CN104815007A - Medicinal composition for preventing and treating infectious bronchitis of chicken as well as preparation method and application thereof - Google Patents
Medicinal composition for preventing and treating infectious bronchitis of chicken as well as preparation method and application thereof Download PDFInfo
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- CN104815007A CN104815007A CN201510243344.XA CN201510243344A CN104815007A CN 104815007 A CN104815007 A CN 104815007A CN 201510243344 A CN201510243344 A CN 201510243344A CN 104815007 A CN104815007 A CN 104815007A
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- 208000015181 infectious disease Diseases 0.000 title claims abstract description 23
- 230000002458 infectious effect Effects 0.000 title claims abstract description 23
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 61
- 239000003814 drug Substances 0.000 claims abstract description 25
- 229940079593 drug Drugs 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 239000002671 adjuvant Substances 0.000 claims description 4
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- DTOUWTJYUCZJQD-UJERWXFOSA-N Forsythiaside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H](O)[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O1 DTOUWTJYUCZJQD-UJERWXFOSA-N 0.000 claims description 2
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 claims description 2
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims description 2
- JJVGFDTWFVSBIM-UHFFFAOYSA-N Phillyrin Natural products COc1ccc(cc1OC)C2OCC3C2COC3c4ccc(OC)c(OC5OC(CO)C(O)C(O)C5O)c4 JJVGFDTWFVSBIM-UHFFFAOYSA-N 0.000 claims description 2
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims description 2
- 229960003321 baicalin Drugs 0.000 claims description 2
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 239000002994 raw material Substances 0.000 abstract description 7
- 238000000605 extraction Methods 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
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- 229930194936 Tylosin Natural products 0.000 description 2
- 239000004182 Tylosin Substances 0.000 description 2
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- 238000002651 drug therapy Methods 0.000 description 2
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- 238000004806 packaging method and process Methods 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 2
- 229960004059 tylosin Drugs 0.000 description 2
- 235000019375 tylosin Nutrition 0.000 description 2
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- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 238000007619 statistical method Methods 0.000 description 1
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- 230000003612 virological effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a medicinal composition for preventing and treating infectious bronchitis of chicken as well as a preparation method and application thereof. The medicinal composition is prepared from the following raw material medicines in parts by weight: 1-3 parts of a baikal skullcap root extract, 1-3 parts of a weeping forsythia capsule extract and 10-30 parts of largehead atractylodes rhizome. The preparation method of the medicinal composition comprises the following steps: a, weighing the baikal skullcap root extract, the weeping forsythia capsule extract and a largehead atractylodes rhizome medicinal material in weight proportions respectively; b, picking the largehead atractylodes rhizome medicinal material, adding water for decoction and extraction, filtering, concentrating and drying for later use; and c, uniformly mixing the baikal skullcap root extract, the weeping forsythia capsule extract and a largehead atractylodes rhizome extract, and then adding pharmaceutically acceptable auxiliary materials or auxiliary components to prepare a pharmaceutically commonly-used preparation. The invention also provides application of the medicinal composition in preparation of medicines for preventing and treating infectious bronchitis of chicken. Compared with clinically commonly-used anti-viral or anti-bacterial medicines, the medicinal composition prepared by using the method provided by the invention is significant in curative effect, and ensures that the cure rate can reach 98%, so that a brand-new medicinal composition for treating infectious bronchitis of chicken can be provided for veterinary clinical sciences.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition preventing and treating infectious bronchitis of chicken and its production and use, belong to drug world.
