃ of sterilizations of fill 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93120005A CN1048881C (en) | 1993-12-13 | 1993-12-13 | Medicine for curing tumour and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93120005A CN1048881C (en) | 1993-12-13 | 1993-12-13 | Medicine for curing tumour and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1093594A CN1093594A (en) | 1994-10-19 |
| CN1048881C true CN1048881C (en) | 2000-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93120005A Expired - Fee Related CN1048881C (en) | 1993-12-13 | 1993-12-13 | Medicine for curing tumour and preparation method thereof |
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| Country | Link |
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| CN (1) | CN1048881C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT408610B (en) * | 1998-11-11 | 2002-01-25 | Tchin Liou Dr | COMPOSITION OF PLANT EXTRACTS, IN PARTICULAR FOR USE IN CANCER THERAPY |
| CN101317965B (en) * | 2008-06-27 | 2010-11-03 | 王德振 | Traditional Chinese medicinal preparation for treating cancer |
| CN102670859B (en) * | 2012-01-31 | 2013-08-14 | 河南科技大学 | Topical traditional Chinese medicinal composition for preventing and treating sarcomas |
| CN104207124A (en) * | 2014-08-21 | 2014-12-17 | 席安胜 | Dietary therapy formula for colon cancer |
| CN104161926A (en) * | 2014-08-27 | 2014-11-26 | 四川金堂海纳生物医药技术研究所 | Orally-taken drug for treating esophagus cancer and preparation method thereof |
| CN106038680A (en) * | 2016-06-24 | 2016-10-26 | 通化师范学院 | Pharmaceutical composition for treating gastric cancer and preparation method thereof |
| CN111122764B (en) * | 2020-01-18 | 2022-03-11 | 河北中医学院 | A fast multi-information thin-layer identification method for Tiankuizi granules and standard decoction dry powder |
-
1993
- 1993-12-13 CN CN93120005A patent/CN1048881C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《沈阳药学院学报》1987,4(3) 1987.3.31 张野平，胡桃醌抗肿瘤作用的研究 * |
| 《陕西中医》1989,10(9) 1989.9.30 李明瑞，中药扶助化疗治疗68例晚期肿瘤的临床观察 * |
| 《陕西中医》1989,10(9) 1989.9.30 李明瑞，中药扶助化疗治疗68例晚期肿瘤的临床观察;《沈阳药学院学报》1987,4(3) 1987.3.31 张野平，胡桃醌抗肿瘤作用的研究 * |
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| Publication number | Publication date |
|---|---|
| CN1093594A (en) | 1994-10-19 |
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