Background technology
Infectious bronchitis of chicken (Infectious bronchitis, IB) be the viral disease that a kind of acute, the high degree in contact of the chicken that caused by infectious bronchitis virus (Infectious bronchitisvirus, IBV) infects.Infected chicken clinical symptoms shows as cough, sneeze, trachea rale, price of deed decline, productivity's forfeiture, mortality rate increase etc.Laying hen infects this after being ill, and egg production reduces greatly, and protein quality declines fairly obvious.One of serious infectious diseases of this Bing Shi serious harm world aviculture, primary disease is popular throughout the year, but the most serious for cold season with Winter-Spring, and this disease has spread to national most area at present, causes huge economic loss to poultry husbandry.Because the serotype of IBV is more, variation is fast, and each strain Virulence Difference is large, and between strain, cross-protection is low, brings larger difficulty to the preventing and controlling of this disease.
The treatment of this disease at present adopts the biochemical drugs such as interferon, immunoglobulin, immune ribonucleic acid to treat more, there is price costly, the shortcomings such as curative effect is not remarkable.In recent years, explore the attention that cheap, eutherapeutic treatment by Chinese herbs infectious bronchitis is more and more subject to veterinary clinic, as the treatment adopting the Chinese medicine with heat-clearing and toxic substances removing and relieving cough and resolving phlegm to carry out this disease, achieve certain curative effect.
Radix Scutellariae, Fructus Forsythiae have effect of heat-clearing and toxic substances removing, and the Rhizoma Atractylodis Macrocephalae has effect of spleen invigorating and dampness, are used for the treatment of the diseases such as the heating of poultry epidemic febrile disease, cough due to lung-heat clinically.The pharmaceutical composition of existing control infectious bronchitis of chicken mostly is one or both the large prescription comprised in Radix Scutellariae, Fructus Forsythiae, the Rhizoma Atractylodis Macrocephalae three kinds of primary crude drugs, not yet has with the pharmaceutical composition of Radix Scutellariae extract, Fructus Forsythiae extract and the Rhizoma Atractylodis Macrocephalae control infectious bronchitis of chicken that is prescription.
Summary of the invention
Technical scheme of the present invention there is provided a kind of pharmaceutical composition preventing and treating infectious bronchitis of chicken and its production and use.
The invention provides a kind of pharmaceutical composition preventing and treating infectious bronchitis of chicken, it is prepared from by the raw material of following weight proportioning:
Radix Scutellariae extract 1-3 part, Fructus Forsythiae extract 1-3 part, Rhizoma Atractylodis Macrocephalae 10-30 part.
Wherein, 85.0% is no less than containing baicalin in Radix Scutellariae extract; Be no less than 6.0% containing forsythiaside A in Fructus Forsythiae extract, phillyrin is no less than 0.5%.
Preferably, the weight proportion of raw material is:
Radix Scutellariae extract 1 part, Fructus Forsythiae extract 2 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.
Pharmaceutical composition prepared by the present invention is by the protogenic medicinal powder of the Rhizoma Atractylodis Macrocephalae, water or extractive with organic solvent, adds Radix Scutellariae extract and Fructus Forsythiae extract as active component, adds pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
Wherein, described preparation is decoction, powder, granule, mixture, tablet or capsule.
Present invention also offers a kind of method preparing described pharmaceutical composition, it comprises the steps:
A. the Radix Scutellariae extract of each weight proportion, Fructus Forsythiae extract, Rhizoma Atractylodis Macrocephalae is taken;
B. get Rhizoma Atractylodis Macrocephalae, add 20 times amount water boiling and extraction 3 times, each 1.5 hours, filter, filtrate concentrates, and drying under reduced pressure is for subsequent use;
C., after Rhizoma Atractylodis Macrocephalae extract mix homogeneously Radix Scutellariae extract, Fructus Forsythiae extract and step b obtained, add pharmaceutically acceptable adjuvant or complementary composition and be prepared into pharmaceutically conventional preparation.
Present invention also offers the purposes of this pharmaceutical composition in the medicine of preparation control infectious bronchitis of chicken.
Radix Scutellariae extract, Fructus Forsythiae extract, the Rhizoma Atractylodis Macrocephalae three kinds of medicines are carried out combination and are used for the treatment of infectious bronchitis of chicken by the present invention, compare with antibacterials with clinical conventional antiviral, evident in efficacy, cure rate reaches 98%, for veterinary clinic provides a kind of pharmaceutical composition for the treatment of infectious bronchitis of chicken completely newly.
Below by way of detailed description of the invention, the present invention is described in further detail, but do not limit the present invention, the various change that those skilled in the art make according to the present invention and replacement, only otherwise depart from spirit of the present invention, all should belong to the scope of claims of the present invention.
Detailed description of the invention
The preparation of embodiment 1 pharmaceutical composition of the present invention
Raw material is taken according to following weight proportioning:
Radix Scutellariae extract 1g, Fructus Forsythiae extract 1g, Rhizoma Atractylodis Macrocephalae 10g;
Preparation method:
A. the Radix Scutellariae extract of each weight proportion, Fructus Forsythiae extract, Rhizoma Atractylodis Macrocephalae is taken;
B. get Rhizoma Atractylodis Macrocephalae, add 20 times amount water boiling and extraction 3 times, each 1.5 hours, filter, filtrate concentrates, and drying under reduced pressure is for subsequent use.
C. add starch to 100g, mix homogeneously after Rhizoma Atractylodis Macrocephalae extract mix homogeneously Radix Scutellariae extract, Fructus Forsythiae extract and step b obtained, packaging, to obtain final product.
The preparation of embodiment 2 pharmaceutical composition of the present invention
Raw material is taken according to following weight proportioning:
Radix Scutellariae extract 1g, Fructus Forsythiae extract 1g, Rhizoma Atractylodis Macrocephalae 20g;
Preparation method is with embodiment 1.
The preparation of embodiment 3 pharmaceutical composition of the present invention
Raw material is taken according to following weight proportioning:
Radix Scutellariae extract 1g, Fructus Forsythiae extract 2g, Rhizoma Atractylodis Macrocephalae 10g;
Preparation method is with embodiment 1.
The preparation of embodiment 4 pharmaceutical composition of the present invention
Raw material is taken according to following weight proportioning:
Radix Scutellariae extract 1g, Fructus Forsythiae extract 2g, Rhizoma Atractylodis Macrocephalae 10g;
Preparation method:
A. the Radix Scutellariae extract of each weight proportion, Fructus Forsythiae extract, Rhizoma Atractylodis Macrocephalae is taken;
B. get Rhizoma Atractylodis Macrocephalae, add 20 times amount water boiling and extraction 3 times, each 1.5 hours, filter, filtrate concentrates, and extractum is for subsequent use;
C. after Rhizoma Atractylodis Macrocephalae extractum mix homogeneously Radix Scutellariae extract, Fructus Forsythiae extract and step b obtained, add purified water and be settled to 100ml, mix homogeneously, add 0.2% sodium benzoate, adjust ph is 6.5-7.0, and packaging, sterilizing, to obtain final product.
Above-mentioned Radix Scutellariae extract, Fructus Forsythiae extract are standby by the metric system of " People's Republic of China's veterinary drug allusion quotation " 2010 editions second Radix Scutellariae extracts, Fructus Forsythiae extract.
Beneficial effect of the present invention is proved below by way of specific experiment.
The clinical verification of experimental example 1 medical treatment infectious bronchitis of chicken of the present invention is tested
(1) Experimental agents
The medicine that sample 1 is prepared according to embodiment 1
The medicine that sample 2 is prepared according to embodiment 2
The medicine that sample 3 is prepared according to embodiment 3
The medicine that sample 4 is prepared according to embodiment 4
(2) laboratory animal is selected and grouping
Choose in clinical 30 ages in days, the symptoms such as performance rhinorrhea, dyspnea, sneeze, are diagnosed as the chickling of infectious bronchitis of chicken as clinical trial object, amount to 300, be divided into 6 groups, often organize 50, be respectively 1,2,3,4 groups, sample, positive drug group and blank group.
(3) medication and dosage
1,2,3,4 groups, sample respectively spice gives corresponding medicine (daily measure and count 0.01g/kg body weight with Radix Scutellariae extract), positive drug group gives tylosin Drug therapy (daily amount is 0.01g/kg body weight), blank group does not give any Drug therapy, successive administration 7 days.
(4) test index and method
Respectively at during administration and administration complete after in 7 days, observe clinical symptoms and the Cure of each group of ill chicken, the indexs such as statistical analysis cure rate, mortality rate.
(5) result of the test and analysis
Table 1 clinicing symptom observation result
From clinicing symptom observation result, matched group is under non-administrations, in group, the disease of the respiratory symptom such as rhinorrhea, dyspnea, sneeze of chickling continues the time is 13 days, it is 10 days that the respiratory symptom disease given after tylosin treatment continues the time, and respiratory symptom disease continues the time and greatly reduces after giving sample 1-4 group, concentrate on about 6-7 days, interpret sample 1-4 group all has the effect significantly alleviating infectious avian bronchitis acute attack symptom, and curative effect is better than positive drug group.
Table 2 clinical test results
From clinical verification result of the test, matched group mortality rate is 22%, and the mortality rate of positive drug group is 12%, the mortality rate of sample 1-4 group reduces greatly, all protect disease below 5%, all have the curative effect of significant treatment infectious avian bronchitis, curative effect is better than positive drug group.In his-and-hers watches, data carry out X 2 test, result shows, positive drug group is compared with matched group, there is significant difference (P<0.05), 1,2,3,4 groups, administration sample is compared with matched group, there is pole significant difference (P<0.01), optimum with the curative effect of 3,4 groups, administration sample, can 98% be reached to the cure rate of infectious avian bronchitis.Wherein, at crude drug weight proportion be: the drug effect of Radix Scutellariae extract 1 part, Fructus Forsythiae extract 2 parts, the Rhizoma Atractylodis Macrocephalae 10 parts is best.
Claims (6)
1. prevent and treat a pharmaceutical composition for infectious bronchitis of chicken, it is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Radix Scutellariae extract 1-3 part, Fructus Forsythiae extract 1-3 part, Rhizoma Atractylodis Macrocephalae 10-30 part;
Wherein, 85.0% is no less than containing baicalin in Radix Scutellariae extract; Be no less than 6.0% containing forsythiaside A in Fructus Forsythiae extract, phillyrin is no less than 0.5%.
2. pharmaceutical composition according to claim 1, is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Radix Scutellariae extract 1 part, Fructus Forsythiae extract 2 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.
3. pharmaceutical composition according to claim 1 and 2, it is characterized in that: it is by the protogenic medicinal powder of the Rhizoma Atractylodis Macrocephalae, water or extractive with organic solvent, add Radix Scutellariae extract and Fructus Forsythiae extract as active component, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
4. the pharmaceutical composition according to claim 1-3 any one, is characterized in that: described preparation is decoction, powder, granule, mixture, tablet or capsule.
5. prepare the method for the pharmaceutical composition described in claim 1-4 any one, it comprises the steps:
A. the Radix Scutellariae extract of each weight proportion, Fructus Forsythiae extract, Rhizoma Atractylodis Macrocephalae is taken;
B. get Rhizoma Atractylodis Macrocephalae, extracting in water, filter, concentrated, drying under reduced pressure, for subsequent use;
C., after Rhizoma Atractylodis Macrocephalae extract mix homogeneously Radix Scutellariae extract, Fructus Forsythiae extract and step b obtained, add pharmaceutically acceptable adjuvant or complementary composition and be prepared into pharmaceutically conventional preparation.
6. the purposes of the pharmaceutical composition described in claim 1-4 any one in the medicine of preparation control infectious bronchitis of chicken.
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| CN106377610A (en) * | 2016-11-21 | 2017-02-08 | 成都乾坤动物药业股份有限公司 | Pharmaceutical composition for preventing and treating livestock/poultry virus diseases and preparation method thereof |
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